Vim li cas Cistanche tuaj yeem txhim kho kev kawm thiab nco, thiab tiv thaiv kev laus?

Kev tshawb fawb txog cov tshuaj lom neeg ntawm Cistanche thiab kev txhim kho kev txawj ntse thiab kev tiv thaiv kev laus

Hu rau:joanna.jia@wecistanche.com/ WhatsApp: 008618081934791

Wang Yan, Zhang Yaochun, Wang Liwei (Institute of Medicinal Plants, China Academy of Medical Sciences thiab Peking Union Medical College, Beijing, 10094)

Abstract: Nrog rau kev nce ntawm cov neeg laus, qhov tshwm sim ntawm Alzheimer's tus kab mob tau nce thiab siab dua. Nrhiav thiab tsim cov tshuaj ntuj uas muaj kev ywj pheej ntawm kev txawj ntse cov cai los tiv thaiv thiab kho Alzheimer's thiab lwm yamkev kawm thiab kev ncoCov kev tsis sib haum xeeb tau dhau los ua ib qho kev tshawb fawb hotspots hauv xyoo tas los no. Kev tshawb fawb niaj hnub qhia tiasCistanchemuaj cov tshuaj ua haujlwm xws li antioxidant, tshem tawm cov dawb radicals, txo cov cell apoptosis, thiab txhim kho kev tiv thaiv. Nws tuaj yeem txhim kho kev txawj ntse thiab txhim kho covkev kawm thiab kev ncopeev xwm nas. Nws muaj lub zeem muag ntawm kev tshawb fawb thiab kev loj hlob ntxiv. Tsab ntawv xov xwm no qhia txog cov txiaj ntsig kev tshawb fawb ntawm kev tshawb fawb hauv tsev thiab txawv teb chaws ntawm cov tshuaj muaj pes tsawg leeg ntawmCistanche, anti-aging, thiab txhim kho kev kawm thiab kev nco tsis zoo.

Ntsiab lus: Cistanche; tshuaj muaj pes tsawg leeg;kev kawm thiab kev nco; anti-aging

Nrog rau kev nce ntawm cov neeg laus, qhov tshwm sim ntawm Alzheimer's tus kab mob tau nce thiab siab dua. Nws kwv yees tias los ntawm 2025, tus naj npawb ntawm cov neeg cuam tshuam los ntawm tus kab mob yuav ncav cuag 14 lab hauv ntiaj teb. Alzheimer's tus kab mob yog ib qho kab mob neurodegenerative uas muaj ntau yam etiological yam ntxwv los ntawm kev nco thiab kev paub tsis meej. Vim tias tsis muaj cov qauv tsiaj uas tuaj yeem ua tau zoo dua simulate cov kev hloov pauv pathological ntawm Alzheimer's tus kab mob, nws coj qee yam nyuaj rau kev txhim kho thiab kev tshawb fawb ntawm cov tshuaj zoo. . Cov kev tshawb fawb niaj hnub no qhia tau hais tias cov nqaij muab tshuaj txhuam muaj cov tshuaj siv tshuaj xws li tshuaj tiv thaiv oxidation, tshem tawm cov dawb radicals, txo cov cell apoptosis, thiab txhim kho kev tiv thaiv ntawm lub cev. Nws tuaj yeem txhim kho kev txawj ntse thiab txhim kho covkev kawm thiab kev ncopeev xwm nas. Nws yog ib qho hotspots ntawm kev tshawb fawb nyob rau hauv xyoo tas los no.

