Ntu Ⅱ Hydrogen: Ib Txoj Kev Kho Mob Tshiab hauv Kab Mob Raum
May 23, 2023
Lub luag haujlwm ntawm Kab Mob raum
Cov teebmeem ntawm H2nyob rau hauv cov kab mob raum muaj nyob rau hauv Table 1.
1. Tshuaj-Induced Nephrotoxicity
Kev txhaj tshuaj nephrotoxicity tau dhau los ua ntau niaj hnub no. Ib qho ua rau lub raum toxicity tuaj yeem yog tshuaj, xws li tshuaj tua kab mob lossis tshuaj tua kab mob. Cisplatin, siv dav siv tshuaj kho mob cancer, muaj txiaj ntsig zoo rau ntau cov qog nqaij hlav, nrog rau lub ntsws, zes qe menyuam, thiab mob qog noj ntshav mis. Nephrotoxicity yog qhov tseem ceeb ntawm kev txwv tshuaj lom ntawm cisplatin. Txawm hais tias saline hydration thiab diuresis, qhov tshwm sim ntawm nephrotoxicity yog nyob rau hauv thaj tsam ntawm 20-30 feem pua [33]. Cisplatin muaj kev sib raug zoo rau SH (sulfhydryl) pawg, ntxiv rau DNA, nws yog lub hom phiaj tseem ceeb [34]. Kev sib cuam tshuam ntawm cisplatin thiab SH pawg ua rau GSH depletion, ua rau txo qis ntawm cellular antioxidant system thiab tsub zuj zuj ntawm ROS thiab nws cov khoom [34]. Cisplatin feem ntau yog nyob rau hauv lub raum raws li nws tau tawm feem ntau los ntawm lub cev [35]. Kev sib sau ntawm cisplatin thiab tiam ntawm ROS hauv lub raum yuav raug ntaus nqi rau cisplatin-induced nephrotoxicity. Nakashima-Kamimura et al. [36] pom tias qhov nqus ntawm cov pa roj hydrogen muaj kev tiv thaiv cisplatin. Rau qhov mob hnyav thiab muaj zog OS tshwm sim los ntawm I / R, 1 feem pua ntawm cov pa roj hydrogen muab kev tiv thaiv txaus, thaum nqus tau ntawm 1 feem pua lossis 2 feem pua hydrogen gas tuaj yeem siv rau kev kho lub sijhawm luv. Ntxiv nrog rau cov pa roj hydrogen, txoj kev tshawb fawb no tau pom tias haus dej hydrogen ad libitum kuj tseem muaj txiaj ntsig kom tau txais txiaj ntsig zoo tiv thaiv. Tom qab ntawd, qee cov kws tshawb fawb tau lees paub tias cov dej nplua nuj hydrogen (HW) ameliorates lub raum tsis ua haujlwm los ntawm cisplatin-induced nephrotoxicity hauv cov nas, siv cov dynamic sib piv-txhim kho CT thiab ntshav oxygenation qib-nyob ntawm cov hlau nplaum resonance imaging [37, 38]. Tsis tas li ntawd, HW tau rov qab kho qhov sib npaug ntawm qhov sib npaug, txo qis OS kev puas tsuaj, thiab txhim kho lub raum ua haujlwm raug ntxias los ntawm cyclosporine A los ntawm kev ua kom lub Keap1/Nrf2 signaling pathway [39]. Cov kev tshawb pom saum toj no [36–39] lees paub tias HW tuaj yeem yog qhov kev cog lus kho mob rau kev kho mob raum thiab tiv thaiv kev kho mob ntev allograft nephrotoxicity tom qab hloov pauv hauv nruab nrog cev.
