"Tus kab mob-cov tsos mob-tshuaj ntsuab" Supernetwork Analysis Thiab Core Formula Discovery Of Postmarketing Suav Patent Tshuaj Rau Kev Kho Mob Raum-yang Deficiency Ⅱ

2 Cov txiaj ntsig thiab kev txheeb xyuas

2.1 Kev Tshawb Fawb Txog Kev Tshawb Fawb

Qhov kev tshawb fawb tau ua rau 233 hom tshuaj suav tshuaj patent, uas tau lim kom khaws cov txiaj ntsig tshwj xeeb raws li lub teb chaws pom zoo tshuaj lub npe, lub npe lag luam, thiab lub npe tshuaj, thiab 190 Suav patent tshuaj tshuaj thaum kawg suav nrog.

2.1.1 Efficacy statistics Raws li kev lag luam Suav patent tshuaj rau kev kho mob raum yang deficiency syndrome

Kev faib tawm ua tau zoo (Daim duab 1-a) qhia tau hais tias feem coob ntawm Suav cov tshuaj patent rau lub raum yang deficiency syndrome yog tsuas yog rau kev ntxiv dag zog rau lub cev, ntxiv dag zog rau cov hlab ntsha, tshem tawm cov ntshav stasis, thiab lwm yam.

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2.1.2 Statistics ntawm concurrent syndromes: Kev kho mob raum yang deficiency syndrome raws li kev lag luam suav tshuaj patent

Los ntawm kev faib tawm ntawm concurrent syndromes (Daim duab 1-b), nws tuaj yeem pom tias cov tsos mob ntawm lub raum-yang deficiency feem ntau suav nrog spleen-yang deficiency syndrome, qi-blood deficiency syndrome, thiab essence-blood deficiency syndrome.

2.1.3 Kab mob thiab cov tsos mob ntau zaus Statistics

Kev txheeb xyuas cov kab mob hauv 190 daim ntawv tshuaj, tag nrho ntawm 43 kab mob thiab 19 cov tsos mob, xaiv

Sab saum toj 10 feem ntau cov kab mob (impotence, insomnia, thiab lwm yam) thiab cov tsos mob (kev qaug zog, kiv taub hau, nquag tso zis, thiab lwm yam) tau tshwm sim, raws li qhia hauv daim duab 2.

Fig. 1 Efficacy (a) thiab concurrent pov thawj (b) postmarketing Suav patent tshuaj rau kev kho mob raum-yangdeficiency

2.1.4 Ntau zaus txheeb cais ntawm cov tshuaj suav tshuaj

A statistical analysis was conducted on the traditional Chinese medicines in 190 prescriptions, involving 293 single medicines. The medicines with a frequency of >30 muaj nyob rau hauv Table 1.

2.2 Kev kho mob daim ntawv thov ntawm cov tshuaj suav suav patent rau raum yang deficiency syndrome

Ntawm 190 Suav cov tshuaj patent, 64 cov ntawv sau tshuaj muaj cov ntaub ntawv soj ntsuam, suav nrog 135 cov ntaub ntawv Askiv thiab 672 cov ntaub ntawv Suav, suav nrog 146 Suav cov ntaub ntawv uas suav nrog kev sim ntsuas, 180 kev soj ntsuam, thiab 83 kev tshuaj xyuas thiab ntsuas ntsuas. Muaj 263 cov ntaub ntawv xov xwm thiab lwm yam ntaub ntawv. Sab saum toj 10 feem ntau tshwm sim cov tshuaj raug xaiv los tso saib. Kev faib tawm ntawm Suav cov ntaub ntawv kho mob ntawm cov tshuaj suav tshuaj muaj nyob rau hauv daim duab 3. Muaj 16 Suav cov tshuaj patent nrog cov ntaub ntawv qhia txog kev tswj xyuas, xws li Compound Xuanju Capsules, Yougui Pills, thiab lwm yam.

Cov kev kho mob tshwj xeeb, cov teebmeem, thiab lwm yam ntaub ntawv muaj nyob rau hauv Table 2.

