Kev nce qib hauv Kev Kawm Ntawm Oxidative Stress Thiab raum - Tonifying Suav Tshuaj ntsuab hauv Parkinson's Disease
Mar 13, 2023
XU Yihui 1, Huang Lufen2, CAI Jing 1
(1. Academy of Integrative Medicine, Fujian University of Traditional suav tshuaj, Fuzhou 350122, Fujian, Suav teb;
2. College of Integrative Medicine, Fujian University of Traditional suav tshuaj, Fuzhou 350122, Fujian, Suav teb)
Abstract: Parkinson’s disease (PD) yog ib qho kev txav tsis zoo thiab feem ntau tshwm sim hauv cov neeg laus, thiab cov kev hloov pauv tseem ceeb ntawm cov kab mob hauv lub substantia nigra. Cov kev tshawb fawb tau qhia tias degeneration thiab poob ntawm dopaminergic neurons ntawm substantia nigra yog txuam nrog ntau yam, xws li oxidative kev nyuaj siab, cell apoptosis. Nyob rau hauv xyoo tas los no, lub raum - tonifying Suav tshuaj ntsuab tau ua qee yam kev vam meej hauv kev kho mob ntawm tus kab mob Parkinson. Hauv qhov kev tshuaj xyuas no, lub luag haujlwm ntawm oxidative kev nyuaj siab thiab lub raum - tonifying Suav tshuaj ntsuab hauv PD yog sau luv luv.
Cov lus tseem ceeb: oxidative kev nyuaj siab; Parkinson tus kab mob; raum - tonifying; Suav tshuaj ntsuab
Cistanche hmoov cov txiaj ntsig kev noj qab haus huv
Parkinson's disease (PD), tseem hu ua "primary tremor paralysis", yog Parkinson's disease. Tus kab mob no yog ib tug kab mob degenerative ntawm lub paj hlwb uas tshwm sim nyob rau hauv cov neeg laus. Cov tsos mob ntawm tus kab mob Parkinson yog static tremors, nqaij rigidity, lub cev muaj zog retardation, txawv txav posture thiab gait, thiab lwm yam tsos mob. Cov kab mob tseem ceeb yog nyob rau hauv substantia nigra thiab striatum [1-2]. Nws cov yam ntxwv tseem ceeb ntawm cov kab mob yog qhov poob ntawm dopaminergic neurons nyob rau hauv substantia nigra ntawm midbrain thiab tsim ntawm intracellular inclusion lub cev hu ua Lewy lub cev [3]. Txog tam sim no, qhov ua rau degeneration thiab necrosis ntawm substantia nigra hlwb tsis paub.
1. Oxidative stress thiab Parkinson's disease
Lub etiology thiab pathogenesis ntawm Parkinson tus kab mob tseem tsis tau paub meej. Qee tus neeg ntseeg tias qhov kev poob ntawm dopaminergic neurons nyob rau hauv substantia nigra muaj feem xyuam rau oxidative kev nyuaj siab, excitotoxicity, mitochondrial tsis ua hauj lwm, thiab lwm yam mechanisms. Cov kev tshawb fawb tau pom tias qhov kev txhim kho oxidative kev ntxhov siab yog ib qho ntawm cov ntsiab lus tseem ceeb ua rau apoptosis ntawm dopaminergic neurons, thiab ntau cov pa oxygen dawb radicals (ROS) ua rau oxidative puas tsuaj [4]. Txoj kev tshawb nrhiav pom tias cov txheej txheem molecular ntawm kev puas tsuaj neuronal muaj xws li: ① calcium overload, ntau ntawm calcium influx; ② Kev tso tawm loj ntawm excitatory amino acids; ③ Cov nyhuv ncaj qha ntawm cov dawb radicals ntawm cov paj hlwb. Peb yam no cuam tshuam nrog ib leeg. Kev raug mob ntawm paj hlwb ua rau apoptosis, uas muaj feem xyuam rau oxidative kev nyuaj siab. Cov dawb radicals ntau dhau hauv cov hlwb ua rau apoptosis los ntawm kev hloov pauv hauv lub cev [5].
