Cistanche ua lub luag haujlwm tiv thaiv neuroprotective li cas: tiv thaiv thiab kho Alzheimer's kab mob thiab Parkinson's?

Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com

1. Anti-Alzheimer's kab mob

AD stands rau senile dementia, thiab nws yog ib tug kab mob degenerative ntawm lub hauv paus paj hlwb nrog kev paub tsis meej thiab kev nco tsis zoo raws li cov kev kho mob tseem ceeb. Cov yam ntxwv ntawm pathological yog cov plaques senile tsim los ntawm kev tso tawm ntawm B-amyloid peptides sab nraum lub paj hlwb cortex thiab hippocampal neurons thiab qhov txawv txav ntawm tau protein nyob rau hauv lub hlwb neurons los tsim neurofibrillary tangles. Tsis tas li ntawd, qhov txo qis ntawm acetylcholinergic neurons nyob rau hauv lub hlwb cov ntaub so ntswg ntawm cov neeg mob AD ua rau txo qis ntawm cov neurotransmitter ACH.

Cistanche deserticola muaj ntau yam teebmeem, nyem qhov no kom paub ntau ntxiv

1.1 Cov nyhuv anti-AD ntawm Cistanche

Liu Fengxia thiab lwm tus tau npaj AD nas qauv los ntawm kev txhaj tshuaj quinolinic acid rau hauv lub hlwb ventricle. Txoj kev tshawb nrhiav pom tias tag nrho glycosides ntawmcistanchetuaj yeem nce qib kev kawm thiab kev nco ntawm AD nas, txo qhov nce hauv cov ntsiab lus ntawm malondialdehyde (MDA) hauv cov ntaub so ntswg hlwb tshwm sim los ntawm QA, thiab nce cov super Oxide dismutase (SOD), glutathione peroxidase (GSH.Px) kev ua, txo acetylcholinesterase. (ChE) kev ua haujlwm, hlwb hlwb apoptosis tus nqi thiab calcium tsub zuj zuj hauv lub hlwb. Tsis tas li ntawd, GCs tuaj yeem txhim kho qhov poob ntawm kev kawm thiab kev nco hauv AD nas qauv tshwm sim los ntawm AB thiab txhuas trichloride. Nws tuaj yeem txo cov ntsiab lus ntawm MDA hauv lub paj hlwb ntawm AD nas, nce cov haujlwm ntawm SOD16 thiab GSH-Px, thiab txo tus nqi ntawm apoptosis. Qhov kev qhia ntawm Bax tsis muaj zog thiab qhov kev qhia ntawm Bcl -2 yog txhim kho.

Wang Qing tau tshawb fawb txog kev siv tshuaj tiv thaiv AD ntawm GCs capsules thiab pom tias qhov ncauj GCs capsules muaj kev kho mob rau cov neeg mob AD, uas tuaj yeem txhim kho cov neeg mob kev txawj ntse, txhim kho cov neeg mob lub peev xwm saib xyuas tus kheej, thiab ncua kev kawm ntawm dementia. Nws cov nyhuv zoo ib yam li cov tshuaj kho AD. Cov ntsiav tshuaj Donepezil hydrochloride zoo ib yam, tab sis qhov tsis zoo tshwm sim ntawm GCs capsules yog qhov qis dua li cov ntsiav tshuaj ntawm cov tshuaj Donepezil hydrochloride. Tsis tas li ntawd, tus nqi ntawm GCs capsules yog nruab nrab, uas yog qis dua li cov ntsiav tshuaj donepezil hydrochloride thiab tau yooj yim txais los ntawm cov neeg mob. Wang Qing ntseeg tias nws yog tshuaj tiv thaiv AD tsim nyog txhawb nqa.

Echinacoside yog ib qho ntawm cov khoom sivCistanchephenethyl cawv glycosides. Cov kev tshawb fawb tau pom tias echinacoside tuaj yeem ua rau muaj cov ntsiab lus ntawm cov protein ntau thiab tag nrho cov antioxidant muaj peev xwm ntawm lub hlwb cov ntaub so ntswg ntawm AD qauv SAMP/8 nas, thiab txo cov kev ua ntawm ChE thiab cov ntsiab lus hauv cov ntshav. Txij li cov ntsiab lus ntawm interleukin -2.

