Immunoglobulin Therapy Rau Myalgic Encephalomyelitis

Rov qab mus rau yav tom ntej? Immunoglobulin Therapy rau Myalgic

Encephalomyelitis / Chronic Fatigue Syndrome

Cov kev tshawb pom ntawmcistanche extractonKev siv catananche los kho myalgic encephalomyelitis / chronic fatigue syndrome (ME / CFS) feem ntau pom tias yog sawv cev sib xyaw ua ke. Hauv kev tshuaj xyuas kom ntxaws, daim duab pom tseeb tshwm sim, uas qhia tias qhov muaj peev xwm kho tau tus nqi ntawm qhov nokev kho mobtau underestimated. Peb qhov kev ntsuam xyuas yog ua raws li cov lus pom zoouas:kho mobmuaj txiaj ntsig zoo rau ib feem ntawm cov neeg mob hnyav thiab tus yam ntxwv zoo ME / CFS; (2) Cov neeg teb tuaj yeem raug kwv yees nrog qib siab ntawm qhov raug raws li cov cim ntawm immune dysfunction. Cov kauj ruam nruj tau ua nyob rau hauv kev tshawb fawb sim los sau cov xwm txheej tsis zoo, nrog cov tsos mob tsis zookuaj rau flavonoidsfeem ntautau ntsib nyob rau hauv ob qho tib si kev cuam tshuam thiab cov pab pawg tswj hwm cov placebo, qhia tias qhov no tau cuam tshuam qhov cuam tshuam ntawm kev koom tes rau cov neeg muaj mob uas tshwm sim los ntawm cov tsos mob tom qab exerbation exacerbation. Kev mob hnyav ntawm qee cov tsos mob tshwj xeeb, tshwj xeeb yog mob taub hau, tau tshwm sim ntau dua nrog kev kho mob thiab tej zaum yuav ua rau muaj kev kho mob zoo, yog txuam nrog kev kho mob.

peb cov khoom

Cov kev tshawb pom tshwm sim los ntawm qhov kev tshuaj xyuas no tau txais kev txhawb nqa los ntawm kev soj ntsuam soj ntsuam txog kev kho mob ntawm cov neeg mob hnyav thiab hnyav heev ME / CFS, rau leej twg intramuscular thiab subcutaneous tswj muab lwm txoj kev xaiv. Peb xaus lus tias: (1) muaj ib rooj plaub muaj zog rau thaj tsam ntawm kev tshawb fawb no yuav tsum tau rov kho dua; (2) tseem tab tom tshawb nrhiav ntxiv,subcutaneous kevyuav muaj kev ncaj ncees nyob rau hauv muab ib chav kawm ntawm IgG rau xaiv ME / CFS cov neeg mob ntawm qhov kawg ntawm cov spectrum. Raws li feem ntau ntawm cov neeg koom nrog sim tau ntsib tus kab mob hnyav lossis kab mob zoo li pib, peb hais ntxiv tias kev kho IgG yuav cuam tshuam rau kev saib xyuas qee tus neeg mob uas tseem mob tom qab kis tus kab mob.. Taw qhiaKev txaus siab rau kev tshawb fawb txog kev kho immunoglobulin (IgG) hauv cov neeg mob uas muaj myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) tau pib nyob rau hauv nruab nrab -1980s, tshwm sim los ntawm cov pov thawj tshwm sim ntawm kev tiv thaiv kab mob tsis xws luag nrog rau kev tsis sib haum xeeb ntawm tes-mediated immunity (CMI) thiab immunoglobulin subclass deficiency.

