Immunoglobulin Therapy Rau Myalgic Encephalomyelitis Chronic Fatigue Syndrome
Apr 28, 2022
Thov hu raujimmy.wu@wecistanche.com yog xav paub ntxiv
1. Taw qhia
dab tsi yog cistancheKev txaus siab rau kev tshawb fawb txog kev kho immunoglobulin (IgG) hauv cov neeg mob uas muaj myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) tau pib nyob rau nruab nrab -1980s, tshwm sim los ntawm cov pov thawj tshwm sim ntawm kev tiv thaiv kab mob tsis xws luag nrog rau kev tsis sib haum xeeb ntawm tes-mediated immunity (CMI)thiab immunoglobulin subclass deficiency?Ib daim ntawv teev cov kab mob tshwm sim hauv qee tus neeg mob, ua qauv qhia ntawm enteroviral RNA hauv cov leeg nqaij, thiab muaj cov enteroviral antigen hauv cov ntshavtau saib raws li kev txhawb nqa qhov kev xav tias ME / CFS tuaj yeem txhim kho raws li qhov tshwm sim ntawm kev ua tsis tiav ntawm cov kab mob lossis lwm yam antigensthiab ntxiv dag zog rau rooj plaub rau kev tshawb nrhiav kev cuam tshuam los ntawm kev muaj lub cev tiv thaiv kab mob. High-dose intravenous (IV) IgG tau paub los kho lwm yam kab mob ntawm kev tiv thaiv kab mobthiab cov kev tshawb pom zoo hauv kev tshawb fawb crossover ntawm kev kho mob intramuscular IgG hauv cov neeg mob uas muaj 'chronic mononucleosis syndrome', nyob rau hauv tandem nrog ntau tus neeg cov ntaub ntawv qhia txog cov txiaj ntsig tau zoo tom qab IV IgG hauv cov neeg mob nrog ME / CFS, muab kev txhawb ntxiv rau kab ntawm kev nug no.cov cai tswj xyuas yogcistache nyab xeeb
Yellow-xim av hmoovthiabAnti Fatigue Cistanche
2. Nomenclature thiab Case Definitions
Cov kev tshawb fawb soj ntsuam xyuas hauv daim ntawv no tau luam tawm thaum xyoo 1990 thiab 1999 thiab xa mus rau qhov teeb meem tshawb fawb xws li 'chronic fatigue syndrome lossis 'chronic fatigue syndrome (CFS). Lub sijhawm ntawd, CFS yog qhov kev nkag mus rau cov ntaub ntawv kho mob tsis ntev los no, tau tshaj tawm xyoo 1988 los ntawm United States Centers for Disease Control (US CDC) nrog rau lub hom phiaj ntawm kev hloov cov ntsiab lus uas tam sim no, piv txwv li, ' mob Epstein- Barr virus syndrome' lossis 'chronic mononucleosis', thiab variations [36]. 'Myalgic encephalomyelitis (ME) tsis tau siv hauv Asmeskas tab sis tau siv ntau hauv tebchaws United Kingdom (UK), xws li 'post-viral fatigue syndrome (PVFS). Yog li ntawd, tag nrho cov kev txheeb xyuas no tau siv ntau yam los hais txog qhov teeb meem uas tau kawm hauv cov ntaub ntawv hais los ntawm lub sijhawm no. Daim ntawv tam sim no yuav xa mus rau 'ME / CFS', ua raws li kev siv tam sim no. Nyob nruab nrab ntawm ntau cov ntsiab lus piav qhia, cov ntsiab lus txhais rau kev xaiv ntawm cov neeg mob tseem yog qhov tseem ceeb tshaj plaws rau kev soj ntsuam kev tshawb fawb: qhov cuam tshuam yuav tau tham.
