Cov Chemical Cheebtsam ntawm Cistanche Deserticola

Nyob rau hauv thaum ntxov 1980s, nrog rau kev loj hlob ntawm tej yam ntuj tso tshuaj chemistry, Japanese scholars pib ua kev tshawb fawb ntau yam ntawm cov tshuaj Chemical Chemistry ntawm genus Cistanche. Thaum xyoo 1980s, cov kws tshawb fawb hauv tsev tau pib mob siab rau cov tshuaj lom neeg muaj pes tsawg leeg ntawm Cistanche deserticola thiab luam tawm ntau cov ntaub ntawv tshawb fawb. Cov qauv zoo ntawm Cistanche deserticola kuj tseem txhim kho txuas ntxiv nrog kev tshawb fawb tob zuj zus. Nrog txoj kev loj hlob sai ntawm kev sib cais thiab kev siv thev naus laus zis, ntau yam tshuaj lom neeg tau txais los ntawm cov nroj tsuag ntawm genus Cistanche, feem ntau suav nrog phenylethanoid glycosides, iridoids thiab lawv glycosides, lignans, thiab glycosides. Tus sau phau ntawv no, raws li lawv cov kev tshawb fawb tshawb fawb, tau tham txog ntau yam ntaub ntawv luam tawm txij li xyoo 1983 thiab xaus lus tias 34 phenylethanoid glycosides, 21 cyclic ether terpenes thiab lawv glycosides, 9 monoterpenes thiab lawv glycosides, 21 volatiles thiab lignan Cheebtsam. Lawv glycosides tau raug cais tawm ntawm Cistanche deserticola.

Cov tshuaj tseem ceeb ntawm Cistanche deserticola

1, Extraction thiab cais cov tshuaj lom neeg los ntawm Cistanche Deserticola

Muaj ntau txoj hauv kev rau kev rho tawm thiab cais cov tshuaj lom neeg los ntawm Cistanche deserticola, thiab ntau tus kws tshawb fawb thiab cov kws tshaj lij tau txais cov khoom sib txawv uas siv cov txheej txheem sib txawv thiab cov kuab tshuaj.

Ntawm cov phenylethanol glycosides muaj nyob rau hauv Cistanche deserticola, lub ntsiab chemical muaj pes tsawg leeg ntsuas rau kev ntsuam xyuas qhov zoo ntawm Cistanche deserticola yog mas quercetin thiab piloside. Lub formulation ntawm cov qauv zoo rau Cistanche deserticola tau ua tsis tu ncua kev txhim kho nrog kev sib sib zog nqus ntawm kev tshawb fawb, los ntawm qhov tsis muaj tshuaj muaj pes tsawg leeg indicators, As mus rau lub ntsiab nrhiav pom cov cim ntawm echinoside thiab piloside. Lub sijhawm sib txawv, cov kws tshaj lij thiab cov kws tshawb fawb sib txawv tau txheeb xyuas thiab sib piv ntau hom, qhov chaw, theem kev loj hlob, cov tsiaj qus thiab cog qoob loo, thiab cov chaw tsim khoom ntawm Cistanche deserticola. Peb yuav tham txog qhov no hauv tshooj tom ntej. Raws li cov ntsiab lus kev txiav txim siab cov cai ntawm 2005 tsab ntawm Suav Pharmacopoeia, cov ntsiab lus ntawm nws cov ntsiab lus qhia, suav nrog quercetin thiab anthocyanin, siab dua li ntawm Cistanche deserticola. Cov ntsiab lus ntawm nws qhov ntsuas qhov ntsuas, ergosterol, kuj txwv, thiab cov ntsiab lus ntawm ergosterol hauv cov tshuaj ntsuab yuav tsum tsis pub tsawg dua 0.080%. Xyoo 2005 tsab ntawm Pharmacopoeia kuj tau ntxiv cov nroj tsuag tshiab, Cistanche tubulosa (Schrenk) Wight, raws li Cistanche deserticola. Ntxiv rau cov khoom siv tshuaj tshiab tshiab Cistanche deserticola, cov ntsiab lus ntawm echinoids hauv cov tshuaj ntsuab yuav tsum tsis pub tsawg dua 1.0%. Cov ntsiab lus txwv ntawm echinoids hauv Cistanche deserticola kuj tau nce ntxiv, uas tau teev tseg tias tag nrho cov nyiaj ntawm echinoid thiab ergosterol hauv Cistanche deserticola yuav tsum tsis pub tsawg dua 0.30%. Pinellia glycoside thiab piloside yog siv los ua cov cim qhia.