Cistanchedeserticola YCma (Cistanche deserticola YCma) yog qhuav, scaly-leaved fleshy qia ntawm Cistanche cog ntawm Onsanchaeceae genus Cistanche. Cov nyhuv ntawm nourishing essence thiab ntshav, moisturizing plob tsis so tswj thiab laxative, muaj lub koob npe nrov ntawm "suab puam ginseng", uas yog thawj zaug sau tseg nyob rau hauv "Shen Nong's Materia Medica" thiab teev nyob rau hauv lub sab saum toj qeb. CovCistanchegenus cog suav nrog hauv Suav Pharmacopoeia yog cistanche. Kab lus no tshuaj xyuas cov chemistry ntawm Cistanche nyob rau hauv xyoo tas los Kev tshuaj xyuas ntawm cov txiaj ntsig kev tshawb fawb ntawm cov khoom xyaw,kev kawm thiab kev nco, thiabanti-agingtshuab.

Cistancheua tautxhim kho kev nco

1 Tshuaj muaj pes tsawg leeg ntawm Cistanche^[2-4]

Kev tshawb fawb ntawm cov tshuaj muaj pes tsawg leeg ntawmCistanchepib thaum ntxov 1980s. Los ntawm cov ntaub ntawv qhia txog kev ua haujlwm ntawm Kobayashi thiab lwm tus hauv xyoo 1983 ntawm cov tshuaj muaj pes tsawg leeg ntawm cov suab puam Cistanche, cov kws tshawb fawb Nyij Pooj tau ua haujlwm ntau yam kev tshawb fawb. Cov khoom siv tshuaj lom neeg ntawm Cistanche tau kawm feem ntau hauv tib genus, thiab 69 cov tebchaw tau raug cais tawm.

1.1 Phenylethanol glycosides (phenylethanoid glycosides, PhGs)

Tam sim no, tag nrho ntawm 17 tau raug cais tawm, uas Cistanoside AH, decaffeovlacteoside, manthuside E, thiab salidroside yog tshwj xeeb rau Cistanoside AH. Tsis tas li ntawd, nws kuj suav nrog ib sab 2-acetylate. tubuloside AB, syringalide A 3"-dL-rhamnopy landside, isnucleoside, acteoside, echinacoside, thiab lwm yam khoom xyaw.

1.2 Cycloalkenyl ethers thiab lawv glycosides (iridoids thiab iridoid glycosides)

Tam sim no, 10 ntawm lawv tau sib cais, uas yog 6-deoxycatalpol.8- epiloganie acid, (geniposidic acid) glucoside Leonurine, mussacnowidic acid, iridoid tivthaiv cistachlorin (Sistani), iridoid glycoside bartsioside-epidoxyloganic acid. , cov uas plaub tom kawg yog tshwj xeeb rauCistanche.

1.3 lignans thiab lignan glycosides (lignans thiab lignan glycosides)

Tam sim no, cais (ntxiv rau) pinoresinol, liriodendron (ntxiv rau)-syringaresinol-o-glucopyranoside Ntawm lawv, (ntxiv rau) pinoresinol 3 yog ib qho tshwj xeeb ntawm cov nqaij mashed.

1.4 Lwm cov khoom xyaw

Xws li phenol glycosides, monoterpene glycosides, alkaloids, suab thaj, qab zib cawv, sterols, thiab lwm yam hauv galactitol. Cistanoside F(VII), sucrose, cistanoside(VIII), M, N dimethylglycine methyl ester, 2. 5-dioxo-4-}imidazolidimyl carbamic acid, - valerolactone, polysaccharides, B-sitosterol. glucoside 3'-0-heptadecoicute(X), 2-nonacosanone, tria muaj acid, bis-2-ethyl-hexyl-phthalate, I-triacontanol, catalpol, thiab lwm yam khoom xyaw tshwj xeeb ntawm Cistanche. Phenylethanol glycosides yog cov khoom tseem ceeb ntawmCistanche. Nws tau raug tshaj tawm nyob rau hauv cov ntaub ntawv hais tias chlorogenic acid tau siv los ua tus qauv sab hauv los txiav txim siab cov ntsiab lus ntawm echinacoside hauv tag nrho glycosides ntawm Cistanche ua ib qho kev ntsuas rau kev tswj xyuas zoo ntawm Cistanche. Cov txiaj ntsig tau ntseeg tau. ^(5-6)

