Cov Tshuaj Nephrotoxic Tej Yam Koj Yuav Tsum Paub!

Tsis ntev los no, cov xov xwm uas Kobayashi Pharmaceuticals, lub tuam txhab tshuaj Japanese paub zoo (tom qab no hu ua Kobayashi Pharmaceuticals), tau tshaj tawm txog kev rov qab los ntawm peb cov khoom noj qab haus huv uas muaj cov poov xab liab tau los ua lub ntsiab lus kub thiab ua rau muaj kev sib tham ntawm cov netizens. Raws li cov lus ceeb toom, noj cov poov xab liab cov khoom noj qab haus huv uas tsim los ntawm lub tuam txhab no tuaj yeem ua rau mob raum. Raws li lub Peb Hlis 29, cov khoom noj qab haus huv muaj teeb meem tau ua rau tsib tus neeg siv khoom Nyij Pooj tuag thiab ntau tshaj li ib puas tus neeg tau mus pw hauv tsev kho mob [1-2].

Nyem rau Cistanche rau mob raum

Cov xov xwm no tau coj cov tshuaj nephrotoxic rov qab los rau hauv tib neeg pom dua, thiab txhua tus tsis tuaj yeem pab tab sis xav tsis thoob: Puas yog qhov teeb meem mob raum no yog teeb meem ntawm Kobayashi Pharmaceutical lossis yog cov poov xab liab nws tus kheej nephrotoxic? Puas yog Xuezhikang, uas muaj cov poov xab liab ua nws cov khoom tseem ceeb, nephrotoxic? Dab tsi yog cov tshuaj nephrotoxic uas siv hauv kev kho mob? Cia peb kawm!

Liab poov mov nplej tsis txhaum, Xuezhikang tsis tau lees paub tias muaj nephrotoxicity

Kobayashi Pharmaceutical tau hais tias tom qab tshuaj xyuas cov khoom xyaw ntawm cov khoom noj qab haus huv cov poov xab liab, nws tau pom tias qee cov khoom siv poov xab liab tuaj yeem muaj cov khoom xyaw uas tsis paub dhau lub peev txheej ntawm lub tuam txhab kev tswj hwm, tab sis tseem tsis tau txiav txim siab seb cov khoom xyaw tsis paub muaj feem xyuam rau cov neeg siv khoom. ' mob [3]. Vim li no, cov kab mob raum tshwm sim los ntawm cov neeg siv khoom noj cov khoom noj qab zib liab rau lub sijhawm no tuaj yeem yog vim Kobayashi Pharmaceutical tsis ua raws li kev tswj hwm cov khoom siv raw zoo, ua rau cov khoom tsis paub uas ua rau lub raum noj qab haus huv ntawm cov neeg siv khoom, ua rau muaj kev phom sij txaus ntshai. , thiab ua ke nrog cov khoom xyaw liab poov xab. tsis cuam tshuam.

Tsis tas li ntawd, Xuezhikang yog tsim los ntawm japonica mov inoculated nrog tshwj xeeb Monascus kab mob thiab fermented thiab refined siv niaj hnub biopharmaceutical technology. Nws cov khoom tseem ceeb yog lovastatin (cov khoom tseem ceeb ntawm Monascus) [4-5]. Cov ntaub ntawv soj ntsuam soj ntsuam thiab cov kev tshawb fawb soj ntsuam ntawm Xuezhikang rau ntau tshaj 20 xyoo ntawm kev ua lag luam qhia tias cov tshuaj muaj kev nyab xeeb heev thiab muaj kev phiv tsawg. Qhov tsis zoo tshwm sim tseem ceeb yog kev tsis xis nyob hauv plab, lub siab enzyme thiab cov leeg nqaij enzymes tsis tshua muaj, thiab rhabdomyolysis tshwm sim los ntawm Xuezhikang tsis tau tshwm sim hauv kev kho mob. thiab lwm yam kev phiv loj heev [4].

Yog li, tsis muaj kev tshawb fawb tau lees paub tias Xuezhikang muaj lub raum toxicity. Nws tuaj yeem siv los ua ib qho kev siv tshuaj lipid-txo qis hauv kev kho mob. Cov neeg mob yuav tsum tau saib xyuas cov tsos mob ntawm plab hnyuv, mob nqaij, thiab qaug zog thaum noj tshuaj [4].

Dab tsi yog cov tshuaj kho mob nephrotoxic?