Echinacoside (ECH), tseem hu ua hiav txwv urchin lossis echinacoside, tshuaj npe

Echinoside, cov tshuaj tseem ceeb ntawm Cistanche deserticola

Nyem qhov no mus saib Ntuj Cistanche Echinacoside

【Nug ntxiv】 Email: cindy.xue@wecistanche.com / Whats App: 0086 18599088692 / Wechat: 18599088692

Glucopyranoside, 2- (3, 4-dihydroxyphenyl) ethyl O-6-deoxyalpha-L manopy-ranosyl - (1-3) - O - [beta-D-glucopyranosyl - ({ {13}})] -, 4- [3- (3,4-dihydroxyphenyl) 2-propeno ate], molecular formula C35H45O20, yog amorphous brownish daj crystalline hmoov uas yooj yim soluble hauv methanol thiab dej. Nws yog ib qho derivative ntawm caffeic acid nrog ntau yam kev ua ub no xws li neuroprotection, daim siab tiv thaiv, tiv thaiv kab mob, antioxidant, kev tiv thaiv kab mob, txhim kho kev nco, thiab tiv thaiv qog noj ntshav. Xyoo 1950, Echinoside tau tsim los ntawm Swiss tus kws tshawb fawb Stoll A thiab nws pab pawg thawj zaug tau rho tawm Echinacea angustifolia, ib tsob nroj hauv tsev neeg Asteraceae. Raws li Echinacea belongs rau genus Echinacea, tseem hu ua Echinacea, nws muaj npe tom qab genus Echinacea. Tom qab ntawd, hauv Echinacea genus, Echinacea purpurea, Echinacea pallida, Lagotis brevituba Maxim. Hauv tsev neeg Scrophulariaceae, Echinacea purpurea, thiab Cistanche genus nroj tsuag. Xyoo 1984, cov kws tshawb fawb Nyij Pooj Kobayashi, H., thiab lwm tus thawj zaug tau tshaj tawm kev cais tawm los ntawm cov ntsev-yob Cistanche salsa cog ntawm Cistanche genus (tom qab txheeb xyuas los ntawm Shouwu Ming, Tu Pengfei, thiab lwm tus, Kobayashi, H. thawj ntsev borne Cistanche cog yuav tsum yog suab puam Cistanche). Xyoo 1987, Kobayashi, H., thiab lwm tus kuj raug cais tawm ntawm Cistanche tubulosa. Hauv xyoo 1993, Suav cov kws tshawb fawb xws li Du Niansheng tau tshaj tawm thawj zaug qhov chaw sib cais los ntawm Cistanche deserticola (tiag tiag Kobayashi, H. et al.)

