Kev Koom Tes Ntawm Cov Mob Cancer Mis Thiab Lub Raum Cell Carcinoma
Mar 25, 2022
Hu rau:joanna.jia@wecistanche.com/ WhatsApp: 008618081934791
Khalid Jazieh, Firas Baidoun, & et al.
Abstract
Lub hom phiaj Muaj cov ntaub ntawv qhia txog cov neeg mob nrog ob qho tib si thawjmob cancer mis(BC) thiablub raum cell carcinoma(RCC). Peb tshawb nrhiav kev koom tes ntawm ob qhov kev phem no siv SEER cov ntaub ntawv pej xeem thiab peb cov ntaub ntawv hauv tsev.
Txoj Kev Peb tau kawm txog kev koom tes ntawm BC (mob cancer mis) thiab RCC (lub raum cell carcinoma) nyob rau hauv 2000-2016 Kev Tshawb Fawb, Kab Mob Sib Kis, thiab Kev Xeem Kawg (SEER)database. Peb mam li tshuaj xyuas peb lub tsev kho mob cov ntaub ntawv ntawm cov neeg mob uas muaj ob qho tib si BC(mob cancer mis)thiab RCC(lub raum cell carcinoma)thiab sau cov ntaub ntawv suav nrog tus kheej thiab tsev neeg keeb kwm ntawm mob qog noj ntshav, kuaj caj ces, thiab cov txiaj ntsig ntawm tus neeg mob.
Cov txiaj ntsig ntawm 813,477 cov poj niam kuaj mob BC(mob cancer mis)hauv SEER database, 1914 tom qab tsim RCC(lub raum cell carcinoma). Qhov kev pheej hmoo ntawm kev tsim RCC tau nce ntxiv hauv thawj 6 lub hlis, 7-12 hli, thiab 1-5 xyoo tom qab BC(mob cancer mis)Kev kuaj mob nrog tus qauv sib piv (SIRs) ntawm 5.08(95 feem pua CI4.62-5.57), 2.09(95 feem pua CI 1.8-2.42), thiab 1.15(95 feem pua CI1.{{16 }}.24), feem ntawm 56,200 poj niam nrog RCC(lub raum cell carcinoma), 1087 tom qab tsim BC(mob cancer mis). Kev pheej hmoo ntawm kev tsim BC(mob cancer mis)raws li RCC(lub raum cell carcinoma) tau nce siab hauv thawj 6 lub hlis (SIR ntawm 1.45[95 feem pua CI 1.20-1.73]). Rau peb cov neeg mob hauv tsev kho mob, 437 muaj ob BC(mob cancer mis)thiab RCC(lub raum cell carcinoma).427 (97.71 feem pua) yog poj niam, thiab 358 (81.92 feem pua) yog dawb, thiabmob cancer mistau kuaj pom ua ntej RCC(lub raum cell carcinoma) hauv 246 (56.3 feem pua) cov neeg mob. Muaj 15 qhov kev hloov pauv ntawm cov kab mob hauv cov neeg uas muaj kev kuaj caj ces.
Xaus Peb qhov kev tshawb pom qhia tias BC(mob cancer mis)Cov neeg mob muaj kev pheej hmoo siab ntawm kev tsim RCC(lub raum cell carcinoma)thiab vice versa. BC(mob cancer mis)nyiam ua ntej RCC(lub raum cell carcinoma), thiab cov neeg mob feem ntau muaj keeb kwm ntawm lwm tus neeg mob thiab tsev neeg keeb kwm ntawm mob qog noj ntshav, tshwj xeeb tshaj yog BC(mob cancer mis).
dr vita opc fda pom zoorauraum
Taw qhia
Ntau tus mob qog noj ntshav tau paub tias muaj feem cuam tshuam nrog ib leeg, feem ntau yog vim muaj kev pheej hmoo ntau. Cov piv txwv classic ntawm cov kev pheej hmoo muaj xws li kev hloov pauv hauv cov noob xws li BRCA uas ua rau muaj kev pheej hmoo ntau ntxivmob qog noj ntshavthiab cov qog nqaij hlav zes qe menyuam [1], nrog rau kev haus luam yeeb thiab haus cawv uas cuam tshuam nrog kev pheej hmoo ntawm cov qog nqaij hlav hauv lub ntsws thiab lub taub hau thiab caj dab [2]. Tsis tas li ntawd, cov neeg mob uas tau txais kev kho mob nrog cov tshuaj tshwj xeeb muaj kev pheej hmoo siab rau cov qog nqaij hlav yav tom ntej xws li leukemia [3].
