Antidepressant Activity Thiab Metabolism Ntawm Cistanche Deserticola hauv Vivo Thiab hauv Vitro Ⅱ

2 Kev tshawb fawb txog kev ua haujlwm hauv vitro thiab hauv vivo metabolism ntawm Cistanche deserticola raws li cov metabolism hauv plab

Cov yam ntxwv uas cov tshuaj suav tshuaj feem ntau yog noj hauv qhov ncauj txiav txim siab tias qhov kev ua tau zoo ntawm cov tshuaj suav tshuaj muaj feem cuam tshuam rau nws txoj hnyuv. Nyob rau hauv xyoo tas los no, kev tshawb pom ntawm cov tshuaj hauv paus ntawm cov tshuaj suav tshuaj suav tshuaj raws li cov metabolism hauv plab thiab covantidepressant pharmacological mechanismraws li "lub plab-hlwb" axis tau nyiam ntau thiab ntau dua los ntawm cov kws tshawb fawb. Feem ntau, qhov muaj zog acidic ib puag ncig ntawm lub plab thiab lub xub ntiag ntawm pepsin tuaj yeem hydrolyze glycosides rau hauv cov suab thaj, theem nrab glycosides lossis aglycones, plab hnyuv plab enzymes (feem ntau yog pancreatic enzymes) hauv cov kua txiv hmab txiv ntoo ntawm cov hnyuv, thiab cov enzymes metabolic nyob rau hauv lub epithelial hlwb. lub plab hnyuv phab ntsa (xws li Muaj ntau theem 1 metabolic enzymes thiab theem Ⅱ metabolic enzymes), nrog rau cov enzymes metabolic uas ua los ntawm cov hnyuv, yuav ua rau ntau yam kev hloov pauv ntawm cov khoom xyaw hauv Suav tshuaj.

Nws yuav siv sij hawm ntev npaum li cas rau CISTANCHE ua haujlwm?

Yog li ntawd, txoj kev tshawb fawb txog cov txheej txheem ntawm lub plab zom mov biotransformation ntawm cov tshuaj suav tshuaj suav tshuaj yog qhov tseem ceeb rau elucidating lub hauv paus ntawm cov tshuaj suav tshuaj. Piv txwv li, cov kev tshawb fawb pharmacokinetic tau lees paub tias qhov ncauj qhov tsis muaj peev xwm bioavailability (F,%) ntawm echinaceaside, ib qho ntawm cov khoom xyaw tseem ceeb thiab cov khoom xyaw cim ntawm Cistanche deserticola, tsuas yog 0.83%, thiab nws T ... tsuas yog 15 feeb xwb. Tn yog 74.4 min…. Tsis tas li ntawd, nyob rau hauv Caco-2 qauv cell, txoj hnyuv permeability kuj tsawg heev (PPmm=0.98x10 cm')4. Qhov zoo li qhov tsis sib haum xeeb no qhia tau hais tias echinacea feem ntau yuav raug tsim tom qab cov metabolism hauv plab hnyuv. Cov metabolites nquag siv lawv cov teebmeem tshuaj tom qab tau nqus rau hauv tib neeg cov ntshav. Kev tshawb fawb qhia tau hais tias ... echinaceaside yog metabolized sai sai rau hauv caffeic acid (CA) thiab hydroxytyrosol (HT) hauv tib neeg txoj hnyuv kab mob, thaum caffeic acid yuav txuas ntxiv mus rau hauv cov kab mob hauv plab hnyuv. Nws yog 3-hydroxyphenylpropionic (3-HPP). Caffeic acid, 3-HPP, thiab hydroxytyrosol muaj tib yam antioxidant,anti-inflammatory, thiabneuroprotective biological kev ua ub noraws liechinaceasidethiablus verbascoside. Yog li, nws tuaj yeem xav tias phenylethanol glycosides yog cov tshuaj ua ntej. Tom qab kev tswj hwm qhov ncauj, nws tau metabolized los ntawm plab hnyuv mus rau hauv tib lub zog hydroxytyrosol thiab 3-HPP, uas tau nqus mus rau hauv cov ntshav thiab sib koom ua ke cov tshuaj siv tshuaj. Kev tshawb fawb ntawm cov metabolism hauv thiab sab nraud ntawm Cistanche deserticola decoction kua tau ua pov thawj tias nws cov tshuaj tseem ceeb yog phenylethanol. Los ntawm cov metabolism hauv plab hnyuv, glycosides tsim cov metabolites phenyl ethanol aglycone hydroxytyrosol thiab caffeic acid, thiab lawv cov derivatives 3-hydroxyphenyl propionic acid nrog tib yam kev ua si raws li cov qauv qauv thiab iridoid glycosides yog metabolized rau hauv lawv cov agly.

