Echinacoside yog dab tsi thiab cov txiaj ntsig ntawm Echinacoside yog dab tsi?

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Echinacosideyog ib qho ntawm cov tseem ceeb ntawm Cistanche tubulosa. Cov mis mos molecular ntawm echinacoside: C35H46O20; molecular hnyav: 786.72; Cov khoom ntawmEchinacoside:dawb crystalline hmoov, soluble nyob rau hauv methanol, ethanol, dej kub, me ntsis soluble nyob rau hauv ethyl acetate, muab tau los ntawm rhizomes ntawm Cistanche thiab liab doog daisy.EchinacosideFeem ntau muab rho tawm los ntawm Cistanche, Nws yog phenylethanoid glycoside compound.

Echinacoside

Echinacosideyog ib yam khoom muaj txiaj ntsig zoo hauv Suav teb, uas muaj ntau yam tshuaj siv tshuaj xws li tshuaj tiv thaiv oxidation, tiv thaiv kab mob, neuroprotection, txhim kho kev kawm thiab nco, tiv thaiv qog, tiv thaiv daim siab, thiab lwm yam, yog li nws tuaj yeem siv rau hauv kev kho mob. ntau yam kab mob. Cov kev tshawb fawb niaj hnub no tau qhia tiasechinacoside cov tshuajnkag mus rau tib neeg lub cev los txhawb lub raum, noj cov ntsiab lus, thiab tiv thaiv lub siab kom ua tiav ntau yam tshuaj. Pharmacological kev tshawb fawb ntawm cov teebmeem ntawmechinacoside cov tshuajtau pom tias echinacoside tuaj yeemtiv thaiv oxidationthiabanti-aging, nwstiv thaiv neuronsthiabibti-inflammatory, nws thiabtxhawb txoj kev kho ntawm qhov txhab, tiv thaiv daim siab, tiv thaiv cov pob txha, tshuaj tiv thaiv qog, nws muajimmunomodulatoryteebmeem,echinacoside cov tshuajntxiv rau cov teebmeem saum toj no Ntxiv rau, nws kuj muajanti-apoptosisthiabtshuaj tiv thaiv mob ntshav qab zibteebmeem.

Echinacoside tiv thaiv daim siab

Pharmacological teebmeem ntawm echinacoside tau lees paub los ntawm kev tshawb fawb hauv qab no:

(1) Antioxidant nyhuv

Sib piv cov teebmeem inhibitory ntawm alkyl amides, polysaccharides, thiab caffeic acid derivatives hauvEchinacosideNyob rau hauv oxidation ntawm tib neeg tsawg-density lipoproteins nyob rau hauv vitro, nws tau pom tias ua ke ntawmEchinacosidethiab alkyl amides los yog macromolecular polysaccharides muaj cov nyhuv antioxidant, uas yog, cov nyhuv lom ntawm Echinacoside. Qhov kev ua si yog synergistically tsim los ntawm ntau yam khoom xyaw hauv nws qhov kev npaj.Echinacosideplays lub luag haujlwm tseem ceeb hauv kev tiv thaiv DNA los ntawm kev puas tsuaj. Hauv luv luv, ntau cov kev tshawb fawb tau pom tiasEchinacosideyog ib tug zoo natural antioxidant.

(2) Neuroprotection

Echinacosidemuaj kev tiv thaiv tseem ceeb ntawm apoptosis ntawm paj hlwb SHSY5Y vim los ntawm qog necrosis factor (TNF- ). Nws cov txheej txheem yog tswj hwm kev ua haujlwm ntawm mitochondria los ntawm cov teebmeem antioxidant, txo cov qib ntawm intracellular reactive oxygen hom, inhibit qhov kev ua ntawm caspase-3 Thiab tswj lub zog siab ntawm mitochondrial membrane muaj peev xwm. Txij li thaumEchinacosidemuaj zog tiv thaiv apoptotic kev ua si, nws yuav siv tau los kho cov kab mob neurodegenerative thiab paj hlwb xws li neuronal apoptosis.

(3) Txhim kho kev kawm thiab kev nco

Echinacosidemuaj cov nyhuv los tiv thaiv kev laus, thiab nws cov txheej txheem yog tias nws tuaj yeem cuam tshuam O2-•, OH•, thiab lwm yam dawb radicals, thiab tib lub sijhawm tuaj yeem ua kom cov haujlwm ntawm GSH-Px thiab SOD, thiab txo cov ntsiab lus ntawm MDA. . Vim qhov inhibition ntawm MAO kev ua haujlwm, lub cim xeeb ntawm cov nas tau txhim kho. Cov txiaj ntsig ntawm qhov kev tshawb fawb no qhia tias qhov cuam tshuam ntawmEchinacosidentawm kev tiv thaiv lipid peroxidation thiab txhim kho kev laus muaj feem xyuam rau nws cov haujlwm antioxidant.Echinacosidetuaj yeem txhim kho kev kawm thiab kev nco muaj peev xwm ntawm SAM-P / 8 nas los ntawm kev txhim kho kev ua haujlwm ntawm lub hauv paus cholinergic system, ua kom tag nrho cov antioxidant muaj peev xwm, txhawb nqa cov protein thiab nucleic acid synthesis, thiab tswj kev tiv thaiv kab mob.

Ehinacoside hauv cistanche tuaj yeem txhim kho kev nco

(4) Anti-inflammatory nyhuv

(5) Anti-tumor nyhuv

Cov kev tshawb fawb tau lees tias covechinacoside cov tshuajlos ntawm cistanche inhibits kev loj hlob ntawm cov qog hlwb, Nws tuaj yeem ua rau qog cell apoptosis los ntawm kev thaiv cov hlwb hauv S theem.Echinacosidetxhawb txoj kev ua kom TGF- 1/Smad signaling pathway thiab nce qib kev qhia ntawm Bax/Bcl-2. Ntxiv mus,Echinacosidetuaj yeem ua rau kev tso tawm ntawm mitochondrial Cyto C, thiab ua rau cov tshuaj tiv thaiv Caspases qib.

Echinacoside Anti-tumor

(6) tiv thaiv daim siab

Verbascum glycosides, isoverbasin glycosides, 2'-acetyl Verbascum glycosides thiabechinacoside cov tshuajtau los ntawm Cistanche deserticola muaj cov haujlwm tseem ceeb hauv hepatoprotective.

(7) Immunomodulatory nyhuv

Echinacosidesmuaj kev tswj cov teebmeem thiab kev tiv thaiv kab mob ntawm tib neeg lub cev tiv thaiv kab mob.EchinacosideCov tebchaw tuaj yeem txhim kho tus nqi ntawm hemolysin thiab fibrinogen thiab muaj zog ntxiv rau lub cev tsis muaj zog tiv thaiv kab mob.

Echinacoside txhim kho kev tiv thaiv kab mob