Lub raum-tiv thaiv lub luag haujlwm ntawm Lipoic Acid hauv raum Kab Mob Ⅱ
Sep 01, 2023
4. Lwm yam
1. Kev laus yog txuas raufunctional poob nyob rau hauv lub raum[132,133]. Nws tau raug tsim los hais tias muaj ntau yam kev hloov pauv hauv cov molecular, cov qauv, thiab morphological hauv lub raum [134,135]. Hauvlaus lub raum, muaj ntau theem ntawm oxidative kev nyuaj siab, raws li xav tau los ntawm kev nce lipid peroxidation, mitochondrial tsis ua haujlwm, thiab txo qis ntawm cov antioxidants, suav nrog superoxide dismutase, catalase, thiab glutathione peroxidase [136–139]. Tsis xav tsis thoob, ALA tuaj yeem txo tag nrho cov kev hloov pauv no hauv cov laus lub raum [136–138]. Tsis tas li ntawd, ALA muab raws li kev noj haus ntxiv tau pom tias muaj peev xwm thim rov qabhnub nyoog txog kev poob qis hauv lub raum ua haujlwmthiab tag nrho cov proteins [140]. Cov kev tshawb fawb no qhia txog kev tiv thaiv thiab kev tiv thaiv ntawm ALA ntawmlub raum laus.
Nyem qhov no kom tau txais CISTANCHE rau CKD kev kho mob
2. Pw tsaug zog apnea yog ib qho teeb meem uas ua rau muaj kev cuam tshuam ntawm hypoxia, uas tuaj yeem ua rau lub raum raug mob hypoxia ntxiv [141–144]. ALA tau pom tias muaj kev tiv thaiv lub raum raug mob los ntawm kev pw tsaug zog apnea hypoxia [145]. Hauv kev tshawb fawb siv tus qauv nas ntawm kev pw tsaug zog apnea, Abuyassin li al. tau ua pov thawj tias nyob rau hauv cov tsiaj uas underwent intermittent hypoxia thiab tau kho nrog ALA-hloov noj zaub mov, lub raum oxidative kev nyuaj siab thiab o ntawm lub raum yog qis dua cov uas raug rau intermittent hypoxia xwb. Ntxiv mus, lub raum cell tuag thiab tubular raug mob kuj tuag nyob rau hauv intermittent hypoxia + ALA pawg, thiab kev kho nrog ALA mitigated intermittent hypoxia-induced glomerular hypertrophy thiab txo albuminuria [145]. Yog li, ALA yog nephroprotective hauvhypoxia cuam tshuam rau lub raum raug mobinduced los ntawm pw tsaug zog apnea.
3. Kev ua haujlwm tsis zoo ntawm lub raumkuj yog ib qho kev mob tsis tu ncua thaum muaj ntshav siab, tseem hu ua hypertension. Nws tau xav tias lub raum puas cuam tshuam nrog kev kub siab yog tshwm sim los ntawm oxidative kev nyuaj siab [146–148]. Hauv qhov no, ALA kuj tau sim rau nws lub luag haujlwm antioxidant hauvhypertension-induced raum raug mob. Martinelli thiab al. [149] tau pom tias thaum spontaneous hypertensive nas nrog ntshav siab tau kho los ntawm kev sib xyaw ntawm ALA, lub raum oxidative puas tsuaj tau txo qis, nrog rau kev txhim kho tseem ceeb hauvlub raum ua haujlwmnrog rau ameliorated glomerular thiab tubular raug mob. Txoj kev tshawb no tseem qhia tau tias thaum exogenous ALA raug tswj hwm, kev sib xyaw ntawm ALA feem ntau siv [149].
4. Mob raum mob(CKD) tuaj yeem tsim tau los ntawm kev pub tsiaj nrog cov ntsiab lus siab ntawm adenine [150–152]. Qhov tseeb, adenine-induced CKD yog ib qho qauv nrov rau kev kawm txog cov kab mob pathophysiology ntawm cmob raum mobthiab kho cov teebmeem ntawm ntau yam khoom ntuj lossis tshuaj [153–155]. Txawm li cas los xij, lub luag haujlwm nephroprotective ntawm ALA tsis tau raug soj ntsuam zoo hauv cov qauv tsiaj no, uas yuav tsum tau tshawb xyuas yav tom ntej. Tsis tas li ntawd, kev tiv thaiv los ntawm ALA ntawm txhua tsib theem ntawmmob raum mob[156–158] kuj yuav tsum tau kawm hauv tus qauv tsiaj ntawm CKD.
