Tej yam yees siv verbascoside, ntau-faceted ntxim nyiam ntawm ntuj muaj nqis

1, pib lees paub ntawm verbascoside

Verbaside yog cov dej-soluble phenylethanoid glycoside compound dav tam sim no nyob rau hauv ntau yam nroj tsuag muaj roj. Ntawm lawv, cistanche Showicola yog ib tug neeg sawv cev muaj kev sawv cev hauv Verbualcoside. Cistanche Squaticola, zoo li cov dej qhuav qia nrog cov nplooj ntawm cov contanche cov nroj tsuag hauv tsev neeg rhamnaceae, yog ib txwm tshuaj ntsuab tshuaj ntsuab tshuaj ntsuab.

Cistance txiv neej muaj txiaj ntsig

Cov miscular ntawm verbascoside yog c29h36o15, nrog tus txheeb ze ceev ntawm 1.6g / cm3. Nws cov xeeb ceem yog dawb koob siv lead ua hmoov, uas yog yooj yim soluble hauv cov kuab tshuaj xws li ethanol, methanol, thiab ethyl acetate. Lub hauv paus tseem ceeb ntawm nws extraction yog cistanche Squaticola, ib tsob nroj hauv tsev neeg ramnaceae. Nws cov ntsiab lus tuaj yeem txiav txim siab los ntawm cov txheej txheem qhia meej xws li kev ua kom zoo ua kua chromatography (HPLC), uas feem ntau yuav tsum tau HPLC ntau dua lossis sib npaug ntawm 98%. Qhov mob chromatographic feem ntau yog ib theem mobile ntawm Methanol acetonitrile 1%}} {} {degree ntawm 303nm. Saib xyuas yuav tsum tau them nyiaj rau khaws cia ntawm 2-8 degree c thiab zam lub teeb thaum lub sijhawm cia.
Mariascoside tsis yog tsuas pom nyob rau hauv cistanche Squaticola, tab sis kuj tseem muaj lwm yam nroj tsuag tshuaj xws li edysthia, Rehmannia, thiab Lucisciscine. Cov nroj tsuag no ua si lub luag haujlwm tseem ceeb hauv cov tshuaj ib txwm muaj, thiab cov khoom xyaw ua ke, tau nyiam ua kom zoo dua thiab tshawb fawb.
2, cov khoom tshwj xeeb thiab siv

(1) Lub cev thiab tshuaj lom neeg
Qhov tseeb verbaside tshwm li dawb koob ua lead ua hmoov. Nws muaj cov solubility zoo thiab yog yooj yim soluble hauv cov kuab tshuaj xws li ethanol, methanol, thiab ethyl acetate. Cov xeeb ceem no ua rau xaiv cov kuab tshuaj uas tsim nyog rau kev rho tawm thiab tsom xam ntawm verbualcoside. Nyob rau hauv cov nqe lus ntawm kev pom, kev ua tau zoo kua chromatography (HPLC) feem ntau siv rau kev txiav txim siab txog cov ntsiab lus HPLC ntau dua lossis sib npaug ntawm 98%. Los ntawm kev mob chratographic tshwj xeeb, xws li mobile theem metanol-acetonitrile {}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} Ib qho ntxiv, kev saib xyuas yuav tsum tau them nyiaj rau khaws cia ntawm {12}} degree c hauv maub los xyuas kom meej nws qhov ruaj khov thiab kev ua si.

Actionoside cov tshuaj tseem ceeb ntawm cistanche Squaticola

(2) Tus nqi tshuaj
Nyob rau hauv liab qab paj liab cream ntsiav tshuaj, Verbualcoside ua lub luag haujlwm tseem ceeb. Nws tuaj yeem ua kom lub sijhawm ua kom lub sijhawm ua kom ib nrab ntawm prothomombin thiab exert hemostatic cov teeb meem los ntawm endogenous coagulation pathway. Nyob rau tib lub sijhawm, nws kuj tseem tuaj yeem nce tus naj npawb ntawm cov platelets thiab txhawb cov pab pawg platelelet ua pa, zoo siv rau kev kho mob los ntshav. Piv txwv li, hauv kev saib xyuas kev ua haujlwm, rau qee cov neeg mob ua pa thiab kab mob zom zaub ntshav tau los ntawm kev raug mob verbarcoside tau txhim kho los ntshav ntau. Raws li kev txheeb cais, nyob rau qee tus neeg mob, lub sijhawm rau kev los ntshav qis dua tom qab siv cov tshuaj, thiab cov ntaub ntawv tshwj xeeb].
Tsis tas li ntawd, Visbascoside kuj tseem muaj kev cuam tshuam los tiv thaiv. Kev sib xyaw ntawm Verbualcoside thiab lwm cov khoom siv hauv liab qab xim hlaws yuav muaj peev xwm ua tau ntau yam tshuaj tiv thaiv kab mob off los ntawm xylene. Nyob rau hauv kev kho mob ntawm cov kab mob hnyav, Verbualcoside ua lub luag haujlwm zoo hauv kev pab cov neeg mob kom paub meej, mob thiab tsis xis nyob. Naked paj yeeb cov ntsiav tshuaj ntsiav tseem muaj qee yam mob rau cov mob o los ntawm kab mob, nrog rau kev sib kis tus kab mob siab thiab lwm yam kab mob.
Hauv cov ntsiab lus, Verbarcoside muaj dav thov cov kev cia siab hauv thaj chaw vim nws tshwj xeeb lub cev thiab muaj txiaj ntsig zoo.