Muaj ntau cov ntaub ntawv qhia txog cov neeg mob nrog ob qho tib si thawj RCC(lub raum cell carcinoma)thiab malignant mis neoplasms [4-9]. Nws kwv yees tias hauv Asmeskas 281,550 tus poj niam thiab 2650 tus txiv neej yuav raug kuaj pom BC.(mob cancer mis)hauv 2021[10]. Tsis tas li ntawd, qhov kev cia siab 43,600 tus poj niam thiab 530 tus txiv neej yuav tuag hauv Asmeskas vim BC(mob cancer mis)xyoo 2021. Lub koom haum American Cancer kuj tau kwv yees tias yuav muaj kwv yees li 76,080 tus neeg mob qog noj ntshav tshiab hauv Tebchaws Meskas uas ua rau 13,780 tus neeg tuag.
Ib cag ntawm cov ntaub ntawv qhia txog cov ntaub ntawv, cov kev tshawb fawb piav qhia txog qhov tshwm sim ntawm cov neeg mob uas muaj mob qog noj ntshav hauv lub raum thiab lub raum tseem ceeb heev. Hauv kev tshawb fawb los ntawm Beislan et al. ntsuam xyuas 1425 cov neeg mob nrog RCC(lub raum cell carcinoma),26 (1.8 feem pua) muaj keeb kwm ntawmmob cancer misas well [11]. Lwm txoj kev tshawb fawb los ntawm Demir et al. nrog 1129 kis ntawm RCC(lub raum cell carcinoma)muaj 13 tus neeg mob (1.15 feem pua) nrog BC(mob cancer mis)[12]. Cov ntaub ntawv no tau ua rau peb ntsuas qhov kev sib raug zoo ntawm BC(mob cancer mis)thiab RCC(lub raum cell carcinoma). Peb tau pib los ntawm kev soj ntsuam cov pej xeem siv Kev Tshawb Fawb, Kab Mob Sib Kis, thiab Kev Tshawb Fawb Kawg (SEER), tom qab ntawd peb tau tshuaj xyuas peb cov ntaub ntawv hauv tsev kho mob los tshawb xyuas cov pej xeem ntawm cov neeg mob nrog ob qho tib si.).
Cov txheej txheem
SEER txoj kev txheeb xyuas pej xeem hauv tebchaws
Cov ntaub ntawv qhov chaw
Peb tau txais cov ntaub ntawv los ntawm Kev Tshawb Fawb, Kev Kab Mob Sib Kis, thiab Kev Xeem Kawg (SEER) database ntawm US National Cancer Institute, siv SEER * stat software (version 8.3.5).Peb siv SEER 18 cov npe (2017 xa) npog txog 27.8 feem pua. (raws li 2010 census) ntawm Teb Chaws Asmeskas cov pej xeem-tion ntawm 2000 thiab 2017 [13,14].
Kawm cov pej xeem
Peb tshuaj xyuas cov neeg mob kuaj mob BC(mob cancer mis) nruab nrab ntawm 2000 thiab 2016 thiab ua raws lawv rau tom qab RCC(lub raum cell carcinoma) Kev kuaj mob, thiab tom qab ntawd tshuaj xyuas cov neeg mob kuaj mob nrog RCC nyob rau tib lub sijhawm thiab ua raws li lawv rau kev kuaj mob tom qab BC(mob cancer mis).Peb tsuas suav nrog cov ntaub ntawv pov thawj histological. Txhawm rau tshem tawm qhov ua tau ntawm qhov kev txiav txim tsis raug ntawm kev mob qog noj ntshav, peb tsis suav nrog RCC.(lub raum cell carcinoma)kuaj pom tsawg dua 2 lub hlis txij thaum pib BC(mob cancer mis)kuaj mob thiab vice versa.