cistanchetuaj yeem txhim khonco

2 Pharmacological kev tshawb fawb txog cov teebmeem ntawm Cistanche ntawm kev txhim khotxawj ntse thiab anti-aging

2.1 Tsoos suav tshuaj txoj kev xav ntawm kev kawm, nco thiab tiv thaiv kev laus ntawm cov nqaij muab tshuaj

Cov tshuaj suav tshuaj suav hais tias lub hlwb yog lub tsev ntawm tus ntsuj plig, thiab kev xav thiab kev nco yog lub luag haujlwm ntawm lub hlwb. "Ben Cao Bei Yao" tau sau tseg ntev: "Lub cim xeeb ntawm tus neeg yog tag nrho hauv lub hlwb." Cov khoom ntawm lub hlwb yog "marrow", uas yog, lub hlwb yog lub hiav txwv ntawm cov hlab ntsws. "Lingshu·Meridian," hais tias: "Tib neeg pib yug, thawj zaug ua kom zoo, ua kom zoo dua qub, thiab tom qab ntawd lub hlwb yug." Kev tsim thiab kev loj hlob ntawm lub hlwb pob txha yog ze ze rau lub raum. Tonic thiab tonic, pib nrog nourishing lub raum thiab sau cov ntsiab lus, rov tsim cov pob txha, thiab muaj txiaj ntsig zoo rau lub hlwb, txhawm rau ua tiav lub hom phiaj ntawm kev txhim kho kev txawj ntse, yog ib txoj cai tseem ceeb ntawm cov tshuaj suav tshuaj Rourong nourishing kev txawj ntse. Cov tsos mob ntawm Cistanche hauv cov tshuaj tiv thaiv kev laus thiab kev tiv thaiv kev laus hauv cov tiam dhau los yog qhov thib ob tsuas yog ginseng, qeb thib ob.

2.2 Kev tshawb fawb tshuaj niaj hnub ntawm kev kawm, kev nco, thiabanti-agingCov teebmeem ntawm Cistanche

2.2.1 Qhov cuam tshuam rau lubkev kawm thiab kev ncoqauv ntawm dementia

Ua ke cov tshuaj suav tshuaj suav tshuaj thiab niaj hnub molecular biotechnology los tsim kom muaj lub hlwb laus thiab tus qauv dementia los tshawb txog cov txheej txheem ntawm kev ua ntawm cov tshuaj suav tshuaj Cistanche. Los ntawm daim ntawv thov ntawm ozone sim aging nas qauv, nws yog kuaj tias covCistanchedeserticola polysaccharide tuaj yeem txhim kho hypoxia kam rau ua thiab kev ua haujlwm antioxidant ntawm lub ntsws ntawm cov nas laus; los ntawm cov neurotoxin 1-methyl 4-phenyl-12.3, 6-tetrahydropyridine (MPP) nas cerebellar granule cell apoptosis qauv, uas ua pov thawj qhov kev tiv thaiv ntawm Campneoside Il ntawm MPP - induced apoptosis; los ntawm DNA kev puas tsuaj qauv tshwm sim los ntawm OH·, nws ua pov thawj tias tag nrho glycosides ntawm sarcoids tuaj yeem tshem tawm ntau hom pa oxygen reactive. Nws tiv thaiv DNA puas los ntawm OH·; Co-ray kev puas tsuaj lub cev tiv thaiv kab mob qauv qhia tau hais tias Cistanche muaj zog tiv thaiv kev tiv thaiv kab mob ntawm cov nas uas raug hluav taws xob. Tsis tas li ntawd, nws yog siv rau kev kawm, kev nco, thiab kev tshawb fawb los tiv thaiv kev laus thiab tuaj yeem cuam tshuam Cistanche. Tsiaj cov qauv ntawm cov tshuaj muaj xws li: ethanol-vim tsis muaj lub cim xeeb rov ua dua tshiab, scopolamine-induced memory impairment, sodium nitrite-induced memory impairment, thiab lwm tus qauv nas; hydrocortisone-induced poob rau hauvkev kawm thiab kev nconyob rau hauv nas nrog raum-yang deficiency, localization Thekev kawm thiab kev ncokev ua haujlwm tsis zoo los ntawm focal cerebral ischemia thiab reperfusion thiab txiv neej Kunming nas qauv thiab cov qauv nas ntuj tsim los ntawm hydroxyurea tag nrho ua pov thawj tias Cistanche muaj cov teebmeem ntawm kev noj qab haus huv raum, txhawb kev nco thiab txhim kho kev txawj ntse.

