Anti-Neuroinflammatory Thiab NO-Inhibiting Activity ntawm Triterpenoids

Thov hu raujimmy.wu@wecistanche.comyog xav paub ntxiv

Anti-Neuroinflammatory thiab NO-Inhibiting teebmeem ntawm FlavonoidsCudraflflavanone A:Cudrania tricuspidataBureau (Moraceae) yog ib txwm siv los kho ntau yam kab mob vim nws yog ib qho chaw nplua nuj ntawm cov tshuaj bioactive uas muaj peev xwm.bioflavonoids lub ntsiab luscov teebmeem, suav nrog kev tiv thaiv kab mob, neuroprotective, thiab kev ua haujlwm antioxidant. Cudraflflavanone A, ib qho tseem ceeb ntawm cov nroj tsuag no, tawm tsam cov teebmeem ntawm neuroinflammatory los ntawm kev tiv thaiv NO, PGE2, thiab iNOS ntau lawm hauv LPS-stimulated BV2 hlwb tag nrho raucistanche cuam tshuam, thiab nws inactivates NF-κB, P38, thiab JNK MAPK qhia txoj hauv kev. Tsis tas li ntawd, qhov sib xyaw no ua rau HO-1 qhia los ntawm Nrf2 translocation; Txawm li cas los xij, tsis muaj kev cuam tshuam rau kev qhia ntawm COX-2 protein tau pom. Cov kev tshawb pom no qhia tau hais tias cudraflflavanone A tuaj yeem siv los tiv thaiv neuroinflammation thiab tiv thaiv kab mob neurodegenerative.

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cistanche cuam tshuam

Daidzein:Glycine max(Fabaceae) feem ntau hu ua taum pauv. Ntau qhov kev tshawb fawb tau tshawb fawb los tshuaj xyuas kev siv cov nroj tsuag no, suav nrog kev tiv thaiv kab mob osteoporosis thiab txo cov roj cholesterol, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, thiab tshuaj tiv thaiv kab mob.cistanche hmoov cov txiaj ntsig kev noj qab haus huv. Tom qab noj cov taum pauv, polysaccharide fatty acids tau hloov mus rau hauv docosahexaenoic acids, uas cuam tshuam nrog ntau yam txiaj ntsig ntawm lub raum thiab cov kab mob inflammatory. Daidzein, ib qho tseem ceeb ntawm isoflavone, nthuav tawm kev ua haujlwm tiv thaiv kab mob hauv cov kab mob hauv lub paj hlwb los ntawm kev txwv tsis pub tsim tawm hauv LPS-stimulated qauv, thiab nws tuaj yeem kho cov kab mob hauv lub paj hlwb los ntawm inhibiting kev qhia ntawm protein-inflammatory cytokines, chemokines, interleukin {{3} } mRNA, thiab monocyte chemoattractant protein-1

cov txiaj ntsig cistanche

zaj tshuaj ntsuab cistanche yog ib txwm siv nyob rau hauv Asia los kho cov kab mob inflammatory, thiab tej zaum kuj yog siv los kho lwm yam mob nrog rau daim siab raug mob, pancreatic puas, thiab gastric ulcers los ntawm kev ua ntawm NF-κB txoj kev. Hauv Kaus Lim Qab Teb, nws yog siv los kho cov kab mob plab hnyuv. Eupatilin, ib qho tseem ceeb ntawm cov khoom siv bioactive, tau pom zoo kom nthuav tawm ntau yam tshuaj ua haujlwm xws li tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob, raws li ntau yam hauv vitro thiab hauv vivo kev tshawb fawb.

Nws tswj cov kab mob microglia nyob rau hauv ib ntus focal cerebral ischemia thiab exertscistanche hmoov cov txiaj ntsig kev noj qab haus huvntawm o. Genistein: Soybean yog cov khoom noj tseem ceeb hauv cov tebchaws Esxias thiab cov roj thiab cov proteins rau tib neeg thiab tsiaj txhu. Nws muaj phytoestrogens uas tau siv los kho ntau yam tshuaj hormone-dependent thiab ywj siab pathologies, nrog rau ntau yam qog nqaij hlav xws li mis, prostate, thiab mob qog noj ntshav, nrog rau lwm yam kab mob xws li rog rog, kab mob plawv, Alzheimer's disease, thiab osteoporosis. Genistein, ib tug bioactive constituent, muajInt. J. Mol. Sci.2021, 22, 4771 7 ntawm 28 tau pom tias muaj kev cuam tshuam los tiv thaiv kab mob thaum muaj kab mob hauv lub paj hlwb los ntawm NO inhibition, thiab nws inhibits NF-κB, proinflammatory cytokines, thiab ua kom cov AMP kinase, yog li exerting anti-inflammatory teebmeem.