Oxygen dawb radicals uas tsim los ntawm tib neeg cov metabolism tuaj yeem raug tshem tawm los ntawm lub cev enzyme, yog li txo qis oxidative puas tsuaj. Cov kab ke enzyme feem ntau suav nrog cov enzymes antioxidant xws li superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx{0}}), thiab antioxidant non-enzyme me me glutathione (GSH). Hauv cov neeg mob PD, kev ua haujlwm ntawm cov tshuaj tiv thaiv oxidation thiab dawb radical scavenging system nyob rau hauv lub hlwb yog tsawg, cov ntsiab lus ntawm CAT, GSH-PX, thiab SOD nyob rau hauv lub substantia nigra yog txo mus rau txawv degrees, zus tau tej cov dawb radicals yog nce, thiab kev puas tsuaj ntawm neurons yog aggravated [6].
H2O2 yog ib feem ntawm cov dawb radicals, uas yooj yim tso tawm oxygen ions los tsim cov dawb radicals. Nws yog siv los tsim ib qho qauv hauv vitro raug mob ntawm lub hom phiaj hlwb, thiab cov qauv hauv vitro yog siv los soj ntsuam cov nyhuv inhibition ntawm cov tshuaj ntawm cov dawb radicals. Cov tshuaj sim tuaj yeem muab ntxiv rau hauv peb daim ntawv hauv qab no: ① Tom qab cov phiaj hlwb raug kho nrog cov tshuaj sim, ntxiv cov tshuaj H2O2 kab lis kev cai; ② Cov tshuaj sim thiab cov tshuaj kab lis kev cai uas muaj qhov sib txawv ntawm H2O2 tau ntxiv rau tib lub sijhawm; ③ Cov tshuaj kab lis kev cai uas muaj qhov sib txawv ntawm H2O2 yog kho ua ntej ntxiv cov tshuaj sim. Thawj txoj kev yog los saib xyuas cov kev tiv thaiv ntawm cov tshuaj ntawm kev puas tsuaj dawb radical, thiab ob txoj hauv kev yog los saib xyuas kev kho thiab kho cov nyhuv ntawm kev sim tshuaj ntawm kev puas tsuaj dawb radical [5]. Kev txiav txim siab ntawm qhov tsis muaj concentration thaum H2O2 ua rau cov paj hlwb raug mob. Ntau lub paj hlwb muab tau los ntawm cov ntaub so ntswg sib txawv thiab ntau tiam neeg muaj qhov sib txawv rau H2O2. Yog li ntawd, qhov concentration ntawm txhua lub paj hlwb siv hauv kev sim ua qauv sib txawv. Txoj kev MTT yog siv los txiav txim siab qhov ntsuas qhov ntsuas ntawm H2O2 qauv. Ntsuas tus nqi ntawm OD490 nrog tus cim enzyme thiab saib xyuas cov haujlwm ntawm cov hlwb. Thaum tus nqi ntawm OD490 nyob rau hauv 50 feem pua, nws yog qhov concentration parameter ntawm H2O2 qauv [5].
Zhang Fang et al. [7] siv hydrogen peroxide (H2O2) ua qhov raug mob los xyuas qhov kev tiv thaiv ntawm 2,3-indolequinone (ISA) ntawm dopaminergic hlwb thiab nws cov txheej txheem. Cov txiaj ntsig tau pom tias ISA tuaj yeem txo qhov DA-zog MES23.5 cell raug mob los ntawm H2O2, thiab nws cov txheej txheem cuam tshuam txog kev txo qis [Ca2 ntxiv] qib.
Xu Shengli et al. [8] tau kawm tias oxidative stress-induced nuclear translocation ntawm C-terminal ntu ntawm a-synaptophysin hauv dopaminergic MES23.5 hlwb thiab kho dopaminergic neurons nrog 200umol / LH2O2 raws li cov qauv ntawm tes ntawm oxidative kev nyuaj siab. Immunofluorescence, sulfur S histochemical staining, thiab immunoblotting tau siv los txheeb xyuas cov xwm txheej qhia thiab subcellular localization ntawm a-Synuclein hauv cov lus teb oxidative kev nyuaj siab ntawm cov hlwb. Cov txiaj ntsig tau pom tias oxidative kev nyuaj siab tuaj yeem ua rau kev hloov pauv ntawm 10 kD tawg ntawm C-terminal ntawm a-synaptophysin hauv dopaminergic MES23.5 neurons.