5. IgA nephropathy (IgAN) paub tias ua rau glomerulonephritis vim qhov tso tawm ntawm IgA 1 [159–161] thiab yog ib qho kev nthuav dav.mob raum mob[162–164]. Nws lub ntsiab feature yog mesangial hlwb thiab mononuclear leukocyte infiltration nyob rau hauv lub raum interstitial ntaub so ntswg thiab lub glomerulus. Nws tau raug pom tias oxidative kev nyuaj siab-induced protein oxidation thiab lipid peroxidation yog ib co ntawm cov hauv paus pathogenic mechanisms [165-169]. Thaum cov qauv tsiaj ntawm IgAN muaj rau kev kawm txog cov kab mob ntawm IgAN thiab tshawb nrhiav cov kev kho mob [170,171], cov teebmeem ntawm ALA hauv qhov nomob raumtsis tau raug soj ntsuam. Txawm li cas los xij, nws ntseeg tau tias ALA yuav nthuav tawm cov teebmeem nephroprotective hauv IgAN, muab nws lub peev xwm antioxidant muaj zog.
6. Nws tseem tsim nyog sau cia tias cov kev tshawb fawb sib piv cov txiaj ntsig renoprotective ntawm ALA nrog rau lwm cov neeg sawv cev kuj tau ua nyob rau xyoo tas los no. Piv txwv li, ALA tau muab piv nrog cov tshuaj suav tshuaj Huangkui capsule hauv cov nas uas muaj ntshav qab zib nephropathy [172]. Cov kws sau ntawv pom tias ALA yog sib npaug rau Huangkui capsule hauv kev tiv thaiv kev tiv thaiv.mob ntshav qab zib raum raug mob, thiab ob qho tib si cov neeg ua haujlwm txhim kho lub raum ua haujlwm los ntawm kev txo qis oxidative kev nyuaj siab thiab txo qis kev ua haujlwm ntawm p38MAPK thiab Akt txoj hauv kev. ALA kuj tau muab piv nrog N-acetylcysteine (NAC) hauv ib txoj kev tshawb fawb, uas cov kws sau ntawv pom tias NAC zoo dua ALA hauv kev tiv thaiv oxidative raum raug mob vim yog cov tshuaj chemotherapeutic ifosfamide, uas yog tshuaj lom heev rau lub raum [173–176] . Txawm li cas los xij, cov kws sau ntawv siv NAC concentration (200 mg / kg) uas yog ob npaug ntawm ALA (100 mg / kg) [176]. Yog li ntawd, qhov kev txiav txim siab tias NAC yog ntau dua renoprotective tshaj ALA nyob rau hauv cov tsiaj qauv ntawm lub raum raug mob tej zaum yuav tsis meej. Nws tseem yuav tsum raug sau tseg tias daim ntawv tshaj tawm tsis ntev los no qhia tias ALA tseem tuaj yeem txo qis rau lub raum toxicity vim yog kub nanoparticles, uas feem ntau siv los ua cov neeg nqa tshuaj [177]. Qhov tseeb, poly (lipoic acid) nanoparticles lawv tus kheej kuj tuaj yeem siv los ua cov cuab yeej kho mob rau kev xa cov tshuaj nquag [178].
5. Cov ntsiab lus
Hauv tsab xov xwm no, peb tau tshuaj xyuas cov txheej txheem tiv thaiv ntawm ALA hauv ntau hom tsiaj ntawm lub raum raug mob. Cov qauv no suav nrog AKI thiab CKD, uas suav nrog DKD,ischemia-reperfusion-induced raum raug mob, sepsis-induced raum raug mob, thiab lub raum mob tshwm sim los ntawm UUO, cisplatin, cadmium, folic acid, thiab hlau. Cov txheej txheem hauv qab ntawm ALA's renoprotection tau sau tseg hauv daim duab 7.
Daim duab 7. Mechanisms hauv qab lipoic acid lub luag hauj lwm nyob rau hauv ntau yam tsiaj qauv ntawm lub raum raug mob yog tham nyob rau hauv cov ntawv nyeem. Lipoic acid alleviates raum raug mob thiab txhim kho lub raum ua haujlwm los ntawm kev siv ntau yam kev ua lom neeg, raws li tau piav qhia hauv daim duab no.
