AI-powered Renal Tumor Prediction Model Pab Ua Kev Ntsuas Ua Ntej Ua Ntej

Qhov kev cia siab ntau tshaj 39th European Association ntawm Urology Lub Rooj Sib Tham Txhua Xyoo (EAU24) hauv 2024 yuav muaj nyob rau hauv Paris, Fabkis txij lub Plaub Hlis 5 txog rau 8 lub sijhawm hauv zos. Raws li lub rooj sib tham loj tshaj plaws thiab muaj txiaj ntsig tshaj plaws hauv Tebchaws Europe, EAU24 muaj kev cuam tshuam tshwj xeeb rau lub zej zog urology thoob ntiaj teb. Qhov kev tshwm sim no tsis tsuas yog nyiam cov kws tshaj lij urology thiab cov kws tshawb fawb los ntawm thoob plaws lub ntiaj teb tab sis kuj tau coj los ua ke cov txiaj ntsig kev tshawb fawb tshiab thiab cov thev naus laus zis hauv kev lag luam urology, txhaj tshuaj tshiab tseem ceeb rau hauv kev txhim kho ntawm urology.

Nyem rau Cistanche rau mob raum

Artificial txawj ntse siv cov ntaub ntawv tiag tiag hauv ntiaj teb los kwv yees cov yam ntxwv ntawm cov kab mob thiab cov txiaj ntsig kev kho mob ntawm lub raum qog los ntawm kev ua haujlwm ua ntej ntau theem CT duab

1 Tshawb nrhiav keeb kwm yav dhau

Nrog rau qhov nrov ntawm kev tshuaj ntsuam xyuas thev naus laus zis xws li CT thiab MRI, qhov kev kuaj pom tus mob asymptomatic lub raum tau nce zuj zus txhua xyoo. Raws li qhov tshwm sim tshwm sim hauv lub raum loj, kev txiav txim siab kho mob feem ntau tau ua thaum tsis muaj qhov pom tseeb ntawm pathological. Yog li ntawd, kev txhim kho qhov tseeb ntawm kev kuaj mob ntawm cov qog nqaij hlav hauv lub raum benign thiab malignant thiab ntxiv qhov sib txawv ntawm cov kab mob malignancy (invasive / indolent) ntawm lub raum qog yog qhov tseem ceeb rau kev xaiv cov kev kho mob tom ntej.

2 Kev tshawb fawb tsim

Pab pawg tshawb fawb tau tshuaj xyuas 4,557 tus neeg mob hauv 6 lub tsev kho mob hauv tsev suav nrog Tsev Kho Mob Zhongshan Koom Tes nrog Fudan University, Thawj Cov Tsev Kho Mob Ua Haujlwm rau Zhejiang University, Zhangye Tib Neeg Tsev Kho Mob, Tsev Kho Mob Quanzhou Tib Neeg, Tsev Kho Mob Zhongshan Koom Tes nrog Fudan University Xiamen Tsev Kho Mob, thiab tsib pej xeem cov ntaub ntawv qog nqaij hlav. Los ntawm 13,261 preoperative CT dluab ntawm cov neeg mob, ob tug multi-theem neural convolutional networks tau siv los tsim ib tug sib sib zog nqus-kawm qauv kuaj mob rau kwv yees benign, malignant, thiab invasive raum hlav. Kev muaj sia nyob sib txawv ntawm AI-predicted indolent thiab aggressive qog tau muab piv siv Kaplan-Meir tsom xam thiab Cox regression tsom xam. Ntsuas cov genomic, transcriptomic, thiab lub cev tiv thaiv kab mob siv bioinformatics tsom xam thiab immunohistochemistry.

3 Cov txiaj ntsig tshawb fawb

Cov qauv kuaj mob tsis zoo thiab tsis zoo muaj qhov ua tau zoo ntawm kev kwv yees zoo dua li cov qauv kev kwv yees xov tooj cua tam sim no thiab RENAL tus qhab nia twv ua qauv hauv txhua pawg validation. Tus nqi AUC nce mus txog {{0}}.853 ~ 0.898 nyob rau hauv sib txawv validation cohorts, thiab nws diagnostic raug tshaj ntawm cov prospective validation cohort. Qhov nruab nrab kev ua tau zoo ntawm xya tus kws paub txog hluav taws xob. Tsis tas li ntawd, AI cov qauv kuaj mob tuaj yeem pab cov kws kho mob radiologist txhim kho qhov tseeb ntawm kev kuaj mob.

Cov qauv kev kawm tob uas paub qhov txawv ntawm cov qog nqaij hlav los ntawm cov qog nqaij hlav tsis zoo kuj tseem ua tau zoo tshaj li cov qauv xov tooj cua tam sim no thiab RENAL cov qhab nia twv ua qauv hauv ntau pawg validation, nrog rau AUC qhov tseem ceeb mus txog {{0}}}.763 ~ 0.792 nyob rau hauv sib txawv validation cohorts. Nyob rau sab nraud validation cohort, AI-predicted aggressive raum mob cancer tau luv luv ciaj sia taus AI-predicted indolent raum mob cancer [kab mob tshwj xeeb ciaj sia taus (DSS), p<0.001, HR=20.81; recurrence-free survival (RFS) , p<0.001, HR=9.71; overall survival (OS), p<0.001, HR=13.27]. The invasiveness probability score determined by AI can be used as an independent adverse prognostic factor for patient survival outcomes, and its predictive effect on clinical outcomes is higher than postoperative pathological indicators such as TNM staging and the WHO/ISUP grading system. Finally, bioinformatics analysis showed that aggressive renal cancer has an immunosuppressive microenvironment with higher infiltration of CD8+ T cells and regulatory T cells than indolent renal cancer.

4 Kev tshawb fawb xaus

Ib qho qauv kev kawm tob tuaj yeem ua rau tsis muaj kev cuam tshuam txog qhov yuav tshwm sim ntawm cov kab mob malignant thiab invasive nyob rau hauv lub raum loj raws li preoperative multi-phase CT duab. Tsis tas li ntawd, AI-predicted invasive distemper tau cuam tshuam nrog cov txiaj ntsig tsis muaj sia nyob.

Cistanche kho mob raum li cas?

Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrograumkab mob. Nws yog muab los ntawm qhuav stems ntawmCistanchedeserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Lub ntsiab active Cheebtsam ntawm cistanche yogphenylethanoidglycosides, echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rauraumnoj qab haus huv.

Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tshuab.

Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.

Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.

Tsis tas li ntawd, cistanche tau pom tias muaj cov nyhuv anti-inflammatory. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.

Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv kab mob raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.

Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.

Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.

Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.