Cistanche rau Txhim Kho Kev Nco

Cov kev tshawb fawb tau pom tias Cistanche tuaj yeem txhim kho kev nco tau zoo, suav nrog cov tib neeg ib txwm muaj, cov neeg mob tsis nco qab los ntawm kev siv yeeb tshuaj, cov neeg mob tsis nco qab los ntawm kev ua xua, thiab cov neeg mob uas tsis nco qab los ntawm kev haus dej ntau dhau. Cistanche tuaj yeem txhim kho kev nco ntawm cov neeg mob uas muaj vascular dementia tshwm sim los ntawm cerebral ischemia-reperfusion raug mob, thiab txhim kho kev nco tsis zoo los ntawm hydrocortisone.

Kev tshawb fawb xyoo tau pom tias Cistanche tuaj yeem txhim kho kev nco hauv plaub txoj hauv kev:

1. Tiv thaiv cov paj hlwb thiab inhibit paj hlwb apoptosis;

2. Txhawb kev loj hlob thiab kho cov paj hlwb;

3. Ua kom tso tawm cov neurotransmitters hauv lub hlwb;

4. Txhim kho cerebral ncig.

Cov kev tshawb fawb tsis ntev los no tau pom tias cov nyhuv neuroprotective ntawm Cistanche ua rau nws yog "tus neeg sib tw zoo tshaj" rau kev txhim kho cov kab mob neurological. Cistanche cistanche yog nplua nuj nyob rau hauv echinacosides. Cov extract ntawm cistanche tau pom tias yuav ua rau cov paj hlwb kev loj hlob zoo synthesis hauv vivo thiab hauv vitro thwmsim, txhawb kev tso tawm ntawm lwm yam hauv lub hlwb, thiab txhim kho ntau lub hlwb ua haujlwm ntsig txog kev nco.

Anti Alzheimer tus kab mob

Cov kab mob tseem ceeb ntawm Alzheimer's kab mob yog nyob rau hauv lub paj hlwb cortex, uas yog ib tug degenerative kab mob ntawm lub hauv paus paj hlwb nrog kev loj hlob ntawm kev txawj ntse thiab kev nco impairment raws li lub ntsiab kev kho mob tshwm sim. Hauv cov neeg mob Alzheimer's disease, cerebral cortex shrinks, lub paj hlwb ntim qis, lub hlwb sulcus widens, thiab ventricles nthuav. Cov yam ntxwv tshwj xeeb tshaj plaws yog cov plaques senile (SPs) tsim los ntawm kev tso tawm ntawm amyloid-peptide (A) sab nraum lub paj hlwb cortex thiab hippocampal neurons. Lawv feem ntau faib nyob rau hauv lub cortex thiab yog ntom ntom extracellular deposits. Nws cov khoom tseem ceeb yog tsim los ntawm 39-43 amino acids) thiab txawv txav ntawm tau protein nyob rau hauv lub hlwb neurons tsim neurofibrillary tangle (NFT).

Cistanche glycosides (glycoside ntawm cistanche, GC) tuaj yeem txhim kho cov kev kawm thiab kev nco ntawm cov neeg mob Alzheimer's disease, txo cov ntsiab lus ntawm malondialdehyde (MDA) hauv cov ntaub so ntswg hauv hlwb, thiab nce glutathione peroxidase (GSH). -Px), superoxide dismutase (superoxide dismutase, SOD) kev ua haujlwm, txo acetylcholine esterase (acetylcholine esterase, TChE) kev ua, lub hlwb apoptosis tus nqi, thiab txo cov calcium tsub zuj zuj hauv lub hlwb. Lub tshuab yog tias tag nrho glycosides ntawm cistanche txhim kho kev ua haujlwm ntawm cov dawb radical scavenging enzymes, txo cov lipid peroxidation cov tshuaj tiv thaiv, txo cov calcium cov ntsiab lus ntawm lub paj hlwb, thiab inhibits apoptosis ntawm hlwb hlwb induced los ntawm QA; cov txheej txheem ntawm kev ua haujlwm kuj tseem cuam tshuam nrog kev ua haujlwm antioxidant ntawm tag nrho glycosides ntawm cistanche. Tag nrho cov glycosides ntawm cistanche tuaj yeem muaj kev tiv thaiv zoo ntawm ultrastructure ntawm hippocampus hauv cov neeg mob Alzheimer's. Tag nrho glycosides ntawm cistanche tuaj yeem ncua kev laus thiab tiv thaiv thiab kho Alzheimer's kab mob los ntawm kev siv tshuaj antioxidant.