Ib daim ntawv teev cov kab mob tshwm sim hauv qee cov neeg mob, ua qauv qhia ntawm enteroviral RNA hauv cov leeg nqaij, thiab muaj cov kab mob enteroviral hauv cov ntshav tau pom tias txhawb cov kev xav tias ME / CFS tuaj yeem txhim kho raws li qhov ua tsis tiav ntawm kev tshem tawm cov kab mob lossis lwm yam antigensand ntxiv dag zog rau lub cev. rooj plaub rau kev soj ntsuam ib qho kev cuam tshuam predicated nyob rau hauv lub xub ntiag ntawm immunologic dysfunction. High-dose intravenous (IV) IgG tau paubua kom zooLwm yam kev puas tsuaj ntawm kev tiv thaiv kab mob thiab kev tshawb pom zoo hauv kev tshawb nrhiav kev kho mob intramuscular IgG hauv cov neeg mob.intramuscular, nyob rau hauv tandem nrog ntau tus neeg cov ntaub ntawv qhia txog cov txiaj ntsig tau zoo tom qab IV IgG hauv cov neeg mob nrog ME / CFS, muab kev txhawb nqa ntxiv rau kab ntawm kev nug no.Kev kho mob2021, 9, 1546.

cistanche tshuaj ntsuab

Cov ntawv ceeb toom ntawm kev ua tau zoo sib txawv, nrog cov kev tshawb pom sib sau ua ke soj ntsuam"sib xyaw"thiab"tsis paub meej". Tom qab tshaj tawm xyoo 1997 ntawm qhov kawg ntawm cov no, [24] asserting ib"tsis ua haujlwm"xaus, txaus siab rau kev tshawb fawb txog kev kho mob no hauv cov neeg mob nrog ME / CFS waned. Tsis ntev los no, tau rov qab qhia txog kev tshawb fawb txog kev txaus siab thiab qhov muaj feem cuam tshuam ntawm IgG hauv kev kho cov neeg mob nrog ME / CFS. Kev tshawb xyuas ntxaws ntxaws ntawm cov teebmeem ntawm immunoglobulins ntawm adrenergic receptors thiab kev tiv thaiv kab mob hauv ME / CFS tau tshaj tawm xyoo 2020 [27]. Tsis tas li ntawd, xyoo 2020, kev sim ua haujlwm tau tshaj tawm tias muaj kev sib koom ua ke ntawm cov kab mob autoimmune-fiber polyneuropathy (aaSFPN) - ib qho mob uas paub tias yuav teb rau IV IgG - tej zaum yuav tshwm sim hauv cov neeg mob ntau, ua rau tus kws tshawb fawb los xaus:"Nws yuav yog ib qho tseem ceeb los txheeb xyuas ME / CFS cov neeg mob uas muaj comorbid aaSFPN".

Nyob rau lub Peb Hlis 2021, ib daim ntawv tshaj tawm txog kev tiv thaiv kab mob tiv thaiv kab mob tau qhia tias ntau yam immunoglobulin noob tau nce ntau hauv ME / CFS cov neeg mob piv nrog kev tswj hwm [29]. Ntawm kev nthuav tawm ntawm 2020 International Association for Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (IACFS / ME) Lub Rooj Sab Laj, tus thawj coj tau hais tawm lub tswv yim meej uas qhov kev tshawb pom qhia tias kev tshawb fawb txog kev kho mob immunoglobulin tau lees paub.. Cov lus qhia txog kev tswj hwm ntawm IgG nta hauv cov lus pom zoo kho mob uas tsim los ntawm US ME / CFS Clinician Coalition hauv Lub Ob Hlis 2021, thaum IgG suav nrog cov ntsiab lus ntawm kev kho mob hauv ib lub Yim Hli 2021 daim ntawv los ntawm Mayo Foundation rau Kev Kawm Kho Mob thiab Kev Tshawb Fawb, teeb tsa cov lus pom zoo rau kev kuaj mob thiab kev tswj hwm.