Cov txiaj ntsig
Peb suav qhov Standardized Incidence Ratios (SIR) ntawm RCC(lub raum cell carcinoma)raws li BC(mob cancer mis)Kev kuaj mob thiab SIR ntawm BC tom qab RCC(lub raum cell carcinoma)kuaj mob. Qhov 'Observed'value sawv cev rau tus lej thib ob BC(mob cancer mis)los yog RCC(lub raum cell carcinoma)Cov mob qog noj ntshav tau kuaj pom tom qab pib BC(mob cancer mis)los yog RCC(lub raum cell carcinoma)kev kuaj mob, thaum tus nqi 'Xav tau' sawv cev rau tus lej ntawm BC(mob cancer mis)los yog RCC(lub raum cell carcinoma)cov xwm txheej yuav tsum tau kuaj pom hauv cov pej xeem zoo sib xws hauv tib lub sijhawm. SIR sawv cev rau kev hloov hauv RCC(lub raum cell carcinoma)pheej hmoo tom qab BC(mob cancer mis) Kev kuaj mob thiab rov ua dua piv rau cov pej xeem hauv Teb Chaws Asmeskas.
Kev txheeb cais
Peb tau siv ntau qhov kev sib tham ntawm Thawj Tswj Hwm SIR ntawm SEER * stat software (version 8.3.5) los xam cov txheej txheem sib piv (SIR) nrog 95 feem pua ntawm kev ntseeg siab (CD).Qhov kev pheej hmoo ntawm BC(mob cancer mis)/ RCC(lub raum cell carcinoma)tau txhais raws li tus naj npawb ntawm pom BC(mob cancer mis)/ RCC(lub raum cell carcinoma)cov xwm txheej yog ntau tshaj li qhov xav tau BC(mob cancer mis)/ RCC(lub raum cell carcinoma)Cov xwm txheej hauv cov pej xeem.Cov kev tshuaj ntsuam SIR tau hloov kho rau hnub nyoog, poj niam txiv neej, haiv neeg, thiab xyoo ntawm kev kuaj mob.Tus neeg mob cov yam ntxwv thiab cov pej xeem raug muab piv, cov kev hloov pauv tau raug muab piv nrog Mantel-Haenszel chi-square test, thiab qhov sib txawv tsis tu ncua yog piv nrog cov tub ntxhais kawm t xeem yog ib txwm muab faib thiab qhia raws li txhais tau tias los yog los ntawm kev tshuaj xyuas ntawm qhov sib txawv ntawm qhov kev xeem thiab qhia tawm raws li qhov nruab nrab yog tias tsis nquag faib-uted. Kev txheeb xyuas txheeb cais tau ua los ntawm kev siv RStudio software (RStudio, Boston, Massachusetts) lossis SPSS soft-ware, version 26 (IBM SPSS Statistics, IBM, Armonk, New York)[15,16]A 2-sided tus nqi ofp<0.05 was="" set="" for="" statistical="">
Cov txheej txheem soj ntsuam cov neeg mob hauv tsev kho mob
Kev pom zoo IRB tau txais los ntawm peb lub koom haum saib xyuas IRB pawg neeg saib xyuas, thiab tau lees paub qhov kev tso cai raug zam vim qhov no yog kev kawm rov qab. Peb siv ntau yam kev kuaj mob ICD raumob cancer mis(piv txwv li, thawj lub mis adenocarcinoma-C50.919, tus kheej keeb kwm ntawmmob cancer mis— Z85.3) thiab raum mob cancer (xws li, raum neoplasm-D49.519, raum cell carcinoma-C64.9) los tshawb nrhiav peb cov ntaub ntawv Epic © tus neeg mob rau txhua tus neeg mob uas ua ke daim ntawv kuaj mob ntawmmob cancer misthiab mob qog noj ntshav. Rau kev tshawb fawb dav dav, peb siv 5143 daim ntawv lo rau lub mis thiab 1414 lub raum daim ntawv lo.