2.3 Kev soj ntsuam ntawm "kab mob-cov tsos mob-tshuaj" koom haum cov cai rau lub raum-yang deficiency syndrome

Los ntawm kev txheeb xyuas txoj cai koom nrog, cov kev cai sib raug zoo ntawm cov tshuaj sib xyaw thiab kev sib raug zoo sab hauv ntawm cov tsos mob thiab cov kab mob raug tshawb pom. Cov tshuaj sib xws rau cov tsos mob tseem ceeb ntawm lub raum yang deficiency syndrome muaj nyob rau hauv Table 3. Piv txwv li, cov tshuaj suav tshuaj suav nrog kev qaug zog suav nrog epimedium, wolfberry, ginseng, thiab lwm yam, thiab cov tshuaj suav tshuaj suav nrog kiv taub hau suav nrog Epimedium, wolfberry. , velvet antler, thiab lwm yam.

Table 1 Zaus txheeb cais ntawm cov tshuaj suav tshuaj (frequency> 30)

Fig. 3 Suav cov ntaub ntawv kho mob cov ntaub ntawv txheeb cais ntawm Suav patentmedicines

2.4 Ib txheej txheej network tsom xam cov txiaj ntsig

2.4.1 Kab Mob Layer Network Analysis Results

Kev lag luam suav tshuaj patent sau los ntawm txoj kev tshawb no rau kev kho mob raum-yang deficiency syndrome muaj 43 hom kab mob. Saib daim duab kos duab.

Daim duab 4; Cov nodes tseem ceeb ntawm nws txheej network yog impotence, insomnia, spermatorrhea, thiab lwm yam. Cov yam ntxwv tshwj xeeb ntawm cov yam ntxwv ntawm lub network tau qhia hauv Table 4.

2.4.2 Cov tsos mob txheej txheej network tsom xam cov txiaj ntsig

Kev lag luam suav tshuaj patent sau los ntawm txoj kev tshawb no rau kev kho mob raum-yang deficiency syndrome muaj 19 hom tsos mob, daim duab kos duab

Saib daim duab 4; cov core nodes ntawm nws lub network txheej yog qaug zog, tsis tshua muaj mob rov qab, kiv taub hau, thiab lwm yam. Cov yam ntxwv tshwj xeeb ntawm lub network yam ntxwv muaj nyob rau hauv Table 4.

2.4.3 Drug layer network analysis results

Sau cov khoom lag luam uas muaj tswv hauv Suav

Kev kho mob raum-yang deficiency syndrome suav nrog 293 tshuaj suav tshuaj. Daim duab kos duab tau pom nyob rau hauv daim duab 4. Lub hauv paus ntawm cov txheej txheem network muaj xws li epimedium, ginseng, cinnamon, thiab lwm yam. Cov yam ntxwv tshwj xeeb ntawm cov yam ntxwv ntawm lub network tau qhia hauv Table 4.

2.5 "Cov kab mob-cov tsos mob-tshuaj" super network tsom xam cov txiaj ntsig

Cov "kab mob-cov tsos mob-tshuaj" ntau txheej network thiab tsis muaj kev lag luam hauv Suav teb cov tshuaj patent rau kev kho mob raum-yang deficiency syndrome muaj nyob rau hauv daim duab 5 thiab Table 5. Ntawm lawv, 157 super-edges spanning 3 txheej thiab 136 hyper-edges spanning 2 txheej.

2.6 Hypernetwork-raws li kev tshuaj xyuas ntawm cov ntawv sau tseem ceeb thiab cov kab mob cuam tshuam rau lub raum yang deficiency syndrome

Kev faib tawm ntau tshaj ntawm cov tshuaj rau lub raum yang deficiency syndrome yog qhia nyob rau hauv Table 6, uas muab cov hyperedge tshaj qhov tseem ceeb nyob rau hauv 3 txheej ntawm "mob-symptom-drug" thiab cov 2-txheej hyperedge tshaj qhov tseem ceeb thoob plaws "kab mob-tshuaj" "los yog "symptom-drug". Tau lub raum yang deficiency syndrome super network

Cov tshuaj tseem ceeb: velvet antler, Cistanche deserticola, epimedium, Rehmannia glutinosa, wolfberry, ginseng, dodder, psoralen, Eucommia ulmoides, thiab aconite, thiab txheeb xyuas cov kev sib raug zoo nrog cov tshuaj (velvet antler, cistanche deserticola, epimedium) nrog tus nqi ntau tshaj. tshaj lossis sib npaug li 25 hauv cov ntawv sau tseem ceeb Cov kab mob thiab cov tsos mob. Cov kab mob tseem ceeb kho los ntawm nws yog impotence, spermatorrhea, ejaculation ntxov ntxov, thiab amnesia. Cov tsos mob tseem ceeb muaj xws li qaug zog, tinnitus, thiab kiv taub hau. Saib daim duab 6 kom paub meej.