Cistanche extract tuaj yeem ua kom cov protein qhia qib ntawm nicotinic acetylcholine receptor (nAChR) 3 thiab 7 receptor subunits hauv SH-SY5Y hlwb, thiab tiv thaiv qib ntawm 3 thiab 7 receptor subunits tshwm sim los ntawm A 25-35 Qhov txo qis ntawm A tuaj yeem txo qis. kev puas tsuaj ntawm tes thiab nce lipid peroxidation theem tshwm sim los ntawm A; Nws kuj tseem tuaj yeem txhawb nqa axon kev loj hlob ntawm pheochromocytoma (PC12) hlwb hauv cov neeg mob Alzheimer's kab mob, thiab nce lub hlwb ntawm cov neeg mob Alzheimer's disease. Qib ntawm cov paj hlwb loj hlob (NGF) hauv glioma (Gioomas, C6) hlwb, nrog rau kev loj hlob ntawm hippocampal axon, neuronal sib txawv, thiab synapse tsim nyob rau hauv lub hippocampus ntawm cov neeg mob Alzheimer's kab mob, thiab tuaj yeem ua rau Alzheimer's secretion ntawm NGF hauv cerebral cortex thiab hippocampus ntawm cov neeg mob uas muaj Alzheimer's tus kab mob no txhim kho txoj kev kawm thiab kev nco muaj peev xwm ntawm cov neeg mob Alzheimer's disease. Cov teebmeem no qhia tau hais tias Suav tshuaj Cistanche extract yog ib yam khoom zoo heev rau kev kho Alzheimer's disease.

Echinacoside (echinacoside), cov ntsiab lus siab tshaj ntawm cistanche phenethyl cawv glycosides (PhG), tuaj yeem ua rau kom tag nrho cov ntsiab lus ntawm cov protein thiab tag nrho cov antioxidant muaj peev xwm ntawm lub hlwb, txo cov kev ua ntawm acetylcholinesterase thiab cov ntshav qab zib interleukin -2 (IL- 2). ) Cov ntsiab lus: Verbascoside, cov ntsiab lus tseem ceeb ntawm Cistanche phenoxyethanol glycosides, muaj kev tiv thaiv ntawm SH-SY5Y cytotoxicity los ntawm A 25-35, uas tuaj yeem txhim kho cell ciaj sia taus, txo cov cell apoptosis thiab tsim cov pa oxygen reactive hom, thiab inhibit hlwb Kev tso tawm cov xim c, qhov txo qis ntawm mitochondrial membrane muaj peev xwm thiab tshem tawm ntawm caspase -3; Cov teebmeem ntawm tubulin B thiab echinacoside ntawm qog necrosis factor-alpha (TNF) - ) SH-SY5Y paj hlwb apoptosis tshwm sim los ntawm SH-SY5Y muaj cov nyhuv cytoprotective. Cov kev tshawb fawb saum toj no qhia tias cov tshuaj monomer no tuaj yeem dhau los ua cov tshuaj zoo rau kev kho mob Alzheimer's.

Anti-Parkinson tus kab mob

Parkinson's disease yog ib yam kab mob loj heev uas muaj extrapyramidal dysfunction hauv nruab nrab paj hlwb. Tus kab mob no muaj ntau dua rau cov neeg laus thiab cov laus. Cov neeg mob uas muaj tus kab mob Parkinson muaj ntau cov tsos mob, xws li mob leeg, dyskinesia, postural cuam tshuam, thiab lwm yam.

Phenylethanoid glycoside extract hauv Cistanche deserticola tuaj yeem txhim kho qhov muaj pes tsawg leeg ntawm 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP)-induced PD qauv C57 nas coj cwj pwm cov yam ntxwv, nce substantia nigra tyrosine hydroxylase (tyrosine hydroxylase, TH) mus txog thiab DA cov ntsiab lus hauv striatum ntawm cov neeg mob Parkinson's disease. Tsis tas li ntawd, cistanche phenyl ethanol glycoside extract muaj qhov cuam tshuam zoo ntawm kev poob qis ntawm cerebellar granule cell viability nyob rau hauv cov neeg mob Parkinson tus kab mob thiab tiv thaiv MPP ntxiv rau induced cell apoptosis ntawm cerebellar granule neurons los ntawm inhibiting lub activation ntawm caspase -3 thiab caspase-8. Tuag, exert nws anti-apoptotic nyhuv.