Piv nrog rau cov kab mob plab hnyuv ntawm cov neeg noj qab haus huv, cov txheeb ze ntawm Bacteroidetes, Proteobacteria, thiab Actinobacteria nyob rau hauv cov hnyuv ntawm cov neeg mob uas muaj kev nyuaj siab tau nce, thaum Firmicutes pom kev poob qis. Cov kev hloov pauv no, ntxiv rau kev cuam tshuam rau tus neeg mob lub cev lub cev, ua rau muaj kev cuam tshuam rau cov enzymes metabolic thiab lawv cov haujlwm ntawm ntau yam metabolic tshwm sim los ntawm cov hnyuv, yog li cuam tshuam rau tag nrho cov txheej txheem ntawm qhov ncauj tshuaj metabolism hauv plab hnyuv. Yog li ntawd, kev kawm txog lub plab zom mov metabolism ntawm Cistanche deserticola nyob rau hauv lub xeev pathological ntawm kev nyuaj siab muaj ntau qhov tseem ceeb hauv kev kho mob. Cov kev tshawb fawb tau pom tias qhov sib txawv ntawm cov metabolism hauv Cistanches tubularis extract hauv cov hnyuv ntawm cov nas ib txwm muaj thiab kev nyuaj siab yog feem ntau cuam tshuam hauv cov txheej txheem metabolic. Cov tshuaj tiv thaiv desugaring thiab isomerization cov tshuaj tiv thaiv muaj peev xwm ntawm cov kab mob hauv plab hnyuv ntawm cov nas pathological yog qhov tsis muaj zog dua li cov nas ib txwm muaj. Rat plab hnyuv flora, lub peev xwm metabolic ntawm lub plab hnyuv flora ntawm cov nas nyuaj siab yog qhov tsis muaj zog tshaj li cov nas ib txwm muaj. Qhov sib txawv ntawm cov metabolism hauv Cistanches tubulosa extract hauv cov nas ib txwm muaj thiab kev nyuaj siab tau pom tias feem ntau tshwm sim nyob rau hauv kev qeeb ntawm theem II metabolism thiab excretion tus nqi nyob rau hauv pathological nas. Yog vim li cas tej zaum yuav yog tias lub xeev pathological ntawm kev nyuaj siab ua rau txo qis hauv kev muaj peev xwm metabolic thiab cov metabolism hauv nas. Txo cov qib enzyme. Cov phenylethanoid glycosides nyob rau hauv Cistanche tubulosa tau metabolized los ntawm plab hnyuv flora ntawm kev nyuaj siab nas rau hauv hydroxytyrosol, caffeic acid (nrog rau kev ua kom muaj kev nyuaj siab), thiab 3-hydroxyphenylpropionic acid, thiab iridoid glycosides tau metabolized Raws li nws cov gastrointestinal metabolized, yooj yim dua absorbed los ntawm txoj hnyuv thiab mus rau hauv tib neeg cov ntshav rau exert tshuaj. Yog li, vim muaj kev hloov pauv ntawm cov kab mob hauv plab hnyuv thiab metabolic enzymes hauv lub cev nyob rau hauv cov xwm txheej pathological, muaj qee qhov sib txawv ntawm cov txheej txheem metabolic ntawm cov tshuaj hauv lub cev ib txwm muaj thiab hauv lub cev nyob rau hauv lub xeev pathological ntawm kev nyuaj siab. Feem ntau cov kev tshawb fawb metabolic tsuas yog tsom mus rau cov metabolism hauv lub cev ib txwm muaj, yog li kev soj ntsuam tus nqi ntawm cov ntaub ntawv tau txais tsawg heev. Kawm cov kev cai hauv thiab sab nraud cov metabolism hauv cov tshuaj nyob rau hauv cov xwm txheej pathological thiab muab piv nrog cov cai hauv thiab sab nraud cov metabolism hauv cov tshuaj hauv lub cev ib txwm muaj ntau qhov kev qhia tseem ceeb thiab muaj txiaj ntsig zoo rau kev nthuav dav ntawm cov tshuaj siv tshuaj thiab cov khoom siv cuam tshuam.