2.2.2 Anti-dawb radical nyhuv

Txoj kev xav ntawm cov dawb radicals tam sim no lees paub tias yog txoj kev xav ntawm kev laus. Kev sib sau ntawm ntau cov dawb radicals tuaj yeem ua rau lub hauv paus puas thiab kev hloov ntawm caj ces; ua rau cov proteins, ua rau cov protein metabolism tsis zoo, ua rau pulmonary fibrosis; peroxidation ntawm lipids ntawm unsaturated fatty acids heev tuaj yeem tsim cov lipid peroxides ntau ntxiv, ua rau cov protein, Oxidative puas tsuaj rau cov molecules loj xws li nucleic acid (DNA). Yog li, cov lus teb dawb radical yog ze ze rau kev laus, hluav taws xob puas, cov ntaub so ntswg ischemia / reperfusion raug mob, thiab lwm yam.^(11-13).

Cistanchedesertic polysaccharide (Cistanche desertic polysacchridCDP) tuaj yeem txo cov qauv thiab kev ua haujlwm hloov pauv los ntawm ozone-induced ntsws oxidative puas tsuaj, thiab ncua lub physiological thiab cytomorphological degenerative hloov nyob rau hauv lub ultrastructure ntawm lub ntsws cov ntaub so ntswg hlwb nyob rau hauv sim aging nas. Los ntawm Ca2-Phen-H2OViC-DNA luminescence system, phenoxyethanol glycosides tuaj yeem tshem tawm ntau cov pa oxygen dawb radicals thiab tiv thaiv DNA oxidative puas tsuaj los ntawm lawv. Cistanche extract txo qis tib neeg lipid peroxide (LPO) cov ntsiab lus⁽¹⁵⁾.

Ntau Cistanche phenyl ethanol glycosides, xws li acetonide, 2-acetylated-side, isoacteoaide, tubulose B, cuam tshuam lipid peroxidation hauv hepatocyte microsomes induced los ntawm NADPH-CCL thiab inhibit qhov tso tawm ntawm aspartate aminotransferase hauv cov hlwb. Txo cov hepatocyte toxicity tshwm sim los ntawm CCL thiab D-galactosamine. Kev tshawb fawb tau pom tias ascorbic acid / F2 thiab ADP / NADPH / Fe induced lipid peroxidation nyob rau hauv hepatocyte microsomes. Lub 9 tebchaw muab rho tawm los ntawm Cistanche deserticola nrog acetone-dej (9: 1) tag nrho cov pom tau zoo heev. Muaj zog dawb radical scavenging nyhuv. Nws kuj tau tshaj tawm tias phenoxyethanol glycosides tsis muaj pab pawg scavenging nyhuv, uas tej zaum yuav yog ib qho ntawm cov txheej txheem ntawmCistanche covanti-inflammatory nyhuv. Siv cov electron spin resonance (ESR) spin capture method, nws pom tau tiascistancheglycosides muaj peev xwm tshem tawm qhov muaj zog ntawm cov pa oxygen dawb radicals uas tsim tawm hauv vitro; Nyob rau tib lub sijhawm, lawv muaj kev tiv thaiv thiab kho cov teebmeem ntawm dawb radical puas los ntawm ntshav qab zib nephropathy^{(18 )}.

