Tshawb nrhiav Vim li cas poj niam thiaj li raug Alzheimer's Disease?

Pab neeg ntawm xibfwb Ye Keqiang (yav tas los tus xibfwb qhia ntawv ntawm Emory University) los ntawm Tsev Kawm Ntawv Lub Neej thiab Kev Noj Qab Haus Huv, Shenzhen University of Technology, Suav Academy ntawm Kev Tshawb Fawb tau luam tawm ib tsab xov xwm hauv phau ntawv journal Nature hu ua: FSH blockade txhim kho kev paub hauv nas nrog Alzheimer's disease, nthuav tawm thawj zaug uas follicle-stimulating hormone (Folllicle-Stimulating Hormone) -Hormone, FSH) yog ib qho tseem ceeb vim li cas cov poj niam muaj feem yuav mob Alzheimer's disease (AD) ntau dua li cov txiv neej.

Alzheimer's tus kab mob yog cov neeg tua neeg tuag nyob hauv lub Koom Haum Laus

Alzheimer's disease yog ib hom kab mob neurodegenerative nyob rau hnub nyoog uas feem ntau ua rau dementia rau cov neeg laus, nrog cov tsos mob xws li kev paub tsis meej, tsis nco qab, thiab kev coj cwj pwm txawv txav. Tam sim no muaj ntau dua 50 lab tus tib neeg tau kuaj pom tus kab mob Alzheimer's thoob ntiaj teb, thiab nrog kev tshwm sim ntawm cov neeg laus laus, tus lej no yuav tsum nce ntxiv mus rau 152 lab hauv xyoo 2050. Kev txheeb xyuas kwv yees tias 1 tus neeg raug kuaj mob Alzheimer's txhua txhua 3 vib nas this hauv lub ntiaj teb no. Kev tshawb fawb txog kab mob kis tau pom tias cov poj niam uas muaj tus kab mob Alzheimer yog ob zaug ntau dua li cov txiv neej, tab sis qhov ua rau ntawm qhov tshwm sim no tseem tsis tau paub meej txog tam sim no. Xibfwb Ye qhov kev tshawb fawb kom meej meej teb cov lus tsis meej no uas tau ua phem rau noob neej tau ntau xyoo.

Nyem rau cistanche salsa thiab Cistanche qia rau Alzheimer's kab mob

Ib txoj hauv kev tshiab los nrhiav cov kab mob ntawm Alzheimer's disease

Lub pathological tshwm sim ntawm Alzheimer's Disease yog qhov nyuaj heev. Cov txiaj ntsig ntawm kev kuaj mob hlwb qhia tau tias cov neeg mob Alzheimer's Disease feem ntau muaj senile plaques tsim los ntawm kev tso nyiaj ntau ntawm -amyloid (A) sab nraum lub hlwb paj hlwb, thiab intracellular neurofibrils tsim los ntawm kev txawv txav ntawm phosphorylation ntawm tau protein. Neurofibrillary tangles (NFTs), neuronal poob, neuronal dystrophy, synaptic poob, thiab lwm yam pathological tshwm sim, tab sis qhov cuam tshuam ntawm pathogenesis tseem tsis meej.

Xibfwb Ye pab pawg tau mob siab rau kev tshawb fawb txog cov kab mob pathogenesis, kev kuaj mob ntxov, thiab kev siv tshuaj kho cov kab mob neurodegenerative tau ntau xyoo. Raws li lub hauv paus ntawm kev sau cov ntsiab lus ua tiav ntawm pab pawg ntau pua ntawm cov ntaub ntawv kev kawm tiav, lawv tau npaj ib qho kev xav qub: kev ua kom CEBP / AEP txoj hauv kev yog ib qho tseem ceeb ntawm cov kab mob neurodegenerative. Qhov kev tshawb xav no suav nrog ntau yam Alzheimer's Disease pathogenic hypotheses tau npaj los ntawm cov neeg ua ntej, xws li A thiab Tau protein hypothesis, kev mob ntev mus ntev, thiab lwm yam, thiab yog ua ntej nyob rau hauv lub sij hawm lom neeg thiab ntau tshaj nyob rau hauv lub hauv paus ntsiab lus.

Kev xyaum tsis muaj theoretical qhia yog qhov tsis pom kev. Raws li qhov kev xav no, Prof. Ye's pab pawg tau kawm txog cov tshuaj hormones uas nws cov concentration sib txawv heev hauv cov poj niam ua ntej thiab tom qab lub cev tsis muaj zog thiab kuaj cov tshuaj hormones twg tuaj yeem xaiv txoj hauv kev CEBP / AEP. Thaum kawg, lawv nrhiav pom qhov tseem ceeb ntawm cov kab mob ntawm FSH. Thaum lub sij hawm perimenopausal ntawm cov poj niam, cov ntsiab lus ntawm FSH nyob rau hauv lub cev tau nce sharply mus rau ntau tshaj 10 lub sij hawm, thaum lub sij hawm ntawm FSH nyob rau hauv cov txiv neej laus nce li ntawm 3 npaug piv rau xyoo dhau los. Qhov nce ntxiv ntawm FSH khi rau FSH receptor (FSHR) ntawm lub paj hlwb thiab ua rau txoj hauv kev CEBP / AEP, uas ua rau muaj qhov nce ntawm A thiab cov kev hloov pauv pathological ntawm Tau, uas ua rau lub cim ntawm Alzheimer's Disease.