Echinacoside tuaj yeem txhim kho kev coj tus cwj pwm tsis zoo ntawm MPTP-induced PD qauv nas, nce striatal dopamine (DA) metabolite 3,4-dihydroxypheny lacetic acid (3,4-dihydroxypheny lacetic acid, DOPAC), thiab siab Vanillic acid (homovanillic acid, HVA) cov ntsiab lus tseem ceeb inhibits apoptosis ntawm cerebellar granule neurons tshwm sim los ntawm kev ua kom cov caspase-3 thiab caspase-8; txo qhov overexpression ntawm biliverdin reductase B nyob rau hauv lub hlwb ntawm Parkinson cov neeg mob, qhia Echinacoside yuav txo tau qhov nce ntawm biliverdin reductase B tshwm sim los ntawm oxidative kev nyuaj siab los ntawm nws anti-oxidative kev nyuaj siab, thiab tiv thaiv dopaminergic neurons los ntawm oxidative kev nyuaj siab puas. Nws cov txheej txheem tiv thaiv neuroprotective yuav zoo ib yam li cov kua tsib Cov qib ntawm chlorophyll reductase B muaj feem xyuam; txo cov dopaminergic neurons thiab dopamine transporters nyob rau hauv lub substantia nigra ntawm lub paj hlwb ntawm cov neeg mob Parkinson tus kab mob, thiab tuaj yeem txhim kho neurotrophic factor [neurotrophic factor, NTF. hlwb-derived neurotrophic factor, BDNF) thiab paj hlwb Cov kev ua ub no thiab cov protein qhia theem ntawm glial cell line-derived neurotrophic factor (GDNF) muab tau los ntawm glial cell kab tuaj yeem txo qhov piv ntawm mRNA thiab protein nyob rau hauv apoptosis thiab Bax / Bcl {{10} }. Tsis tas li ntawd, echinacoside tuaj yeem nce cov ntsiab lus ntawm dopamine, DOPAC, thiab HVA hauv cov kua dej ntxiv ntawm cov striatum ntawm cov neeg mob Parkinson's disease.

Acteoside tuaj yeem txhim kho kev coj tus cwj pwm ntawm cov neeg mob Parkinson tus kab mob, nce cov ntsiab lus ntawm dopamine transmitters thiab tus naj npawb ntawm dopaminergic neurons, thiab qib ntawm a-synuclein protein nyob rau hauv substantia nigra striatum. Verbascum glycosides tuaj yeem ua rau SH hauv rotenone -SY5Y cell raug mob muaj cov nyhuv neuroprotective, thiab nws cov txheej txheem ntawm kev ua yog cuam tshuam txog kev txo qis ntawm cov kab mob Parkinson cov proteins uas cuam tshuam thiab inhibiting kev tsim ntawm -synuclein dimers; verbascoside tuaj yeem txo qhov kev raug mob SH-SY5Y cuam tshuam los ntawm neurotoxin MPP ntxiv rau qib ntawm cov pa oxygen reactive, nce qib ntawm Bcl-2, thiab txo cov kev ua ntawm caspase-3 qhia tias cov compound tuaj yeem ua tau zoo. inhibit qhov apoptosis ntawm SH-SY5Y hlwb. Cov txheej txheem ntawm kev ua yog txo qis qib ntawm intracellular reactive oxygen hom thiab inhibit caspase{11}}. Kev ua haujlwm muaj feem xyuam nrog kev tswj xyuas lub zog siab ntawm mitochondrial membrane peev xwm; verbascoside tuaj yeem muaj qhov pom tseeb cytoprotective cuam tshuam rau lub hlwb apoptosis hauv cov neeg mob Parkinson tus kab mob, thiab tuaj yeem tiv taus Parkinson tus kab mob.

Cov monomer compound campneoside II hauv Cistanche muaj cov teebmeem cytoprotective rau cerebellar granule cell apoptosis hauv cov neeg mob Parkinson's disease. Tubuloside B muaj cov nyhuv inhibitory zoo ntawm lub hlwb apoptosis thiab tiv thaiv oxidative kev nyuaj siab rau cov neeg mob Parkinson's disease. Cov tshuaj no tuaj yeem siv los kho tus kab mob Parkinson.

★ Chengdu Wecistanche Bio-Tech Co., Ltd (Wecistanche),

uas tau txhawb nqa nrog kev siv tshuab thiab peev, ua rau kev lag luam ntawm Xinjiang Cistanche thiab nplai, lub sijhawm no txhim kho tus nqi ntawm daim ntawv thov thiab ua kom muaj kev loj hlob ruaj khov thiab noj qab nyob zoo. Nws tsis tsuas yog ua rau muaj txiaj ntsig kev lag luam ntau rau cov neeg nyob hauv thaj chaw txom nyem tab sis kuj ua tiav cov txiaj ntsig tseem ceeb ntawm ecological, tsim cov qauv tshiab ntawm kev tswj xyuas kom ruaj khov ntawm cov suab puam nrog Suav cov yam ntxwv nrog rau kev txo qis kev txom nyem hauv thaj chaw suab puam.

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