cistanche tuaj yeem tiv thaiv kev laus

Melatonin yog lub zog dawb radical scavenger. Kev noj cov tshuaj melatonin los ntawm cov nroj tsuag noj tau yog qhov tseem ceeb heev los tiv thaiv oxidative kev puas tsuaj hauv cov tsiaj. Cov txheej txheem rho tawm thiab cov txheej txheem ua kua ua tau zoo / huab hwm coj spectrometry yog siv los ua pov thawj cov ntsiab lus melatonin hauvCistanchedeserticola. Nws yog 28ng / gm, thiab cov melatonin nyob rau hauv mammalian serum tsuas yog nyob rau theem pg / g, uas muaj ib tug tseem ceeb physiological functions.

2.2.3 Tiv thaiv cov nyhuv ntawm apoptosis

Siv txoj kev xav ntawm kev tuag ntawm tes los kawm txog cov txheej txheem ntawm cov tshuaj tonic muab cov tswv yim tshiab rau kev kho tshiab ntawm Suav tshuaj. Muaj ib tug cell tuag mechanism nyob rau hauv cov txheej txheem pathological ntawm central neurodegenerative kab mob. Cistanche Polysaccharide (CDP) tuaj yeem ua rau SOD kev ua haujlwm ntawm cov ntshav thiab lub ntsws ntawm cov nas laus laus zuj zus, txo cov concentration ntawm NO, cuam tshuam rau lub ntsws cell apoptosis, thiab txhim kho thiab ncua kev hloov pauv ntawm lub ntsws cov hlwb hauv cov nas laus.⁽⁷⁾

Phenyl ethanol glycosides ntawm sarcodes tuaj yeem cuam tshuam D-galactose lipopolysaccharide, neurotoxin MPP-induced cell tuag, thiab apoptosis-txog txoj hauv kev tubulose B tuaj yeem txo qhov apoptosis ntawm PC12 neurons induced los ntawm MPP, txo DNA degradation thiab cell-rau-cell ib reactive oxygen radicals. Ua nrogCistancheUa kom cov hlwb loj thiab me me ua ntej thiab kho lawv nrog MPP. Nws pom tias Cam seaside 1 tuaj yeem cuam tshuam DNA ntaiv lysis, txo cov cell tuag tus nqi, txo cell LDH tso tawm tus nqi, thiab txhim kho cell tuag morphology.⁽⁸⁾

2.2.4 Kev tswj kev tiv thaiv kab mob

Cov kev tshawb fawb thaum ntxov tau ua pov thawj tias cov dej extract ntawmCistanchetuaj yeem txhim kho kev ua haujlwm ntawm mononuclear loj loj hlwb hauv nas kab noj hniav thiab ntshav, nce qhov hnyav ntawm lub cev tiv thaiv kab mob, thiab txhawb kev tiv thaiv kab mob tshwj xeeb. Cov kev tshawb fawb tsis ntev los no tau pom tias tag nrho cov glycosides ntawm cov nqaij paste tuaj yeem tiv thaiv kev tsim cov tshuaj tiv thaiv kab mob hauv nas los ntawm Co raug mob, txo tus naj npawb ntawm T lymphocytes hauv cov ntshav peripheral, thiab muaj kev tiv thaiv pom tseeb ntawm kev ncua sij hawm ntev thiab ua haujlwm tsis zoo ntawm luminal giant. hlwb. Kev tiv thaiv kab mob humoral ntawm cov nas raug mob muaj ntau yam kev cai.