Table 4 Network yam ntxwv ntawm ntau txheej hauv lub raum-yang deficiency supernetwork

Daim duab 5 Lub raum-yang deficiency supernetwork daim duab (ntsuab, daj, thiab ntsuab qhia cov kab mob, cov tsos mob, thiab tshuaj ntsuab, raws li, thiab cov node loj yog proportional rau lawv hyper degree)

2.4 Ib txheej txheej network tsom xam cov txiaj ntsig

2.4.1 Kab Mob Layer Network Analysis Results

Kev lag luam suav tshuaj patent sau los ntawm txoj kev tshawb no rau kev kho mob raum-yang deficiency syndrome muaj 43 hom kab mob. Saib daim duab kos duab.

Daim duab 4; Cov nodes tseem ceeb ntawm nws txheej network yog impotence, insomnia, spermatorrhea, thiab lwm yam. Cov yam ntxwv tshwj xeeb ntawm cov yam ntxwv ntawm lub network tau qhia hauv Table 4.

2.4.2 Cov tsos mob txheej txheej network tsom xam cov txiaj ntsig

Kev lag luam suav tshuaj patent sau los ntawm txoj kev tshawb no rau kev kho mob raum-yang deficiency syndrome muaj 19 hom tsos mob, daim duab kos duab

Saib daim duab 4; cov core nodes ntawm nws lub network txheej yog qaug zog, tsis tshua muaj mob rov qab, kiv taub hau, thiab lwm yam. Cov yam ntxwv tshwj xeeb ntawm lub network yam ntxwv muaj nyob rau hauv Table 4.

2.4.3 Drug layer network analysis results

Sau cov khoom lag luam uas muaj tswv hauv Suav

Kev kho mob raum-yang deficiency syndrome suav nrog 293 tshuaj suav tshuaj. Daim duab kos duab tau pom nyob rau hauv daim duab 4. Lub hauv paus ntawm cov txheej txheem network muaj xws li epimedium, ginseng, cinnamon, thiab lwm yam. Cov yam ntxwv tshwj xeeb ntawm cov yam ntxwv ntawm lub network tau qhia hauv Table 4.

2.5 "Cov kab mob-cov tsos mob-tshuaj" super network tsom xam cov txiaj ntsig

Cov "kab mob-cov tsos mob-tshuaj" ntau txheej network thiab tsis muaj kev lag luam hauv Suav teb cov tshuaj patent rau kev kho mob raum-yang deficiency syndrome muaj nyob rau hauv daim duab 5 thiab Table 5. Ntawm lawv, 157 super-edges spanning 3 txheej thiab 136 hyper-edges spanning 2 txheej.

2.6 Hypernetwork-raws li kev tshuaj xyuas ntawm cov ntawv sau tseem ceeb thiab cov kab mob cuam tshuam rau lub raum yang deficiency syndrome

Kev faib tawm ntau tshaj ntawm cov tshuaj rau lub raum yang deficiency syndrome yog qhia nyob rau hauv Table 6, uas muab cov hyperedge tshaj qhov tseem ceeb nyob rau hauv 3 txheej ntawm "mob-symptom-drug" thiab cov 2-txheej hyperedge tshaj qhov tseem ceeb thoob plaws "kab mob-tshuaj" "los yog "symptom-drug". Tau lub raum yang deficiency syndrome super network

Cov tshuaj tseem ceeb: velvet antler, Cistanche deserticola, epimedium, Rehmannia glutinosa, wolfberry, ginseng, dodder, psoralen, Eucommia ulmoides, thiab aconite, thiab txheeb xyuas cov kev sib raug zoo nrog cov tshuaj (velvet antler, cistanche deserticola, epimedium) nrog tus nqi ntau tshaj. tshaj lossis sib npaug li 25 hauv cov ntawv sau tseem ceeb Cov kab mob thiab cov tsos mob. Cov kab mob tseem ceeb kho los ntawm nws yog impotence, spermatorrhea, ejaculation ntxov ntxov, thiab amnesia. Cov tsos mob tseem ceeb muaj xws li qaug zog, tinnitus, thiab kiv taub hau. Saib daim duab 6 kom paub meej.