2. Lub raum Fibrosis
Lub raum fibrosis, tus cwj pwm los ntawm kev sib sau ntawm cov nti hauv parenchyma, sawv cev rau txoj hauv kev kawg ntawm kev mob ntev thiab mob nephropathy. Lub raum fibrosis cuam tshuam ib nrab ntawm cov neeg laus hnub nyoog tshaj 70 xyoo thiab 10 feem pua ntawm cov neeg hauv ntiaj teb [40]. Yog li ntawd, nquag tshawb nrhiav cov kab mob pathogenesis thiab kev tiv thaiv ntawm lub raum fibrosis yog qhov tseem ceeb los txhim kho cov kab mob raum. Xing et al. [41] siv HW los kho Balb/C nas qauv ntawm lub raum fibrosis tsim los ntawm unilateral ureteral obstruction. Lawv txoj kev tshawb fawb tau pom tias HW txo qis unilateral ureteral obstruction-induced raum fibrosis. Hauv cov qauv ntawm tes, HW tiv thaiv HK-2 hlwb los ntawm kev hloov mus rau epithelial mus rau mesenchymal kev hloov pauv los ntawm TGF- 1, uas Sirt1 uas tsis yog TGF- 1/Smad2 txoj kev koom nrog. Txoj kev tshawb no qhia txog kev kho muaj peev xwm ntawm hydrogen tiv thaiv fibrosis, nrog Sirt1 yog lub hom phiaj latent rau kev kho thiab kuaj mob fibrosis. Chen et al. [42] pom tias hydrogen-nplua nuj saline (HRS) pom muaj kev tiv thaiv kev tiv thaiv ntawm lub raum raug mob thiab tuaj yeem tiv thaiv lub raum fibrosis tom qab IR raug mob hauv cov nas. HRS tej zaum yuav raug siv los ntawm kev tuav Klotho qhia thiab ua kom autophagy hauv lub raum. Kev tshawb fawb yav tom ntej yuav tsum tsom mus nrhiav txoj hauv kev uas tsis muaj kev cuam tshuam rau kev kho lub raum fibrosis.
Nyem qhov no kom tau txais txiaj ntsig Cistanche
3. Ischemia-Reperfusion Injury
IRI, uas tsis tuaj yeem zam tau hauv kev hloov pauv hauv nruab nrog cev, ua rau muaj kev puas tsuaj loj rau lub raum kev ua haujlwm thiab kev ciaj sia. Ib qho ntawm cov xwm txheej tseem ceeb hauv ischemia-reperfusion yog lub cim ntawm cytotoxic oxygen radicals, uas ua rau cov cellular raug mob los ntawm inducing DNA puas, protein oxidation, lipid peroxidation, thiab apoptosis [43]. Xyoo 2001, Noiri et al. [44] pom tau tias tiam ntawm ROS thiab TSIS MUAJ hauv IRI tuaj yeem ua rau muaj kev tsim cov cytotoxic metabolite, peroxynitrite (ONOO-), uas tuaj yeem ua rau lipid peroxidation thiab DNA puas. Kev hloov pauv sai ntawm tus mob ischemic mus rau reperfusion ua rau OS puas tsuaj [45]. Txhawm rau ua rau ischemia, Ohsawa et al. [2] raug cov hlwb neocortical rau oxygen-glucose deprivation (OGD) nyob rau hauv nitrogen los yog hydrogen gas rau 60 min, ua raws li reperfusion nrog nruab nrab uas muaj O2 thiab qabzib. HPF fluorescence pom tau tias 10 min tom qab ua tiav ntawm OGD ua raws li reperfusion, • OH theem tseem ceeb nce ntxiv thaum tsis muaj H2 tab sis ploj zuj zus thaum H2nyob tam sim no. Thaum 24 teev tom qab OGD thiab rov ua dua, H2nce neuron ciaj sia thiab tseem ceeb, qhia tias H2tiv thaiv neurons tiv thaiv OS-induced cell tuag. Tsis tas li ntawd, 8-OHdG thiab malondialdehyde yog cov qauv tseem ceeb ntawm DNA thiab lipid puas-induced ROS, raws li [43]. Muab hais tias H2 molecules tuaj yeem txo IRI los ntawm kev xaiv tshem tawm ROS uas ua rau oxidative puas tsuaj rau DNA, lipids, thiab cov proteins, Kawamura li al. [43] soj ntsuam OS los ntawm kev saib xyuas cov zis 8-OHdG thiab cov qib ntshav malondialdehyde. 