Peb tom qab ntawd daim ntawv tshuaj xyuas cov neeg mob thiab tsis suav nrog cov uas tsis muaj ob qho tib si BC(mob cancer mis)thiab RCC(lub raum cell carcinoma). Cov neeg mob carcinoma-in-situ tau suav nrog hauv peb cov qauv ntawm cov neeg mob. Cov ntaub ntawv khaws tseg rau txhua tus neeg mob suav nrog lawv lub hnub nyoog, poj niam los txiv neej, tus kheej thiab tsev neeg keeb kwm ntawm mob qog noj ntshav, hnub nyoog ntawm kev kuaj mob qog noj ntshav, cov kab mob histological ntawm lawv cov BC(mob cancer mis)thiab RCC(lub raum cell carcinoma), cov cim qog, theem mob qog noj ntshav ntawm kev kuaj mob, kuaj caj ces ua tiav, kev cuam tshuam rau mob qog noj ntshav thiab lub raum, thiab cov txiaj ntsig ntawm tus neeg mob. Cov yam ntxwv ntawm tus neeg mob tau suav nrog hauv qhov nruab nrab rau qhov sib txawv tsis tu ncua, thiab nyob rau hauv fre-quencies thiab feem pua rau categorical variables. Cov khoom tawm tuaj tau sau npe tias yog kev nce qib, ib feem ntawm cov lus teb, lossis ua tiav kev zam txim raws li RECIST cov qauv [17]. Yog hais tias tus neeg mob tau txhim kho kev loj hlob ntawm ib qho chaw, lawv cov txiaj ntsig tau raug sau tias yog kev loj hlob. Cov neeg mob uas tsis muaj mob qog noj ntshav rau 10 xyoo lossis ntau dua tau sau npe tias kho tau.
Cov txiaj ntsig
SEER cov kev txheeb xyuas pej xeem
Thaum lub sijhawm 2000-2016, ntawm 813,477 poj niam nrog BC(mob cancer mis), tag nrho ntawm 1914 tom qab tsim RCC(lub raum cell carcinoma)(tus yam ntxwv ntawm tus neeg mob hauv Table 1).A tag nrho ntawm 456 tus neeg mob (23.82 feem pua) ntawm RCC(lub raum cell carcinoma)tau kuaj pom nyob rau hauv thawj 6 lub hlis ntawm BCdiagnosis, 179 (9.35 feem pua) nyob rau hauv 7-12 hli, 647 (33.8 feem pua) hauv 1-5 xyoo, thiab 632 (33.01 feem pua) tom qab ntau tshaj 5 xyoo. Kev pheej hmoo ntawm kev tsim RCC(lub raum cell carcinoma)raws li BC(mob cancer mis)tau nce siab nyob rau hauv thawj 6 hli, 7-12 hli, thiab 1-5 xyoo ntawm BC(mob cancer mis)diagno-sis nrog standardized incidence ratios(SIRs) ntawm 5.08(95 feem pua CI4.62-5.57),2.09(95 feem pua CI1.8-2.42), thiab 1.15 (95 feem pua CI 1. {25}}.09]).