Tsis tas li ntawd, cimicifuga glycoside (acteoside) nyob rau hauv phenylethanoid glycosides ntawmCistanche deserticolayog tawm tsam A. Qhov tshwm sim SH-SY5Y cytotoxicity muaj kev tiv thaiv kev tiv thaiv, txhim kho cell ciaj sia, txo cell apoptosis thiab tiam ntawm reactive oxygen hom, thiab inhibiting qhov txo ntawm mitochondrial membrane muaj peev xwm, tso tawm cytochrome C, thiab clearance ntawm caspase. -3.

1.2. Cov txheej txheem cuam tshuam ntawm Cistanche tawm tsam AD

Cistanchemuaj cov txiaj ntsig zoo los tiv thaiv AD, thiab nws cov txheej txheem cuam tshuam suav nrog kev txhim kho cov haujlwm ntawm cov dawb radical scavenging enzymes, txo lipid peroxidation, inhibiting cell apoptosis, inhibiting zus tau tej cov pa reactive oxygen hom, thiab tswj apoptotic teeb liab txoj kev. Tsis tas li ntawd, cov extract ntawm Cistanche tuaj yeem nce SH. Cov protein qhia theem ntawm nicotinic acetylcholine receptors thiab subunits hauv SYSY hlwb tiv thaiv kev puas hlwb los ntawm AIS.

2. Anti-Parkinson tus kab mob

PD yog cov kab mob neurodegenerative uas tshwm sim hauv cov neeg laus thiab cov laus. Nws lub ntsiab pathological feature yog qhov kev loj hlob degeneration thiab necrosis ntawm dopamine (DA) neurons nyob rau hauv lub substantia nigra ntawm lub midbrain, thiab muaj eosinophilic inclusion lub cev nyob rau hauv lub cytoplasm ntawm residual neurons nyob rau hauv lub Lewy lub cev. PD yog tus kab mob neurodegenerative thib ob loj tshaj plaws tom qab AD. Nws qhov tshwm sim yog 1 feem pua ​​​​rau 2 feem pua ​​​​ntawm cov neeg muaj hnub nyoog 65 xyoo thiab laus dua, thiab nws nce nrog hnub nyoog. Cov tsos mob tseem ceeb ntawm cov neeg mob PD yog kev tshee hnyo, cov leeg nqaij tawv, kev txav qeeb, gait cuam tshuam, thiab lub cev tsis muaj zog, thiab lwm yam, thiab lawv lub neej zoo tau cuam tshuam loj heev.

Kev tshawb fawb los ntawm Geng et al. paub tseeb tiasCistanche deserticolaExtract phenethyl cawv tag nrho glycosides tuaj yeem txhim kho 1. Methyl 4. Phenyl-1,2,3,6-tetrahydropyridine (1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine, MPTP) induced tus cwj pwm coj cwj pwm ntawm C57BL / 6 nas PD qauv, nce Cov ntsiab lus ntawm DA nyob rau hauv lub striatum thiab kev qhia ntawm tyrosine hydroxylase nyob rau hauv substantia nigra. Tsis tas li ntawd, Phenylethanol Glucoside tuaj yeem cuam tshuam qhov txo qis ntawm nas cerebellar granule cell viability thiab ua kom cov caspase{14}} thiab caspase-g tshwm sim los ntawm methyl 4-phenylpyridineion (MPP).