8-OHdG thiab malondialdehyde, uas yog cov khoom peroxidation ntawm DNA thiab lipids, feem, tau dav siv los ua OS cim [46–48]. Kev kho mob nrog nano-Si ua rau txo qis hauv cov zis ntxiv 8-OHdG thiab malondialdehyde qib vim yog IRI. Piv txwv li, •OH thiab ONOO- yog cov ROS loj uas pab rau IRI, thaum 8-OHdG thiab malondialdehyde tuaj yeem siv los ua cov cim tseem ceeb OS rau IRI. Txij li thaum nrhiav pom cov khoom siv antioxidant ntawm molecular hydrogen (H2) hauv xyoo 2007, ntau qhov kev tshawb fawb tau pom tias hydrogen muaj txiaj ntsig zoo hauv ntau hom tsiaj ntawm OS hauv vivo [2, 49, 50]. H2Kev kho mob tau pom tias tshem tawm IRI tom qab sov thiab txias ischemia, thiab yog li, nws tau raug txheeb xyuas tias yog ib qho kev kho mob los txhim kho lub raum hloov cov txiaj ntsig [8]. Li et al. [51] induced tus qauv nas ntawm lub raum IRI thiab pom tias kev kho mob nrog HRS cov tshuaj (HRSS) txo qis kev sib txuam, edema, thiab hemorrhage piv nrog kev kho ntsev. HRSS tuaj yeem txhawb nqa lub raum rov ua haujlwm tom qab IRI hauv cov nas los ntawm inhibiting inflammatory TNF- / IL-6 txoj hauv kev, nce Bcl- 2/Bax ratio, thiab txo qis raum cell apoptosis. Lwm txoj kev tshawb fawb [52] tau tshaj tawm tias HRS tau txhim kho lub raum teb rau I / R hauv cov nas muaj hnub nyoog, tej zaum los ntawm kev txo OS thiab txhawb nqa HO-1 gene qhia. Tsis tas li ntawd, Nishida et al. [53] tau ua ib txoj kev tshawb fawb los ntsuas qhov cuam tshuam ntawm kev sib xyaw ntawm H2 roj thiab CO roj (dual gas) piv nrog cov roj hydrogen (H2: 2 feem pua) ib leeg ntawm I/R raum raug mob. Lawv tau pom cov teebmeem cytoprotective ntawm kev kho dual hauv kev sib piv nrog H2Kev kho mob thiab I / R raum raug mob nyob rau hauv cov nqe lus ntawm superoxide radical scavenging kev ua si thiab histochemical nta. Cov nas uas tau txais kev kho ob zaug tau pom tias muaj kev txo qis hauv cov ntshav urea nitrogen thiab kev qhia ntawm ntau lub cytokines inflammatory (IL-6, TNF-, ICAM-1, HIF-1 , NF-κB, thiab HO- 1). Txawm hais tias cov txheej txheem ntawm kev tiv thaiv cov nyhuv ntawm hydrogen tseem tsis paub meej, daim ntawv thov ntawm hydrogen therapy tej zaum yuav yog ib qho yooj yim, nyab xeeb, kev lag luam, thiab muaj txiaj ntsig zoo tshiab rau kev tiv thaiv lub raum raug mob.
cov teebmeem ntawm Cistanche
4. Lub raum Calculi
Lub raum pob zeb, tshwm sim los ntawm qhov txawv txav ntawm cov khoom siv crystalline (calcium oxalate - CaOx - feem ntau), yog ib yam kab mob ntawm cov zis. Txhawm rau soj ntsuam cov txiaj ntsig tiv thaiv thiab hauv qab txheej txheem ntawm hydrogen gas (H2) hauv glyoxylate-induced lub raum CaOx crystal deposition hauv nas, Peng li al. [54] tsim cov nas rau lub raum CaOx crystal deposition qauv los ntawm intra-abdominal txhaj ntawm glyoxylate (precursor ntawm oxalate) rau 5 hnub. Raws li cov txiaj ntsig ntawm qib ntawm cov zis calcium excretion, lub raum calcium deposition, cov kua dej tawm ntawm lub raum raug mob molecule-1 (KIM-1) assay, thiab TUNEL assay, qhov nqus tau ntawm H2 tau ua tiav cov crystallization ntawm CaOx thiab tiv thaiv lub raum raug mob. Crystal deposition nyob rau hauv lub raum yog txuam nrog OS. OS ua rau apoptosis thiab necrosis ntawm lub raum tubular epithelial hlwb. Qhov no yog ib qho tseem ceeb rau lub raum tubular epithelial cell puas [55] thiab pab txhawb rau lub raum siv lead ua deposition thiab tshwm sim ntawm lub raum pob zeb [56], vim yog zus tau tej cov ROS [57]. ROS raug suav hais tias yog cytotoxic thiab tuaj yeem ua rau muaj ntau yam macromolecules [58]. Serum metabolomics cov kev tshawb fawb hauv nas [55] pom tias H2 tiv thaiv lub raum raug mob los ntawm crystallization ntawm CaOx, uas tej zaum yuav cuam tshuam nrog kev hloov pauv hauv fatty acid metabolism, phospholipid metabolism, thiab amino acid metabolism. Kev tshawb fawb ntxiv, txawm li cas los xij, xav tau kom nkag siab zoo dua ntawm cov txheej txheem molecular ntawm CaOxinduced raum raug mob thiab kho cov teebmeem ntawm hydrogen gas.