Txhua yam kev puas tsuaj rau lub raum thiab / lossis kev ua haujlwm los ntawm cov tshuaj hu ua tshuaj-induced nephropathy. Nrog rau kev siv tshuaj kho mob thoob plaws tam sim no thiab qhov tshwm sim tsis tu ncua ntawm cov tshuaj tshiab, lub raum kev puas tsuaj los ntawm cov tshuaj kuj tau nce ntxiv, thiab peb yuav tsum ua tib zoo saib xyuas nws [6]. Cov tshuaj nquag uas ua rau muaj tshuaj tua kab mob nephropathy hauv tsev kho mob yog raws li hauv qab no [6]:

1. Tshuaj tua kab mob

1) Cov tshuaj tua kab mob Aminoglycoside: Lawv yog cov tshuaj tua kab mob nephrotoxic tshaj plaws thiab ua rau lub raum puas tsuaj ncaj qha, xws li streptomycin, gentamicin, tobramycin, amikacin, thiab lwm yam. Nephrotoxicity muaj feem xyuam rau lub sijhawm thiab koob tshuaj. Cov tsos mob feem ntau tshwm sim 5 mus rau 7 hnub tom qab noj cov tshuaj, thiab pom tias tsis yog-oliguric raum tsis ua haujlwm.

2) -lactams (xws li cephalosporins): Lawv yuav tsis yog nephrotoxic hauv lawv tus kheej, tab sis lawv feem ntau ua rau muaj kev tsis haum tshuaj interstitial nephritis lossis mob raum tsis ua haujlwm, tsis hais txog koob tshuaj.

3) Lwm tus: Cov xwm txheej ntawm kev puas tsuaj xws li sulfonamides, rifampicin, vancomycin, thiab amphotericin B tuaj yeem muaj ntau yam.

2. Non-steroidal anti-inflammatory analgesics: indomethacin, ibuprofen, phenylbutazone, naproxen, thiab analgesics xws li phenacetin, aminopyrine, acetaminophen, metamizole, thiab lwm yam. Nws tuaj yeem ua rau lub raum papillary necrosis lossis mob interstitial nephritis. Raws li qhov no, nws tuaj yeem ua rau lub raum parenchymal atrophy raum cortical fibrosis, thiab txawm tias mob raum tsis ua haujlwm.

3. Vascular converting enzyme inhibitors: captopril, enalapril, thiab lwm yam, tuaj yeem ua rau muaj kev tsis haum tshuaj interstitial nephritis thiab nephrotic syndrome.

4. Cov tshuaj tiv thaiv kab mob: cyclophosphamide, cyclosporine A, FK506, thiab lwm yam tuaj yeem ua rau lub raum puas.

5. Tshuaj kho mob cancer: cisplatin, methotrexate, plicamycin, mitomycin-C, nitrosoureas, 5-fluorouracil, thiab lwm yam.

6. Cov tshuaj tiv thaiv kab mob vwm: trimethadione, phenytoin, thiab lwm yam.

7. Cov tshuaj loog: ether, methoxyflurane, thiab lwm yam.

8. Hlau thiab complexing agents: penicillamine, etharate, thiab lwm yam.

9. Ntau yam tshuaj angiography.

10. Lwm tus: cyclosporine A, cimetidine, allopurinol, mannitol, heroin, qis molecular hnyav dextran, thiab lwm yam.

11. Cov tshuaj suav tshuaj: Kev tshawb fawb txog tshuaj toxicity ntawm cov tshuaj suav tshuaj tau pom tias ze li 50 hom tshuaj suav tshuaj muaj tshuaj lom rau lub raum. Muaj peb hom tshuaj suav tshuaj uas tuaj yeem ua rau lub raum puas: cov tshuaj suav nrog cov nroj tsuag (xws li Akebia thiab lwm yam tshuaj uas muaj aristolochic acid), tsiaj txhu suav tshuaj (xws li centipedes, nab venom, thiab ntses gallbladders), thiab ntxhia. -raws li suav tshuaj (xws li alum). , realgar, thiab cinnabar).

Cov ntsiab lus

Cov khoom siv kho mob tsis raug tswj hwm nruj thiab tuaj yeem yuav yam tsis muaj daim ntawv tshuaj. Txawm li cas los xij, cov neeg siv khoom feem ntau tsis tuaj yeem nkag siab tag nrho lawv cov kev cuam tshuam tsis zoo thiab tswj xyuas cov koob tshuaj kom raug, ua rau muaj kev nyab xeeb loj heev hauv kev siv cov khoom kho mob. Vim li no, cov kws kho mob yuav tsum qhia cov neeg mob txog qhov muaj feem cuam tshuam thiab ua kom pom tseeb tias cov khoom noj qab haus huv tsis tuaj yeem hloov cov tshuaj. Nyob rau tib lub sijhawm, lawv yuav tsum tau ceev faj txog qhov tshwm sim ntawm cov tshuaj lom nephropathy thiab siv cov tshuaj nephrotoxic nrog ceev faj.

Cistanche kho mob raum li cas?

Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrog kab mob raum. Nws yog muab los ntawm qhuav stems ntawmCistanchedeserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Lub ntsiab active Cheebtsam ntawm cistanche yogphenylethanoidglycosides, echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rau lub raum kev noj qab haus huv.

Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tshuab.

Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.

Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.

Tsis tas li ntawd, cistanche tau pom tias muaj cov nyhuv anti-inflammatory. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.

Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv kab mob raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.

Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.

Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.

Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.