Kev Sib Raug Zoo Ntawm Kev Haus Dej Haus Rau Raum Kev Ua Haujlwm Thiab Kev Ua Haujlwm Saib Xyuas Kev Tuag, Pej Xeem Raws Li, Kev Kawm Cohort

3. Cov txiaj ntsig

3.1. Kev piav qhia Statistics

Daim duab 1 qhia tus naj npawb ntawm cov neeg koom nrog hnub nyoog Ntau dua lossis sib npaug li 18 xyoo thiab ua tiav cov ntaub ntawv ntawm Kev Xeem -1, cov neeg kuaj mob ploj mus tom qab Kev Xeem -1, cov neeg kuaj mob uas tuag ua ntej kev xeem {{5 } }, cov neeg soj ntsuam koom nrog hauv Kev Xeem -2, cov neeg kuaj xyuas poob rau kev soj ntsuam tom qab Kev Xeem -2, cov neeg kuaj xyuas uas tau tuag ua ntej kev xeem -3, thiab cov neeg soj ntsuam koom nrog kev xeem -3. Cov lus teb kho neeg tuag yog 75.7% ntawm Kev Xeem-2 thiab 82.5% ntawm Kev Xeem-3. Ntawm 2075 tus neeg koom hauv txhua qhov kev xeem, 6 tau raug tshem tawm vim tsis muaj cov ntaub ntawv ntawm Kev Xeem -2 thiab / lossis Kev Xeem -3. 2069 cov neeg soj ntsuam nrog cov ntaub ntawv tiav ntawm txhua qhov kev xeem tau tsim los ntawm pawg neeg tshawb fawb rau kev soj ntsuam ntawm cov cim ntsuas ntawm kev haus cawv thiabeGFR, thaum 4524 cov neeg soj ntsuam nrog hnub nyoog Ntau dua lossis sib npaug li 18 xyoo thiab ua tiav cov ntaub ntawv ntawm Kev Xeem-1 tau tsim los ntawm pawg tshawb fawb rau kev tshuaj xyuas ntawm kev tuag

Daim duab 1. Cov neeg soj ntsuam koom nrog hauv txhua qhov kev xeem, cov neeg kuaj xyuas ploj mus tom qab, thiab cov neeg kuaj mob tuag. Table 1 qhia piav qhia txog kev sib deev, hnub nyoog, haus cawv,eGFR, thiab covariates hauv 2069 cov neeg soj ntsuam nrog cov ntaub ntawv tiav ntawm peb qhov kev xeem. Urinary albumin/creatinine ratio tsuas yog ntsuas ntawm Exam-2 hauv cov neeg kuaj mob hnub nyoog 45–64 xyoo (mg/g: nruab nrab=6.0, IQR=3.4/11.8). Hnub nyoog thiabeGFR datatsis skewed (skewness < 0.6). Kev haus dej cawv tau zoo skewed ntawm txhua qhov kev kuaj mob (Daim duab 2). Kev haus cawv nruab nrab yog qhov zoo sib xws hauv peb qhov kev xeem, thaum qhov IQR ntau dua ntawm Kev Xeem -2 (Table 1).

NEW HERBS RAU GFR REDUCE

Table 1. Cov txheeb cais piav qhia hauv cov neeg soj ntsuam nrog cov ntaub ntawv ua tiav ntawm Kev Xeem -1, Kev Xeem -2, thiab Kev Xeem-3: qhov sib txawv rau qhov sib txawv, txhais tau tias ± SD rau qhov tsis sib xws, thiab qhov nruab nrab ( IQR) rau skewed variables.

Daim duab 2. Skewness thiab zaus faib cov cawv kom tsawg (g/d=g/hnub) ntawm Exam-1 (black bars), Exam-2 (grey bars), thiab Exam{{ 4}} (dawb bars) hauv 2069 cov neeg kuaj xyuas nrog cov ntaub ntawv tiav ntawm txhua qhov kev xeem.