D-mannitol thiab nqaij polysaccharides ntawm Cistanche tuaj yeem ua rau kom qhov hnyav ntawm nas hom kab mob thiab txhim kho kev tiv thaiv kab mob ntawm tes. Kev tshawb fawb ntxiv pom tias cov polysaccharides ntawmCistanchedeserticola tuaj yeem ua rau muaj kev tso tawm ntawm L-2 los ntawm nas hom lymphocytes ntawm ntau dua (75g / mL, 125g / mL), thiab -2 tuaj yeem tiv thaiv kev tuag ntawm cov nas ib txwm muaj thiab tib neeg lymphocytes; Tawm tsam cov teebmeem inhibitory ntawm recombinant TNF, isopropyl adrenal gland (SO) thiab dexamethasone (DEX) ntawm lymphocyte proliferation, nws ua rau kom cov hlwb nyob rau theem faib ntawm lub hauv siab cell voj voog. Yog li ntawd, nws ntseeg tau tias cov nyhuv immunoprotective ntawm Cistanche yog los txhawb kev loj hlob ntawm T hlwb los ntawm tus chij polysaccharide, thiab nws tau ua tiav los ntawm autocrine ntawm L-2 thiab lwm yam cytokines los ntawm T hlwb.⁽¹⁰⁾

2.2.5 Qhov cuam tshuam rau cov kab mob neuroendocrine

Cistanchetuaj yeem ua rau cov tshuaj pituitary-adrenal cortex, uas muaj cov nyhuv zoo ib yam li adrenal cortex hormone; Nws tuaj yeem txhim kho qhov kev ua haujlwm luteinizing ntawm hypothalamus-pituitary-qe txiv hmab txiv ntoo, txhim kho pituitary lub teb rau LRH thiab lub qe teb rau H.Cistanchephenoxyethanol glycoside compound cimicifugaoside muaj androgen zoo li cov teebmeem, uas tuaj yeem ua rau qhov hnyav ntawm phev prostate hauv nas thiab nas, thiab txo qhov hnyav ntawm cov qog adrenal.

Kev sib cuam tshuam ntawm cov dawb radicals thiab excitatory amino acids hauv hippocampus ntawm cov nas qub ua rau kev tuag ntawm hippocampal qab haus huv. AD qauv tuaj yeem tsim los ntawm kev txhaj tshuaj excitatory amino acids rau hauv lub cell basal nucleus loj ntawm tib neeg tsiaj. Kev siv Roucong Rong rau cov nas zoo li dementia tuaj yeem txo cov ntsiab lus ntawm inhibitory amino acid GABA hauv cov ntaub so ntswg ntawm lub hlwb, thiab nce cov ntsiab lus ntawm cov amino acid txo qis excitatory LG u, uas tuaj yeem txo cov excitatory amino acid toxicity. Tswj cov dynamic tshuav ntawm excitatory nitrogen-raws li acid toxicity thiab inhibitory amino acid toxicity2.⁽²⁶⁾

Cov nqaij nyoos extract ntawm cov nqaij los ntawm puree txo cov kev yeem ua haujlwm thiab ua kom lub sijhawm pw tsaug zog raug ntxias los ntawm cyclohexene barbital, qhia tias ethanol extract ntawm nqaij los ntawm puree thiab dej-soluble ib feem muaj sedative nyhuv.

2.2.6 Txhawb cov synthesis ntawm protein thiab nucleic acid. Gavage lub decoction ntawm nqaij los ntawm puree mus rau nas, uas yuav ncua lub sij hawm ua luam dej thiab txo qhov nce nyob rau hauv cov ntshav creatine kinase tom qab load ce, tawm tswv yim hais tias nqaij los ntawm puree yuav ua rau kom glycogen reserves, txo cov nqaijrog proteins tom qab ce. Tus qauv yang-deficiency ntawm txiv neej Kunming nas tshwm sim los ntawm meridian thiab 3 HT d R nyob rau hauv vivo incorporation txoj kev ua pov thawj tias Roucong Rong pawg thawj coj muaj kev hloov pauv ntawm qhov txo qis thiab nce cov ntsiab lus nucleic acid ntawm daim siab thiab tus po. Yang-deficiency tsiaj. Nws tuaj yeem txhim kho DN A synthesis muaj peev xwm ntawm Yang-deficiency tsiaj.⁽²⁷⁾