2, Actoside, tshuaj npe

Acteoside, cov tshuaj tseem ceeb ntawm Cistanche deserticola

1-O [- L Rhamnopyransyl - (13) [3,4 dihydroxy E-cinnamoyl - (4)] - D-glucopyranoside], nrog cov mis mos molecular C29H36O15, yog cov hmoov dawb, tseem hu ua sesamin, ergosterol. , eugenoside, syringin, verbenin, thiab piloside. Xyoo 1963, Italian kws tshawb fawb Scarpati ML thiab lwm tus thawj zaug tau muab rho tawm thiab muab lub npe no los ntawm Mediterranean pistil paj, tab sis lawv tsis tau muab cov ntaub ntawv ntxaws ntxaws. Txog xyoo 1968, cov kws tshawb fawb German Birkofer L. thiab lwm tus tau cais cov khoom sib xyaw los ntawm Syringa vulgaris L., piav qhia txog nws cov qauv, thiab qhia lub npe tshiab, acetonide. Tom qab ntawd, muaj ntau yam nroj tsuag hauv genus Cistanche, genus Verbascum L., tsev neeg Scrophulariae, Rehmannia glutinosa Libosch, Siphonostegia chinensis Benth, tsev neeg Lamiaceae, Stachys geopombycis CTWu, Galeobdplon cablinense (Benth. ) Benth Forsythia suspense (Thunb.) Vahl, ib tsob nroj ntawm Oleaceae, paj qhuav ntawm wutong Firmiana simplex (L.), ib tsob nroj ntawm tsev neeg wutong, thiab Callicarpa konchiana Champ, ib tsob nroj ntawm Verbenaceae Cov tshuaj no tau cais tawm ntawm ntau tshaj 150 nroj tsuag. suav nrog Plantago asiatica L. noob hauv tsev neeg Plantago. Raws li cov ntaub ntawv hauv tsev thiab txawv teb chaws, cov plaub hau paj glycosides muaj cov haujlwm xws li tiv thaiv cov hlab ntsha, txo cov ntshav siab, tiv thaiv kab mob, tiv thaiv qog, txhim kho kev tiv thaiv, thiab tshem tawm cov dawb radicals. Xyoo 1984, cov kws tshawb fawb Nyij Pooj Kobayashi, H., thiab lwm tus thawj zaug tau tshaj tawm kev cais tawm los ntawm cov ntsev-yob Cistanche salsa cog ntawm Cistanche genus (tom qab txheeb xyuas los ntawm Shouwu Ming, Tu Pengfei, thiab lwm tus, Kobayashi, H. thawj ntsev borne Cistanche cog yuav tsum yog suab puam Cistanche). Xyoo 1987, Kobayashi, H., thiab lwm tus kuj raug cais tawm ntawm Cistanche tubulosa. Hauv xyoo 1993, Suav cov kws tshawb fawb xws li Du Niansheng tau tshaj tawm thawj zaug qhov chaw sib cais los ntawm Cistanche deserticola (tiag tiag Kobayashi, H. et al.)

3, Cyclone ether terpenes thiab lawv glycosides

Cyclone ether terpenes yog acetal derivatives ntawm malondialdehyde thiab yog ib qho ntawm cov tshuaj tseem ceeb ntawm cov genus Cistanche. Cov tebchaw no muaj dav nyob rau hauv lub nceeg vaj cog thiab muaj ntau yam kev ua ub no xws li tshuaj tua kab mob, tshuaj tua kab mob, thiab tshuaj tua kab mob. Cov iridoid glycosides ntawm cov nroj tsuag hauv genus Cistanche yog tag nrho cov piam thaj monoglycosides, thiab cov piam thaj feem ntau txuas nrog glycoside 1 txoj haujlwm; Cov glycoside feem ntau muaj carboxyl lossis demethylation ntawm txoj haujlwm 4, qee zaus hydrogenation ntawm txoj haujlwm 3 thiab 4, hydroxyl pawg ntawm txoj haujlwm 6, 7, 8, lossis 10, thiab qee zaus dehydroxylation ntawm txoj haujlwm 7 thiab 8 los tsim ob daim ntawv cog lus lossis epoxy ether bonds. Cov pab pawg hydroxyl ntawm txoj haujlwm 10, 1, lossis 3 qee zaus dehydrate los tsim cov qauv epoxy; Cov hydrogen ntawm txoj haujlwm 5 thiab 9 ntawm aglycone yog nyob rau hauv beta configuration. Los ntawm 1984 txog 1985, Hiromi Kobayashi thiab lwm tus tau cais tawm 8-ethylenediamine, 7-deoxy-8-ethylenediamine, thiab geniposide los ntawm Cistanche deserticola ua nyob rau hauv Inner Mongolia, Tuam Tshoj. Xyoo 1994, Xu Wenhao et al. cais thiab txheeb xyuas 8-epirubic acid los ntawm Cistanche deserticola tiag. Xyoo 2000, Song Zhihong et al. siv ntau yam kev siv chromatographic cais plaub iridoid glycosides los ntawm Cistanche deserticola, uas yog 8-epirubiginic acid, pentafolic acid, geniposide, thiab jasmonic acid. Tus sau phau ntawv no, Xie Haihui, cais 16 monomeric tebchaw los ntawm methanol extract ntawm qhuav Cistanche deserticola qia, nrog rau 14 cyclic ether terpenes, 1 acyclic monoterpenoid glycoside, thiab 1 cim cyclic ether uas muaj chlorine atoms.