Cov kev tshawb fawb tau pom tias echinacoside tuaj yeem txhim kho tus cwj pwm tsis zoo ntawm PD nas los ntawm MPTP, nce DA thiab nws cov metabolites 3, 4-dihydroxyphenylacetic acid (3,4dihydroxyphenylacetic acid, DOPAC) thiab homovanillic acid (ho -Cov ntsiab lus ntawm movmficacid (HVA) nce qhov kev qhia ntawm TH hauv substantia nigra, thiab inhibits kev ua haujlwm ntawm casl~se-3 thiab caspase-8 hauv cerebellar granule hlwb. Zhao Xin li al. ntawm proteomics thiab pom tias echinacoside tuaj yeem txo qhov overexpression ntawm biliverdin reductase B, qhia tias nws yuav txo tau biliverdin reductase B tshwm sim los ntawm oxidative kev nyuaj siab los ntawm anti-oxidation. ntawm dopaminergic neurons, DA thiab dopamine transporters hauv substantia nigra ntawm PD nas tshwm sim los ntawm MPI'P, thiab nce glial cell-derived trophic factor (GDNF) thiab hlwb-derived neurotro phic factor (BDNF) mRNA thiab protein qhia theem txo qis · 888 · ChinPharm J, Lub Rau Hli 2011, Vo 1.46 No. 12 Apoptosis, txo qhov piv ntawm Bax/Bcl-2 mRNA thiab protein". Hauv cov nas PD tus qauv tshwm sim los ntawm hydroxydopamine (6-OHDA), echinacoside tuaj yeem ua rau cov kua dej ntxiv ntawm striatum. DA thiab DOPAC thiab cov ntsiab lus HVA siab.

Cistanche tubulosatseem tuaj yeem txhim kho kev coj tus cwj pwm ntawm MPTP-induced C57 nas, nce cov ntsiab lus ntawm DA hauv striatum, tus naj npawb ntawm dopaminergic neurons hauv substantia nigra, thiab synuclein protein nyob rau hauv substantia nigra qib. Kev tshawb fawb los ntawm Gao Yan et al. qhia tau hais tias cimicifugaoside tuaj yeem tiv thaiv kev puas tsuaj ntawm dopaminergic neuron SH-SY5Y hlwb tshwm sim los ntawm rotenone, txo qhov tso tawm ntawm cellular lactate dehydrogenase, inhibit qhov degradation ntawm PD-txog cov protein Parkin thiab. Dimer tsim ntawm synuclein protein.

Deng Min et al. kawm txog cov nyhuv ntawmcistanche extractverbascoside ntawm MPP-induced SH. Qhov cuam tshuam ntawm SY5Y cell puas. Cov kev sim qhia tau hais tias verbascoside tuaj yeem ua rau kom muaj sia nyob ntawm tes, txo qis ntawm cell apoptosis thiab qib ntawm cov kab mob hauv lub cev reactive oxygen, rov ua kom lub zog muaj zog ntawm mitochondrial membrane muaj peev xwm, inhibit qhov kev ua ntawm caspase-3, thiab nce qhov kev qhia ntawm Bcl-2.

Cistanche Anti-Parkinson tus kab mob

3. Txhim kho kev kawm thiab kev nco

Cov haujlwm ntawmCistanche extractGCs txhawm rau txhim kho kev nco tsis zoo tau raug kawm raws li kev kawm, suav nrog GCs ntawm ischemia-reperfusion raug mob vim kev nco tsis ua haujlwm hauv cov nas uas muaj vascular dementia, thiab hydrocortisone-induced kawm thiab nco tsis ua haujlwm hauv nas nrog raum-yang deficiency, Scopolamine-induced impairment ntawm kev kawm thiab nco nyob rau hauv nas, sodium nitrite-induced impairment ntawm kev kawm thiab nco nyob rau hauv nas, thiab ethanol-induced impairment ntawm kev kawm thiab nco nyob rau hauv nas. Nws tau pom tias GCs muaj kev txhim kho cov txiaj ntsig ntawm kev coj tus cwj pwm ntawm cov lus saum toj no-hais txog kev nco tsis zoo rau tsiaj cov qauv. Txo cov naj npawb ntawm cov kev ua yuam kev hauv qhov kev sim dej tshawb nrhiav, nce qhov feem pua ​​​​ntawm cov lus teb raug, txo lub sijhawm kom ncav cuag qhov kawg, thiab txuas ntxiv latency ntawm lub platform dhia sim [22-25].