Hauv cov kab mob network, xaiv qhov tseem ceeb ntawm BC, CC, thiab DC qhov tseem ceeb los txheeb xyuas cov kab mob thawj zaug hauv ob khub, uas yog insomnia thiab impotence, xam lawv cov txiaj ntsig ntau dhau, thiab tshuaj xyuas lawv cov ntawv sau tseem ceeb. Raws li qhia hauv Table 7, cov ntawv sau tseem ceeb rau kev pw tsaug zog yog Epimedium, Schisandra chinensis, Rehmannia glutinosa, Cistanche deserticola, ginseng, thiab pilose antler; Cov tshuaj tseem ceeb rau impotence yog Epimedium, wolfberry, Rehmannia glutinosa, Cistanche deserticola, ginseng, dodder, pilose antler, thiab psoralen. , chive noob, thiab hauj sam. Qhov kev sib raug zoo ntawm "kab mob-cov tsos mob-tshuaj" ntawm impotence thiab raum-yang deficiency syndrome thiab insomnia thiab raum-yang deficiency syndrome yog qhia nyob rau hauv daim duab 7.

2.7 Kev sib piv ntawm cov tshuaj zoo sib xws thiab cov tshuaj sib raug zoo rau cov kab mob loj

Raws li pom nyob rau hauv daim duab 8, cov ntawv sau tseem ceeb ntawm kev lag luam Suav patent tshuaj rau kev kho mob raum yang deficiency syndrome thiab cov tshuaj siv ntau zaus muaj cov tshuaj siv ntau yam: epimedium, Rehmannia glutinosa, velvet antler, ginseng, cistanche, wolfberry, dodder, thiab tonic. .

Psoralen; Cov tshuaj feem ntau ntawm cov tshuaj tseem ceeb rau impotence nrog raum yang deficiency syndrome thiab insomnia nrog raum yang deficiency syndrome yog epimedium, Rehmannia glutinosa, velvet antler, ginseng, thiab cistanche deserticola.

Xaiv cov tshuaj ua ke nrog kev ntseeg siab ntawm ntau dua lossis sib npaug li 90% los tso saib cov tshuaj tseem ceeb sib raug zoo ntawm kev lag luam suav tshuaj patent tshuaj kho impotence thiab insomnia, cov kab mob tseem ceeb ntawm lub raum yang deficiency syndrome. Piv txwv li, feem ntau siv yeeb tshuaj khub hauv Suav patent tshuaj rau kev kho mob ntawm impotence muaj xws li wolfberry-leek noob thiab epimedium- Cuscuta-wolfberry, thiab lwm yam. Feem ntau siv tshuaj khub rau kev kho insomnia xws li Schisandra-Cistanche deserticola, Rehmannia glutinosa-Angelica, thiab lwm yam. , raws li qhia hauv Table 8.

3 Kev sib tham

3.1 Clinical daim ntawv thov ntawm Suav patent tshuaj nyob rau hauv kev kho mob raum-yang deficiency syndrome tom qab lawv tso tawm rau lub lag luam

tsom xam

Los ntawm kev tshawb nrhiav cov ntaub ntawv thiab kev tshuaj xyuas, nws tau pom tias 63 ntawm 190 Suav patent tshuaj koom nrog hauv txoj kev tshawb no muaj cov ntaub ntawv qhia txog kev siv tshuaj kho mob, thiab 16 ntawm lawv tau soj ntsuam cov ntaub ntawv sau tseg. Xws li compound Xuanju

Capsules [19] yog siv los kho infertility hauv chaw kho mob los ntawm kev soj ntsuam cov txiaj ntsig zoo xws li tag nrho cov phev suav, phev ceev, thiab cov phev fructose cov ntsiab lus. Tag nrho cov txiaj ntsig zoo yog siab li 97.50%; Yougui Pills [20] kho cov mob polycystic zes qe menyuam thiab siv tau zoo thaum noj ib leeg. Muaj qhov sib txawv tseem ceeb hauv cov ntshav endocrine cov tshuaj hormones, plab hnyuv thiab plab B-ultrasound, lub tsev menyuam thiab zes qe menyuam qhov ntsuas hauv Ying-35 pawg tswj hwm (P<0.05); the decoction of Jingui Shenqi Pills [21] and the control group were significantly different. There were significant differences in outcome indicators such as Jiangzhi and Glucophage oral treatment for type 2 diabetes mellitus combined with hyperlipidemia between the two groups (P<0.05). Overall, the clinical efficacy of 16 prescriptions reported in the randomized controlled trial literature