5. Hemodialysis
Kev nce OS yog cuam tshuam nrog cov kab mob plawv loj thiab tuag ntxov hauv cov neeg mob kho hemodialysis (HD). Thaum lub sij hawm HD, qhov tshwm sim ntawm kev lim ntshav rau cov ntshav tuaj yeem txhim kho kev tsim tawm ntawm OS [59]. Hauv kev tshawb fawb soj ntsuam [59], 8 cov neeg mob uas tsis tu ncua hemodialysis tau hloov kho nrog cov txheej txheem dialysate thiab dialysate yaj nrog cov ntsiab lus siab ntawm hydrogen, thiab cov txiaj ntsig tau pom tias dialysate muaj hydrogen tuaj yeem txo qib OS hauv cov neeg mob hemodialysis, uas yuav txo tau. qhov tshwm sim ntawm cov kab mob plawv. Yog li, dialysate muaj hydrogen tuaj yeem muab kev kho mob tshiab rau kev tswj uremia. Hauv lwm txoj kev tshawb fawb [60], Nakayama et al. [60] tau tsim ib qho tshiab hemodialysis (E-HD) system xa H2 (30-80 ppb)-enriched dialysis tov los ntawm dej electrolysis thiab ua ib tug nonrandomized, nonblinded, yav tom ntej kev soj ntsuam kev tshawb fawb txog nws cov kev kho mob. Nws tau xaus lus tias E-HD yog ib qho tseem ceeb ntawm kev ywj pheej hauv kev txo cov kev pheej hmoo ntawm cov xwm txheej tseem ceeb ntawm txhua qhov kev tuag thiab kev loj hlob ntawm cov xwm txheej uas tsis yog mob plawv-cerebrovascular. Yog li, daim ntawv thov ntawm H2-cov kev daws teeb meem zoo tuaj yeem ua rau OS thaum lub sijhawm HD, txawm hais tias xav tau kev tshawb fawb ntxiv los txiav txim siab nws qhov kev cuam tshuam.
Cistanche extract thiab Cistanche hmoov
6. Chronic Allograft Nephropathy
Chronic allograft nephropathy (CAN), tseem hu ua interstitial fibrosis thiab tubular atrophy ntawm tsis paub etiology (IF / TA), tseem yog ib qho ntawm cov chaw kho mob siab tshaj plaws rau cov kws kho mob hloov lub raum los kho, vim nws tiv taus cov kev kho tam sim no thiab yog ib qho tseem ceeb. ua rau lub sij hawm graft poob [61]. Yog li ntawd, muaj peev xwm tshiab txoj hauv kev rau kev kho mob ntawm CAN xws li cov lus piav qhia los ntawm Cardinal li al. [62] muaj kev txaus siab heev. Qhov sib ntxiv ntawm hydrogen rau cov dej haus tau txo qhov hnyav ntawm CAN thiab nce graft ciaj sia, qhia tias lub tshuab yuav yog vim qhov txo qis hauv ROS. Yog li ntawd, qhov ncauj HW yog ib qho tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob uas tiv thaiv CAN, txhim kho tus nqi ciaj sia ntawm nas allograft raum hloov pauv, thiab tej zaum yuav muaj txiaj ntsig kho mob hauv kev hloov pauv.