Suav tshuaj ntsuab cistanche-Tonify cev
2. Kev tiv thaiv ntawm lub raum tonifying tshuaj ntsuab rau cov kab mob hauv lub paj hlwb
Raws li txoj kev xav ntawm kev tswj hwm ntawm cov tshuaj suav tshuaj, "lub raum khaws cov ntsiab lus, tswj cov pob txha thiab tsim cov pob txha", thiab "hlwb yog hiav txwv pob txha". Kev nce thiab poob ntawm cov ntsiab lus ntawm lub raum cuam tshuam rau cov txiaj ntsig thiab kev poob ntawm lub paj hlwb thiab kev ua haujlwm ntawm lub hlwb. Yog li ntawd, tonifying lub raum thiab sau cov pob txha yog ib qho tseem ceeb kho txoj cai rau kev kho mob hauv nruab nrab paj hlwb kab mob.
Lu Zhengyu et al. [1] kawm txog cov nyhuv ntawm cov tshuaj rau tonifying lub raum, nourishing lub siab, thiab suppressing cua ntawm cov antioxidant enzymes thiab cell apoptosis nyob rau hauv lub striatum ntawm nas nrog Parkinson tus kab mob, thiab pom tau hais tias cov tshuaj rau tonifying lub raum, nourishing lub daim siab thiab suppressing cua tuaj yeem nce qib ntawm CAT, GSH-PX, thiab SOD hauv striatum, txo cov apoptosis ntawm neurons hauv striatum, thiab txhim kho cov tsos mob ntawm tus kab mob Parkinson.
Cai Jing et al. [9] pib nrog cov tshuaj estrogen receptors thiab kawm txog qhov ua tau ntawm cov nyhuv ntawm Epimedium ntawm lub paj hlwb ntawm qib molecular, thiab pom tias lub raum tonifying tshuaj ntsuab yuav cuam tshuam rau kev qhia ntawm cov tshuaj estrogen receptor, tswj cov kev sau lossis kev qhia ntawm qee yam tseem ceeb. ntawm cov tshuaj estrogen receptor-zoo neurons, yog li tswj kev ncaj ncees kev loj hlob thiab kev tsim dua tshiab ntawm cov neurons, thiab txo qhov kev puas tsuaj ntawm neurons los ntawm ntau yam kev poob xws li ischemia, hypoxia, thiab peroxidation. Hauv kev tshawb fawb niaj hnub no, muaj ntau cov kev tshawb fawb txog kev tiv thaiv lub raum-tonifying tshuaj ntsuab ntawm lub paj hlwb.
2.1 Epimedium
Cov khoom xyaw zoo ntawm Epimedium kom ncua kev laus yog Epimedium polysaccharide (Epimedium polysaccharide muaj mannose, rhamnose, galacturonic acid, thiab lwm yam) [10]. Icariin (ICA) yog nws cov yam ntxwv tivthaiv. Tam sim no, nws tau raug tshaj tawm tias nws muaj cov tshuaj zoo li estrogen thiab tuaj yeem txhim kho kev kawm thiab kev nco tsis zoo vim muaj tshuaj lom neeg txhuas hauv cov nas [11].
Xu Ruixia et al. [12] tau kawm txog kev tiv thaiv thiab kev kho mob ntawm ICA ntawm vascular dementia thiab pom tias ICA tuaj yeem txhim kho kev kawm thiab kev nco muaj peev xwm ntawm VD nas induced los ntawm 2-VO txoj kev. Nws cov txheej txheem yuav cuam tshuam txog kev nce SOD kev ua haujlwm, txo MDA ntau lawm, thiab nce kev nthuav qhia ntawm CAT thiab AchE.