Phenylethanol glycoside yog lub luag haujlwm tseem ceeb ntawm Cistanche deserticola

4, Lignin thiab phenyl propanol Cheebtsam

Lignan yog lub ntuj tsim los ntawm polymerization ntawm ob lub molecules ntawm phenylpropanoid derivatives, feem ntau yog nyob rau hauv ib tug dawb lub xeev, thiab ob peb ua ke nrog suab thaj los tsim glycosides. Hauv 1984-1986, Hiromi Kobayashi cais turpentine thiab melanin glycosides los ntawm Salicornia deserticola, thiab ob lub lignan glycosides tshiab tau raug cais tawm los ntawm Salicornia deserticola: Dehydiconiferol cawv '-0- - D-glucopyranoside thiab Dehydiconiferol cawv {-0- -. Xyoo 2000, Song Zhihong thiab lwm tus thawj zaug cais ib lub lignan glycoside los ntawm Cistanche deserticola, uas yog syringal resin phenolic glucoside.

5, Monoterpenoid Cheebtsam

Tam sim no, 7 monoterpenes thiab lawv cov glycosides tau raug cais tawm ntawm cov nroj tsuag ntawm genus Cistanche. Hom tshuaj no muaj methyl pawg ntawm txoj haujlwm 2 thiab 6, ob daim ntawv cog lus ntawm txoj haujlwm 2 thiab 3, thiab ob daim ntawv cog lus ntawm txoj haujlwm 6, 7, lossis 7 thiab 8; Monoterpene tebchaw feem ntau muaj hydroxyl lossis carboxyl pawg ntawm txoj haujlwm 1, thiab pawg hydroxyl ntawm txoj haujlwm 8; Monoterpenoid glycosides yog tag nrho cov piam thaj aminoglycosides, nrog cov piam thaj txuas ntawm txoj haujlwm 1 lossis 8 ntawm aglycone.

6, Volatile Cheebtsam

Zhang Yong et al. soj ntsuam thiab txheeb xyuas 21 lub tebchaw los ntawm Cistanche deserticola siv roj chromatography-mass spectrometry, nrog rau cov khoom tseem ceeb yog palmitic acid thiab linoleic acid.

Cov tshuaj tseem ceeb ntawm Cistanche deserticola

7, Lwm yam khoom siv

Xyoo 2007, Gong Lidong et al. tau kawm txog monosaccharide muaj pes tsawg leeg ntawm polysaccharides nyob rau hauv ntau hom thiab keeb kwm ntawm Cistanche deserticola qauv. Cov txiaj ntsig tau pom tias polysaccharides hauv Cistanche deserticola los ntawm Xinjiang muaj cov piam thaj, rhamnose, galactose, thiab fructose. Carbohydrates yog cov tshuaj muaj txiaj ntsig zoo hauv Cistanche deserticola, uas muaj cov txiaj ntsig ntawm kev txhim kho yang, txhim kho kev tiv thaiv kab mob, txhawb kev zom zaub mov, tiv thaiv kev laus, sedation, thiab mob nyem. Cov amino acids hauv Cistanche deserticola los ntawm Xinjiang tau pom muaj 17 hom amino acids, nrog rau tag nrho cov amino acid pawg feem ntawm 7.87%. Ntawm lawv, muaj 7 yam tseem ceeb amino acids rau tib neeg lub cev, xws li threonine, valine, methionine, isoleucine, leucine, phenylalanine, thiab lysine. Muaj cuaj cov amino acids zoo, uas yog aspartic acid, glutamic acid, glycine, methionine, isoleucine, leucine, phenylalanine, lysine, thiab arginine. Thiab inorganic kab kawm xws li Fe, Mn, Zn, Sr, Ca, Li, Cu, Se, Mo, I, Mg, thiab lwm yam. Nyob rau hauv lub genus Cistanche, kuj muaj steroid tebchaw xws li - sitosterol, carotene, thiab ecdysone, glycosides xws li mannitol thiab galactose, acids xws li succinic acid thiab vanillic acid, thiab alkyl glucosides xws li ethyl - D-glucopyranose.