cistache yog qhov zoo rau daim tawv nqaij
Cistanche tubulosa ntsiav tshuaj yog peb cov khoom.Plaub ob qhov muag tsis pom kev randomized tswj kev sim (RCTs) ntawm IV IgG ua raws. Cov ntawv ceeb toom ntawm kev ua tau zoo sib txawv, nrog kev tshawb pom sib sau ua ke ntsuas raws li"sib xyaw"thiab"tsis paub meej". Tom qab tshaj tawm xyoo 1997 ntawm qhov kawg ntawm cov no,assert ib"tsis ua haujlwm"xaus, txaus siab rau kev tshawb fawb txog kev kho mob no hauv cov neeg mob nrog ME / CFS waned. Tsis ntev los no, tau rov qab qhia txog kev tshawb fawb txog kev txaus siab thiab qhov muaj feem cuam tshuam ntawm IgG hauv kev kho cov neeg mob nrog ME / CFS. Kev tshawb xyuas ntxaws ntxaws ntawm cov teebmeem ntawm immunoglobulins ntawm adrenergic receptors thiab kev tiv thaiv kab mob hauv ME / CFS tau tshaj tawm xyoo 2020. Tsis tas li ntawd, xyoo 2020, kev sim ua haujlwm tau tshaj tawm tias muaj kev sib koom ua ke ntawm cov kabmob me me-fiber polyneuropathy (aaSFPN) - ib qho mob uas paub tias yuav teb rau IV IgG - tej zaum yuav tshwm sim hauv cov neeg mob ntau, ua rau tus kws tshawb fawb los xaus: tias"Nws yuav yog ib qho tseem ceeb los txheeb xyuas ME / CFS cov neeg mob uas muaj comorbid aaSFPN. Nyob rau lub Peb Hlis 2021, ib daim ntawv tshaj tawm txog kev tiv thaiv kab mob tiv thaiv kab mob tau qhia tias ntau yam immunoglobulin noob tau nce ntau hauv ME / CFS cov neeg mob piv nrog kev tswj hwm.. Ntawm kev nthuav tawm ntawm 2020 International Association for Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (IACFS / ME) Lub Rooj Sab Laj, tus thawj coj tau hais tawm lub tswv yim meej uas qhov kev tshawb pom qhia tias kev tshawb fawb txog kev kho mob immunoglobulin tau lees paub.. Cov lus qhia txog kev tswj hwm ntawm IgG nta hauv cov lus pom zoo kho mob uas tsim los ntawm US ME / CFS Clinician Coalition hauv Lub Ob Hlis 2021, thaum IgG suav nrog cov ntsiab lus ntawm kev kho mob hauv ib lub Yim Hli 2021 daim ntawv los ntawm Mayo Foundation rau Kev Kawm Kho Mob thiab Kev Tshawb Fawb, teeb tsa cov lus pom zoo rau kev kuaj mob thiab kev tswj hwm [32]. Tawm tsam keeb kwm yav dhau los no, thiab nrog kev tshem tawm tsis ntev los no ntawm kev txwv ntev ntev ntawm kev siv cov ntshav ntshav hauv UK los ntawm kev tsim cov tshuaj immunoglobulins tau npaj kom yooj yim thoob ntiaj teb kev tsis txaus ntawm cov khoom no.thiab rov qab txaus siab rau kev tiv thaiv kab mob nruab nrab mus rau lub sijhawm ntev tom qab kis tus kab mob raws li kev mob tshwm sim tom qab ntawm COVID-19 (PASC), qhov kev ntsuam xyuas tshiab ntawm qhov kev tshawb fawb no, txhawb nqa los ntawm kev tshaj tawm kev soj ntsuam los ntawm kev kho mob, yog lub sijhawm.
cistanche deserticolacoj zoo rau kev noj qab haus huv.Cov kev tshawb fawb soj ntsuam xyuas hauv daim ntawv no tau luam tawm thaum xyoo 1990 thiab 1999 thiab xa mus rau qhov teeb meem tshawb fawb xws li 'chronic fatigue syndrome lossis 'chronic fatigue syndrome (CFS). Lub sijhawm ntawd, CFS yog qhov kev nkag mus rau cov ntaub ntawv kho mob tsis ntev los no, tau tshaj tawm xyoo 1988 los ntawm United States Centers for Disease Control (US CDC) nrog rau lub hom phiaj ntawm kev hloov cov ntsiab lus uas tam sim no, piv txwv li, ' mob Epstein- Barr virus syndrome' lossis 'chronic mononucleosis', thiab variations [36]. 