Orobol 40 -O- -D-apiofuranosyl-(1→6)- D-glucopyranoside:Tilia amurensis(Tiliacea) feem ntau hu ua "bee tree" thiab tau dav dav hauv Nyiv, Kaus Lim Qab Teb, Tuam Tshoj, thiab Russia. Cov nplooj ntawm cov nroj tsuag no yog siv los kho mob qog noj ntshav. Tshuaj yej los ntawm cov nroj tsuag no yog nquag noj vim nws sedative, diaphoretic, thiab antispasmodic zog. Orobol 40 -O- -D-apiofuranosyl-(1→6)- -D-glucopyranoside, ib qho isofflavonoid cais los ntawm cov nroj tsuag no, tau tshuaj xyuas txog nws cov kev tiv thaiv neuroprotective tiv thaiv cov kab mob neurodegenerative, thiab ntawm ob peb lwm cov metabolites cais tawm los ntawm cov nroj tsuag no, cov compound no tau pom qhov cuam tshuam zoo tshaj plaws inhibition ntawm NO ntau lawm hauv LPS-stimulated BV2 hlwb. Quercetin:Impatiens balsamina(Balsaminaceae) tau dav dav hauv Is Nrias teb, Tuam Tshoj, thiab Kaus Lim Qab Teb. Nws muaj keeb kwm ntev ntawm kev siv rau kev kho mob dermatitis, scalds, kub hnyiab, neuralgia, thiab lumbago. Ntau cov kev tshawb fawb pharmacological tau txhawb nqa nws txoj kev kho mob zoo li tshuaj tua kab mob antioxidant, anticancer, anti-nociceptive, anti-inflammatory, anti-anaphylactic, thiabcistanche tubulosa ncovim nws cov ntsiab lus flavonoid siab.

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cistanche tubulosa nco txiaj ntsig

Quercetin yog ib qho ntawm cov nquag nquag metabolites uas tau raug soj ntsuam rau nws cov haujlwm tiv thaiv neuroprotective. Cov txiaj ntsig no qhia tiasI. balsaminayog ib qhov chaw tshiab ntawm cov tshuaj tiv thaiv neuroinflammatory ntuj tebchaw uas inhibit NO ntau lawm nyob rau hauv LPS-stimulated BV2 hlwb thiab ntau hom.cistanche hmoov cov txiaj ntsig kev noj qab haus huv . Tsis tas li ntawd, quercetin tswj lub hlwb nitrite qib los tiv thaiv kev ua haujlwm ntawm ntau oxidases thiab elicits antidepressant thiab inflammatory teb. Sophoraflflavanone G:Sophora alopecuroides(Fabaceae) yog ib txwm siv hauv Suav teb los kho mob, mob, thiab ua npaws. Sophoraflflavanone G yog lub ntsiab metabolite thib ob uas cais tawm ntawm cov nroj tsuag no thiab tau pom tias muaj cov teebmeem tiv thaiv kab mob.

S. alopecuroidestau raug soj ntsuam rau lawv cov kev ua haujlwm neuroinflammatory hauv LPS-stimulated BV2 hlwb; nws txo qis kev qhia ntawm NO, PGE2, TNF- , IB -1 , thiab IL-6. Cov kev tshawb fawb ntxiv tau qhia txog qhov cuam tshuam ntawm cov nroj tsuag no tuaj yeem raug ntaus nqi los ntawm kev muaj cov tshuaj sophoraflflavanone G. Tsis tas li ntawd, sophoraflflavanone G inhibits qhov kev qhia ntawm iNOS thiab COX-2, downregulates JAK/STAT, P13K/AKT, thiab MAPK txoj kev, thiab upregulates oxygenase -1 qhia. Ua ke, cov txiaj ntsig no qhia tias sophoraflflavanone G tuaj yeem siv los ua tus neeg sawv cev tiv thaiv neuroinflammatory [72]. Tangeretin:Citrus aurantium(Rutaceae), feem ntau hu ua iab txiv kab ntxwv, tau nthuav dav thoob plaws Asia. Medicinally, cov nroj tsuag no yog siv raws li kev noj qab haus huv suppressant thiab stimulant; Txawm li cas los xij, hauv cov tshuaj suav tshuaj, nws yog siv los kho cov kab mob plawv, mob qog noj ntshav, cem quav, plab zom mov, thiab xeev siab. Cov nroj tsuag no tuaj yeem tiv thaiv qog nqaij hlav cancer vim muaj cov tangeretin, ib qho tseem ceeb. Cov teebmeem ntawm tangeretin ntawm neuroinflammation qhia tias nws inhibits neurodegenerative mob los ntawm inhibiting NO, IL-1 , COX-2, MAPK, NF-κB, IB- , thiab IKK- hauv LPS-stimulated BV2 hlwb, yog li tiv thaiv cov kab mob neurodegenerative.