Ntxiv rau Kev Kho Mob Raum Ntshav Qab Zib, Erythropoietin muaj txiaj ntsig tsis txaus ntseeg ntawm peb lub cev!

Thaum peb tham txog erythropoietin (EPO), thawj qhov peb xav txog yog nws txoj haujlwm tsis muaj zog hauv kev kho mob raum ntshav ntshav. Erythropoiesis stimulating agents uas sawv cev los ntawm recombinant human erythropoietin (rhEPO) tau ntse siv nyob rau hauv kev kho mob raum anemia rau ntau tshaj 20 xyoo thiab tseem yog cov tshuaj tseem ceeb rau kev kho mob raum anemia.

Nyem rau Cistanche rau mob raum

Qhov tseeb, EPO, raws li ib qho endogenous glycoprotein hormone secreted los ntawm ob lub raum, ntxiv rau kev kho cov ntshav liab los ntawm kev txhawb kev tsim cov qe ntshav liab, EPO kuj muaj kev tiv thaiv ntawm ntau lub cev thiab lub cev xws li lub plawv, hlwb, thiab ob lub raum. Hnub no kuv yuav qhia rau koj Sawv thiab kawm txog cov haujlwm muaj zog ntawm EPO[1].

Molecular qauv, ntau lawm, thiab kev faib tawm ntawm EPO

EPO yog ib qho active glycoprotein secreted los ntawm ob lub raum. Nws muaj 166 amino acids thiab muaj qhov txheeb ze molecular loj ntawm kwv yees li 34, 000. Tib neeg EPO noob nyob rau hauv cheeb tsam 22 ntawm caj npab ntev ntawm chromosome 7. Nws muaj 5 exons thiab 4 introns, encoding 193 amino acids. Cov protein nws muaj yog ib qho active EPO precursor tom qab 27 amino acids thiab 27 amino acids tau raug txiav tawm. Sialyl glycosylation thiab tshem tawm ntawm pawg amino pawg tuaj yeem ua rau muaj txiaj ntsig lom neeg [2].

Hauv lub cev, EPO siv nws cov teebmeem lom neeg los ntawm kev khi rau nws cov receptors tshwj xeeb. EPO receptor nyob rau saum npoo ntawm cov qe ntshav liab tsim cov cheeb tsam thiab cov proerythrocytes, thiab muab faib ua extracellular, transmembrane, thiab intracellular functional thaj chaw. Ib qho EPO molecule khi rau sab nrauv ua haujlwm ntawm ob lub receptors, hloov pauv kev ua haujlwm ntawm EPO receptors, qhib JAK2 tyrosine protein kinase thiab 8 tyrosine residues nyob rau hauv intracellular functional domain yog phosphorylated, pib intracellular teeb liab transduction. kev taw qhia, ua rau kev loj hlob ntawm tes thiab sib txawv [3].

EPO noob yog qhia nyob rau ntau theem thiab nyob rau hauv ntau qhov chaw ntawm lub cev. Thaum lub sij hawm embryonic lub sij hawm, EPO feem ntau yog muab los ntawm lub siab. Tom qab yug me nyuam, nws yog tsim los ntawm ob lub raum. Qhov chaw zais cia tshwj xeeb yog cov fibroblasts nyob ib ncig ntawm cov tubules hauv lub raum cortex thiab sab nraud medullary ib feem. Nws ua haujlwm ntawm erythroid hematopoietic qia hlwb hauv cov pob txha pob txha thiab tuaj yeem txhawb nqa lawv txoj kev loj hlob thiab kev sib txawv. , plays lub luag haujlwm tseem ceeb hauv kev tsim cov qe ntshav liab. Kwv yees li 90% ntawm EPO nyob rau hauv lub circulatory system pib los ntawm ob lub raum, tab sis nws kuj yog qhia nyob rau hauv me me nyob rau hauv tib neeg lub hlwb, spleen, ntsws, testicles, placenta, thiab lwm yam kabmob.

Multi-system tiv thaiv EPO

1 Lub raum tiv thaiv cov nyhuv ntawm EPO

rhEPO tuaj yeem txo qhov kev puas tsuaj ntawm podocyte, txo cov proteinuria, thiab ua lub luag haujlwm kho mob hauv glomerulonephritis tshwm sim los ntawm cov tshuaj tiv thaiv glomerular hauv qab daus membrane antibodies. EPO tuaj yeem txo lub raum tubulointerstitial puas tsuaj los ntawm unilateral ureteral obstruction. Nws cov txheej txheem tiv thaiv tej zaum yuav cuam tshuam nrog EPO ib feem tiv thaiv ib feem ntawm ureteral obstruction ntawm cov protein thiab cov qib noob, ua rau txo qis ntawm aquaporin 2 (AQP2) gene thiab protein qhia. Tom qab ureteral obstruction yog relieved, daim ntawv thov ntawm EPO tuaj yeem ua kom rov qab los ntawm kev tswj hwm AQP2 hauv lub raum, yog li ua kom rov qab los ntawm obstructed raum ua haujlwm.