Pab neeg tshawb fawb tau tshawb fawb thiab tshuaj xyuas feem ntau los ntawm plaub qhov sib txawv thiab txoj hauv kev:

1. FSH-specific antibody (FSH-AB) tau txhaj tshuaj intraperitoneally rau hauv ovariectomized Alzheimer's Disease nas (tus qauv tsiaj uas simulates poj niam menopause), thiab tom qab thaiv cov nyhuv ntawm FSH, txoj kev downstream CEBP / AEP tsis tuaj yeem ua haujlwm tau zoo, yog li tias tus cwj pwm pathological ntawm nas tau txo qis thiab kev paub txog qib tau zoo rov qab rau qee yam;

2. Tshem tawm FSHR gene hauv cov neurons ntawm Alzheimer's Disease nas qauv, kom FSH tsis tuaj yeem khi rau cov receptor thiab yog li tsis tuaj yeem qhib txoj hauv kev, uas tuaj yeem txo cov tsos mob ntawm Alzheimer's Disease nas tom qab tshem tawm ntawm zes qe menyuam thiab txhim kho kev nco. rov qab los;

3. Knockout ntawm C/EBP nyob rau hauv Alzheimer's Disease nas qauv thiab inhibition ntawm CEBP / AEP txoj kev yuav txo tau cov pathological hloov ntawm Alzheimer's kab mob nyob rau hauv ovariectomized nas;

4. Cov kab mob Alzheimer's tus qauv nas tau txhaj nrog exogenous FSH, thiab nws tau pom tias kev tsim ntawm Alzheimer's Disease-related pathological hloov tau nrawm rau ob leeg poj niam thiab txiv neej nas nrog FSH.

Cov txiaj ntsig saum toj no tag nrho qhia tias nws yog qhov tseeb vim qhov nce ntawm FSH hauv cov poj niam thaum lub sijhawm perimenopause (qhov txawv ntawm cov txiv neej), uas ua rau txoj hauv kev tshwj xeeb CEBP / AEP tom qab khi rau cov receptor (FSHR), yog li ua rau cov poj niam raug mob. rau Alzheimer's Disease.

Raws li kev ua tiav ntawm kev ua tiav thiab kev xav hauv kaum xyoo dhau los, Xibfwb Ye pab pawg tau pom cov tshuaj hormone FSH, uas hloov pauv hauv cov poj niam perimenopausal concentration, thiab thaum kawg pom qhov ua rau thiab cov txheej txheem ntawm AD kab mob los ntawm cov tshuaj tshwj xeeb. Qhov kev tshawb pom no ntxiv txheeb xyuas qhov tseeb ntawm txoj kev xav. Cov kauj ruam tom ntej yuav yog los ua qhov kev tshawb fawb tob tob txog kev sib raug zoo ntawm cov noob caj noob ces tshwj xeeb xws li ApoE4 thiab FSH los piav qhia vim li cas poj niam cov neeg nqa khoom ntawm ApoE4 muaj kev cuam tshuam ntau dua rau cov kab mob. Tam sim no. Cov tshuaj tiv thaiv tshwj xeeb rau FSH yog nyob rau hauv kev tshawb fawb ua ntej, nrog rau kev pom kom paub txog kev kho mob tshiab rau Alzheimer tus kab mob nyob rau yav tom ntej.

Cistancheglycosides(glycoside ntawm cistanche, GC) tuaj yeem txhim kho qhovkev kawmthiabncotheem ntawm cov neeg mob nrogAlzheimer tus kab mobkab mob, txo cov ntsiab lus ntawm malondialdehyde (MDA) hauv cov ntaub so ntswg hlwb, thiab nce glutathione peroxidase (GSH). -Px), superoxide dismutase (superoxide dismutase, SOD) kev ua haujlwm, txo acetylcholine esterase (acetylcholine esterase, TChE) kev ua haujlwm, lub hlwb apoptosis tus nqi, thiab txo cov calcium tsub zuj zuj hauv lub hlwb. Lub tshuab yog tias tag nrho glycosides ntawm cistanche txhim khu kev ua haujlwm ntawm cov dawb radical scavenging enzymes, txo cov lipid peroxidation cov tshuaj tiv thaiv, txo cov calcium cov ntsiab lus ntawm lub hlwb, thiab inhibit lub apoptosis ntawm hlwb hlwb induced los ntawm QA; cov txheej txheem ntawm kev ua haujlwm kuj tseem cuam tshuam nrog kev ua haujlwm antioxidant ntawm tag nrho glycosides ntawm cistanche. Tag nrho cov glycosides ntawm cistanche tuaj yeem muaj kev tiv thaiv zoo ntawm ultrastructure ntawm hippocampus hauv cov neeg mob Alzheimer's. Tag nrho glycosides ntawm cistanche tuaj yeem ncua kev laus thiab tiv thaiv thiab kho Alzheimer's kab mob los ntawm kevantioxidanttshuab.

Yog xav paub ntxiv:ali.ma@wecistanche.com