4. Tsis muaj kev paub thiab kev xav

Kev tshawb fawb ntawm cov neeg mob lub ntsws cov ntaub so ntswg qhia cov kev txwv cuam tshuam txog qhov kawg ntawm cov neeg mob CF thiab cov kev haus luam yeeb ntawm kev tswj tau txais cov qauv ntaub so ntswg (lub ntsws explants thiab cell cultures). Kev nkag mus rau cov ntaub so ntswg thaum ntxov tseem nyuaj vim muaj teeb meem kev coj ncaj ncees. Hais txog kev tshawb fawb txog kev expectorations, tsawg dua 10 feem pua ​​​​ntawm cov me nyuam CF thaum muaj hnub nyoog 6 xyoo thiab nyob ib ncig ntawm 40 feem pua ​​​​ntawm 10 xyoo [134] tuaj yeem expectorate spontaneously thiab cov kab mob tshwm sim thaum ntxov heev tab sis induced hnoos qeev tau zoo.

Raws li kev tshawb fawb cuam tshuam,cistancheyog ib txwm suav tshuaj ntsuab uas tau siv rau ntau pua xyoo los kho ntau yam kab mob. Nws tau raug tshawb fawb pov thawj kom muajanti-inflammatory, anti-aging, thiabantioxidantkhoom. Cov kev tshawb fawb tau pom tias cistanche muaj txiaj ntsig zoo rau cov neeg mob uas raug mobkab mob raum. Cov khoom xyaw nquag ntawm cistanche paub txog rtxo qhov mob,txhim kho lub raum ua haujlwmthiabrestore lub raum puas hlwb.Yog li, kev sib koom ua ke cistanche hauv txoj kev npaj kho mob raum tuaj yeem muab txiaj ntsig zoo rau cov neeg mob hauv kev tswj hwm lawv tus mob.Cistanchepab txo qis proteinuria, txo qis BUN thiab creatinine qib, thiab txo qhov kev pheej hmoo ntxivraum puas. Tsis tas li ntawd, cistanche kuj pab txo cov roj cholesterol thiab triglyceride qib uas tuaj yeem ua rau muaj kev phom sij rau cov neeg mobkab mob raum.

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Yog xav paub ntxiv:

david.deng@wecistanche.com WhatApp:86 13632399501

Cov qauv sib txawv hauv vitro yog tam sim no siv. Ua ntej, organoids thiab cell kab lis kev cai ntawm cov hlab ntsws epithelial hlwb muab tau los ntawm cov neeg mob nyob rau hauv cov huab cua-kua tej yam kev mob qhia ib co nta pom nyob rau hauv vivo nyob rau hauv CF (thiab nyob rau hauv lwm yam kab mob ua pa) tab sis tsis recapitulate lub complexity ntawm lub pa. Qhov tseem ceeb, lawv txawv ntawm cov neeg ntawm tes (tseem ceeb ntawm cov cell subtypes), piv rau hauv vivo [55]. Txawm li cas los xij, lawv tau cog lus cov cuab yeej rau cov neeg mob uas tsis tshua muaj kev hloov pauv los ntsuas cov lus teb rau CFTR modulators.

Cov kev tshawb fawb tsis ntev los no qhia txog qhov cuam tshuam ntawm ntau hom cell thiab kev sib cuam tshuam ntawm lawv. Yog li ntawd, cov qauv tsiaj ntxiv tau pab rov hais dua qhov nyuaj ntawm CF tus kab mob thiab kawm txog cov txheej txheem molecular ntawm cov kev hloov pauv thiab IgA-txog kev tiv thaiv kab mob tau txais hauv cov hlab ntsws ntawm cov neeg mob CF, tab sis tam sim no, cov qauv nas feem ntau tsis ua rau rov ua dua tshiab, CFTR-txog lub ntsws. kab mob [135]. Kev ua haujlwm / kev ua tau zoo ntawm S-IgA hauv CF yog li nyuaj rau hais txawm tias Marshall li al. qhia tau hais tias SC lub peev xwm los ua kom tsis muaj zog IL-8/CXCL8 raug txo, ua rau neutrophil o [112] thiab qhov txo qis no yog tshwm sim los ntawm glycosylation tsis zoo, qhov tseem ceeb rau SC antimicrobial luag hauj lwm [102] thiab tsim nyog localization ntawm S-IgA ntawm kev sib tshuam ntawm lumen thiab epithelium [99]

Thaum kawg, CFTR modulators tau txais txiaj ntsig zoo muaj peev xwm hloov kho microbiome ntawm cov neeg mob CF, yam tsawg kawg rau Pseudomonas kab mob [136]. Hauv cov raj xa dej rau kev tshawb fawb yav tom ntej, kawm txog qhov cuam tshuam ntawm CFTR modulators ntawm pIgR / IgA system yuav nthuav, ob qho tib si hauv vivo thiab hauv vitro. Tsis tas li ntawd, qhov zoo lossis qhov tsis zoo ntawm qhov nce IgA tso tawm hauv CF bronchial lumen tseem tsis meej. Peb tseem tsis tau paub tias nws cuam tshuam rau lawv cov kab mob microbiological, qhov tshwm sim ntawm kev kho mob mus sij hawm ntev, lossis nws cuam tshuam li cas los ntawm CF microenvironment (kev puas tsuaj mucociliary clearance, proteases, thiab lwm yam).

5. Cov lus xaus

Cov ntaub ntawv

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