Ntawm qhov tod tes, tib lub sijhawm, ntawm 56,200 tus poj niam nrog RCC(lub raum cell carcinoma), tag nrho ntawm 1087 tom qab tsim BC(mob cancer mis)(tus yam ntxwv ntawm tus neeg mob hauv Table 2), uas 121 (11.13 feem pua) tau nyob hauv thawj 6 lub hlis ntawm RCC(lub raum cell carcinoma)Kev kuaj mob, 65 (5.98 feem pua) nyob rau hauv 7-12 hli, 472 (43.42 feem pua ) nyob rau hauv 1-5 xyoo, thiab 429 (39.47 feem pua) tau tom qab ntau tshaj 5 xyoos.Qhov kev pheej hmoo ntawm kev loj hlob BC(mob cancer mis)raws li RCC(lub raum cell carcinoma)tau nce siab hauv thawj 6 lub hlis ntawm RCC(lub raum cell carcinoma)Kev kuaj mob nrog SIR ntawm 1.45 (95 feem pua CI 1.20-1.73), thaum qhov kev pheej hmoo ntawm lwm lub sijhawm latency tsis txawv heev thaum piv rau cov pej xeem (Daim duab 1B). Cov neeg hauv tsev kho mob tshwm sim
822 tus neeg mob nyob rau hauv peb cov ntaub ntawv hauv tsev kawm ntawv muaj ib tugmob cancer misthiab lub raum mob cancer diagnostic label. Tom qab tshuaj xyuas cov kab kos 437 tus neeg mob tau txheeb pom tias muaj ob qho tib simob cancer misthiab mob cancer ntawm lub raum. Cov neeg mob uas muaj lwm yam kev kuaj mob xws li lub mis fibroadenomas, los yog cov qog nqaij hlav uas muaj metasta-loj rau ob lub raum raug cais tawm. Ntawm 437 tus neeg mob, 427 (97.71 feem pua) yog poj niam, thiab 358 (81.92 feem pua) qhov twg dawb (Table 3).
Mob cancer mistau kuaj pom ua ntej RCC(lub raum cell carcinoma)hauv 246 (56.3 feem pua) ntawm cov neeg mob.152 cov neeg mob tau BC(mob cancer mis)thiab RCC(lub raum cell carcinoma) nyob rau tib sab (76 sab xis, 76 sab laug), 35 muaj BC(mob cancer mis) ob sab, thiab 16 muaj RCC(lub raum cell carcinoma)ob sab. Tsis muaj tus neeg mob tau mob qog noj ntshav ob sab. Ntawm 437 tus neeg mob, muaj lwm 142 malignancies xws li mob qog noj ntshav thiab qog nqaij hlav ntawm zes qe menyuam, thiab cov mob qog nqaij hlav tshaj plaws tau tshaj tawm hauv cov neeg mob tsev neeg keeb kwm yog.mob cancer mis(125), mob qog noj ntshav (51), mob ntsws cancer (45), thiab mob qog nqaij hlav prostate (34) (Table 3). Muaj 15 qhov paub tseeb tias cov kab mob hloov pauv / hloov pauv ntawm qhov tsis tseem ceeb hauv cov neeg mob uas tau kuaj cov caj ces (Table 4), feem ntau yog BRCA1/2 (tam sim no hauv 5 tus neeg mob).
Qhov feem ntau txheeb xyuas BC(mob cancer mis) stages at diagnosis for these patients was stage IA(16.93%)and stage IIA(11.9%)(Table 5a), but the stage at diagnosis was unavailable for>56 feem pua ntawm cov neeg mob.Invasive ductal carcinoma yog cov feem ntau pathological subtype pom. Hais txog kev kho mob, 89.47 feem pua tau txais kev phais mob xws li lumpectomy lossis mastectomy, 45.77 feem pua tau txais kev kho hluav taws xob, 31.81 feem pua tau txais tshuaj kho mob, thiab 38.9 feem pua tau txais tshuaj tiv thaiv estrogen lossis anti-HER2. Ntau tshaj li ib feem peb ntawm cov neeg mob (39.58 feem pua) tau txiav txim siab tau kho lawvmob cancer mis (either by being disease-free for>10 xyoo lossis los ntawm cov ntaub ntawv los ntawm lawv tus kws kho mob oncologist), thiab 16.71 feem pua yog nyob rau hauv kev zam txim (Table 5a).
