Cov txiaj ntsig ntawm Cov Khoom Siv Tshwj Xeeb thiab Kev Tiv Thaiv Kev Tiv Thaiv Kom Txom Nyem Tsis Txaus Hauv Cov Neeg Mob Me Me Me Me Me Me Me Me Me Me Me thiab Alzheimer's Disease Dementia Part 2
Jun 28, 2024
Kev txheeb cais
Rov ua dua-kev ntsuas ANOVAs tau ua rau (1) hits, ceeb toom tsis tseeb rau lwm yam lures, thiab ceeb toom tsis tseeb rau cov lures tsis cuam tshuam, (2) d' rau gist thiab cov khoom tshwj xeeb recollection, thiab (3) C forgist thiab cov khoom tshwj xeeb nco nrog pab pawg (AD, MCI, thiab OC) raws li qhov nruab nrab ntawm cov ntsiab lus thiab cov xwm txheej (tsis muaj lub tswv yim, kev saib xyuas cov lus teb, sib sib zog nqus encoding, thiab ua ke) asa hauv cov ntsiab lus. Kev sib piv Post hoc tau ua los ntawm Tukey HSD.
Kev sib raug zoo ntawm kev saib xyuas cov tshuaj tiv thaiv thiab kev nco ib txwm yog ib qho kev tshawb fawb tseem ceeb hauv kev puas siab puas ntsws. Cov tshuaj tiv thaiv kev saib xyuas yog hais txog tib neeg kev tawm tsam rau yam tshiab, thiab kev nco yog lub peev xwm tseem ceeb uas tib neeg xav tau hauv cov txheej txheem kev paub. Yog li dab tsi yog kev sib raug zoo ntawm kev saib xyuas thiab kev nco?
Ua ntej, muaj qee qhov kev sib raug zoo ntawm kev saib xyuas thiab kev nco. Cov neeg saib xyuas feem ntau tsis tshua muaj kev txaus siab rau yam tshiab, thiab lawv nyiam tuav lawv txoj kev ua neej thiab txoj kev xav. Tus cwj pwm ntawm kev tawm tsam tej yam tshiab no yuav txo tau lawv txoj hauv kev los tiv tauj yam tshiab, uas yuav ua rau kev nco poob.
Qhov thib ob, kev saib xyuas kev noj qab haus huv kuj tseem cuam tshuam rau tib neeg lub peev xwm kev txawj ntse. Thaum cov neeg saib xyuas ntsib tej yam tshiab, kev paub txog kev txawj ntse ntawm lub hlwb yuav dhau mus, uas yuav ua rau txo qis hauv kev txawj ntse. Yog li ntawd, kev saib xyuas kev noj qab haus huv kuj yuav muaj qee yam tsis zoo rau tib neeg txoj kev xav thiab kev nkag siab muaj peev xwm.
Txawm li cas los xij, cov tshuaj tiv thaiv kev saib xyuas tsis zoo tag nrho. Raws li cov lus qhuab qhia ntawm qhov txhais tau hais tias, "Ntau dhau yog phem li tsawg dhau." Nws tsis yog ib qho kev xaiv zoo los mus nrhiav tej yam tshiab radically. Cov neeg saib xyuas kev paub thiab kev nkag siab txog tej yam uas twb muaj lawm kuj pab kom lawv muaj lub siab ruaj khov thiab lub siab xav, thiab tseem tiv thaiv kev ruaj ntseg ntawm lawv lub cim xeeb.
Hauv luv luv, muaj qee qhov kev sib raug zoo ntawm kev saib xyuas cov tshuaj tiv thaiv thiab kev nco, tab sis nws tsis yog ib qho txiaj ntsig zoo lossis tsis zoo. Peb yuav tsum tswj hwm tus cwj pwm ntawm tej yam uas twb muaj lawm hauv peb lub neej niaj hnub, thiab tib lub sij hawm sim txais tej yam tshiab kom ua tiav kev sib npaug thiab kev loj hlob. Nws tuaj yeem pom tias peb yuav tsum txhim kho kev nco, thiab Cistanche tuaj yeem txhim kho kev nco zoo vim Cistanche muaj cov tshuaj tiv thaiv antioxidant, tiv thaiv kev laus, thiab tiv thaiv kev laus, uas tuaj yeem pab txo qis oxidation thiab inflammatory tshwm sim hauv lub hlwb, yog li tiv thaiv kev noj qab haus huv. paj hlwb. Tsis tas li ntawd, Cistanche tseem tuaj yeem txhawb txoj kev loj hlob thiab kho cov paj hlwb, yog li txhim kho kev sib txuas thiab kev ua haujlwm ntawm cov neural network. Cov teebmeem no tuaj yeem pab txhim kho kev nco, kev kawm muaj peev xwm, thiab kev xav nrawm, thiab tseem tuaj yeem tiv thaiv qhov tshwm sim ntawm kev paub tsis meej thiab cov kab mob neurodegenerative.