Cov kev ua tau zoo yog tag nrho cov siab, lossis qhov sib txawv ntawm ob pawg ntawm cov cim qhia tseem ceeb. Txawm li cas los xij, cov txiaj ntsig ntawm kev soj ntsuam kev ua tau zoo yog cov ntsiab lus tseem ceeb, thiab tsis muaj cov ntaub ntawv pov thawj kho mob zoo los txhawb kev siv tshuaj hauv Suav teb patent tshuaj tom qab lawv tau pib. Yog li ntawd, nws yog ib qho tseem ceeb tshwj xeeb rau tom qab tsim cov tshuaj suav patent rau lub raum-yang deficiency syndrome thiab nrhiav cov ntaub ntawv pov thawj zoo los txhawb kev siv tshuaj kho mob.

3.2 Cov kev cai siv feem ntau ntawm Suav cov tshuaj patent rau kev kho mob raum-yang deficiency syndrome tom qab lawv tso tawm hauv khw

tsom xam

Txoj kev tshawb no pom tau hais tias txij li tib lub syndrome muaj tib yam pathogenesis, Suav patent tshuaj siv los kho lub raum-yang deficiency syndrome tom qab lawv pib muaj ib co yam ntxwv, xws li velvet antler, cistanche deserticola, epimedium, Rehmannia glutinosa, wolfberry, ginseng. , dodder, thiab pob txha-boosting rog, Eucommia, thiab Aconite. Sib txawv los ntawm kev tshuaj ntsuam xyuas tshuaj ntau zaus, nws tuaj yeem pom los ntawm super network tsom xam tias qhov tseem ceeb ntawm velvet antler thiab cistanche deserticola hauv kev siv lub raum yang deficiency syndrome yog siab dua qhov zaus ntawm kev siv, uas tseem qhia txog qhov tseem ceeb ntawm kev siv. raum yang-tonifying tshuaj rau cov neeg mob raum yang deficiency. qhov tseem ceeb. Kev tshawb fawb tshuaj niaj hnub no [35] pom tias phenylethanoid glycosides hauv Cistanche deserticola tuaj yeem tso cov khoom xa tawm thiab cov tshuaj hormones hauv lub cev, ua lub luag haujlwm tiv thaiv kev qaug zog, thiab txhim kho lub cev ua haujlwm; velvet antler yog dav siv nyob rau hauv lub cev pob txha, kab mob raum, thiab cov txiv neej cov kab mob [36], tuaj yeem txhim kho kev sib deev muaj nuj nqi thiab txhim khu kev tiv thaiv.

Cov txiaj ntsig ntawm kev tshuaj ntsuam xyuas cov tshuaj siv ntau zaus thiab kev tshuaj xyuas super network qhia tau hais tias ob yam tshuaj, Rehmannia glutinosa thiab Lycium barbarum, uas txhawb nqa yin thiab ntshav, feem ntau siv cov tshuaj thiab cov tshuaj tseem ceeb. Ntawm cov tshuaj yang-tonifying, wolfberry, Rehmannia glutinosa, thiab lwm yam yin-nourishing tshuaj yog ua ke, uas yog raws li Zhang Jingyue hais tias, "Cov neeg uas zoo ntawm tonifying yang yuav tsum nrhiav yang los ntawm yin, kom yang yuav pab tau. los ntawm yin thiab dhau los ua cov txheej txheem biochemical tsis kawg" [37]. Cov kev tshawb fawb tau pom tias cov koob tshuaj ntau ntawm wolfberry polysaccharide tuaj yeem txhim kho kev ua haujlwm ntawm cov nas infertile nrog raum yang deficiency [38]; Rehmannia glutinosa tuaj yeem tswj hwm cov haujlwm ntawm osteoblasts thiab osteoclasts los ntawm qee yam cannabinoid hom 2 receptor agonistic ua haujlwm [39].