Raws li RCC(lub raum cell carcinoma), feem ntau pom tau hais tias theem ntawm kev kuaj mob yog kab mob theem I (34.78 feem pua) tab sis theem tsis paub nyob rau hauv 48.28 feem pua ntawm cov neeg mob, thiab cov kab mob qog nqaij hlav ntshiab sawv cev rau 45.54 feem pua ntawm cov neeg mob ua raws li papillary cell carcinoma (7.55%) thiab chromophobe cell hlav. (4.12 feem pua) (Table 5b. Ntau tshaj 90 feem pua ntawm cov neeg mob tau txais kev phais mob (xws li, ua tiav lossis ib nrab nephrectomy), 38.92 feem pua tau kho RCC(lub raum cell carcinoma), thiab 14.87 feem pua yog nyob rau hauv kev zam txim raws li kev kho mob.Thaum lub sij hawm ntawm peb cov ntaub ntawv sau, 92 (21.05 feem pua) ntawm cov neeg mob kawm tau tuag (Table 3).RCC(lub raum cell carcinoma)yog qhov feem ntau txheeb xyuas qhov ua rau tuag (20.65 feem pua), thiab BC(mob cancer mis)suav txog 10.87 feem pua ntawm cov neeg tuag.
Kev sib tham
Rau peb txoj kev paub, txoj kev tshawb no muaj qhov loj tshaj plaws ntawm ob lub teb chaws cov ntaub ntawv thiab cov ntaub ntawv hauv tsev uas qhia txog kev sib koom ua ke ntawm BC(mob cancer mis)thiab RC. Peb tau txheeb xyuas cov ntaub ntawv ntawm ntau dua 3000 Asmeskas cov neeg mob ntawm SEER thiab 437 cov neeg mob tau kho peb lub tsev kho mob uas muaj keeb kwm ntawm ob qho tib si BC.(mob cancer mis)thiab RCC(lub raum cell carcinoma). Raws li SEER cov txiaj ntsig kev txheeb xyuas pej xeem, cov neeg mob BC(mob cancer mis)muaj kev pheej hmoo siab dua ntawm kev kuaj mob nrog RCC(lub raum cell carcinoma)nyob rau hauv 5 xyoo ntawm lawv BC(mob cancer mis)Kev kuaj mob tom qab kho lub hnub nyoog, poj niam txiv neej, haiv neeg, thiab xyoo ntawm kev kuaj mob, thiab qhov kev pheej hmoo siab tshaj plaws hauv thawj 6 lub hlis. Conversely, RCC(lub raum cell carcinoma)Cov neeg mob kuj muaj kev pheej hmoo siab dua ntawm kev kuaj mob BC(mob cancer mis)nyob rau hauv 6 lub hlis ntawm lawv RCC(lub raum cell carcinoma)kev kuaj mob, tab sis qhov kev pheej hmoo no qis dua. Qhov tseem ceeb, cov xwm txheej no tshwm sim nyob rau hauv 6 lub hlis ntawm ib leeg yuav raug cais raws li kev mob qog noj ntshav synchronous.
Nws tsis paub meej tias vim li cas thiaj muaj kev koom tes zoo li no. Ib txoj kev xav yog RCC(lub raum cell carcinoma)Cov neeg mob raug kuaj pom qhov xwm txheej vim qhov kev ntsuas ua rau cov neeg mob uas muaj kev pheej hmoo siab BC(mob cancer mis)leej twg tau txais kev qhia txog kev ua haujlwm, uas yuav piav qhia vim li cas thiaj muaj feem ntau dua ntawm kev kuaj mob RCC(lub raum cell carcinoma)hauv thawj 6 lub hlis tom qab BC(mob cancer mis)kuaj mob. Txawm li cas los xij, qhov no tsis suav tias yog vim li cas thiaj li muaj ntau tus RCC(lub raum cell carcinoma)cov xwm txheej ntawm BC(mob cancer mis)cov neeg mob. Qhov no taw qhia rau cov neeg mob uas yog predisposed rau ob qho tib si BC(mob cancer mis)thiab RCC(lub raum cell carcinoma), tej zaum yog vim muaj kev pheej hmoo zoo sib xws, thiab tejzaum nws yog vim muaj kev hloov hauv caj ces. Qhov tseeb tias qhov kev pheej hmoo poob qis nrog lub sijhawm qhia tau hais tias kev loj hlob ntawm tus mob qog noj ntshav thib ob yog qhov tsawg dua vim muaj kev kho mob tshwj xeeb ntawm qhov pib malignancy.