4. Tiv thaiv cerebral ischemia thiab cerebral ischemia-reperfusion raug mob

Cerebral ischemia thiab reperfusion ua rau ntau tus neuronal degeneration thiab necrosis, ua rau lub hlwb puas tsuaj. Cov txheej txheem muaj xws li kev tso tawm ntau ntxiv ntawm excitatory amino acids, intracellular calcium overload, dawb radical ntau lawm, ib tug loj tso ntawm nitric oxide (NO), thiab tiv thaiv kab mob teb, thiab lwm yam. Meng Xinzhen li al. [27 tsim kom muaj tus qauv cerebral ischemia-reperfusion los ntawm ligating txoj cai carotid artery nyob rau hauv nas, thiab soj ntsuam cov nyhuv ntawm kev tiv thaiv.Cistancheglycosides ntawm cerebral ischemia-reperfusion raug mob hauv cov nas nco qab. Cov txiaj ntsig tau pom tias GCs tuaj yeem txo qis kev mob stroke, cerebral infarction feem pua, cov ntaub so ntswg hlwb MDA cov ntsiab lus, thiab nitric oxide synthase (NOS) kev ua haujlwm thaum lub sij hawm cerebral ischemia-reperfusion, thiab ua kom cov hlwb SOD ua haujlwm. Tom qab kho SD nas nrog GCs, Zhu Zucheng tau tsim cov qauv kev rov ua dua ntawm cerebral ischemia hauv cov nas thiab pom cov teebmeem ntawm GCs ntawm cov ntsiab lus ntawm aspartic acid, glutamic acid, -aminobutyric acid, thiab glycine nyob rau hauv lub hlwb cov ntaub so ntswg. Cov txiaj ntsig tau pom tias GCs tuaj yeem txo cov ntsiab lus ntawm aspartic acid nyob rau hauv lub hlwb cov ntaub so ntswg ntawm nas tom qab cerebral ischemia thiab reperfusion, qhia tias lub mechanism ntawm GCs tiv thaiv ischemic hlwb raug mob tej zaum yuav muaj feem xyuam rau qhov nce ntawm excitatory amino acid tom qab reperfusion tiv thaiv cerebral ischemia.

Tsis tas li ntawd, echinacoside kuj muaj kev tiv thaiv ntawm cerebral ischemia hauv nas. Nws tuaj yeem txo qhov apoptosis ntawm hippocampal paj hlwb tshwm sim los ntawm cerebral ischemia thiab monoamine neurotransmitter norepinephrine (norepinephrine) nyob rau hauv cov kua extracellular ntawm lub striatum. , NE), DA, 5-hydroxytryptamine (5-hydroxytryptamine, 5-HT), DOPAC, HVA, thiab 5-hydroxy indole acetic acid (HIAA) cov ntsiab lus.

5.lwm

Xuan Guodong et al. tau kawm txog kev tiv thaiv kev laus ntawmCistanche phenylethanoid glycosidesntawm D-galactose-induced aging model nas. Cov txiaj ntsig tau pom tias piv nrog rau pawg qauv, cov lej ntawm kev kawm thiab kev nco tsis raug hauv pawg phenethyl cawv glycoside raug txo, lub sijhawm kawm cov lus teb tau luv luv, thiab lub sijhawm nco latency tau ntev. Cov phenethyl cawv glycoside tuaj yeem ua rau muaj kev ua haujlwm SOD ntawm nas hlwb. Wang Xinyuan et al. pom tias nyob rau hauv D-galactose-kho nas pab pawg, cov neurons hauv thaj av hippocampal CA1 pom qhov txawv txav xws li shrinkage ntawm lub cev ntawm tes, txo protrusions, txo mitochondria hauv cytoplasm, thiab tsis tshua muaj nuclei tsis tu ncua, thaum GCs muaj kev cuam tshuam rau |D galactose laus qauv nas. Lub ultrastructure ntawm lub hippocampus pom ib koob tshuaj tiv thaiv nyhuv. Hauv cov koob tshuaj GCs siab, muaj cov kab mob neuronal ntau ntxiv, puag ncig nuclei, thiab cov chromatin tsis sib xws hauv thaj tsam hippocampal CA1 ntawm pawg nas, uas zoo ib yam li cov qauv morphological ntawm pawg tswj hwm ib txwm muaj.

