Kev Tshawb Fawb Txog Kev Tiv Thaiv Kab Mob Nephritis Hauv 2023Ⅵ
Jan 29, 2024
Acute interstitial nephritis (AIN) ·
(1) Urinary CXCL9 tuaj yeem siv los ua biomarker ntawm AIN
Thaum Lub Xya Hli 2023, ib tsab xov xwm luam tawm los ntawm J Clin Invest tau thov cov chemokine CXCL9 hauv cov zis (IFN- -induced chemokine koom nrog hauv lymphocyte chemotaxis) raws li kev kuaj mob biomarker rau AIN. Cov kws sau ntawv pom tias CXCL9 nyob rau hauv cov zis ntawm cov neeg mob uas mob tubulointerstitial nephritis tau nce 7.6 npaug piv nrog rau pawg tswj hwm, thiab mRNA qhia ntawm CXCL9 hauv lub raum cov ntaub so ntswg tau nce 3.9 npaug piv nrog pawg tswj hwm. AUC ntawm nephritis mus txog 0.94. Cov txiaj ntsig qhia tau hais tias CXCL9 hauv cov zis tuaj yeem siv los ua cov cim biomarker rhiab heev rau kev kuaj mob sai ntawm AIN.
Nyem rau Cistanche rau mob raum
(2) GWAS tshawb nrhiav pom AIN susceptibility noob
Nyob rau lub Tsib Hlis 2023, Phau Ntawv Xov Xwm ntawm American Society of Nephrology tau tshaj tawm lub ntiaj teb thawj GWAS txoj kev tshawb fawb txog mob tubulointerstitial nephropathy (ATIN). Txoj kev tshawb no tau ua ib txoj kev tshawb fawb genome-wide koom nrog kev tshawb fawb raws li 2 kev tshawb fawb pawg thiab 2 kev tshawb pom platforms. Meta-analysis tau ua rau 544 ATIN cov neeg mob thiab 2346 kev tswj hwm kev noj qab haus huv thiab pom ob qhov tseem ceeb gene loci ntawm qib genome-wide: HLA-DRB1 thiab PLEKHA5. Ib txoj haujlwm HLA amino acid (HLA-DRB1 60th AA) tuaj yeem piav qhia cov cim caj ces ntawm tag nrho HLA locus. Cov amino acid no nyob rau hauv peptide khi zawj ntawm HLA-DRB1 antigen nthuav qhia hnab tshos P10. Thaum tshem tawm los ntawm kev tiv thaiv tyrosine Thaum nws hloov mus rau hauv kev pheej hmoo-hom histidine, tus nqi zoo ntawm qhov chaw ntawm cov molecule yog txhim kho, ua kom yooj yim rau cov grooves, uas txhawb kev nthuav qhia antigen. Cov tshuaj HLA serotype DR14 (DRB1*14-DQA1*0101-DQB1*0503) yog hom kab mob txaus ntshai, thiab DRB15 serotype (DRB1*1501-DQA1*0102-DQB1 * 0602) yog hom kev tiv thaiv. Cov neeg mob nqa HLA kev pheej hmoo genotypes muaj kev puas tsuaj rau lub raum hnyav dua tab sis teb zoo dua rau kev kho tshuaj hormone / immunosuppressive, qhia tias cov noob caj noob ces tuaj yeem siv los tshuaj xyuas cov tib neeg uas muaj lub cev tiv thaiv kab mob thiab pab xaiv cov tshuaj tiv thaiv kab mob hnyav. Cov noob tshiab PLEKHA5 yog txuam nrog myeloid cell infiltration.
Txoj kev tshawb no kuj pom muaj plaub yam muaj feem cuam tshuam cov noob: RAB32, RFPL1, COL6A3, thiab SLC9A9. ATIN tshwm sim los ntawm qhov sib txawv ua rau txhua tus sib koom cov noob caj noob ces thiab cuam tshuam nrog biomarkers ntawm mob raum raug mob thiab qib creatinine. Txoj kev tshawb no tsis tsuas yog txheeb xyuas cov noob tshiab ua rau ATIN thiab nthuav tawm nws cov txheej txheem molecular, tab sis kuj tseem muab cov ntsiab lus tseem ceeb thiab lub hauv paus rau kab mob kev pheej hmoo stratification thiab kev cuam tshuam meej rau yav tom ntej.
Cistanche kho mob raum li cas?
Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrograumkab mob. Nws yog muab los ntawm qhuav stems ntawmCistanchedeserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Lub ntsiab active Cheebtsam ntawm cistanche yogphenylethanoidglycosides, echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rau lub raum kev noj qab haus huv.
Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tswv yim.
Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.
Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.
Tsis tas li ntawd, cistanche tau pom tias muaj cov nyhuv anti-inflammatory. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.
Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv kab mob raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.
Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.
Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.
Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.