Nyem paub 10 txoj hauv kev los txhim kho kev nco
Ntaus
Txhua tus neeg koom tau pom zoo qis dua ntawm cov khoom muaj tseeb hauv qhov kev saib xyuas zoo (qhov tseem ceeb ntawm cov xwm txheej: F(3,135)=24.14; p<0.001, η 2=0.350; M=0.55, SE=0.05) compared to the no strategy (M=0.75, SE=0.03; p<0.001), deep encoding (M=0.83, SE=0.02; p<0.001), and combined (M=0.85, SE=0.02; p<0.001) conditions (Figure 1).
Tsis muaj kev cuam tshuam loj ntawm pawg (F(2,45)=2.68; p=0.080, η2=0.11) thiab tsis muaj kev cuam tshuam ntawm pab pawg thiab cov xwm txheej (F(6,135){ {10}}.50; p=0.809, η{14}}.02) tau pom.
False alarms rau lwm yam lures
Pab pawg AD tau pom ntau dua ntawm cov lus ceeb toom tsis tseeb rau cov kev cuam tshuam (cov txiaj ntsig tseem ceeb ntawm pab pawg: F(2,45)=13.81; p<0.001, η 2=0.38; M=0.59, SE=0.05) compared to the OC (M=0.25, SE=0.05; p<0.001) and MCI (M=0.36, SE=0.05; p=0.002) groups across all conditions.
Nodifference nyob rau hauv lub tswb tsis tseeb rau lwm yam lures tau pom ntawm MCI (M{0}}.36, SE=0.05) thiab OC (M=0.25, SE=0. 05; p=0.502) pawg. Tawg thoob plaws hauv pab pawg, muaj ntau dua ntawm kev ceeb toom tsis tseeb rau cov kev cuam tshuam hauv qhov tsis muaj lub tswv yim zoo (cov txiaj ntsig tseem ceeb ntawm cov xwm txheej: F(3,135)=9.82; p<0.001, η 2=0.18; M=0.51, SE=0.04) compared to the conservative (M=0.37, SE=0.04; p<0.001), deep encoding (M=0.38, SE=0.03; p<0.001), and combined (M=0.33, SE=0.03; p<0.001) conditions.
Ib qho kev sib cuam tshuam ntawm pab pawg thiab tus mob kuj tseem pom (F(6,135)=2.68; p<0.001, η 2=0.11) (Figure 2). After conducting a Tukey HSD test, no significant differences in endorsing related lures were found across conditions in each of the OC and AD groups.
Cov neeg koom nrog MCI tau pom ntau dua ntawm cov lus ceeb toom tsis tseeb uas cuam tshuam nrog kev ntxias hauv qhov tsis muaj lub tswv yim zoo (M=0.54, SE=0.07) piv rau qhov sib sib zog nqus encoding (M=0.30, SE=0.05; p<0.001), and combined (M=0.21, SE=0.06; p<0.001) conditions.
False alarms rau unrelated lures
Cov neeg koom nrog AD tau pom ntau dua ntawm cov lus ceeb toom tsis tseeb rau qhov tsis sib xws (cov txiaj ntsig tseem ceeb ntawm pab pawg: F(2,45)=19.24; p<0.001, η 2=0.46; M=0.30, SE=0.03) compared to OC (M=0.07, SE=0.03; p<0.001) and MCI (M=0.08, SE=0.03; p=0.004) participants; OC and MCI did not differ. Collapsed across the group, there was a higher proportion of false alarms to unrelated lures in the no strategy condition (main effect of condition (F(3,135)=7.34; p<0.001, η 2=0.14; M=0.22, SE=0.03) compared to the combined (M=0.11, SE=0.02; p<0.001) condition.