Tsis tas li ntawd, txoj kev tshawb no coj impotence thiab insomnia, cov kab mob tseem ceeb tshaj plaws ntawm lub raum-yang deficiency syndrome kho los ntawm Suav patent tshuaj tam sim no nyob rau hauv kev ua lag luam, ua piv txwv. Nws siv txoj hauv kev super-network los txheeb xyuas cov ntawv sau tseem ceeb thiab pom tias ob daim ntawv tshuaj tseem ceeb siv cov tshuaj tsom rau lub raum-yang tsis txaus. Cov tshuaj uas muaj ntau yam pathogenesis: Epimedium, Rehmannia glutinosa, Cistanche deserticola, ginseng, thiab pilose antler, uas yog raws li cov lus qhia tseem ceeb rau kev kho mob raum-yang deficiency syndrome, tag nrho embodying lub ntsiab ntawm "kho cov kab mob sib txawv nrog tib txoj kev kho mob".

3.3 Heterogeneity tsom xam tom qab kev lag luam Suav patent tshuaj rau kev kho mob loj nrog raum-yang deficiency syndrome

Txoj kev tshawb no pom tias txawm hais tias lawv txhua tus muaj nyob rau hauv lub raum-yang deficiency syndrome, vim qhov tshwj xeeb ntawm tus kab mob thiab tus kheej sib txawv ntawm cov neeg mob, cov tshuaj kho mob muaj nws qhov tshwj xeeb raws li cov yam ntxwv ntawm cov kab mob sib txawv. Piv txwv li, noj tam sim no cov lag luam suav tshuaj patent tshuaj kho impotence thiab insomnia, cov kab mob tseem ceeb tshaj plaws ntawm lub raum-yang deficiency syndrome, ib txoj hauv kev super-network tau siv los tshuaj xyuas cov ntawv sau tseem ceeb. Nws tau pom tias ob daim ntawv sau tseem ceeb tshwj tsis yog rau cov tshuaj siv tib yam pathogenesis ntawm lub raum-yang deficiency syndrome. , txhua yam tshuaj muaj nws lub hom phiaj. Cov tshuaj tshwj xeeb hauv cov tshuaj tseem ceeb rau insomnia yog Schisandra chinensis. Hauv kev tshawb fawb tshuaj niaj hnub no, Schisandra chinensis lignans tswj 5-hydroxytryptamine (5-HT) thiab 5-hydroxyindoleacetic acid (5-}hydroxytryptamine) nyob rau hauv hypothalamus ntawm insomnia nas. hydroxyindoleacetic acid, 5-HIAA) qib, ua tiav cov nyhuv hypnotic [40].

Qhov sib xyaw ua ke siab tshaj plaws ntawm cov tshuaj rau insomnia yog Rehmannia glutinosa, Angelica sinensis, yam, thiab dogwood. Cov tshuaj uas tau hais los saum toj no yog txhua yam zoo rau kev noj qab haus huv qi, ntshav, yin, thiab yang ntawm ob lub raum. Rehmannia glutinosa nourishes lub siab thiab ob lub raum, yam ntxiv dag zog rau tus po thiab qi, thiab dogwood nourishes yin ntawm daim siab thiab ob lub raum. , nws compatibility tuaj yeem pom hauv Liuwei Dihuang Pills. Danggui nourishes thiab activates ntshav ncig tswj cov hlab ntsha thiab tuaj yeem pab kev thauj mus los thiab kev hloov pauv ntawm ntau yam tshuaj. "Cov neeg uas muaj kev noj qab haus huv zoo yuav tsum nrhiav yang los ntawm yin." Yog li ntawd, feem ntau ntawm kev sib raug zoo hauv pab pawg no yog rau kev txhawb nqa lub siab thiab lub raum. Yin tshuaj ua lub luag haujlwm tseem ceeb hauv qhov tshwm sim ntawm lub raum yang, thiab tag nrho cov tshuaj sov so, uas tuaj yeem txo qhov hluav taws kub thiab npau taws, thiab sov so zoo dua thiab txhawb lub raum yang. Ib qho tsos mob ntawm insomnia yog tias yang tsis nkag yin thiab yin tshuav yang.

Tsis pub leej twg paub, tus ntsuj plig tau kho, yin thiab yang raug cais, thiab cov ntsiab lus thiab qi tau qaug zog. Yog li, tus neeg mob tsis tuaj yeem tswj hwm lub zog yang ntawm lub cev vim lub siab tsis txaus thiab lub raum yin, yog li nws pw tsis zoo thiab pw tsaug zog me ntsis.