EPO kuj tseem muaj peev xwm kho tau los ntawm tib neeg lub raum ischemia-reperfusion raug mob. Cov kev tshawb fawb tau pom tias daim ntawv thov ntawm EPO ua ntej kev kho ischemia-reperfusion tuaj yeem txo lub raum tubular cell apoptosis, thiab kev kho EPO tom qab ischemia-reperfusion raug mob tseem tuaj yeem tiv thaiv lub raum. EPO tuaj yeem txo cov tubulointerstitial fibrosis los ntawm unilateral ureteral obstruction thiab ncua kev loj hlob ntawm cov kab mob raum [2].

2 Kev tiv thaiv ntawm EPO ntawm lub paj hlwb

rhEPO tuaj yeem txhawb kev rov qab los ntawm oligodendrocytes tom qab cerebral infarction hauv cerebral ischemia nas qauv thiab tseem muaj kev tiv thaiv rau lub hlwb ntawm nas nrog kev puas tsuaj rau lub hlwb. Cov txheej txheem yuav ua rau cov teebmeem neuronal los ntawm inhibiting degradation ntawm hlwb neurofilament proteins. Kev tiv thaiv.

Nws kuj tau tshaj tawm tias EPO muaj cov txiaj ntsig zoo rau kev nco tsis zoo thiab tuaj yeem ua lub luag haujlwm tseem ceeb hauv cov kab mob hauv lub paj hlwb uas tshwm sim los ntawm mitochondrial dysfunction thiab oxidative kev nyuaj siab, lossis hauv kev nco ua haujlwm tsis zoo los ntawm kev laus thiab kev puas tsuaj sab nraud. EPO activates Mitochondrial muaj nuj nqi thiab nce hemoglobin qhia, yog li exerting neuroprotective teebmeem.

Kev tshawb fawb tseem pom tau tias EPO muaj kev kho mob ntawm tus kab mob Parkinson los ntawm kev tiv thaiv kab mob antioxidant, tiv thaiv kab mob, thiab txhawb kev tsim cov paj hlwb. EPO muaj ntau yam kev siv peev xwm hauv ntau yam kab mob neurological, thiab nws cov txheej txheem ntawm kev txiav txim xav tau kev tshawb nrhiav ntxiv.

3 Kev tiv thaiv ntawm EPO ntawm lub plawv

Cov kev tshawb fawb tau pom tias EPO tuaj yeem txo qhov chaw ntawm myocardial infarction thiab txo myocardial cell apoptosis hauv cov nas sim. EPO tseem tuaj yeem cuam tshuam qhov kev qhia ntawm cov kab mob inflammatory (interleukin -1 , interleukin -6, thiab qog necrosis factor ) hauv kev kho mob plawv tom qab mob myocardial infarction hauv nas, yog li ua rau cov nyhuv cardioprotective. EPO muaj kev tiv thaiv tseem ceeb ntawm myocardial raug mob los ntawm ischemia-reperfusion, thiab tseem tuaj yeem cuam tshuam myocardial fibrosis thiab txo qis ventricular remodeling.

Tsis tas li ntawd, EPO kuj tseem tuaj yeem txo tus nqi ntawm cov pob txha lacunae, nce cov microvessels muab cov ntshav rau lub taub hau femoral, tiv thaiv qhov tshwm sim thiab kev loj hlob ntawm femoral taub hau necrosis; txo cov kev hloov inflammatory hauv lub ntsws ntawm cov nas mob ntsws asthma, thiab txo cov pa reactivity, uas muaj kev cuam tshuam tsis zoo rau cov pob txha thiab lub ntsws ntawm lub cev. , retina, thiab lwm yam. ua lub luag haujlwm tiv thaiv.

Cistanche kho mob raum li cas?

Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrograumkab mob. Nws yog muab los ntawm qhuav stems ntawmCistanchedeserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Lub ntsiab active Cheebtsam ntawm cistanche yogphenylethanoidglycosides, echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rauraumnoj qab haus huv.

Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tswv yim.

Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.

Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.

Tsis tas li ntawd, cistanche tau pom tias muaj cov nyhuv anti-inflammatory. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.

Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv cov kab mob hauv lub raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.

Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.

Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.

Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.