Thaum txheeb xyuas qhov kev sib cuam tshuam ntawm pab pawg thiab cov xwm txheej (F(6,135)=2.26; p=0.041,η2=0.09) nrog Tukey HSD, cov neeg koom nrog AD pom tias muaj feem ntau ntawm ceeb toom tsis tseeb tounrelated lures nyob rau hauv tsis muaj lub tswv yim mob (M=0.45, SE=0.05) piv rau conservative (M=0.25, SE=0.04 ; p=0.032) thiab ua ke (M=0.22, SE=0.03; p=0.002) cov xwm txheej (Figure3).
d' thiab C
D thiab C cov txheeb cais tau suav los kwv yees qhov kev ntxub ntxaug thiab cov lus teb tsis zoo nyob rau hauv ib qho xwm txheej, feem.
Kev kwv yees kev ntxub ntxaug raug suav rau ob qho kev nco gist (d' gist sib npaug ntawm qhov kev pom zoo ntawm cov khoom muaj tseeb rho tawm qhov feem ntawm cov khoom tshiab uas tsis muaj feem cuam tshuam) thiab cov khoom tshwj xeeb recollection (d' yam khoom tshwj xeeb recollection sib npaug qhov feem ntawm cov khoom muaj tseeb pom zoo rho tawm qhov feem ntawm kev pom zoo ntsig txog lures) (Daim duab 4 thiab 5). Cov lus teb tsis ncaj ncees (C) los ntawm cov xwm txheej tau suav nrog cov txiaj ntsig zoo ntawm C sawv cev rau cov lus teb tsis ncaj ncees thiab cov txiaj ntsig tsis zoo uas qhia txog kev ywj pheej teb kev tsis ncaj ncees (Daim duab 6 thiab 7).
Cov kev ntsuas no tau suav nrog raws li cov qauv muab los ntawm Macmillan thiabCreelman (2005), thiab cov ntaub ntawv no tau hloov kho thaum qhov kev faib ua feem ntawm cov lus teb sib npaug 1 lossis 0 nrog qhov kho qhov ntsuas ± ½N nrog N sawv cev rau tag nrho cov muaj peev xwm ua tsis raug. teb.
d' Gist
Pab pawg AD tau qhia txog kev ntxub ntxaug qis dua rau cov ntaub ntawv gist dua li pawg MCI, uas, dhau los, tau qhia cov ntsiab lus qis dua li pawg OC (cov txiaj ntsig tseem ceeb ntawm pab pawg: F(2, 45)=22.59, p<0.001, η 2=0.50; OC: M=2.55, SE=0.14; MCI: M=2.12, SE=0.14; AD: M=1.26, SE=0.14 (OC-MCI p=0.005; OC-AD p<0.001, MCI-AD p<0.001)).
Hais txog qhov tshwm sim ntawm tus mob (qhov tseem ceeb ntawm tus mob: F(3, 135)=24.84,p<0.001, η 2=0.36), post-hoc analysis revealed that participants showed higher discrimination in the deep encoding (M=2.35, SE=0.10) and combined (M=2.50, SE=0.12) conditions compared to the no strategy (M=1.73, SE=0.12; p<0.001; p<0.001 respectively) and conservative ((M=1.32, SE=0.15); p<0.001, p<0.001 respectively) conditions.
Nodifference tau pom ntawm qhov sib sib zog nqus encoding thiab cov xwm txheej sib xyaw ua ke (p=0.772). Nointeraction ntawm tus mob thiab pab pawg tau pom nyob rau hauv cov kev ntsuam xyuas ntawm kev ntxub ntxaug rau gistinformation (F(6, 135)=1.27, p=0.274, η2=0.05) (Daim duab 4 ).
d' Yam khoom tshwj xeeb Recollection
Qhov sib txawv ntawm kev ntxub ntxaug rau cov ntaub ntawv tshwj xeeb tau pom nyob thoob plaws txhua pawg: qis tshaj hauv pawg AD, zoo dua hauv pawg MCI, thiab qhov zoo tshaj plaws hauv pawg OC (qhov tseem ceeb ntawm pawg F(2, 45)=29.82 ,ua p<0.001, η 2=0.57; OC: M=1.89, SE=0.14; MCI: M=1.16, SE=0.14; AD: M=0.35, SE=0.14 (OC-MCI p=0.005; OC-AD p<0.001; MCI-AD p<0.001)) (Figure 5).