'Myalgic encephalomyelitis (ME) tsis tau siv hauv Asmeskas tab sis tau siv ntau hauv tebchaws United Kingdom (UK), xws li 'post-viral fatigue syndrome (PVFS). Yog li ntawd, tag nrho cov kev txheeb xyuas no tau siv ntau yam los hais txog qhov teeb meem uas tau kawm hauv cov ntaub ntawv hais los ntawm lub sijhawm no. Daim ntawv tam sim no yuav xa mus rau 'ME / CFS', ua raws li kev siv tam sim no. Nyob nruab nrab ntawm ntau cov ntsiab lus piav qhia, cov ntsiab lus txhais rau kev xaiv ntawm cov neeg mob tseem yog qhov tseem ceeb tshaj plaws rau kev soj ntsuam kev tshawb fawb: qhov cuam tshuam yuav tau tham.3. Kev sim tshuaj ImmunoglobulinPlaub ob qhov muag tsis pom kev randomized placebo-tswj kev sim (RCTs) ntawm kev siv IV IgG los kho cov neeg mob uas raug kev txom nyem los ntawm ME / CFS tau ua. Cov txiaj ntsig los ntawm thawj ob tau luam tawm ua ke hauv American Journal of Medicine thaum lub Kaum Ib Hlis 1990 [13,14]. Cov kws sau ntawv tau mus txog qhov sib txawv heev. Ib txoj kev tshawb fawb tau tshaj tawm tias immunoglobulin muaj txiaj ntsig zoo hauv a"Tus naj npawb tseem ceeb ntawm cov neeg mob", lwm yam uas IV IgG"tsis zoo li yuav muaj txiaj ntsig kho mob hauv CFS".Cov qauv no tau rov qab ua dua. Thaum Lub Ib Hlis Ntuj xyoo 1997, RCT tau tshaj tawm cov txiaj ntsig zoo ntawm IV IgG rau cov neeg mob hluas [22]; Tom qab xyoo ntawd, ntxiv, thiab txog hnub kawg, qhov kev sim qhia tias IV IgG"yog ineffective"[24]. Kev kho mob2021, 9, 1546 3 ntawm 21 Nws yog qhov pom tseeb opaque thiab divergent daim duab uas tam sim no tshuaj xyuas nrhiav kom pom. Kev tshuaj xyuas ntawm cov txiaj ntsig tau sau tseg qhia tau tias qhov kev tshawb pom ntawm cov kev sim no tsis sib haum xeeb. Yuav kom tsim tau qhov no, nws yog ib qho tseem ceeb tsis txhob txwv tsis pub txiav txim siab rau cov ntsiab lus tshaj tawm tshaj tawm, tab sis coj mus rau hauv tus account cov yam ntxwv ntawm cov kev tshawb fawb thiab lawv cov kev tshawb pom tshwj xeeb. Rau qhov yooj yim, peb yuav xa mus rau plaub qhov kev sim no raws li Kev Kawm 1. Rooj1 thiab2 qhia txog cov yam ntxwv ntawm kev sim thiab cov neeg koom nrog, feem3.
Cov ntsiab lus ntawm Kev Tshaj Tawm Txog Kev Tshawb Fawb Peb lub hlis tom qab qhov kawg infusion, 10 immunoglobulin cov neeg tau txais (43 feem pua) thiab peb cov neeg tau txais placebo (12 feem pua) tau raug xaiv los ua 'tus neeg teb' ntawm kev ntsuas qhov muag tsis pom los ntawm tus kws kho mob tom qab kev xam phaj cov neeg koom nrog qhov tshwj xeeb ntawm kev ua haujlwm, kev sib raug zoo thiab kev lom zem. cov dej num tau txais. Qhov tshwm sim ntau dua ntawm 'cov neeg teb' hauv pawg IV IgG yog qhov tseem ceeb.Kev kho mob2021, 9, 1546 5 ntawm 21 Raws li qhov no, cov kws sau ntawv xaus lus:"Cov txiaj ntsig ntawm txoj kev tshawb fawb no qhia tau hais tias feem ntau ntawm cov neeg mob (43 feem pua) uas muaj tus cwj pwm zoo, mob hnyav, thiab ntev CFS tau teb rau cov koob tshuaj txhaj tshuaj tiv thaiv kab mob hauv lub cev."Nws yog ib qho tseem ceeb uas qhov kev faib cov neeg koom ua 'tus neeg teb' lossis 'cov neeg tsis teb' tsis yog qhov kev txiav txim zoo. Txhua tus 'tus neeg teb' tau txhim kho zoo heev: "Cov lus teb no tau tshwm sim los ntawm kev rov pib ua haujlwm, kev lom zem, thiab kev ua si hauv zej zog, nrog rau kev txo qis hauv lub cev thiab kev puas siab puas ntsws thiab los ntawm kev txhim kho hauv kev tiv thaiv kab mob ntawm tes.."
peb pab neeg ua lag luam cistache ntsej muag daim npog qhov ncauj