2.2 Cistanche deserticola
Cov tshuaj suav tshuaj ntseeg tau tias"desert ginseng" Cistanche deserticola mamuaj cov nyhuv tonifying raum yang thiab pab cov ntshav essence. Nws tsuas yog kho cov txiv neej impotence, poj niam infertility, ntshav qhuav cem quav, thiab lwm yam tsos mob, thiab muaj lub koob npe nrov ntawm "desert ginseng". Kev tshawb fawb tshuaj niaj hnub no qhia tau hais tias Cistanche deserticola tuaj yeem cuam tshuam cov haujlwm ntawm monoamine oxidase B thiab nce cov ntsiab lus ntawm dopamine.
Cov txiaj ntsig ntawm cistanche tubulosa-Kev kho tus kab mob Parkinson
Nyem qhov no mus saib Cistanche hmoov khoom
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Wang Hu et al. [13] tau kawm txog kev tiv thaiv ntawm Cistanche deserticola extract ntawm lub cell puas qauv ntawm Parkinson tus kab mob thiab soj ntsuam cov teebmeem ntawm Cistanche deserticola extract ntawm txawv concentrations ntawm cell productivity, kev loj hlob inhibition, thiab DNA puas-induced noob 153 thiab nws cov protein qhia ntawm tus qauv.Cov txiaj ntsig tau pom tiasCistanche extract hmoovmuaj kev tiv thaiv los ntawm MPP ntxiv rau kev kho cell puas tsuaj, thiab nws cov txheej txheem ntawm kev ua haujlwm yuav cuam tshuam nrog kev qhia ntawm GADD153 mRNA thiab qib protein.Kev tshawb fawb los ntawm TianXF et al. [14] qhia tiasCistanche deserticola tuaj yeem nce cov ntsiab lus ntawm ntau yam hauv nruab nrab neurotransmitters, muaj zog antioxidant nyhuv, thiab tuaj yeem tiv taus kev laus thiab apoptosis.
Cistanche extract hmoov - Tonify cev
2.3 Cuscuta chinensis
Cuscuta chinensis yog qab zib thiab sov. Nws tuaj yeem nkag mus rau hauv daim siab, lub raum, thiab spleen meridians, txhawb lub siab thiab lub raum, thiab tseem txhawb nqa tus po. Nws cov teebmeem pharmacological suav nrog kev ua haujlwm ntawm kev sib deev, kev tiv thaiv kev laus, kev tiv thaiv cerebral ischemia, thiab lwm yam.
Wang Zhijun et al. [15] tau kawm txog cov txiaj ntsig ntawm cawv extract ntawm Cuscuta chinensis ntawm oxidative puas thiab complex enzyme kev ua ntawm daim siab mitochondria hauv cov laus qauv nas. Cov txiaj ntsig tau pom tias cov cawv extract ntawm Cuscuta chinensis tuaj yeem ua rau muaj kev ua haujlwm ntawm Mn-SOD thiab muaj peev xwm tshem tawm cov dawb radicals hauv daim siab mitochondria ntawm cov laus qauv nas, txo cov ntsiab lus ntawm cov dawb radical metabolites, thiab nce cov kev ua ntawm mitochondrial enzyme complex, thiab nws cov txiaj ntsig tseem ceeb dua nrog kev ncua sijhawm ntawm kev tswj hwm. Sun Jie et al. [16] tau kawm txog cov nyhuv antioxidant ntawm cawv extract ntawm Cuscuta chinensis ntawm lub paj hlwb ntawm D-galactose-induced aging nas. Cov nas tsuag tau txhaj D-galactose tom qab rau hauv plab. Tom qab 6 lub lis piam, lawv tau noj tsis tu ncua nrog cawv ntawm Cuscuta chinensis rau 30 hnub. Cov kev ua ub no ntawm superoxide dismutase (SOD) thiab glutathione peroxidase (GSH-Px) nyob rau hauv lub hlwb cov ntaub so ntswg ntawm nas raug kuaj pom feem; Cov ntsiab lus ntawm malondialdehyde (MDA) hauv paj hlwb ntawm lub paj hlwb cortex. Cov txiaj ntsig tau pom tias cov cawv cawv ntawm Cuscuta chinensis tuaj yeem ua rau muaj kev ua haujlwm ntawm antioxidant enzymes hauv paj hlwb ntawm cov nas laus, txo cov ntsiab lus ntawm cov dawb radical metabolites, thiab muaj qee yam kev tiv thaiv kev laus.