Licorice yog sib xws nrog Polygonum multiflorum thiab Epimedium. Licorice replenishes qi thiab daws phlegm. Nws tseem hu ua "Guo Lao Cao". Licorice yog siv nyob rau hauv ntau cov tshuaj. Nws kuj tseem siv tau los ua tshuaj ntsuab. Nyob ntawm nws qhov kev npaj, nws muaj qhov sib txawv ntawm cov tshuaj sib txawv. Sib txawv, piv txwv li, Zhigancao belongs rau lub plawv, spleen, ntsws, thiab plab meridians, thiab muaj peev xwm ntxiv dag zog rau tus po, pab kev thauj mus los, thiab replenish kub thiab yang. Thaum siv cov tshuaj yang-tonifying, nws tuaj yeem txhawb nqa kev nqus ntawm ntau yam tshuaj. Polygonum multiflorum yog iab thiab sov, nkag mus rau lub plawv thiab lub raum meridian, thiab zoo rau kev noj qab haus huv daim siab thiab ob lub raum. Epimedium, tseem hu ua fairy spleen, tuaj yeem txhawb nqa lub raum yang, ntxiv dag zog rau cov leeg thiab pob txha, thiab tshem tawm rheumatism.

Kev sib xyaw ua ke ntawm Polygonum multiflorum thiab Epimedium feem ntau yog siv rau hauv cov ntawv sau los txhawb nqa lub raum yang, xws li Guilu raum Pills. Txawm li cas los xij, Polygonum multiflorum yog tshuaj lom ua ntej ua tiav, thiab licorice tuaj yeem tshem tawm thiab ua kom nws cov khoom siv tshuaj.

Cov tshuaj tshwj xeeb rau cov ntawv sau tseem ceeb rau impotence yog cov noob qoob loo, aconite noob, wolfberry, psoralen, thiab dodder noob. Noj leek noob, aconite, thiab wolfberry ua piv txwv, wine-roasted leek noob tuaj yeem sov thiab txhawb nqa lub raum yang los ntawm ntau txoj hauv kev xws li tswj cov lipids thiab N-acetyl glycoproteins [41]; dej-soluble extracts ntawm aconite noob [42] tuaj yeem txhim khu hydroxyl Lub humoral kev tiv thaiv ntawm nas nrog "yang deficiency" tshwm sim los ntawm urea tuaj yeem txo lawv txoj kev tuag; wolfberry tuaj yeem cuam tshuam rau kev ua haujlwm ntawm hypothalamic-pituitary-gonadal axis, yog li txhim kho kev ua haujlwm ntawm kev ua me nyuam [43]. Qhov sib xyaw ua ke tshaj plaws hauv kev kho mob impotence yog psoralen, epimedium, thiab cinnamon. Ntawm lawv, psoralen warms lub raum, pab yang, absorbs qi, thiab relieves raws plab. "Treatise on Medical Properties" sau tseg tias psoralen "kho txiv neej mob nraub qaum thiab mob hauv caug." Dampness nyob rau hauv lub hnab yuav tshem tawm cov tawv nqaij tuag tes tuag taw, nres tso zis, thiab ua rau mob khaub thuas hauv plab."

"Rihuazi Materia Medica" sau tseg tias nws tuaj yeem "txhawb yang, kho mob khaub thuas qaug zog, thiab ua kom lub pob ntseg thiab qhov muag ci." Epimedium nourishes lub raum yang thiab ntxiv dag zog rau cov leeg thiab pob txha, thiab cinnamon induces hluav taws kom rov qab mus rau yuan, uas tuaj yeem nqus raum qi; impotence yog tshwm sim los ntawm tsis muaj kev noj haus ntawm cov leeg thiab so. , tus kab mob ntawm impotence ntawm noov uas tsis muaj zog, tsis tuaj yeem ruaj khov thaum sib deev, los yog khov tab sis tsis kav ntev, yog kho los ntawm kev txhawb nqa lub siab thiab ob lub raum, ua kom sov lub raum, txhawb yang, thiab ntxiv dag zog rau cov leeg thiab cov leeg. Psoralen thiab epimedium tuaj yeem txhawb nqa lub raum. Rehmannia glutinosa, wolfberry, thiab lwm yam tshuaj txhawb yin ntawm daim siab thiab ob lub raum thiab txhawb nqa cov ntsiab lus thiab cov ntshav; aconite, eucommia, dodder noob, leek noob, Cynomorium cynomorium, thiab lwm yam. sov lub raum thiab ntxiv dag zog rau yang; cinnamon coj hluav taws rov qab mus rau yuan; velvet antler yog ib yam khoom ntawm cov nqaij thiab cov ntshav, uas yog qhov zoo rau cov neeg tsis muaj zog lossis cov neeg laus Cov neeg mob tuaj yeem nqus tau astragalus sai sai los ua kom cov qi, ua rau tib neeg muaj zog thiab ncig qi thiab ntshav.

