Lub luag hauj lwm ntawm kev cuam tshuam kev ua neej, ntxiv rau cov tshuaj, rau ntshav qab zib raum kab mob nrog Sarcopenic Obesity Ⅲ
Jun 07, 2024
6. Kev sib tham
Sarcopenic rog yog txuam nrogmob mob qis qis, nce insulin tsis kam, thiabadipocytes hypertrophy. Txog hnub no, qee qhovproinflammatory cytokines muaj peev xwm inducingcov leeg tsis ua haujlwmnyob rau hauv ib tug auto/paracrine yam, nrog rau IL-1, IL-6, IL-8, IFN- , TNF-, MCP-1, thiab NFκB. Hauv Vitro, kev tshawb fawbqhia tau tias muaj kev tiv thaiv insulin thiabLipotoxic ib puag ncig tau tshwm sim los ntawm intramuscular lipids txuam nrog mitochondrialdysfunction, impaired - oxidation muaj peev xwm, thiab ncereactive oxygenhom kev tsim. Thaum txo cov rog rog muaj txiaj ntsig zoo hauv kev txo qhov mob thiab de-ntev kab mob pib thiab kev loj hlob, suav nrogntshav qab zib, CKD, thiabmetabolic syndrome, Cov teebmeem metabolic ntawm hyperglycemia kuj ua rau kev tsim cov AGE, TGF-, thiab cov protein kinase.C. Cov khoom siv tshuaj lom no muaj qee lub luag haujlwm hauv nephropathy thiab kev kho mob albuminuriaNrog histological hloov ntawm thickening ntawm glomerular qab daus daim nyias nyias, mesangialmatrix expansion, thiab arteriolar hyalinosis. Ntxiv mus, lwm yam tsis-inflammatory yam cuam tshuamraum tsis ua haujlwm xws li metabolic acidosis, renin-angiotensin-aldosterone systemuremic toxins, thiab vitamin D tsis txaus
NEW HERB FOR KIDNEY DISEASE
Nrog kev paub nplua nuj ntawm pathophysiological ntawm metabolic syndrome thiab ntshav qab zib,tseem muaj cov kev tiv thaiv zoo tshaj plaws, kev kho mob, thiab kev cuam tshuam rauCov neeg mob uas tsim muaj sarcopenic rog thiab CKD. Txawm hais tias myostatin inhibitors thiabAST-120 tau pom tias ua kom cov leeg nqaij hauv cov nas tshawb nrhiav [49,50], muajkev txhawj xeeb txog cov pov thawj tsis txaus ntawm cov inhibitors siv rau hauv cov leeg nqaij nkoos hauvtib neeg los yog leeg nqaij hypertrophy hauv kev ua kis las. Cov ntshav ntshav qis 25 (OH)D tshwm simcuam tshuam nrog kev rog, insulin tsis kam, cov leeg pob txha qis, thiab poob saintawm lub raum ua haujlwm. Systemic L-carnitine depletion yog lwm qhov laj thawj rausarcopenia. Cov txiaj ntsig thiab qhov pib ntawm cov khoom noj khoom haus rau cov vitamin D thiab LCarnitine deficiency yog qhia nrog cov kev sim tshuaj tsis tu ncua thiab kev pom zoo. Hmoov zoo,ob leeg sarcopenic rog thiab lub cev ua tau zoo, xws li tuav lub zog thiab taug kev ceev,raug hloov kho zoo los ntawm kev cuam tshuam kev ua neej, xws li kev hloov pauv khoom noj khoom haus thiabkev cob qhia kev tawm dag zog hauv cov neeg mob lub raum [51]. Ib qho randomized tswj kev sim qhia tias aKev saib xyuas thiab kev cob qhia hauv tsev yog qhov ua tau zoo, ua raws, thiab muaj kev nyab xeeb rau cov neeg mobnrog rau mob raum [52]. Yuav tsum muaj ntau yam kev kho dua tshiab ntawm cov kev ua tau zoothiab kev cob qhia muaj peev xwm ua kom muaj kev ua raws li cov neeg mob CKD
7. Cov lus xaus
Raws li cov ntsiab lus tsim nyog ntawm sarcopenic rog, kev paub txog cov ntsiab lus no thiab cov txheej txheem metabolic nyuaj, hloov kho txoj kev ua neej, kev ua si lub cev, thiab qhov hnyav poob ib qho ua rau lub cev muaj zog thiab khaws cia cov leeg nqaij. Cov tswv yim zoo tshaj plaws los daws cov teeb meem yav tom ntej ntawm kev mob ntshav qab zib nephropathy yog tiv thaiv hyperglycemia, kev kuaj mob ntxov ntawm lub raum, pib kho nrog cov tshuaj tiv thaiv hypertensive uas txo qis kev ua haujlwm ntawm renin-angiotensin system, thiab lipid-modifying therapy. Kev ntsuam xyuas txaus ntawm lub cev muaj pes tsawg leeg kuj tseem ceeb heev los ntsuas qhov cuam tshuam ntawm cov tshuaj tshiab, khoom noj khoom haus, thiab kev tawm dag zog lub cev rau kev cuam tshuam metabolic. Txawm li cas los xij, cov ntaub ntawv pov thawj ntxiv thiab kev tshawb fawb sib xyaw ua ke yuav tsum tau ua.