2.4 Npaj Polygonum multiflorum Thunb
Cov npaj Polygonum multiflorum muaj cov teebmeem ntawm kev hloov kho lub siab thiab lub raum, muaj txiaj ntsig zoo rau cov ntshav, thiab cov plaub hau dub, thiab ntxiv dag zog rau cov leeg thiab pob txha.
Miao Mingsan et al. [17] pom cov nyhuv antioxidant ntawm Polygonum multiflorum polysaccharides. Tus qauv nas laus tau tsim dua tshiab nrog D-galactose. Cov txiaj ntsig tau pom tias Polygonum multiflorum polysaccharide tuaj yeem ua rau muaj txiaj ntsig zoo ntawm SOD, CAT, thiab GSH-Px hauv cov ntshav ntawm D-galactose aging qauv nas, thiab txo qis LPO hauv cov ntshav, lub hlwb homogenate, thiab daim siab homogenate. Yog li, nws tau pom tias polysaccharide los ntawm Polygonum multiflorum Thunb muaj cov nyhuv antioxidant.
Yang Xiaoyan [18] tau kawm txog cov txiaj ntsig ntawm Polygonum multiflorum polysaccharides ntawm kev kawm thiab kev nco muaj peev xwm thiab lub hlwb enzyme ua haujlwm hauv cov qauv nas dementia. Tus nas dementia qauv tau tsim nrog D2 galactose, thiab polysaccharide extract ntawm Polygonum multiflorum tau muab los ntawm gavage, thiab vitamin E, Naofuxin, thiab estradiol tau siv los ua cov tshuaj tswj tau zoo raws li. Cov txiaj ntsig tau pom tias rau cov qauv nas dementia, kev npaj ntawm polygonum multiflorum polysaccharide tuaj yeem txhim kho lawv txoj kev kawm thiab kev nco muaj peev xwm, txo cov ntsiab lus ntawm lipofuscin thiab kev ua haujlwm ntawm monoamine oxidase hauv lub hlwb, thiab ua rau muaj kev ua haujlwm ntawm superoxide dismutase thiab catalase hauv lub hlwb. lub hlwb thiab kev ua haujlwm ntawm nitric oxide synthase hauv hippocampus. Nws tau pom tias cov tshuaj npaj polysaccharide ntawm Polygonum multiflorum Thunb muaj kev tiv thaiv kev sim dementia.
2.5 Grilled tortoiseshell
Suav tshuaj ntsuab rau tonifying lub raum yog qab ntsev, qab zib, thiab du. Nws tuaj yeem nkag mus rau hauv lub raum meridian, nourish yin, nourish lub raum thiab latent yang, nourish lub raum thiab pob txha, txhawb cov ntshav, thiab txhawb lub plawv. Raws li cov tshuaj suav tshuaj, lub raum tswj kev loj hlob. Lub raum yin yog lub hauv paus ntawm tib neeg yin kua, uas plays lub luag hauj lwm nyob rau hauv moistening thiab nourishing lub viscera thiab cov ntaub so ntswg.
Tang Xiang et al. [19] tau soj ntsuam kev ua tau zoo thiab kev nyab xeeb ntawm Ziyin Xifeng Granule (sib xyaw ntawm cov pob txha tortoiseshell, antler qab zib, Cornus officinalis, Suav yam, eucommia ulmoides txiv ntseej, thiab lwm yam) nyob rau theem pib ntawm Parkinson tus kab mob (PD). Rau caum tus neeg mob nrog PD thaum ntxov tau muab faib ua ob pawg. 30 tus neeg mob hauv pab pawg kho mob tau kho nrog Ziyin Xifeng Granule; 30 tus neeg mob hauv pawg tswj hwm tau kho nrog xov xwm. 2 lub hlis yog thawj chav kho mob hauv ob pawg. Cov txiaj ntsig tau pom tias qhov kev kho mob zoo ntawm Ziyin Xifeng Granule hauv kev kho mob ntawm PD thaum ntxov yog sib npaug ntawm Medopa, thiab nws muaj kev nyab xeeb thiab siv tau.