3.4 Super network tsom ntawm qhov zoo ntawm "kab mob-cov tsos mob-tshuaj" network

Cov tshuaj tau los ntawm super network tsom xam siv nyob rau hauv txoj kev tshawb no muaj ntau tshaj li cov ntsiab lus ntawm yooj yim high-frequency tsom xam los yog ib-txheej network tsom xam. Kev soj ntsuam ntau zaus ntawm cov ntawv sau tseem ceeb tsuas yog txiav txim siab qhov zaus ntawm cov tshuaj uas tshwm sim hauv khw muag khoom hauv Suav teb thiab tsis xav txog cov kev hloov pauv ntawm cov qauv siv tshuaj rau cov kab mob sib txawv thiab cov tsos mob. Ib yam yog qhov tseeb rau qhov kev soj ntsuam ib leeg-txheej network, uas tsuas yog txiav txim siab txog kev sib raug zoo ntawm cov tshuaj, cov tsos mob thiab cov tsos mob, thiab cov kab mob, yog li txiav tawm kev sib txuas ntawm "mob-cov tsos mob-tshuaj-tshuaj-tshuaj".

Lub network super muaj cov yam ntxwv ntawm ntau txheej, ntau theem, thiab ntau qhov sib txawv. Kev tsom xam ntawm kev lag luam cov tshuaj suav ua lag luam los ntawm qhov kev xav holistic yog ntau nyob rau hauv txoj kab nrog lub ntiaj teb tiag tiag cov tshuaj thiab cov xwm txheej tshuaj. Txoj kev tshawb no tshuaj xyuas cov ntawv sau tseem ceeb ntawm kev lag luam Suav patent tshuaj rau kev kho mob raum yang deficiency syndrome los ntawm hyper network, thiab txuas peb qhov ntev ntawm tus kab mob, cov tsos mob, thiab cov tshuaj los ntawm hyperedges rau ntau intuitively tso saib peb-txheej hyperedge sum txuas "kab mob. -symptom-drug" Lub 2-txheej hyperedge txuas "mob-tshuaj" lossis "kab mob-tshuaj", noj cov tshuaj velvet antler nrog rau qhov siab tshaj plaws ntawm hyper degree ua piv txwv, los ntawm cov hyperedges xws li "antler-tinnitus " thiab "antler-fatigue-amnesia", nws pom tau tias Cov tsos mob ntawm kev lag luam hauv Suav teb patent tshuaj rau kev kho mob raum-yang deficiency syndrome yog qaug zog, tinnitus, kiv taub hau, mob nraub qaum, thiab tso zis ntau zaus; Cov kab mob uas muaj xws li insomnia, ejaculation ntxov ntxov, impotence, spermatorrhea, thiab amnesia.

Nyob rau hauv cov txheej txheem ntawm kev kuaj mob thiab kev kho mob, kev siv tshuaj ntxiv thiab rho tawm kev kho mob feem ntau yog ua los ntawm kev sib txawv ntawm cov kab mob sib txawv thiab ua ke nrog tus kab mob nws tus kheej. Txoj kev tshawb xyuas super network hauv txoj kev tshawb fawb no txheeb xyuas cov ntsiab lus tseem ceeb ntawm ntau txheej txheej network, xaiv cov ntawv sau tseem ceeb rau kev kho mob raum yang deficiency syndrome, qhia txog cov yam ntxwv thiab cov cai ntawm Suav cov tshuaj patent rau kev kho mob raum yang deficiency syndrome, thiab tuaj yeem coj tus cwj pwm. soj ntsuam daim ntawv thov ntawm Suav patent tshuaj thiab kev txhim kho cov tshuaj tshiab. Qee qhov kev siv.

Cov ntaub ntawv

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