Thoob plaws txhua qhov xwm txheej, cov neeg koom tau pom muaj kev ntxub ntxaug ntau dua hauv kev sib sib zog nqus encoding (maineffect of condition: F(3, 135)=40.41, p<0.001, η 2=0.47; M=1.50, SE=0.10), and combined (M=1.73, SE=0.14) conditions compared to the no strategy condition (M=0.79, SE=0.11; p<0.001, p<0.001 respectively). Furthermore, participants showed higher discrimination in the deep encoding and combined conditions compared to the conservative condition (M=0.52, SE=0.10; p<0.001, p<0.001 respectively).
Tsis muaj qhov sib txawv ntawm kev sib sib zog nqus thiab kev sib xyaw ua ke (p=0.078).Raws li kev ntxub ntxaug rau cov khoom tshwj xeeb, kev tshuaj xyuas ze ntawm kev sib cuam tshuam ntawm cov xwm txheej thiab pab pawg (F(6, 135){{5} }.77, p=0.002, η2=0.14) qhia tias cov neeg koom nrog OCand MCI tau pom muaj kev ntxub ntxaug ntau dua hauv kev nkag siab tob (OC: M=2.44,SE{{13 }}.17; MCF M=1.60, SE=0.17) thiab ua ke (OC: M=2.54, SE=0.24; MCE M{ {23}}.98,SE=0.24) cov xwm txheej piv rau qhov tsis muaj tswv yim (OC: M=1.61, SE=0.18; p<0.001, p<0.001 respectively; MCE M=0.63, SE=0.18; p<0.001, p<0.001 respectively)) and conservative conditions (OC: M=0.97, SE=0.19; p<0.001, p<0.001 respectively; MCE M=0.44, SE=0.19; p<0.001, p<0.001 respectively).
Qhov zoo siab, cov neeg koom nrog OC tau pom tias muaj kev ntxub ntxaug ntau dua hauv qhov tsis muaj lub tswv yim zoo piv rau qhov kev saib xyuas (p<0.005) while MCI participants did not (p=0.397). No difference was found between deep encoding and combined conditions (OC: p=0.646; MCE p=0.083).
Cov koom nrog hauv pab pawg AD tau pom cov kev hloov pauv mus rau qhov siab dua qhov tshwj xeeb ntawm cov khoom tshwj xeeb recollectiondiscrimination hauv cov xwm txheej ua ke (M=0.66, SE=0.24) piv rau qhov tsis muaj tswv yim (M=0.13 , SE=0.18, p=0.054) and conservative condition (M=0.15, SE=0.19; p=0.074) , txawm hais tias cov no tsis tau ncav cuag qhov tseem ceeb tom qab kev hloov kho tom qab.
Tsis muaj qhov sib txawv thaum muab piv rau qhov tsis muaj lub tswv yim rau kev saib xyuas (p=0.948) thiab cov xwm txheej ua ke (p=0.121). Tsis muaj qhov sib txawv ntawm qhov sib sib zog nqus encoding (M=0.48,SE=0.17) thiab cov xwm txheej ua ke (p=0.388).
Teb Bias Gist
Pab pawg AD tau pom muaj kev ywj pheej ntau dua rau cov ntaub ntawv gist (cov txiaj ntsig tseem ceeb ntawm pab pawg: F(2, 45)=4.11, p<0.001, η 2=0.15; M=−0.01, SE=0.09) than the MCI group (M=0.37, SE=0.09; p<0.001).
Tsis muaj qhov sib txawv ntawm cov lus teb tsis ncaj ncees thaum muab piv OC(M=0.24, SE=0.09) rau MCI (p=0.590) thiab AD (p=0 .168) pawg. Thoob plaws txhua pab pawg, cov neeg koom tau pom cov lus teb tsis zoo rau kev saib xyuas ntau dua rau cov ntaub ntawv gist hauv qhov kev saib xyuas (cov txiaj ntsig tseem ceeb ntawm tus mob: F(3, 135)=15.92, p<0.001, η 2=0.26; M=0.56, SE=0.10) compared to the no strategy (M=0.08, SE=0.08; p<0.001), deep encoding (M=0.07, SE=0.06; p<0.001), and combined (M=0.09, SE=0.05; p<0.001) conditions. No interaction between condition and group for gist memory was found (F(6, 135)=0.68, p=0.666, η 2=0.03).