Peb tshawb nrhiav cov ntaub ntawv sab hauv ntawm cov neeg mob nrog BC(mob cancer mis)thiab RCC(lub raum cell carcinoma)qhia cov pej xeem uas feem ntau yog poj niam thiab dawb, thiab qhov kev kuaj mob ntawm BC(mob cancer mis)nyiam ua ntej ntawm RCC(lub raum cell carcinoma). Cov neeg mob feem ntau muaj keeb kwm ntawm tus kheej ntawm lwm yam mob phem thiab tsev neeg keeb kwm ntawm mob qog noj ntshav, tshwj xeeb tshaj yog BC(mob cancer mis).Ib tug me me ntawm cov neeg mob tau kuaj cov kab mob genetic germline los ntawm qhov peb txheeb xyuas 15 kev hloov pauv / hloov pauv ntawm qhov tsis paub tseeb, feem ntau yog BRCA1/2.Om, muaj lwm yam kev hloov pauv uas tuaj yeem ua rau ob qho tib si.mob cancer misthiab lub raum mob cancer xws li CHEK2 variant[18], tab sis cov no tsis tau sim rau hauv peb cov neeg mob.
Qhov cuam tshuam ntawm peb qhov kev tshawb pom yog qhov tseem ceeb tshwj xeeb rau cov kws kho mob tswj cov neeg mob nrog BC(mob cancer mis)los yog RCC(lub raum cell carcinoma). Ntau tshaj li ib nrab ntawm cov neeg mob RCC(lub raum cell carcinoma)yog asymptomatic thiab raug kuaj los ntawm qhov teeb meem. Thaum cov neeg mob tshwm sim, lawv tuaj yeem muaj hematuria tag nrho, mob flank, thiab palpable plab plab [19]. Oncologists tswjmob cancer misCov neeg mob tuaj yeem txiav txim siab kuaj xyuas cov tsos mob no thiab saib xyuas cov palpable raum loj thaum lawv kuaj. Ib yam li ntawd, nws tseem ceeb tshwj xeeb rau RCC(lub raum cell carcinoma)cov neeg mob kom nyob twj ywm nrog lawv cov BC(mob cancer mis)kev tshuaj ntsuam.
Cov kev txwv ntawm peb txoj kev tshawb fawb suav nrog nws qhov kev rov qab los thiab tsis muaj qee cov ntaub ntawv los ntawm cov ntaub ntawv ntawm peb cov neeg mob. Raws li peb qhov kev tshawb pom, peb xaus lus tias nws yog ib qho tseem ceeb kom paub tias cov neeg mob BC(mob cancer mis)tej zaum yuav muaj kev pheej hmoo siab dua ntawm kev muaj lossis txhim kho RCC concomitant(lub raum cell carcinoma)thiab vice versa. Kev tshawb fawb txog kev sib kis ntau ntxiv yog xav tau los kawm txog kev sib koom ua ke ntawm BC(mob cancer mis)thiab RCC(lub raum cell carcinoma)tshwj xeeb los tshawb txog qhov muaj feem cuam tshuam rau txoj kev loj hlob ntawm cov kab mob no, thiab qhov zoo tshaj plaws kev ntsuam xyuas caj ces yuav tsum tau ua rau cov neeg mob no los piav qhia txog cov kev hloov pauv hauv qab thiab cov caj ces txawv txav.