Kev ua tau zoo ntawm qhov ncauj GCs hauv 37 cov neeg mob uas muaj vascular dementia tau txheeb xyuas, thiab nws tau pom tias GCs tuaj yeem txhim kho kev paub txog kev ua haujlwm ntawm cov neeg mob vascular dementia, txo qis dementia, thiab txhim kho kev tu tus kheej txhua hnub ntawm cov neeg mob.

6. Summary thiab Outlook

Cov tshuaj suav tshuajCistancheyog ib qho tshuaj suav tshuaj rau kev noj qab haus huv raum yang, tab sis kev tshawb fawb tshuaj niaj hnub no tau nthuav tawm ntau txoj haujlwm tshiab thiab kev ua ub no. Hauv neuropharmacology,Cistanchemuaj ntau yam kev ua haujlwm, thiab cov tshuaj muaj feem xyuam twb tau siv hauv tsev kho mob. Kuv ntseeg tias raws li kev tshawb fawb ntawmCistanche tubulosatxuas ntxiv, peb yuav tshawb pom nws cov haujlwm tshiab lossis cov txheej txheem los muab cov tswv yim tshiab rau kev txhim kho cov tshuaj ntsig txog Cistanche. Tshwj xeeb tshaj yog nrog lub advent ntawm lub neej laus, cov neeg laus thiab cov kab mob muaj feem xyuam yog nce, uas coj lub nra hnyav rau tib neeg. Lub luag hauj lwm tiv thaiv ntawmCistanchehauvneuropharmacologyyuav ua rau muaj kev cia siab rau kev daws cov kab mob kev laus.

REFERENCES

[1] Ch. P (2005) Vol I • (Suav Pharmacopoeia 2005 edition. One) [S]. Xyoo 2005: 90.

[2] WU XC, SHI Y. Kev tshawb fawb thiab kev kho mob ntawm HerbaCistanches[J]. Gansu J Tradit Chin Med (Gansu Traditional Chinese Medicine), 2007, 20(12): 49-51.

[3] ZHAO XJ, XIA HL, WANG SJ. The advance in pharmacological research of HerbaCistanches[J]. Tuam Tshoj Pharm, 2009, 18 (17): 77-79.

[4] CHENG SM, LIU JY, LENG DL, et al. Kev nce qib hauv kev tshawb fawb txog kab mob Alzheimer [J 1. Biol Teach (Biology Teaching), 2011, 36(1): 8-10.

[5] LIU FX, WANG XW, WANG XF, et al. Cov nyhuv ntawm glycosides ntawmCistanchentawm kev kawm thiab kev nco hauv Alzheimer * nas kab mob thiab nws cov txheej txheem [J]. J Xinjiang Med Unit (Journal of Xinjiang Medical University), 2005, 28 (12): 1131-1135.

[6] LIU FX, WANG XW, LUO L, et al. Cov teebmeem ntawm glycosides ntawmCistanchentawm kev kawm thiab kev nco hauv jB-amyloid peptide-induced Alzheimer kab mob hauv cov nas thiab nws txoj kev ua tau [J]. Chin Pharmacol Bull (中国药学Bulletin), 2006, 22(5): 595-599.

[7] LUO Lt WANGX W, LIU FX, et al. Kev tiv thaiv los ntawm glycosides ntawmCistanchentawm kev coj cwj pwm thiab kev nco tsis zoo nas vim yog txhuas trichloride [J]. Clin J New Drugs Clin Rem (Chinese Journal of New Drugs and Clinical Medicine), 2007, 26(1): 33-36.

[8] WANG Q. Kev tshawb fawb soj ntsuam ntawm Rou Cong Rong Zonggan Jiaonang hauv kev kho mob Alzheimer's [J]. Strait Pharm J (Strait Pharmacology), 2009, 21(3): 103-104.