7. Sepsis-Related AKI
AKI feem ntau tshwm sim nyob rau theem pib ntawm sepsis, nrog qhov tshwm sim ntawm 55-73 feem pua [62], nws tus kheej cuam tshuam nrog kev tuag [63]. Kwv yees li 70 feem pua ntawm cov kab mob septic AKI yog cov neeg tuag. Yog li, kev tiv thaiv raum yog qhov tseem ceeb rau cov neeg mob txoj sia nyob [64]. Cov lus teb inflammatory ntau dhau thiab OS raug suav tias yog cov txheej txheem tseem ceeb ntawm septic AKI [65]. Tsis ntev los no, nws tau pom tias txo qhov mob yog qhov tseem ceeb hauv kev kho mob sepsis, tawm tswv yim txog kev kho mob tshiab rau kev tiv thaiv septic AKI [66]. Yao et al. [67] tshawb xyuas lub raum tiv thaiv cov teebmeem ntawm aerosol inhalation ntawm hydrogen-nplua nuj kua nyob rau hauv tus nas qauv ntawm septic AKI. Septic AKI raug ntxias los ntawm 18-h cecal ligation thiab puncture. AKI tshwm sim thaum lub sij hawm ntxov ntawm sepsis thiab yog tus cwj pwm los ntawm kev nce ntshav urea nitrogen thiab ntshav creatinine qib, kev hloov pauv pathological, lub raum fibrosis thiab lub raum tubular epithelial cell apoptosis, macrophage infiltration, thiab M1 macrophage-associated pro-inflammatory cytokine (IL{{14). }} thiab TNF-) tsim nyob rau hauv lub raum cov ntaub so ntswg. Aerosol inhalation ntawm HRS nce kev tiv thaiv kab mob cytokine (IL-4 thiab IL-13) mRNA qib hauv lub raum cov ntaub so ntswg thiab txhawb nqa macrophage polarization rau hom M2, uas tsim cov tshuaj tiv thaiv kab mob ntxiv (IL{{ 21}} and TGF- ). Thaum kawg, aerosol inhalation ntawm HRS tiv thaiv lub raum thiab nce kev ciaj sia ntawm cov nas septic. Yog li, HRS aerosol inhalation zoo nkaus li muaj txiaj ntsig zoo rau kev tiv thaiv lub raum thiab txo qis hauv cov kab mob AKI.
8. Lwm Cov Haujlwm
Xin et al. [68] tshawb xyuas cov txiaj ntsig tiv thaiv ntawm HW ntawm lub raum raug mob hauv cov nas uas muaj ntshav siab (SHR). Cov 8- cov txiv neej hnub nyoog ib asthiv SHR thiab cov hnub nyoog sib tw Wistar-Kyoto nas tau randomized rau hauv HW-kho thiab pab pawg kho tsheb. Txawm hais tias HW tsis muaj qhov cuam tshuam loj rau cov ntshav siab, nws ua rau lub raum raug mob, txo qhov tsim ntawm ROS, inhibiting NADPH oxidase kev ua, thiab txhawb kev ua haujlwm ntawm superoxide GSH peroxidase, dismutase, GSH-S-epoxide transferase, thiab catalase. Kev kho mob nrog HW hauv SHR-kev nyuaj siab qhia txog kev tiv thaiv cytokines xws li IL-6, IL-1b, TNF-a, thiab macrophage chemoattractant protein 1, uas tuaj yeem kho tau los ntawm inhibiting kev ua kom cov nuclear factor-kB. Tsis tas li ntawd, kev kho HW muaj kev tiv thaiv kev ua haujlwm ntawm mitochondrial nrog rau kev tsim adenosine triphosphate thiab kev ua haujlwm ntawm daim nyias nyias hauv SHR. Raws li cov ntsiab lus, HW yog ib lub tswv yim zoo rau kev txo lub raum raug mob thaum siv nrog kev kho mob ntshav siab.
Guan et al. [23] qhia tias H2 tuaj yeem kho CIHinduced raum raug mob los ntawm kev txo qis ER kev ntxhov siab thiab ua kom autophagy los ntawm inhibiting OS-dependent p38 thiab JNK MAPK activation. Kev nthuav qhia ntau ntxiv ntawm lub raum transferrin receptor thiab divalent hlau thauj khoom-1 kev qhia, nrog rau kev txo qis ceruloplasmin qhia, tej zaum yuav ua rau cov hlau tsub zuj zuj nyob rau hauv proximal tubule epithelial hlwb ntawm nas tom qab CIH kho. Kev nqus pa ntawm H2 tuaj yeem tiv thaiv lub raum raug mob los ntawm CIH los ntawm inhibition ntawm hlau overload nyob rau hauv lub raum epithelial hlwb, uas yog koom nrog rau hauv lub mechanism ntawm OS-mediated raug mob [69].