cistanche poob teb chaws Ottoman tshuaj ntsuab
Cov ntaub ntawv
1. Paul A, Paul S(2014)Themob cancer missusceptibility genes (BRCA) hauv cov qog nqaij hlav ntawm lub mis thiab zes qe menyuam. Pem hauv ntej Biosci (Landmark Ed)19:605-618
2. Dikshit RP, Boffetta P, Bouchardy C, Merletti F, Crosignani P, Cuchi T et al (2005) Kev pheej hmoo rau kev loj hlob ntawm cov qog thib ob ntawm cov txiv neej tom qab laryngeal thiab hypopharyngeal carcinoma.Cancer 103:2326-2333. https://doi.org/10.1002/cncr. 21051 ib
3. Boffetta P, Kaldor JM(1994)Secondary malignancies after cancer chemotherapy.Acta Oncol (Madr)33:591-598.https://doi. org/10.3109/02841869409121767
4. Arjunan R, Kumar D, Kumar KVV, Premlatha CS (2016)Mob cancer misnrog synchronouslub raum cell carcinoma: ib qho kev nthuav qhia tsis tshua muaj. J Clin Diagn Res 10:XD03-XD05.https://doi.org/10.7860/JCDR/2016/20362.8683
5. Sheng IY, Kruse M, Leininger KM, Ornstein MC (2019) Kev kho cov tshuaj tiv thaiv kab mob ntawm synchronouslub raum cell carcinoma(RCC) thiab triple-negativemob cancer mis(TNBC). Case Rep Oncol Med 2019:6246209.https://doi.org/10.1155/2019/6246209.
6. Kurlekar UA, Rayate AS (2015) Synchronous thawj malignancies nyob rau hauv lub mis thiab lub raum: ib tug tsis tshua muaj ntaub ntawv ceeb toom.Indian J Surg 77:6-9. https://doi.org/10.1007/s12262-013-1031-0
7. Sidoun M, Elfageih M, Albolatti K, Elrgaig M, Eltruki A, Salah K, thiab al (2021) Metachronousmob cancer misnyob rau hauv tus neeg mob uas muaj lub raum mob qog noj ntshav, kev paub dhau los ntawm lub koom haum mob qog noj ntshav hauv tebchaws hauv Misrata-Libya. Int J Stem Cell Regen Med.https://doi.org/10.36266/IJSCRM/110
8. Rayan A, Ashraf AAM, Bakri HAM(2018)Multiple malignancies: metastatic renal with early cancers and endometrial cancers: a case report. J Cancer Ther 09:907-913.https://doi.org/10.4236/ict.2018.911075
9. Hassan MA, Fakhrudin N, Farhat F(2020) Synchronous invasive ductal carcinoma of the mis thiab clear cell renal carcinoma with rare presentation and behavior: a case report with a literature review.Ecancermedicalscience.https://doi.org/10.3332 /ECANC ER.2020.1120
10. American Cancer Society (2021)Cancer facts & figures 2021. American Cancer Society, Atlanta
11. Beisland C, Talleraas O, Bakke A, Norstein J (2006) Ntau yam kab mob hauv cov neeg moblub raum cell carcinoma: kev tshawb fawb pej xeem hauv teb chaws. BJU Int 97: 698-702. https://doi.org/10.1111/j.1464-410X.2006.06004.x
12. Demir H, YülekO, Oruc E, Gulle B, Demir D, Demirdag Cet al (2021) Secondary malignant hlav hauv cov neeg moblub raum cell carcinoma.Bull Urooncol 20:49-55.https://doi.org/10.4274/uob.galenos.2020.1785
13. Kev soj ntsuam, kab mob sib kis, thiab cov txiaj ntsig kawg (SEER) Txoj Haujlwm (1969) SEER * Stat database: tshwm sim—SEER 18 regs cov ntaub ntawv kev cai (nrog rau kev kho mob ntxiv), Kaum Ib Hlis 2016 Sub(1973-2014 txawv)—txuas mus rau lub nroog attributes—tag nrho USwww.seer.can-cer.gOV
14. Kev Tshawb Fawb Kev Tshawb Fawb, National Cancer Institute SEER*Stat software, version 8.3.4.www.seer.cancer.gov/seerstat 15.IBM Corp (2019)IBM SPSS cov txheeb cais rau windows, version 26.0. IBM Corp, Armonk