3 Kev xaus

Kev nyuaj siab yog ib qho kev puas siab puas ntsws uas tshwm sim los ntawm kev sib cuam tshuam ntawm ntau yam, uas ua rau tib neeg kev noj qab haus huv. Kev tshawb fawb txog nws txoj kev tiv thaiv thiab kev kho mob tau raug cuam tshuam vim tias cov txheej txheem tsis tau ua tiav tag nrho. Tam sim no, cov tshuaj nquag hauv kev kho mob tuaj yeem txhim kho cov tsos mob, tab sis tseem tsis muaj kev kho mob thiab muaj kev phiv loj heev. Tsoos suav tshuaj muaj kev nplua nuj nyob hauvtiv thaiv thiab kho kev nyuaj siab. Cistanche yog lub npe nrov tonic hauv cov tshuaj suav tshuaj. Nws cov kev ua haujlwm qub qub tau raug sau tseg rau hauvkho kev nyuaj siabthiab lwm yam kab mob neurological. Nyob rau tib lub sijhawm, nws yog cov tshuaj feem ntau siv raum-yang yav dhau los. Yog tias nws muaj cov tshuaj tiv thaiv kev ntxhov siab zoo thiab tuaj yeem daws qhov tsis txaus ntawm kev kho mob kev nyuaj siab thiab cov tshuaj uas twb muaj lawm thiab txhim kho kev sib deev tsis zoo, nws yuav muaj txiaj ntsig zoo rau kev tshawb fawb thiab daim ntawv thov tus nqi. Niaj hnub nimno pharmacology kuj tau lees paub tias nws cov tshuaj lom neeg tseem ceeb thiab cov extracts muaj zog tiv thaiv kev ntxhov siab. Yog li ntawd, nws yuav yog ib txoj hauv kev zoo los nrhiav cov tshuaj kho kev nyuaj siab uas tsis tshua muaj tshuaj lom neeg los ntawm cov tshuaj Cistanche deserticola. Nyob rau hauv tas li ntawd, raws li lub luag hauj lwm tseem ceeb ntawm gastrointestinal metabolism hauv kev ua tau zoo ntawm cov tshuaj, tag nrho elucidating lub hauv paus thiab mechanism ntawm nws antidepressant active tshuaj nyob rau hauv lub cev los ntawm lub foundations ntawm gastrointestinal metabolism yog ib qho tseem ceeb rau txoj kev loj hlob thiab kev loj hlob ntawm lub cev.Cistanche-related antidepressant tshuaj. qhov tseem ceeb.

Siv:

Whiteford HA, Degenhardt L, Rehm J, et al. Ntiaj teb lub nra ntawm tus kab mob tshwm sim los ntawm kev puas siab puas ntsws thiab kev siv yeeb tshuaj: kev tshawb pom los ntawm Kev Tshawb Fawb Ntiaj Teb Kev Tshawb Fawb Txog Kab Mob 2010. Lancet, 2013, 382(9904):1575-1586.

Collins PY, InselTR, Chockalingam A, Daar A, et al. Grand2 kev sib tw hauv ntiaj teb kev puas siab puas ntsws; kev koom ua ke hauv kev tshawb fawb, txoj cai, thiab kev coj ua. PLoS Medicine, 2013,10(4): el001434.

Strekalova T, Couch Y, Kholod N, et al. Hloov tshiab hauv cov txheej txheem ntawm kev ntxhov siab ntev ntev: kev tswj hwm sab hauv. Behav BrainFunct, 2011, 7:9.

Mathers C, Loncar D.Projections of global mortality and load of disease from 2002 to 2030. PloS Medicine, 2006, 3: e442.

Xue R, Jin ZL, Chen HX, et al. Antidepressant-zoo li cov teebmeem ntawm 071031B, ib qho tshiab serotonin thiab norepinephrine reuptake inhibitor.European Neuropsychopharmacology, 2013, 23(7): 728-741.

Schildkraut JJ, Catecholamine hypothesis ntawm kev puas siab puas ntsws: Kev tshuaj xyuas cov pov thawj txhawb. Phau ntawv Journal of Neuropsychiatry, 2006, 7(4):524-533.

Anderson I M. Meta-analytical kev tshawb fawb ntawm cov tshuaj tiv thaiv kev nyuaj siab tshiab. British Medical Bulletin, 2001,57(1):161-178.

Klerman GL, Cole J0.Clinical pharmacology ntawm imipramine thiab lwm yam tshuaj tiv thaiv kev nyuaj siab. International Journal of Psychiatry1967,17(4):267-304.

Steffens DC, Krishnan KR, Helms M J. Puas yog SSRIs zoo dua li TCAs? Kev sib piv ntawm SSRls thiab TCAs: kev tshuaj ntsuam meta. Kev nyuaj siab & Kev ntxhov siab, 1997, 6(1): 10.

10 Nutt D J. Lub neuropharmacology ntawm serotonin thiab noradrenaline hauv kev nyuaj siab.International Clinical Psychopharmacology,2002,17(1):1-12