2.3 Daim ntawv thov kev kho mob ntawm Cistanche ua ib qho tshuaj los yog ib qho tshuaj sib xyaw nrog lwm cov tshuaj suav

Cov kws kho mob ntawm yav dhau los dynasties tau soj ntsuam cov nqi tshuaj ntawmCistanche. Suav tshuaj tau sau cov kev nplua nuj nyob rau hauv kev kho mob ntawm cerebral dysfunction kab mob nrogCistanche, "Lub plawv ntawm cov tshuaj", "Holy Wisdom Prescription", "Sanji General Record", "Jisheng Prescription", "Materia Medica Supplements", "Medicinal Properties" "On" thiab "Qian Jin Yao Fang" sau Cistanche ntsiav tshuaj, cistanche mov muab tshuaj, Cistanche hmoov, cistanche porridge, cistanche kua zaub, Jinsuozhengyuan ntsiav tshuaj, Taiping Huimin thiab Jiju tshuaj, Yanshou ntsiav tshuaj, thiab lwm yam. Naoyizhi daim ntawv qhia kho cov kab mob no. Tam sim no, qhov zoo tshaj plaws-muag "Yangmeijiu" nyob rau hauv Nyiv ua lag luam yog ua nrog nqaij los ntawm muab tshuaj txhuam raws li cov khoom xyaw tseem ceeb thiab tsim los ntawm ancient Suav zaub mov.

Nyob rau hauv peb lub teb chaws, ob qho tib si muaj feem xyuam rau kev lag luam thiab kev tshawb fawb cov tsev kawm ntawv qib siab yog nquag tshawb nrhiav kev txhim kho thiab kev siv ntawmCistanche. Piv txwv li, lub teb chaws thib ob-chav kawm tshiab tshuaj "cistanche zongxi capsule" sib koom ua ke tsim los ntawm Peking University Modern Research Center of Traditional suav tshuaj thiab Hangzhou Xinghui Tianli Pharmaceutical Co., Ltd. yog tab tom ua theem n kev sim tshuaj; cov khoom nrog Roucong Rong ua cov khoom tseem ceeb hauv Xinjiang yog "Hongyun Oral Liquid", "Siyun Oral Liquid", thiab lwm yam; Cov tshuaj suav tshuaj zib ntab tshuaj "Congrong Sibei Pill" tsim los ntawm Wei Qing thiab lwm tus, thiab cov granules ua los ntawm Cistanche cistanche extract los ntawm Xue Dejun thiab lwm tus tuaj yeem txhim kho kev laus ntawm tib neeg lub cev. , Restoring lub zog thiab lub cev lub zog ntawm nruab nrab-hnub nyoog thiab cov neeg laus uas muaj lub raum tsis muaj zog muaj ib tug zoo anti-aging nyhuv. Tsis tas li ntawd, cov tshuaj sib xyaw xws li Huan Shao Dan, Guipi Decoction, Jinbian Shenqi Pills, Congyu Decoction (xws li Dangshen, Huang Miao, Roucong Rong, thiab lwm yam) hauv kev kho mob ntawm senile dementia muaj txiaj ntsig zoo.