Li Yiwei et al. [20] tshawb nrhiav cov txiaj ntsig ntawm tortoiseshell, tshuaj raum tonic, ntawm tus cwj pwm thiab lub hlwb dopamine qib ntawm nas nrog Parkinson tus kab mob. Tus qauv kab mob Parkinson tau npaj los ntawm kev txhaj tshuaj intracerebral ntawm 6-hydroxydopamine. Lub tortoiseshell, ib txwm suav tshuaj rau tonifying lub raum, muaj peev xwm siv tshuaj kho mob tus nqi rau Parkinson tus kab mob hauv nas.
2.6 Morinda officinalis
Morinda Officinalis, ntsim thiab qab zib; Kub kub. Rov qab mus rau lub raum, thiab lub siab channel. Nourishing lub raum thiab Yang, dispelling cua thiab dampness, ntxiv dag zog rau tendons thiab pob txha. Fu Jia et al. [21] tau kawm txog cov txiaj ntsig ntawm Morinda officinalis ntawm cov kab mob antioxidant ntawm cov nas laus vim yog D-galactose. Qhov kev sim pom tau hais tias ob qho tib si loj thiab me me ntawm Morinda officinalis decoction tuaj yeem ua rau muaj kev ua haujlwm ntawm cov ntshav qab zib SOD thiab GSH-Px thiab txo cov ntsiab lus ntawm cov ntshav MDA. Nws qhia tias Morinda officinalis tuaj yeem tshem tawm cov dawb radicals, inhibit lipid peroxidation kev puas tsuaj thiab ncua kev laus los ntawm kev ntxiv cov tshuaj antioxidant exogenous lossis txhawb kev tsim cov tshuaj tua kab mob endogenous hauv lub cev.
Guo Chongyi et al. [22] tau kawm txog cov teebmeem ntawm Morinda officinalis nrog cov txheej txheem sib txawv ntawm kev ua haujlwm antioxidant thiab cellular tiv thaiv kab mob hauv nas. Cov ntsiab lus ntawm SOD, MDA, thiab GSH-Px hauv plasma ntawm nas, lymphocyte transformation, thiab NK cell kev ua tau raug ntsuas raws. Cov txiaj ntsig tau pom tias Morinda officinalis (suntanned) pab pawg thiab Morinda officinalis (salted) pab pawg tuaj yeem nce qib ntawm cov ntshav plasma superoxide dismutase (SOD) thiab glutathione peroxidase (GSH-Px), txo cov ntsiab lus ntawm lipid peroxide (MDA), thiab tseem ceeb heev. txhim kho cov lymphocyte transformation thiab NK cell kev ua piv nrog rau pawg tswj hwm (P<0.05~0.01). It is suggested that Morinda officinalis has antioxidant and immune functions.
3. Prospect thiab prospect
Superman tshuaj ntsuab cistanche-Tonifying raum
Piv txwv li, Parkinson's disease yog ib hom kab mob neurodegenerative. Txawm hais tias qhov ua rau substantia nigra cell puas yog tsis paub, ntau cov kev tshawb fawb qhia tias oxidative kev nyuaj siab yog nws txoj kev ua tau. Ntau cov kev tshawb fawb tau pom tias cov tshuaj ntsuab raum-tonifying yog siv los ncua kev laus thiab kho cov kab mob paj hlwb los ntawm kev tiv thaiv oxidation.. Txawm hais tias qee qhov kev ua tiav tau ua tiav hauv kev kho mob Parkinson tus kab mob nrog rau cov tshuaj tua kab mob hauv lub raum hauv xyoo tas los no, kev tshawb fawb mechanism tsis tau ua tiav hauv qhov tob. Peb yuav tsum sib txuas cov tshuaj suav tshuaj suav nrog cov qib molecular biology niaj hnub txhawm rau tshawb nrhiav cov txheej txheem ntawm lub raum tonifying suav tshuaj hauv kev kho cov kab mob paj hlwb. Peb ntseeg hais tias los ntawm kev tshawb fawb zoo, nrog rau kev daws teeb meem rau cov teeb meem no thiab kev qhia meej ntawm cov txheej txheem ntawm kev ua, Suav cov tshuaj rau tonifying lub raum yuav ua rau muaj kev cuam tshuam hauv kev kho mob Parkinson's disease.
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