Teb Bias Yam khoom tshwj xeeb Recollection
Pab pawg AD kuj tau ua kom pom kev ywj pheej ntau dua rau cov lus qhia tshwj xeeb (cov txiaj ntsig tseem ceeb ntawm pab pawg: F(2, 45)=20.74, p<0.001, η 2=0.48; M=0.17, SE=0.12) compared to the OC (M=1.18, SE=0.12; p<0.001), and MCI (M=0.95, SE=0.12; p<0.001) groups.
Nodifference nyob rau hauv cov lus teb tsis ncaj ncees lawm tau pom nyob nruab nrab ntawm OC thiab MCI pawg (p=0.342).Calllapsed hla pawg, cov neeg koom tau pom ib tug ntau liberal teb bias rau cov khoom-specificinformation nyob rau hauv tsis muaj lub tswv yim mob (qhov tseem ceeb ntawm cov xwm txheej: F (3, 135)=11.91, p<0.001, η 2=0.21; M=0.47, SE=0.10) compared to conservative (M=0.82, SE=0.09; p<0.001), deep encoding (M=0.81, SE=0.07; p<0.001), and combined (M=0.96, SE=0.08; p<0.001) conditions. No interaction between condition and group was found (F(6, 135)=1.42, p=0.212, η 2=0.06).
Kev sib raug zoo ntawm Neuropsychological Tasks thiab Memorial Discrimination
Tsis muaj cov qauv meej ntawm kev sib raug zoo ntawm kev ua tau zoo ntawm cov kev ntsuam xyuas neuropsychological thiab kev siv cov tswv yim kev txawj ntse tau pom. Kev kho Benjamini-Hochberg ((i/m)Q) tau siv los tswj kev tshawb pom cuav uas tshwm sim los ntawm ntau qhov sib piv (Table 2).
Kev sib tham
Cov txiaj ntsig ntawm qhov kev sim no tau qhia tias kev siv cov tswv yim kev txawj ntse cuam tshuam qhov kev ua tau zoo ntawm peb pawg. Cov ntaub ntawv ntau ntxiv tau pom zoo los ntawm kev sib sib zog nqus ib leeg lossis cov tswv yim ua ke txhim kho kev ntxub ntxaug rau cov ntaub ntawv gist hauv peb pawg (Daim duab 4).
Tsis tas li ntawd, hauv pawg OC thiab MCI, ob qho tib si sib sib zog nqus encoding thiab ua ke cov tswv yim kuj tau txhim kho kev ntxub ntxaug rau cov khoom tshwj xeeb; bycontrast, pawg AD tsis tau qhia cov txiaj ntsig zoo rau cov khoom tshwj xeeb kev nco qab (Daim duab 5).
Thaum kawg, pawg AD tau qhia txog kev tsis txaus siab teb rau cov kev tshawb fawb yav dhau los (Budson, Wolk, et al., 2006), thiab txhua tus neeg tuaj koom tau txais kev saib xyuas ntau dua los ntawm kev siv lub tswv yim kev saib xyuas ib leeg (Deason et al., 2017; Waring et al. Ib., 2008).
Hauv kev tshawb fawb tam sim no, cov txiaj ntsig ntawm cov tswv yim ua ke tsis txawv ntawm cov kev sib sib zog nqus ib leeg. Yog li, nws yuav zoo li tias tag nrho cov txiaj ntsig zoo hauv kev tshawb fawb no tau tsav los ntawm kev sib sib zog nqus encoding. Nws yog, yog li ntawd, tsim nyog ncua los txiav txim siab seb qhov tob npaum li cas, cov khoom tshwj xeeb encoding tuaj yeem txhawb nqa tsis tau tsuas yog cov khoom tshwj xeeb kev nco, tab sis kuj gistmemory-tshwj xeeb hauv pawg AD.
Raws li tau hais nyob rau hauv Kev Taw Qhia, gist nco yog kev paub dav dav los ntawm kev sau cov khoom lossis kev paub dhau los (Reyna & Brainerd, 1995; Schacter et al., 1998).