Raws li txoj kev xav ntawm tsoos suav tshuaj, ntau yam extracts ntawmCistanchetau raug tshuaj xyuas rau lawv cov tshuaj tiv thaiv Alzheimer, nrhiav tshuaj tshiab tiv thaiv Alzheimer's. Kev tshawb fawb ntawm cov khoom xyaw nquag ntawm cov tshuaj ib leeg ntawm Cistanche thiab kev txhim kho cov tshuaj tshiab kuj ua rau muaj kev vam meej. Nws tau raug tshaj tawm nyob rau hauv cov ntaub ntawv hais tias tag nrho cov phenethoxylate ntawm tib tsob nroj Cistanche tubulosa los ntawm cov suab puam fleshy nroj tsuag muaj kev tiv thaiv tseem ceeb ntawm Alzheimer's kab mob (tshwj xeeb tshaj yog vascular dementia), thiab tau tsim los ua ib tug thib ob-chav kawm tshuaj tshiab thiab nkag mus rau theem. m kev sim tshuaj. Kev sim theem.⁽³⁰⁾

Cistanche tuaj yeem txhim kho kev kawm thiab kev nco

3 Cov kev cia siab thiab kev cia siab

Txij li thaum xyoo 1980s, Suav tshuaj txoj kev xav tau siv los coj kev kawm txog cov tshuaj suav tshuajCistanchecov tshuaj ib leeg thiab nws cov ntawv sau ua ke, thiab cov khoom siv tau zoo thiab muaj txiaj ntsig zoo thiab cov monomers zoo tau raug rho tawm tas li, nthuav tawm cov tshuaj lom neeg thiab cov txheej txheem ntawm kev ua ntawm Roucong Rong los txhawb nqa thiab ntxiv dag zog thiab ncua kev laus. Txawm li cas los xij, nyob rau theem tam sim no, feem ntau txoj kev tshawb fawb tsuas yog txwv rau kev sim kev tshawb fawb, thiab tsis muaj kev ntsuam xyuas ntawm "cov tsos mob" ntawm cov txheej txheem nyuaj ntawm tib neeg lub cev. Los ntawm cov kev xav ntawm tsoos suav tshuaj genomics thiab tsoos suav tshuaj chemomics, lub pharmacological kev ua, metabolism, thiab mechanism ntawmCistanchetau piav qhia, muaj feem xyuam rau nws txoj kev cuam tshuam ntawm "syndrome" - ntsig txog cov noob qhia kev tswj hwm ntawm lub xeev laus, thiab niaj hnub genomics yog siv los piav qhia.Cistanchenyob rau theem molecular. Cistanche muaj ib txwm muaj txiaj ntsig ntawm kev noj qab haus huv thiab ntxiv dag zog thiab ncua kev laus, uas yuav tsum yog cov kev taw qhia ntawm kev tshawb nrhiav yav tom ntej.

Txog tam sim no, kev kho mob ntawm Alzheimer's tus kab mob tseem yog cov tshuaj siv tshuaj. Vim tias cov tshuaj uas twb muaj lawm muaj cov tshuaj pharmacological thiab qhov tshwj xeeb tsawg, muaj ntau yam tshuaj lom thiab muaj kev phiv, tsis yooj yim rau nqus thiab nkag mus rau hauv cov ntshav-hlwb barrier, thiab lwm yam, kev siv tshuaj raug txwv. Cov kws kho mob hauv Suav teb hauv Suav teb muaj qee qhov kev paub zoo hauv kev kho mob ntawm senile dementia thiab kuj tau ua qee qhov kev tshawb fawb hauv kev sim kev tshawb fawb thiab tau pom tias muaj kev cia siab zoo. Yog li ntawd, nyob rau hauv tsis muaj ib tug tiag tiag zoo tshuaj synthesis tshuaj, Suav tshuaj yog undoubtedly ib qho kev xaiv tsim nyog xav txog.

[Profile of the author l Wang Yan, poj niam, master's degree menyuam kawm ntawv, feem ntau koom nrog kev tshawb fawb ntawm cov tshuaj suav tshuaj suav tshuaj Tel: (010) 6289735

Los ntawm: Pharmacological Application and Monitoring in China, Issue 2 of 2004

Suav Cov Tsev Qiv Ntawv Cov Npe: 2R 8 5.5 Cov Ntaub Ntawv Qhia Tus Kheej Code: Ib Tshooj Naj Npawb: 1672-8157 (2004) 02-0008-04