Cov nyhuv Anti-tumor ntawm Phenylethanol Glycosides Los ntawm Cistanche Deserticola

Cov ntsiab lus

Cov qog nqaij hlav qog nqaij hlav ib txwm tau lees paub tias yog qhov teeb meem kev noj qab haus huv tseem ceeb rau tib neeg kev noj qab haus huv thoob ntiaj teb. Nrog rau kev nrawm ntawm cov txheej txheem kev laus hauv zej zog thiab kev cuam tshuam ntawm qee yam ntawm lwm yam, qhov tshwm sim ntawm ntau yam qog nqaij hlav tau pom muaj kev nce siab, thiab feem ntau cov qog tau nkag mus rau theem lig thaum lawv pom, nrog cov kab mob sai sai thiab kev pom tsis zoo. . Txawm hais tias cov kev kho mob tshiab rau kev kho mob qog noj ntshav tau tshwm sim nyob rau xyoo tas los no nrog cov txiaj ntsig kho mob tseem ceeb, tseem muaj kev cuam tshuam loj heev thiab qee cov neeg mob tsis zoo. Yog li ntawd, kev tshawb nrhiav thiab tsim cov tshuaj tshiab cov neeg sib tw sib xyaw nrog cov tshuaj tiv thaiv qog nqaij hlav muaj zog, tsis tshua muaj kev cuam tshuam, thiab tsis muaj zog, tshwj xeeb tshaj yog bioactive molecules tau los ntawm Suav tshuaj ntsuab, muaj qhov tseem ceeb hauv kev kho mob. Cistanche depraved phenylethanol glycosides (CPhGs) yog ib chav kawm ntawm cov khoom xyaw nquag muaj nyob rau hauv cov khoom siv tshuaj suav tshuaj Cistanche deserticola. Cov kev tshawb fawb tau pom tias lawv muaj ntau yam kev ua haujlwm lom neeg xws li tshuaj tiv thaiv qog, kev tiv thaiv kab mob, thiab kev ua haujlwm antioxidant, ua kom pom qhov zoo ntawm daim ntawv thov. Tsab ntawv xov xwm no qhia luv luv txog cov teebmeem tiv thaiv qog thiab cov txheej txheem ntawm phenylethanolamine glycosides los ntawm Cistanche deserticola, nrog rau kev nkag siab txog kev tshawb fawb tam sim no, txhawm rau muab cov ntaub ntawv siv rau kev tshawb fawb ntxiv thiab kev kho mob ntawm Cistanche deserticola thiab nws cov phenylethanolamine glycoside extracts.

Ntsiab lus

Cistanche deserticola; Cistanche deserticola phenylethanoid glycoside; qog nqaij hlav; Cell proliferation thiab apoptosis

Qhov tshwm sim ntawm cov qog nqaij hlav malignant tau nce thoob plaws ntiaj teb, thiab nws tseem ceeb dua los tshawb txog cov txheej txheem kho mob zoo thiab kev txhim kho tshuaj tshiab los ntawm ntau cov lus qhia thiab lub kaum ntse ntse. Cov me me molecule tebchaw muab tau los ntawm cov nroj tsuag, tshwj xeeb tshaj yog cov tshuaj suav tshuaj, muaj ib tug dav neeg sib tw puag thiab daim ntawv thov kev cia siab nyob rau hauv txoj kev loj hlob ntawm tshiab tshuaj tiv thaiv qog. Cistanche deserticola yog ib hom tshuaj suav tshuaj suav nrog keeb kwm ntev. Nws tau ib txwm siv los ua cov khoom noj tonifying nyob rau hauv cov tshuaj suav tshuaj suav tshuaj thiab hu ua "desert ginseng". Nws yog dav siv hauv kev kho mob, nrog rau cov txiaj ntsig zoo thiab kev nyab xeeb siab. Kev tshawb fawb tshuaj niaj hnub no tau pom tias ib qho ntawm cov khoom tseem ceeb ntawm Cistanche deserticola, Cistanche phenylethanoid glycosides (CPhGs), tuaj yeem txhim kho kev tiv thaiv kab mob thiab tiv thaiv qog los ntawm kev cuam tshuam ntau lub xov tooj ntawm tes hloov txoj hauv kev thiab tswj cov noob qhia. Nws hom ntawm kev ua yog lub sij hawm-nyob ntawm kev tua ntawm cov qog hlwb los yog inhibiting qog proliferation, ntxeem tau, thiab metastasis, uas muaj zoo daim ntawv thov kev cia siab. Tsab ntawv xov xwm no nthuav tawm cov teebmeem los tiv thaiv qog thiab cov txheej txheem ntawm CPhGs, txhawm rau muab cov ntaub ntawv siv rau kev siv Cistanche deserticola, tshuaj suav tshuaj, thiab nws cov extract ntawm CPhGs hauv kev kho mob qog.