[9] TIAN F, ZHANG K, KANG AJ, et al. Cov nyhuv thiab cov txheej txheem ntawm echinacoside ntawm SAM-P/8's kev kawm thiab kev nco muaj peev xwm [J]. Lab Animal Sci Administ (Experimental Animal Science thiab Management), 2006,

23(2): 14-16.

[10] WANG H, XU Y, YAN J, et al. Acteoside tiv thaiv tib neeg neuroblastoma SH-SY5Y hlwb tiv thaiv beta-amyloid-induced cell raug mob [J]. Brain Res, 2009, 1283: 139-147.

[11] QI XL, GU R, HAO XY, Chengal. Kev tiv thaiv los ntawm HerbCistanchetawm tsam neurotoxicity ntawm Amyloid peptide hauv SH-SY5Y hlwb [J]. Chin Hosp Pharm J (Chinese Hospital Pharmaceutical Journal), 2008, 28(6): 440442.

[12] CHOI JG, MOON M, JEONG HU, or al.CistanchesHerf) txhim kho kev kawm thiab kev nco los ntawm kev ua rau cov paj hlwb loj hlob [J]. Behav Brain Res, 2011, 216(2):652-658.

[13] GENG XC, SONG LW, PU XP, et al.NeuroprotectiveCov teebmeem ntawm phenylethanoid glycosides los ntawmCistanchessalsa tawm tsam 1-meth- yl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) -induced dopaminergic toxicity hauv C57mice [J]. Biol Phann Bull, 2004, 27 (6): 797- 801.

[14] TIAN XF, PU X P. Phenylethanoid glycosides los ntawmCistanchessalsa inhibit apoptosis induced los ntawm 1 -methyl-4-phenylpyridinium ion hauv neurons [J]. J Ethnopharmacol, 2005, 97(1): 59-63.

[15] GENG XC, TIAN XF, TU PF, et al.NeuroprotectiveCov teebmeem ntawm echinacoside hauv nas MPTP qauv ntawmParkinson tus kab mobmob [J]. Eur J Pharmacol, 2007, 564 (1-3): 66-74.

ZHAO X, PU XP, GENG X C. Cov teebmeem ntawm echinacoside ntawm cov protein qhia los ntawm substantia nigra thiab striatal cov ntaub so ntswg hauv nas MPTP qauv ntawm

[16]Parkinson tus kab mob los ntawm kev siv 2-dimensional electrophoresis tsom xam [J]. Chin Pharmacol Bull (Suav Pharmacology Bulletin), 2008, 24(1): 28-32.

[17] ZHAO Q, GAO J, LI W, et al. Neurotrophic thiab neurorescue teebmeem ntawm echinacoside nyob rau hauv subacute MPTP nas qauv ntawm Parkinson tus kab mob [J]. Brain Res, 2010, 1346: 224-236.

[18] CHEN H, JING FC, LI CL, et al. Echinacoside tiv thaiv cov qib striatal extracellular ntawm monoamine neurotransmitters los ntawm kev txo qis hauv 6-hydroxydopamine lesion nas [J]. J Ethnophar-mail, 2007, 114(3); 285- 289.

[19] ZHAO L, PU X P.NeuroprotectiveCov nyhuv ntawm acteoside tiv thaiv MPTP-vim nas qauv ntawmParkinson tus kab mobmob [J]. Chin Pharmacol Bull (Suav Pharmacological Bulletin), 2007, 23(1): 4246.

[20] Gao Y, PU X P.NeuroprotectiveCov nyhuv ntawm acteoside tawm tsam rotenone-vim kev puas tsuaj ntawm SH-SY5 Y hlwb thiab nws cov txheej txheem ua tau [J]. Chin Pharmacol Bull (Suav Pharmacological Bulletin), 2007, 23 (2): 161-165.

[21] DENG M, JU XD, FAN DS, et al. Verbascoside cawm SH-SY5Y neuronal hlwb los ntawm MPP ntxiv -induced apoptosis [J]. Chin Pharmacol Bull (Suav Pharmacological Bulletin), 2008, 24(10):1297 -1302.