Cov Nyiaj Txiag: Cov kev tshawb fawb no tsis tau txais nyiaj txiag sab nraud.
Institutional Review Board Statement: Tsis siv tau.
Cov ntaub ntawv
1. Tebchaws Asmeskas Lub Raum Cov Ntaub Ntawv (2020). Cov ntaub ntawv qhov chaw: National Health and Nutrition Examination Survey (NHANES). 2003-2006, 2007-2010, 2011-2014 thiab 2015-2018. Muaj nyob online: http://adr.usrds.org/2020/chronic-kidney-disease/1-ckd-in the-general-population ( nkag mus rau 2 Lub Peb Hlis 2022).
2. Philips, AO Diabetic nephropathy. Tshuaj 2011, 39, 470–474. [CrossRef]
3. O'Brien, F. Merck Manual Professional Version. Washington University hauv St. Louis, 2021. Muaj nyob online: https://www.msdmanuals.com/professional/genitourinary-disorders/glomerular-disorders/diabetic-nephropathy ( nkag mus rau 2 Lub Peb Hlis 2022). 4. Teb Chaws Asmeskas Lub Raum Cov Ntaub Ntawv Txheej Txheem (2020) ESRD Database: Kev sib piv thoob ntiaj teb. Muaj nyob online: https://adr.usrds.org/ 2020/end-stage-renal-disease/11-international-comparisons ( nkag mus rau 2 Lub Peb Hlis 2022). 5. Matoba, K.; Takeda, Y.; Nagai, Y.; Kawanami, D.; Utsunomiya, K.; Nishimura, R. Unraveling lub luag hauj lwm ntawm o nyob rau hauv lub Pathogenesis ntawm Diabetic raum kab mob. Int. J. Mol. Sci. 2019, 20, 3393. [CrossRef] 6. Ferrannini, E.; Simonson, DC; Katz, LD; Reichard, G., Jr.; Bevilacqua, S.; Barrett, EJ; Olsson, M.; ib. DeFronzo, RA Kev pov tseg ntawm qhov ncauj cov piam thaj hauv cov neeg mob uas tsis yog-insulin-dependant ntshav qab zib. Metabolism 1988, 37, 79–85. [CrossRef]
7. Ma, RCW; Chan, JCN Hom 2 mob ntshav qab zib mellitus hauv East Asians: Zoo sib xws thiab sib txawv nrog cov neeg nyob hauv Europe thiab Tebchaws Meskas. Ann. NY Acad. Sci. 2013, 1281, 64–91. [CrossRef] 8. Ohse, T.; Inagi, R.; Tanaka, T.; Ota, T.; Miyata, T.; Kojima, I.; Ingelfinger, JR; Ogawa, S.; Fujita, T.; Nangaku, M. Albumin induces endoplasmic reticulum stress thiab apoptosis nyob rau hauv lub raum proximal tubular hlwb. Raum Int. 2006, 70, 1447–1455. [CrossRef]
9. Fang, L.; Xie, D.; Wu, X.; Cai, H.; Su, W.; Yang, J. Kev koom tes ntawm endoplasmic reticulum stress nyob rau hauv albuminuria induced inflammasome activation nyob rau hauv lub raum proximal tubular hlwb. PLoS ONE 2013, 8, e72344. [CrossRef] 10. Cao, Y.; Fei, D.; Chen, M.; ib. Sun, M.; Xu, J.; Kang, K.; Jiang, L.; Zhao, M. Lub luag haujlwm ntawm nucleotide-binding domain-like receptor protein 3 inflammasome hauv mob raum raug mob. FEBS J. 2015, 282, 3799–3807. [CrossRef]