Tsis tas li ntawd, Shi et al. [70] pom tau tias HRS tuaj yeem txo qis lub raum raug mob hauv sodium taurocholate-vim mob hnyav pancreatitis nas qauv. Los ntawm inhibiting NF-κB activation thiab scavenging ROS, HRS tiv thaiv txoj kev loj hlob ntawm inflammatory cascade thiab eased raum oxidative puas. Homma et al. [71] pom tias qhov sib piv-induced AKI hauv nas tau nqa los ntawm kev siv cov tshuaj txhaj tshuaj ntawm qhov sib piv nruab nrab, lovers. Thaum lub sij hawm txhaj tshuaj ntawm cov reagents, cov nas nqus H2 roj los yog tswj roj. Kev nqus pa ntawm H2 tau ua haujlwm zoo hauv kev ua kom muaj qhov hnyav ntawm qhov sib txawv-induced AKI hauv cov nas los ntawm kev txo lub raum cell apoptosis thiab OS.
Herba Cistanche
Xaus
Tam sim no, muaj ob peb tsab ntawv ceeb toom ntawm hydrogen ua rau muaj kev cuam tshuam tsis zoo hauv cov hlwb. Hydrogen tau kawm txog nws cov mutagenicity, genotoxicity, thiab subchronic toxicity. Saitoh et al. [72] tshawb xyuas cov tshuaj lom thiab kev phiv ntawm nruab nrab-pH hydrogen-enriched electrolyzed dej ntawm nas (20 mL / kg / hnub, kav ntev li 28 hnub). Tsis muaj toxicity cuam tshuam nrog kev haus dej hydrogen-nplua nuj electrolytic nyob rau hauv cov nqe lus ntawm cov tsos mob, hematology, thiab histopathology. Nakao et al. [73] tau ua txoj kev tshawb nrhiav qhib-label ntawm kev haus HW, uas pom tias haus HW down-regulated aspartate aminotransferase thiab alanine aminotransferase thaum nce gamma-GSH hloov pauv thiab tag nrho bilirubin. Txawm li cas los xij, qhov kev hloov pauv ntawm cov kev txwv no tau txwv rau ib tug poj niam los txiv neej, thiab qhov txiaj ntsig ntawm qhov tsis sib xws yog nyob rau hauv ib txwm siv tau rau cov txiv neej thiab poj niam. Txog tam sim no, tsis muaj kev tshawb fawb tau pom tias hydrogen muaj qhov cuam tshuam tsis zoo rau kev kho mob raum.
Raws li qhov tshwm sim, hydrogen ua lub luag haujlwm tshwj xeeb hauv kev tiv thaiv oxidation, tiv thaiv kab mob, tiv thaiv apoptosis, thiab cell tuag. Ntau qhov kev tshawb fawb tsiaj tam sim no tau lees paub qhov kev kho mob ntawm hydrogen hauv cov kab mob hauv lub raum, xws li lub raum calculi, lub raum fibrosis, thiab tshuaj tua kab mob nephrotoxicity. Cov txheej txheem molecular tshwj xeeb tom qab kho cov nyhuv ntawm hydrogen tseem tsis paub. Kev tshawb fawb yav tom ntej yuav tsum tsom mus rau qhov tsis zoo ntawm hydrogen thiab nws cov txheej txheem tshwj xeeb ntawm kev ua haujlwm hauv cov kab mob raum. Kev sim tshuaj loj loj yuav xav tau los ua kom pom qhov ua tau zoo thiab tus nqi ntawm hydrogen raws li kev kho mob raum kab mob.
Cov ntaub ntawv
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Bo WangaZhuoshu Lib, cLongfei MaodMingyi ZhaobBingchang YangeXiaowu TauaYuxiang Lia Guangming Yina
ib lub Department of Urology, Lub Tsev Kho Mob Thib Xiangya, Central South University, Changsha, Suav;
bDepartment of Pediatrics, Lub Tsev Kho Mob Thib Peb Xiangya, Central South University, Changsha, Suav;
c Xiangya Tsev Kawm Ntawv Tshuaj, Central South University, Changsha, Suav teb;
d Bioinformatics Center, College of Biology, Hunan University, Changsha, Suav;
e Department of Critical Care Medicine, Central South University, Changsha, Suav