cistances 200mg

Nyem qhov no mus saib cistranche txhim kho cov khoom siv tiv thaiv kev tiv thaiv

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3, Cov teebmeem pharmological

(1) Cov nyhuv neuroprotective
Mariascoside muaj cov teebmeem tseem ceeb neuroproteftive. Nws tuaj yeem kho tau cov neurons puas hauv Alzheimer tus kab mob thiab txhim kho kev kawm thiab kev nco ua haujlwm. Nws tseem muaj kev txhim kho cov nyhuv ntawm oxidative kev puas tsuaj, mob oxidative, mob neuropathic, thiab Parkinson tus kab mob hauv lub hlwb. Kev tshawb fawb tau pom tias Verbascoside tuaj yeem cuam tshuam txog kev ua kom tsis txhob muaj qhov - amyloBlastoma Cov txheej txheem yuav cuam tshuam nrog kev ua siab ntev ntawm cov teeb liab txig uas muaj kev txwv tsis pub /}}
Hauv kev tshawb fawb ntawm High-Estitude Hypoxia Mice, Verbarcoside muaj kev txhim kho zoo ntawm high-contitude hypoxia nco tsis taus. Yim yim txhais caj npab tau siv los cob qhia lub peev xwm ntawm lub peev xwm ntawm cov nas. Tom qab kev cob qhia ua tiav, lawv tau muab faib ua ke rau hauv Permymic tswj pab pawg, thiab cov pab pawg hypox, thiab cov pab pawg ntawm cov txheej txheem ntawm Verbascoside. Cov txiaj ntsig tau pom tias piv nrog Hypoxia Model Reflectase, thiab ntshav malondeshde, thiab ntshav malondeshde, thiab ntshav qhia txog lub hlwb sib txawv ntawm cov Nce. Qhov no qhia tau tias Verbascoside yuav cuam tshuam nrog ruaj khov qhov sib npaug ntawm lub cev cov tshuaj tiv thaiv kab mob antioxidant thiab txo cov oxidative kev ntxhov siab.
Tsis tas li ntawd, nyob rau hauv kev kawm ntawm neuroprotecive cuam tshuam rau Alzheimer cov kab mob kab mob, pawg nruab nrab thiab siab dua cov peev xwm txhim kho kev kawm thiab cov peev xwm nco tau ntawm cov nas; Tuaj yeem nce tus naj npawb ntawm neurons, txo cov neuronal apoptosis thiab beta amyloid outition. Tej zaum nws yuav ua tiav los ntawm kev txhawb nqa neuronal ciaj sia, txo tus ntxhiab, thiab txo cov kev tso tawm.

Cov txiaj ntsig ntawm cistanche tubulosa-inhibit tyrosinase hais tawm

(2) anti atherosclerotic effectic
Piloside ua si lub hom phiaj atherosclerotic los ntawm kev tswj hwm cov metabolism ntawm glyciac phospholipids nyob rau hauv daim siab. Tom qab 16 lub lim tiam ntawm kev noj haus muaj rog muaj roj ntau, cov pab pawg ua haujlwm tseem ceeb rau cov roj av chocolate (TC), thiab cov roj (LDL) Pib txij plaub lub lim tiam ntawm kev tiv thaiv kev noj tshuaj, muaj koob tshuaj ntau rau cov txheej txheem rau (293)%)% rau (16.74) rau (10.84 ± 1.23)%. Ib qho ntxiv, tom qab 12 lub lis piam ntawm kev kho sib txawv, piv nrog cov qauv kev hloov pauv tsis tau muaj ldl-c, thaum tsis muaj cov roj av cholesterol high-ripoprotein)
H & E staining cov txiaj ntsig tau pom tias muaj kev txo qis ntawm cov teepid tee, thiab txo qis mob infiltration hauv pawg kho mob. Piv nrog cov pab pawg tswj, cov qib ntawm Aspartate Aminotransferase (LTH Cov pab pawg kho tau muaj peev xwm tswj tau lawv rov qab mus rau qib li qub.
Los ntawm daim siab laspidomics, nws tau pom tias piv rau cov pab pawg tsis muaj 504 Kev tswj hwm ntawm cov tshuaj siab thiab nruab nrab ntawm Verbascoside tuaj yeem tswj hwm 40 thiab 166 cov qib lipid sib txawv. Kev tshawb xyuas ntxiv txoj kev soj ntsuam ntxiv rau ntawm cov lipids sib txawv, qhia tias cov kua qaub sib txawv cuam tshuam nrog cov metabolism micrwipid me me. Maorui Paj Glycoside tuaj yeem tswj hwm metabolic tsis zoo xws li hexatic cheeb tsam, thiab oxidized phosphatidylcholine, thiab oxidized phosphatidylcholine, thiab oxidized phosphatidylcholine, thiab oxidized phosphatidylcholine, thiab oxidized phosphatidylcholine, thiab oxidized phosphatidylcholine, thiab oxidized phospepholine, thiab oxidized phosphatidylcholine, thiab oxidized phospepholine, thiab oxidized phosphatidylcholine, thiab oxidized phospepholine, thiab oxidized phospepholine, rov kho lawv kom tau ib txwm.
Elisa cov txiaj ntsig tau pom tias phospholhonease A2 hauv pawg qauv tau raug txo qis, thaum cov koob tshuaj zoo heev tuaj yeem tswj nws rov qab mus rau theem li qub. Txawm hais tias muaj tsis muaj qhov tseem ceeb nyob rau theem ntawm Lecithin cov roj choltransferase ntawm tus qauv pab pawg thiab pawg tswj hwm ntawm Verbualccoside tau nce ntxiv. Tsis tas li ntawd, qhov tseem ceeb txo qis hauv Lysophosphaatidcholine AcylartSide 3 hauv pawg kho mob qhia tias Verbaside muaj qhov cuam tshuam rau nws. Cov txiaj ntsig saum toj no tau ua raws li cov pab laspid cov txiaj ntsig tau.
4, ntau thaj tsam ntawm daim ntawv thov