Pearson correlation coefficient ntawm kev haus cawv yog {{0}}.686 ntawm Kev Xeem-1 thiab Kev Xeem-2 thiab yog 0.664 ntawm Kev Xeem-2 thiab Kev Xeem-3 . Hauv cov neeg haus cawv, kev haus cawv hauv daim ntawv cawv suav txog 97.1% ntawm kev haus cawv tag nrho ntawm Kev Xeem-1, rau 98.8% ntawm Kev Xeem-2, thiab rau 94.7% ntawm Kev Xeem{{17} }}. Ntawm txhua qhov kev kuaj mob, muaj cov kev sib raug zoo ntawm kev qhia txog kev haus cawv thiab erythrocytic txhais tau tias corpuscu lar ntim (Daim duab 3). Ib qho piv txwv zoo sib xws tau pom nrog gamma-glutamyl transferase ntawm Kev Xeem -2 (Daim duab 4).

Daim duab 3. Qhov nruab nrab thiab 95% CI ntawm erythrocytic txhais tau tias lub cev ntim los ntawm stratum ntawm cawv kom tsawg (g/d=g/hnub) ntawm Exam-1, Exam-2, thiab Exam{{ 5}} ib. Tus naj npawb ntawm cov neeg kuaj xyuas ib lub stratum tau tshaj tawm hauv Table 1. p-values ​​yog los ntawm ANOVA tsis kho.

Daim duab 4. Qhov nruab nrab thiab 95% CI ntawm serum gamma-glutamyl transpeptidase los ntawm stratum ntawm kev haus cawv (g/d=g/hnub) ntawm Kev Xeem-2. Tus naj npawb ntawm cov neeg kuaj xyuas ib lub stratum tau tshaj tawm hauv Table 1. p-value yog los ntawm ANOVA tsis kho.

Ntawm txhua qhov kev kuaj mob, txiv neej pw ua ke, hnub nyoog, tso zis creatinine, lub cev qhov hnyav, thiab systolic siab sib raug zoo nrog kev haus cawv (Sab Ntxiv Table S2). Kev haus dej cawv tau cuam tshuam zoo nrog systolic siab tab sis tsis yog nrog kev kho tshuaj tiv thaiv hypertensive ntawm txhua qhov kev kuaj mob (Table S3). Kev piav qhia cov txheeb cais nyob rau hauv Ntxiv Table S4 qhia cov ntaub ntawv ntawm Exam-1 nyob rau hauv cov neeg soj ntsuam koom nyob rau hauv tag nrho cov kev xeem thiab cov neeg soj ntsuam nrog uas ploj lawm Exam-2 los yog Exam-3 vim hais tias ntawm kev tuag thaum lub sij hawm rov qab los yog poob mus tom qab- nce. Hais txog kev haus cawv, qhov sib txawv ntawm pab pawg neeg kuaj nrog txhua qhov kev kuaj mob thiab pab pawg neeg kuaj mob uas tsis tau kuaj pom muaj tsawg dua lossis sib npaug li 2.0% thiab tsis sib haum: cov neeg kuaj xyuas nrog txhua qhov kev xeem muaj 2.{{11 }}% ​​ntau dua ntawm kev tsis haus cawv (29.0% thiab 27.0%), 2.0% qis dua ntawm kev haus cawv 1–24 g / hnub (43.5 % thiab 45.5%), 1.9% qis dua ntawm kev haus cawv ntawm 25-48 g / hnub (11.1% thiab 13.0%), tab sis 1.9% ntau dua ntawm kev haus cawv> 48 g / hnub (16.4% thiab 14.5%). Cov kev hloov pauv ntawm eGFR txhua xyoo thiab eGFR nqes hav yog qhov tsis zoo. Txhua xyooeGFRhloov ntawm Exam-2 mus rau Exam-3 yog 1.67-lub sij hawm ntau dua nyob rau hauv kev sib piv rau txhua xyoo eGFR hloov ntawm Exam-1 mus rau Exam-2 (Table 2).