Thaum cov ntsiab lus kawm categorized cov npe, qhov encoding ntawm tus kheej cov khoom ua rau muaj feem cuam tshuam txog kev ua haujlwm (Reyna & Brainerd, 1995). Yog li, kev kawm robin, xiav jay, crow, andcanary activates tsis tau tsuas yog cov nodes tshwj xeeb rau cov khoom no tab sis kuj lwm yam noog xws li cardinal, chickadee, thiab nquab-zoo li tus superordinate qeb, noog. Txawm li cas los xij, cov semanticnetworks no yuav ua kom muaj zog dua thaum encoding sib sib zog nqus thiab semantically raws li piv rau thaum nws ntiav thiab perceptually.
Qhov ua kom muaj zog dua thenetworks yog, qhov muaj zog lub cim xeeb gist yuav. Cov kev tshawb fawb yav tom ntej yuav tsum tshawb nrhiav kev siv cov encoding sib sib zog nqus hauv kev nco txog kev siv cov lus tsis sib xws, vim tias cov kev xav tsis zoo no yuav tsis xav tias yuav ua rau muaj kev nkag siab zoo ntawm cov ntaub ntawv gist.
Txoj kev tshawb no tam sim no qhia tias thaum cov neeg mob nrog AD tsis tau muab cov tswv yim tshwj xeeb encoding, lawv tsis nkag siab cov khoom ntau npaum li lawv tuaj yeem ua tau thiab, yog li ntawd, lawv tsis ua tiav lawv cov kev sib txuas lus uas cuam tshuam nrog cov khoom ntawd.
Hauv qhov kev tshawb fawb no qhia tau hais tias cov neeg mob nrog AD tuaj yeem ua tiav qhov kev sib sib zog nqus encoding zoo uas yuav muab kev ua kom muaj zog ntau dua, yog li ntxiv dag zog rau gist nco hauv AD. Tag nrho cov kev ua tau zoo ntawm cov neeg koom hauv pawg AD qhia txog kev cia siab rau gist nco, xav txog kev tshawb nrhiav raws li cov ntaub ntawv ua ntej uas qhia txog qhov tsis zoo ntawm lub cim xeeb nyob rau hauv cov tsos mob ntawm tus kab mob Alzheimer's dementia (Budson li al., 2000).
Lub tswv yim tob tob tuaj yeem txhawb nqa gist nco, ib qho kev tshawb nrhiav tshiab ntawm txoj kev tshawb fawb tam sim no raws li kev tshawb fawb yav dhau los tsis tau txhawb nqa cov tswv yim kev txawj ntse hauv cov neeg no (Abe li al., 2011; Simmons-Stern li al., 2012; Tat et al. ., 2016; Waring et al., 2008).
Tsis tas li ntawd tsim nyog xav txog yog vim li cas, nyob rau hauv pab pawg neeg OC, cov kev saib xyuas teb cov tswv yim ib leeg txo cov khoom tshwj xeeb recollection txheeb ze tsis muaj lub tswv yim, tab sis nws tsis txo cov khoom tshwj xeeb thaum ua ke nrog kev sib sib zog nqus encoding. Txawm hais tias cov kev tshawb fawb ntxiv yuav xav tau los teb cov lus nug no, peb xav tias, tsis muaj kev nkag siab tob, peb cov neeg koom nrog OC tsis tau muaj kev nco txog txaus kom tso cai rau lawv pom zoo cov khoom yav dhau los.
Txhawm rau muab nws yooj yim dua, hauv cov lus teb rau kev saib xyuas, lawv tau tso tseg qhov kev kwv yees uas lawv tau ua nyob rau hauv qhov tsis muaj lub tswv yim zoo, ntau yam tsis raug! Txawm li cas los xij, kev siv lub tswv yim sib sib zog nqus ntawm cov khoom tshwj xeeb ntawm kev encoding yuav tsum tau pab kom toprove vivid, yam khoom tshwj xeeb recollections ntawm retrieval, xws li cov lus teb rau conservative nyob rau hauv kev sib xyaw ua ke yog nyiam siv rau cov khoom uas tsis tau kawm.
Thaum cov kev tshawb fawb yav dhau los tau qhia tias lub peev xwm ua haujlwm hauv pem hauv ntej yuav yog qhov tseem ceeb hauv kev siv cov tswv yim kev txawj ntse (Plancher, Guyard, Nicolas, & Piolino, 2009), tsis muaj pov thawj ntawm kev sib raug zoo ntawm kev ua haujlwm ntawm frontal executiveneuropsychological ntsuas thiab kev siv xws li cov tswv yim hauv kev tshawb fawb tam sim no.