(1) kev txhim kho yeeb tshuaj
Vim nws cov tshuaj tua kabmob zoo heev, verbascoside tau pom muaj peev xwm zoo hauv kev tsim cov tshuaj. Kev tshawb fawb tau pom tias Verbascoside muaj qhov ua tau zoo ntawm cov kab mob xws li tus kab mob avian thiab tus kab mob HIV. Piv txwv li, hauv kev kawm txog kis cov kab mob uas muaj zog hauv pawg neeg siv tshuaj muaj zog, thiab cov pov thawj tau zoo dua qub]. Thaum siv cov tshuaj tua kab mob lossis tshuaj tua kab mob, verbascomide muaj cov nyhuv synigistic uas tuaj yeem txhim kho lawv cov txiaj ntsig kho kom zoo. Ntxiv mus, lub qhov muag ntuj, cov tshuaj lom tsawg, thiab cov kev xaiv tsis tshua muaj kev sib kis tau xws li cov menyuam yaus, cov poj niam cev xeeb tub, thiab cov neeg laus.

cistanche ntxiv nyob ze kuv

(2) Cov Khoom Noj Ntxiv
Daim ntawv thov kev cia siab ntawm Verbascoside hauv thaj teb ntawm cov zaub mov muaj ntxiv kuj tseem muaj ntau yam. Nws muaj antioxidant, txuag hluav taws xob, thiab ua kom zoo dua qub, uas tuaj yeem txuas ntxiv rau lub txee lub neej xws li nqaij, ntses, thiab txiv hmab txiv ntoo. Raws li kev txheeb cais, cov zaub mov nrog ntxiv vrebascoside muaj qhov nruab nrab ncua txee lub neej lub neej [sijhawm tshwj xeeb]. Lub caij no, Verbascoside tuaj yeem txhim kho cov saj thiab zaub mov muaj txiaj ntsig ntawm cov zaub mov. Piv txwv li, hauv cov nqaij cov khoom, verbarcoside tuaj yeem txo cov rog oxidation thiab ua kom cov nqaij tshiab thiab muaj siab tawv nqaij; Hauv cov txiv hmab txiv ntoo, nws tuaj yeem ncua cov txheej txheem ripening, tswj cov qab zib thiab cov ntsiab lus vitamin ntawm cov txiv hmab txiv ntoo. Cov txiaj ntsig zoo ua rau koj muaj cov ntawv thov tseem ceeb hauv kev lag luam khoom noj.
(3) Kev Zoo Nkauj thiab Kho Mob
Hauv kev tshav pob ntawm kev zoo nkauj thiab kev noj qab haus huv, verbarcoside tseem muaj kev xav. Nws muaj antioxidant thiab anti-anti-anti-anti-antiing cuam tshuam, uas tuaj yeem txhim kho cov tawv nqaij elasticity thiab radiance ntawm daim tawv nqaij thiab cov xim rigisces, thiab ncua kev laus ntawm daim tawv nqaij. Kev tshawb nrhiav tau pom tias Verbascoside yog cov nplua nuj nyob rau hauv polyphenolic active compounds, uas tuaj yeem txo cov kev ua kom dawb huv, pab rau tus tawv nqaij tiv thaiv sab nraud stimuli. Hauv kev sim tshuaj ntsuam ntawm cov khoom lag luam zoo nkauj, cov neeg siv uas tau siv cov khoom sib xws ntawm daim tawv huv (cov ntaub ntawv tshwj xeeb], txo pob thiab pigmentation me ntsis. Verbarcoside tau dhau los ua kev nyiam tshiab hauv kev zoo nkauj thiab kev noj qab haus huv, muab cov neeg muaj kev xaiv tshiab rau nrhiav kev zoo nkauj thiab kev noj qab haus huv.