Table 2. Cov ntaub ntawv piav qhia hauv 2069 cov neeg soj ntsuam nrog cov ntaub ntawv ua tiav ntawm txhua qhov kev xeem rau kev ua raws sijhawm thiab cov ntaub ntawv eGFR (txhais tau tias ± SD).

3.2. Kev Ntsuam Xyuas Hla Ntu ntawm eGFR

Ntawm txhua qhov kev kuaj mob, eGFR txawv ntawm strata ntawm kev haus cawv (Daim duab 5, ANOVA yam tsis muaj kev hloov kho thiab nrog kev hloov kho rau covariates). Ib txoj hauv kev zoo ntawm eGFR nrog rau cov cawv cawv yog qhov tseem ceeb hauv ntau qhov kev hloov pauv ntawm txhua qhov kev xeem (Kev Xeem-1: B= 1.70, 95%CI=1.00/2.40 ,ua p< 0.001; Exam-2: B = 1.03, 95%CI = 0.59/1.48, p < 0.001; Exam-3: B= 0.55, 95%CI = 0.13/0.98, p = 0.010). At Exam-2, the trend was identical also when controlling for log-transformed urinary/albumin ratio in the subgroup with measured urinary albumin (n = 956, age = 45–64 years, B = 1.02, 95%CI = 0.38/1.66, p= 0.002). Compared to no intake, alcohol intake in the range 25–48 g/day was found to be related to higher eGFR both at Exam-1 and at Exam-2, while alcohol intake > 48 g/day related to higher eGFR at all exams (Table 3). Findings were similar when the multivariable model for Exam-1 was analyzed in the examinees who did not participate in follow-up exams (Supplementary Table S5). Covariates independently associated with eGFR at all exams were sex, age, tso zis creatinine, body mass index, thiabcov roj (cholesterol) tag nrho(Cov lus ntxiv S6).

Daim duab 5. Kev txheeb xyuas hla ntu: txhais tau tias thiab 95% CI ntawm eGFR los ntawm stratum ntawm kev haus cawv (g/d=g/hnub) ntawm Kev Xeem-1, Kev Xeem -2, thiab Kev Xeem -3 hauv ANOVA tsis kho (kab dub) thiab ANOVA kho rau covariates (kab grey). Tus naj npawb ntawm cov neeg soj ntsuam ib stratum yog nyob rau hauv Table 1. p-values ​​yog los ntawm ANOVA. Covariates hauv kev hloov kho ANOVA rau Kev Xeem{10}} cov ntaub ntawv: poj niam txiv neej thiab cov ntaub ntawv ntawm Kev Xeem-1 rau hnub nyoog, kev kawm, log-transformed urinary sodium/creatinine ratio, log-transformed urinary potasium/creatinine ratio, urinary creatinine, lub cev Kev ntsuas huab hwm coj, systolic siab, diastolic siab, kev kho tshuaj tiv thaiv kab mob siab, cov roj cholesterol tag nrho, haus luam yeeb, thiab ntshav qab zib. Covariates hauv kev hloov kho ANOVA rau Kev Xeem{15}} cov ntaub ntawv: poj niam txiv neej thiab cov ntaub ntawv ntawm Kev Xeem-2 rau hnub nyoog, kev kawm, log-transformed urinary sodium/creatinine ratio, log-transformed urinary potassium/creatinine ratio, log-transformed uri Nary urea nitrogen / creatinine piv, urinary creatinine, lub cev hnyav Performance index, systolic siab, diastolic siab, tshuaj tiv thaiv kab mob ntshav siab, ntshav siab tag nrho, haus luam yeeb, thiabntshav qab zib.Covariatesnyob rau hauv kho ANOVA rau Exam-3 cov ntaub ntawv: poj niam txiv neej thiab cov ntaub ntawv ntawm Exam-3 rau hnub nyoog, kev kawm, urinary creatinine, lub cev loj Performance index, systolic siab, diastolic siab, antihypertensive tshuaj kho,cov roj (cholesterol) tag nrho, haus luam yeeb, thiab ntshav qab zib.