Cov pab pawg MCIand OC tau ua zoo sib xws ntawm kev ntsuas ntawm kev ua haujlwm ntawm cov thawj coj hauv ntej, thaum pawg AD tau ua haujlwm qis dua li ob pawg. Txawm hais tias yav dhau los kev tshawb fawb qhia tias Alzheimer's kab mob pathology cuam tshuam rau kev ua haujlwm muaj peev xwm (Budson li al., 2002; Kirova, Bays, & Lagalwar, 2015; Marshall et al., 2011), muaj qhov tsis zoo hauv txoj kev tshawb fawb tam sim no uas muaj qee theem ntawm kev ua haujlwm. yog tsim nyog los siv cov tswv yim zoo.Qhov kev kawm tam sim no tsis muaj kev txwv.
Cov pab pawg me me uas siv hauv qhov kev tshawb fawb no tuaj yeem ua rau muaj kev pheej hmoo ntawm qhov tsis zoo tsis raug. Nws kuj tseem muaj peev xwm hais tias cov neeg tuaj koom yuav tau siv lub tswv yim uas tau qhia yav dhau los hauv kev kawm tom qab kev sib tham yog li muaj peev xwm ua rau tsis pom qhov ua tau zoo ntawm cov tswv yim. Txawm li cas los xij, txoj kev tshawb fawb tam sim no tau koom nrog kev ceev faj xws li tiv thaiv cov xwm txheej thiab xav tau yam tsawg kawg ntawm ib lub lim tiam ntawm kev sib tham los txo qhov kev pheej hmoo no.
Thaum kawg, cov neeg koom nrog txhua tus tau thov los ntawm thaj chaw me me, muaj peev xwm ua rau muaj kev cuam tshuam dav dav ntawm cov txiaj ntsig no.Txawm tias cov kev txwv no, txoj kev tshawb no qhia tau tias cov tib neeg uas muaj mob me me AD dementia oramnestic single-domain MCI tuaj yeem siv lub tswv yim sib sib zog nqus los txhim kho lawv kev ntxub ntxaug rau gist. cov ntaub ntawv txawm hais tias tsis muaj kev nco thiab kev ua haujlwm ntawm kev ua haujlwm.
Txawm li cas los xij, cov txiaj ntsig no tseem qhia txog cov kev txwv ntawm cov tswv yim kev txawj ntse hauv AD raws li ADgroup tau pom los txo qis tsuas yog daim ntawv loj tshaj plaws ntawm kev nco distortions-tsis muaj kev cuam tshuam- whereas cov tib neeg uas muaj kev txawj ntse ntau dua (piv txwv li, MCI pab pawg) tuaj yeem kho cov cim xeeb ntau dua. distortions-related yuam kev. Kev tshawb fawb ntxiv rau kev ua haujlwm zoo ntawm cov tswv yim no txhawm rau txhim kho kev ua haujlwm txhua hnub rau cov tib neeg uas muaj kev paub tsis meej me ntsis thiab mob Alzheimer's dementia yog lav-tshwj xeeb tshaj yog thaum cov txiaj ntsig no tau saib hauv cov ntsiab lus ntawm qhov tsis muaj kab mob hloov kho.
Thaum kawg, peb yuav sib cav hais tias cov txiaj ntsig ntawm qhov kev tshawb fawb no ntxiv rau lub cev loj hlob ntawm cov ntaub ntawv uas qhia tias nws yog ib qho tseem ceeb kom tsis txhob txhim kho qhov nco tseeb xwb tab sis kuj txo qis kev nco tsis tseeb thaum tsim cov kev cuam tshuam los ncua kev ua haujlwm tsis zoo thiab txhim kho lub neej zoo rau cov tib neeg uas muaj mob me. Kev paub tsis meej thiab Alzheimer's diseasedementia (Devitt & Schacter, 2016; Silverberg li al., 2011; Turk et al., 2020).
Kev lees paub:
Tsis muaj cov kws sau ntawv tuav cov kev txaus siab lossis kev nqis peev (nyiaj txiag lossis lwm yam) uas yuav ua rau muaj kev tsis sib haum xeeb ntawm kev txaus siab. Txoj haujlwm no tau txais kev txhawb nqa los ntawm National Institutes of Health thiab National Institute on Aging (AEB, P30-AG013846) thiab los ntawm Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv (AEB, CX 001698).
Cov ntaub ntawv
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