Phenylethanol glycoside yog lub luag haujlwm tseem ceeb ntawm Cistanche deserticola

Nyem qhov no mus saib Cistanche cov khoom

【Ask for more】 Email: xue122522@foxmail.com / Whats App: 0086 18599088692 / Wechat: 18599088692

1 Txheej txheem cej luam ntawm CPhGs

Txij li thaum xyoo 1970, cov kws tshawb fawb hauv tsev thiab txawv teb chaws tau pib kawm txog cov tshuaj muaj pes tsawg leeg thiab kev ua haujlwm ntawm genus Cistanche. Txog tam sim no, ze li ntawm ib puas yam tshuaj lom neeg thiab kab mob tau raug cais tawm thiab txheeb xyuas los ntawm Cistanche deserticola. Ntawm lawv, phenylethanol glycosides muaj cov ntsiab lus siab tshaj plaws thiab yog ib qho tseem ceeb ntawm cov nroj tsuag Cistanche. Lawv kuj yog cov cim qhia txog kev txheeb xyuas thiab kev txiav txim siab cov ntsiab lus raws li kev cai hauv tebchaws ntawm "Cistanche deserticola". Tom qab unremitting in-debth kev tshawb fawb los ntawm Tu Pengfei pab neeg ntawm Peking University, ze li ntawm 40 hom phenylethanol glycosides tau raug cais tawm kom meej thiab txheeb xyuas txog niaj hnub no. Tsis tas li ntawd, phenylethanol tag nrho glycosides muab tau los ntawm Cistanche deserticola tau tsim, feem ntau yog tsim los ntawm echinaside thiab piloside.

Lub ntsiab chemical constituents ntawm Cistancnws tubulosa-Echinacoside

Main chemical constituents ntawm Cistanche tubulosa-Acteoside

Phenylethanol glycosides (PHGs) yog ib hom glycoside compound tsim los ntawm kev sib xyaw ntawm phenylethanol aglycones thiab pawg suab thaj. Feem ntau ntawm cov phenylethanoid glycosides hauv Cistanche deserticola muaj cov qauv qauv, thiab lawv cov suab thaj feem ntau yog cov piam thaj thiab rhamnose; Lub hauv paus qab zib txuas ncaj qha rau aglycone yog cov piam thaj; Tsuas yog aminoglycosides, tag nrho 3 txoj haujlwm ntawm cov piam thaj hauv nruab nrab yog txuas rau rhamnose; Cov piam thaj thib ob hauv triglycoside feem ntau txuas nrog 6 txoj haujlwm ntawm cov piam thaj hauv nruab nrab; Ntawm txoj haujlwm 4 lossis 6 ntawm cov piam thaj hauv nruab nrab, nws feem ntau tsim cov esters nrog phenylacryloyl pawg xws li caffeioyl, ferulic, lossis coumarinyl.

Ntau qhov kev tshawb fawb tau pom tias phenylethanol glycosides ntawm Cistanche deserticola ua rau cov qib cellular ntawm lub cev, feem ntau los ntawm kev tswj hwm cov txheej txheem ntawm tes. Tam sim no, ntau tus kws tshawb fawb feem ntau tswj cov ntsiab lus ntawm phenylethanol glycosides hauv Cistanche deserticola los ntawm UV spectrophotometric thiab ua haujlwm siab ua kua chromatography. Cov cim qhia tseem ceeb yog echinaside, anthocyanin A, piloside, thiab isopiloside. Lub ntsiab zoo ntawm Cistanche deserticola extract yog phenylethanoside, piloside, thiab echinaside.

2 CPhGs thiab Malignant qog

Superman cistanchetshuaj ntsuab-Antitumor

2.1 mob qog noj ntshav

2.2 mob ntsws cancer

2.3 Kab mob qog noj ntshav

2.4 mob cancer mis

2.5 Ovarian cancer

2.6 Prostate cancer

2.7 mob qog noj ntshav pancreatic

3 Outlook

Suab puam ginseng - Antitumor

Cov kev tshawb fawb saum toj no qhia tau hais tias CPhGs tuaj yeem ua tiav cov teebmeem xws li inhibiting proliferation thiab migration, inducing apoptosis, txhawb kev tiv thaiv kab mob, thiab inhibiting angiogenesis nyob rau hauv ntau hom qog hlwb los ntawm influencing ntau yam cell signaling pathways. Zuag qhia tag nrho, CPhGs, raws li cov khoom xyaw muaj txiaj ntsig zoo ntawm cov tshuaj suav tshuaj Cistanche deserticola, tau paub ntau ntxiv rau lawv cov tshuaj tiv thaiv qog noj ntshav, thiab lawv cov tshuaj tiv thaiv qog tau maj mam ua kom pom tseeb. Lawv cia siab tias yuav tsim los ua cov tshuaj tiv thaiv qog noj ntshav tshiab. Nws yog ib qho tsim nyog hais tias tseem muaj kev tshawb fawb txwv tsis pub dhau lub luag haujlwm ntawm CPhGs hauv lymphoma, thiab peb pab pawg cov kev tshawb fawb tshiab tau pom tias lawv tuaj yeem ua rau muaj apoptosis thiab pyroptosis hauv cov qog ntshav qog ntshav, thiab cuam tshuam rau ntau txoj hauv kev qhia (cov ntaub ntawv tsis tau tshaj tawm), qhia tias cov muaj peev xwm kho lub luag haujlwm ntawm CPhGs hauv ntau yam kab mob tsim nyog ntxiv rau kev tshawb fawb tob.