Table 3. Kev txheeb xyuas hla ntu: ntau qhov sib txawv ntawm cov kab rov ua dua tshiab rau cov ntaub ntawv ntawm Kev Xeem -1, Kev Xeem -2, thiab Kev Xeem -3 nrog eGFR regressed tshaj stratum ntawm kev haus cawv.

Regression coefficient (B), 95% kev ntseeg siab lub sijhawm (italic), thiab p-tus nqi. Covariates suav nrog hauv Qauv 1: poj niam txiv neej thiab cov ntaub ntawv ntawm Kev Xeem -1 rau hnub nyoog, kev kawm, kev hloov pauv zis sodium / creatinine piv, log-transformed urinary poov tshuaj / creatinine piv, tso zis creatinine, lub cev huab hwm coj Performance index, systolic siab, diastolic siab, kev kho tshuaj tiv thaiv kab mob siab, cov ntshav tag nrho cov cholesterol, haus luam yeeb, thiab ntshav qab zib. Covariates suav nrog hauv Qauv 2: poj niam txiv neej thiab cov ntaub ntawv ntawm Kev Xeem-2 rau hnub nyoog, kev kawm, kev hloov pauv zis sodium / creatinine piv, log-transformed urinary poov tshuaj / creatinine piv, log-transformed urinary urea nitrogen / creatinine piv, tso zis creatinine, lub cev qhov hnyav, qhov siab systolic, siab diastolic, kev kho tshuaj tiv thaiv kab mob siab, cov roj cholesterol tag nrho, haus luam yeeb, thiab ntshav qab zib. Covariates suav nrog hauv Qauv 3: poj niam los txiv neej thiab cov ntaub ntawv ntawm Kev Xeem -3 rau hnub nyoog, kev kawm, urinary creatinine, lub cev qhov hnyav, qhov siab systolic, siab diastolic, kev kho tshuaj tiv thaiv kab mob siab, cov roj cholesterol tag nrho, haus luam yeeb, thiab ntshav qab zib. Tus naj npawb ntawm cov neeg soj ntsuam ib stratum ntawm kev haus cawv yog tib yam li qhia hauv Table 1.

3.3. Longitudinal Analyzes ntawm eGFR

Kev hloov pauv eGFR ib xyoos ib zaug sib txawv ntawm cov strata ntawm kev haus cawv nyob rau hauv kev soj ntsuam los ntawm Kev Xeem -1 mus rau Kev Xeem -2 thiab hauv kev rov qab los ntawm Kev Xeem -2 mus rau Kev Xeem -3 hauv ANOVA tsis muaj kev hloov kho thiab nrog kev hloov kho rau covariates (Daim duab 6, sab sauv thiab nruab nrab panels). Ib txoj hauv kev zoo ntawm eGFR hloov pauv raws li dej cawv strata yog qhov tseem ceeb hauv ntau qhov sib txawv ntawm kev rov qab los ntawm Kev Xeem -1 mus rau Kev Xeem -2 (B {{10}}}.133, 95%CI=0. }} (B=0.065, 95%CI=0.024/0.111, p=0.004). Qhov sib txawv rau kev soj ntsuam los ntawm Kev Xeem -2 mus rau Kev Xeem -3 yog qhov zoo sib xws thaum tseem con trolling rau log-transformed urinary/albumin ratio nyob rau hauv pab pawg neeg nrog ntsuas urinary albumin (n=956, hnub nyoog=45–64 xyoo, B=0.063, 95%CI=0.013/0.132, p=0.035).