[22] GAO C, WANG CS, WU GZ, et al. Cov teebmeem thiab kev tshawb fawb mechanism o£ glycosides ntawmCistanchentawm kev kawm thiab nco txog vascular dementia nas [J]. Chin Trade Herb Drugs (Suav tshuaj ntsuab), 2005, 36(12): 1852-1855.

[23] GAO C, WANG CS, WUGZ, et al. Cov teebmeem ntawm Cistanchis glycosides ntawm kev kawm thiab kev nco ntawm lub raum yang deficiency nas [J]. Chin J Basic Med Tradit Chin Med (Chinese Journal of Basic Medicine in Traditional Chinese Medicine), 2005, 11(5): 330-332.

[24] GAO C, WANG CS, WU GZ, e/ al. Cov teebmeem ntawm Cistanchis glycosides ntawm kev kawm thiab kev nco tsis zoo hauv nas [J]. Trail Chin Drug Res Clin Pharmacol (New Chinese Medicine and Clinical Pharmacology), 2005, 16 (3): 162-164.

[25 J WANG CS, Li YZ, SONG ZH, e/al. Cov teebmeem ntawm phenylethanoid glycosides rau nas nco rov ua haujlwm tsis zoo tshwm sim los ntawm ethanol [J J. China Set Technol Info, 2005, 17: 240- 241.

[26] YAN L. Kev tshawb fawb pathomechanism ntawm ischemia-reperfusion puas [J]. J Hubei Univ Nat (Med Ed) (Journal of Hubei University for Nationalities: Medical Edition), 2010, 27(4): 8-10.

[27] Meng XZ, WANG XW, JIANG XY, et al. Kev tiv thaiv los ntawm glycosides ntawmCistanchentawm cerebral ischemia-reperfusion raug mob hauv cov nas tsaug zog [J]. Chin J Clin Neurosci (Suav Clinical Neurosci), 2003, 11(3): 239-242.

[28] ZHU Z C. Cov teebmeem ntawm glycosides ntawm Cistanche ntawm excitatory amino acid cov ntsiab lus nyob rau hauv lub hlwb cov ntaub so ntswg ntawm nas nrog cerebral ischemia thiab reperfusion [J]. Anhui Med Pharrn J (Anhui Tshuaj), 2010, 14 (12): 1393-1394 .

[29] DU J, CHEN H, JIANG Y, et al. Kev tiv thaiv los ntawmechinacoside cov tshuajhauv cerebral ischemia nas [J]. Lishizhen Med Mater Medica Res (Lishizhen Traditional Suav Tshuaj thiab Materia Medica), 2010, 21(6): 1324- 1325.

[30] WEI LL, Chen H, JIANG Y, et al. Cov teebmeem ntawm echinacoside ntawm striatal extracellular theem ntawm monoamine neurotransmitter hauv cerebral ischemia nas [J]. Chin Pharmacol Bull

Report), 2011, 27(2): 174-177.

[31] XUAN GD, LIU C Q. Kev tshawb fawb txog cov nyhuv ntawm phenylethanoid glycosides (PEG) ntawm covCistanche deserticolantawm kev tiv thaiv kev laus hauv cov nas muaj hnub nyoog tshwm sim los ntawm D-galactose [J]. J Chin Med Maier, 2008, 31(9): 1385-1388.

[32] WANG XY, WANG XW, WANG XF, et al. Kev cuam tshuam ntawm glycosides ntawmcistanchenyob rau hauv lub ultrastructure ntawm lub hippocampus ntawm D-galactose induced hlwb laus qauv nas [J]. Chin J Behav MedSci (China Behavioral Medical Science), 2005, 14(11): 966-967.

[33]YANG P, LIU S Y. Cov nyhuv tsom xam ntawm glycosides ntawmcistanchentawm kev kho mob vascular dementia [J]. Chin J Pract Nervous Dis (Chinese Journal of Practical Nervous Diseases), 2010, 13(23): 68-69.