Raws li tau piav qhia ntxiv hauv Table 1, cov txheej txheem no suav nrog kev txo qis oxidative kev nyuaj siab, nce endogenous antioxidant tiv thaiv muaj peev xwm, tiv thaiv kab mob los ntawm inhibiting NF-kB thiab tso tawm cov kab mob cytokines, txo lub raum fibrosis, thiab txo cov cell tuag, xws li apoptosis, necrosis, thiab ferroptosis. . Qhov kawg tshwm sim ntawm ALA kev kho mob, tsis hais txog ntawm lub raum raug mob qauv thiab cov txheej txheem tiv thaiv tsis tau hloov, yog kev txhim kho lub raum ua haujlwm. Yog li ntawd, ALA yog tus neeg sawv cev pheej hmoo rau lub raum mob.
Table 1. Mechanisms ntawm ALA lub raum tiv thaiv nyob rau hauv ntau yam tsiaj qauv ntawm lub raum raug mob yog tham nyob rau hauv no tsab xov xwm.
6. Kev xav yav tom ntej
Feem ntau cov kev tshawb fawb tau sib tham hauv tsab xov xwm tshuaj xyuas no tau siv kev tswj hwm ntawm ALA hauv lawv cov kev tshawb fawb txog kev tiv thaiv ntawm ALA ntawm cov qauv tsiaj ntawm lub raum raug mob. Kev tswj hwm ntawm ALA yuav ua rau muaj kev faib tawm ntawm ALA rau cov kabmob lossis cov ntaub so ntswg uas yuav tsis xav tau ALA, uas dhau ALA tuaj yeem ua rau muaj teebmeem tshwm sim [59]. Yog li ntawd, cov kev tshawb fawb yav tom ntej yuav tsum tau tsom mus rau kev tsim txoj hauv kev uas ALA tsuas yog xa mus rau ob lub raum. Xws li cov kev tshawb fawb ntawm lub hom phiaj xa tawm ntawm ALA mus rau lub raum yuav muaj kev nkag siab ntau ntxiv rau cov txheej txheem tiv thaiv ntawm ALA hauv cov qauv kev raug mob raum sib txawv, qhia ob qho tib si redox- thiab lub zog-modulatory zog ntawm ALA. Hauv qhov no, nanoparticle xa lossis nanomedicines ntawm ALA tsom rau lub raum tuaj yeem yog txoj hauv kev pheej hmoo [179–184]. Tsis tas li ntawd, kev sib xyaw ua ke ntawm ALA nrog rau lwm cov khoom ntuj hauv kev kho mob raum raug mob thiab tiv thaiv kev hloov pauv ntawm AKI mus rau CKD yuav txaus siab los tshawb xyuas. Tsis tas li ntawd, kev tshawb fawb txog kev kho mob thiab tib neeg yog xav tau los ntsuas qhov ua tau zoo ntawm ALA hauv kev teeb tsa ntawm AKI thiab CKD, nrog rau kev hloov pauv ntawm AKI rau CKD.
Sau Kev Koom Tes: Kev Tsim Nyog, SFK thiab L.-JY; thawj daim ntawv npaj, SFK; tshuaj xyuas thiab kho, JL thiab L.-JY Txhua tus kws sau ntawv tau nyeem thiab pom zoo rau cov ntawv luam tawm ntawm cov ntawv sau.
Cov Nyiaj Txiag: Jiankang Liu tau txais kev txhawb nqa los ntawm National Natural Science Foundation ntawm Tuam Tshoj Integrated Project ntawm Cov Kev Tshawb Fawb Loj 92249303 thiab Cov Haujlwm Loj 32171102 thiab 31770917.
Institutional Review Board Statement: Tsis siv tau.
Cov Lus Qhia Txog Kev Pom Zoo: Tsis siv tau.
Cov Lus Qhia Muaj Cov Ntaub Ntawv: Tsis siv tau.
Kev tsis sib haum xeeb ntawm kev txaus siab: Cov neeg sau ntawv tshaj tawm tsis muaj teeb meem ntawm kev txaus siab.
Cov ntaub ntawv
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