Kawm Txog Echinacoside Ntawm Cistanche hauv Kev Kho Mob Ntshav Qab Zib nephropathy

Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com

Lub pathogenesis ntawmntshav qab zib nephropathynyuaj. Tam sim no, cov neeg mob nrogntshav qab zib nephropathytseem tsis muaj txoj kev kho mob zoo. Nrhiav cov tshuaj zoo tshiab yog tus yuam sij rau kev kho mob ntshav qab zib nephropathy.Echinacoside(ECH)hauvCistancheyog ib qho ntawm cov khoom xyaw zoo ntawm Cistanche extract, uas muaj cov nyhuv tiv thaiv lub raum. Cov kev tshawb fawb pharmacological niaj hnub tau pom tiasEchinacosidehauvCistanchemuaj anti-oxidation, anti-apoptosis, anti-inflammatory, thiab pharmacological teebmeem xws li kev txhim kho cov ntshav khiav thiab microcirculation. Nws tuaj yeem tswj hwm lub cev cov piam thaj hauv cov metabolism, txhim kho cov piam thaj siab, thiab muaj txiaj ntsig ntawm kev kho mobntshav qab zib nephropathy.

Echinacoside hauv Cistanche tuaj yeem kho mob ntshav qab zib nephropathy

Nyob rau hauv xyoo tas los no, kev tshawb fawb tau pom tiasEchinacosidehauvCistanchetuaj yeem cuam tshuam qhov Transforming Growth Factor (TGF-) signaling pathway, inhibit lub raum fibrosis hauvntshav qab zib nephropathynas, thiab tiv thaiv nas raum cov ntaub so ntswg.EchinacosidehauvCistanchemuaj txiaj ntsig zoo rau lub raum fibrosis thiab lub raum cov ntaub so ntswg apoptosis hauvntshav qab zib nephropathynas thiab nws lub peev xwm mechanism.EchinacosideHauv Cistanche muaj txiaj ntsig zoo rau kev kho mob ntshav qab zib nephropathy.

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Echinacoside hauv kev kho mob ntshav qab zib nephropathy

"Kev tiv thaiv ntawm Echinacoside ntawm Cistanche ntawm lub raum ua haujlwm, lub raum cov ntaub so ntswg thiab mesangial cell puas nyob rau hauv nas nrog mob ntshav qab zib nephropathy" kev sim xaus:

Cov koob tshuaj qis Echinacoside tsis muaj kev cuam tshuam rau lub raum cov ntaub so ntswg ntawm nas nrogntshav qab zib nephropathy, thaum nruab nrab thiab high-doseEchinacosidetuaj yeem txhim kho cov kev hloov pauv pathological ntawm lub raum cov ntaub so ntswg hauv nas nrogntshav qab zib nephropathythiab txhim kho lub raum puas tsuaj:

1. Nyob rau hauv txoj kev tshawb no, qhov nruab nrab thiab siab koob tshuajEchinacosidehauvCistancheyuav ua rau kom lub cev loj ntawm nas nrogntshav qab zib nephropathylos ntawm kev txo cov ntshav qab zib thiab txo lawv cov dej kom tsawg, tso zis tso zis, thiab ceev cov ntshav qab zib.

2. Cov txiaj ntsig ntawm qhov kev tshawb fawb no qhia tiasEchinacosidentawmCistanchetuaj yeem txo cov ntshav qab zib, txhim kho lub raum ua haujlwm, txo cov ntshav creatinine, urea nitrogen, thiab cov zis microalbumin qib, thiab txhim kho lub raum cov ntaub so ntswg cell puas.

3. Nyob rau hauv txoj kev tshawb no, qhov nruab nrab thiab siab koob tshuajEchinacosidehauvCistanchetuaj yeem txo qis- tswj kev qhia ntawm Bax thiab Caspase-3 mRNA hauvntshav qab zib nephropathynas, thiab tswj kev qhia ntawm Bcl-2 mRNA. CovEchinacosidentawm Cistanche tuaj yeem cuam tshuam apoptosis ntawm ntau lub hlwb thiab tuaj yeem tiv thaiv lub raum cov ntaub so ntswg los ntawm kev puas tsuaj los ntawm inhibiting apoptosis ntawm lub raum cov ntaub so ntswg.

4. Nyob rau hauv txoj kev tshawb no, qhov nruab nrab thiab siab koob tshuajEchinacosidetuaj yeem txo qis- tswj cov kev qhia ntawm VCAM-1 cov protein nyob rau hauv cov kab mob ntshav qab zib nephropathy nas, thiab inhibit lub raum cov ntaub so ntswg cell apoptosis hauvntshav qab zib nephropathynas.

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5. Nyob rau hauv txoj kev tshawb no, qhov nruab nrab thiab siab koob tshuajEchinacosidetuaj yeem txo qis qib ntawm HA, TIMP-1 thiab LN hauvntshav qab zib nephropathynas, thiab inhibit qhov tshwm sim thiab kev loj hlob ntawm lub raum fibrosis.

6. Nyob rau hauv txoj kev tshawb no, qhov nruab nrab thiab siab koob tshuajEchinacosidehauvCistanchetuaj yeem txo qis- tswj kev qhia ntawm TGF- thiab -SMA proteins hauvntshav qab zib nephropathynas, thiab inhibit lub raum cov ntaub so ntswg fibrosis.

Cov ntsiab lus:Nyob rau hauv cov ntsiab lus, nruab nrab thiab siab koob tshuajEchinacosidehauvCistanchetuaj yeem txo cov ntshav qab zib hauv nas nrogntshav qab zib nephropathy. Nws tuaj yeem cuam tshuam lub raum interstitial fibers ntawm nas nrog ntshav qab zib nephropathy los ntawm inhibiting cov protein qhia ntawm TGF- thiab VCAM-1. Nws tuaj yeem txhim kho lub raum ua haujlwm ntawm nas los ntawm tshuaj lom neeg thiab lub raum cov ntaub so ntswg apoptosis.

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