cistanche salsa cov txiaj ntsigHauv keeb kwm yav dhau los no, thiab nrog kev tshem tawm tsis ntev los no ntawm kev txwv ntev ntev ntawm kev siv cov ntshav ntshav hauv UK hauv kev tsim cov tshuaj immunoglobulins tau npaj kom yooj yim thoob ntiaj teb kev tsis txaus ntawm cov khoom no [33] thiab rov qab txaus siab rau kev tiv thaiv kab mob nruab nrab mus rau lub sijhawm ntev tom qab kis tus kab mob raws li kev mob tshwm sim tom qab ntawm COVID-19 (PASC), qhov kev ntsuam xyuas tshiab ntawm qhov kev tshawb fawb no, txhawb nqa los ntawm kev tshaj tawm kev soj ntsuam los ntawm kev kho mob, yog lub sijhawm.2. Nomenclature thiab Case DefinitionsCov kev tshawb fawb soj ntsuam xyuas hauv daim ntawv no tau luam tawm thaum xyoo 1990 thiab 1999 thiab xa mus rau qhov teeb meem tshawb fawb xws li 'chronic fatigue syndrome lossis 'chronic fatigue syndrome (CFS).

Lub sijhawm ntawd, CFS yog qhov kev nkag mus rau cov ntaub ntawv kho mob tsis ntev los no, tau tshaj tawm xyoo 1988 los ntawm United States Centers for Disease Control (US CDC) nrog rau lub hom phiaj ntawm kev hloov cov ntsiab lus uas tam sim no, piv txwv li, ' mob Epstein- Barr virus syndrome' lossis 'chronic mononucleosis', thiab variations. 'Myalgic encephalomyelitis (ME) tsis tau siv hauv Asmeskas tab sis tau siv ntau hauv tebchaws United Kingdom (UK), xws li 'post-viral fatigue syndrome (PVFS). Yog li ntawd, tag nrho cov kev txheeb xyuas no tau siv ntau yam los hais txog qhov teeb meem uas tau kawm hauv cov ntaub ntawv hais los ntawm lub sijhawm no. Daim ntawv tam sim no yuav xa mus rau 'ME / CFS', ua raws li kev siv tam sim no hais thiab sau los ntawmdr vita opc

peb pab neeg ua lag luam

Nyob nruab nrab ntawm qhov ntau ntawm cov ntsiab lus piav qhia,catanancheyog rau kev xaiv ntawm cov neeg mob tseem yog qhov tseem ceeb tshaj plaws kev txiav txim siab txog kev soj ntsuam kev tshawb fawb: qhov cuam tshuam yuav tau tham txog.3. Kev sim tshuaj ImmunoglobulinPlaub ob qhov muag tsis pom kev randomized placebo-tswj kev sim (RCTs) ntawm kev sivcatananchelos kho cov neeg mob uas raug mob los ntawm ME / CFS tau ua. Cov txiaj ntsig los ntawm thawj ob tau luam tawm ua ke hauv American Journal of Medicine thaum lub Kaum Ib Hlis 1990. Cov kws sau ntawv tau mus txog qhov sib txawv heev. Ib txoj kev tshawb fawb tau tshaj tawm tias immunoglobulin muaj txiaj ntsig zoo hauv a"Tus naj npawb tseem ceeb ntawm cov neeg mob", lwm yam uas IV IgG"tsis zoo li yuav muaj txiaj ntsig kho mob hauv CFS".

Cov qauv no tau rov qab ua dua. Thaum Lub Ib Hlis Ntuj xyoo 1997, RCT tau tshaj tawm cov txiaj ntsig zoo ntawm IV IgG rau cov neeg mob hluas; Tom qab xyoo ntawd, ntxiv, thiab txog hnub kawg, qhov kev sim qhia tias IV IgG"yog ineffective"[24]. Kev kho mob2021, 9, 1546 3 ntawm 21 Nws yog qhov pom tseeb opaque thiab divergent daim duab uas tam sim no tshuaj xyuas nrhiav kom pom. Kev tshuaj xyuas ntawm cov txiaj ntsig tau sau tseg qhia tau tias qhov kev tshawb pom ntawm cov kev sim no tsis sib haum xeeb. Yuav kom tsim tau qhov no, nws yog ib qho tseem ceeb tsis txhob txwv tsis pub txiav txim siab rau cov ntsiab lus tshaj tawm tshaj tawm, tab sis coj mus rau hauv tus account cov yam ntxwv ntawm cov kev tshawb fawb thiab lawv cov kev tshawb pom tshwj xeeb. cistanche tubulosa khoom: