Siv Lub Hwj Chim Ntawm Cistanche Tubulosa: Tshawb Nrhiav Nws Lub Luag Haujlwm hauv Kev Txhim Kho Kev Tiv Thaiv

Apr 22, 2024

Taw qhia:

Cistanche tubulosa, tshuaj ntsuab revered nyob rau hauv tsoos suav tshuaj, tau ntev tau muaj nuj nqis rau nws lub peev xwm los txhawb kev noj qab haus huv thiab tseem ceeb heev. Nrog rau keeb kwm nplua nuj ntawm kev siv ntau pua xyoo, cov nroj tsuag suab puam no tau txais kev saib xyuas ntau ntxiv nyob rau xyoo tas los no rau nws lub peev xwm rautxhim khu kev tiv thaiv. Lub hauv paus rau nws txoj kev kho mob zoo yog ntau yam ntawm cov khoom xyaw bioactive pom nyob rau hauv Cistanche tubulosa, txhua tus pab txhawb rau nws cov teebmeem immunomodulatory.

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1. Cistanche Tubulosa thiab nws cov khoom xyaw:

Cistanche tubulosa, feem ntau hu ua "Rou Cong Rong" lossis "Desert Hyacinth," yog cov nroj tsuag suab puam uas nyob hauv tsev neeg Orobanchaceae. Nws yog dav faib nyob rau hauv arid cheeb tsam ntawm Tuam Tshoj, Mongolia, thiab lwm qhov chaw ntawm Central Asia. Cov tshuaj ntsuab tau siv ib txwm siv hauv Suav tshuaj los txhawb kev ua neej ntev, ntxiv dag zog rau lub cev, thiab txhim kho qhov tseem ceeb.

Cov cuab yeej kho mob ntawm Cistanche tubulosa yog ntaus nqi los ntawm nws cov khoom sib txawv ntawm cov khoom xyaw bioactive, suav nrog phenylethanoid glycosides, polysaccharides, oligosaccharides, iridoids, lignans, flavonoids, amino acids, terpenoids, sterols, thiab kab noj hniav. Txhua qhov sib xyaw ua ke ua lub luag haujlwm tshwj xeeb hauv kev txhawb nqa ntau yam ntawm kev noj qab haus huv thiab kev noj qab haus huv, suav nrog kev tiv thaiv kab mob.

2. Kev ua haujlwm ntawm Cistanche Tubulosa hauv kev txhim kho kev tiv thaiv:

2.1 Phenylethanoid Glycosides:

Phenylethanoid glycosides, xws liechinacoside thiab acteoside, yog cov tseem ceeb ntawm Cistanche tubulosa nrog lub zog immunomodulatory zog. Cov tebchaw no tau pom tias yuav txhim khu kev tiv thaiv kab mob los ntawm kev txhawb nqa kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li macrophages, T hlwb, thiab cov neeg tua neeg ntuj (NK) hlwb. Tsis tas li ntawd, phenylethanoid glycosides muaj cov tshuaj tua kab mob antioxidant thiab tiv thaiv kab mob, uas pab tiv thaiv oxidative kev nyuaj siab thiab txo qhov mob, yog li txhawb kev tiv thaiv kab mob.

Kev tshawb fawb tau pom tias echinacoside, ib qho loj phenylethanoid glycoside pom nyob rau hauv Cistanche tubulosa, tuaj yeem txhim kho kev tsim cov cytokines, xws li interleukin -2 (IL-2) thiab interferon-gamma (IFN- ), uas yog qhov tseem ceeb. lub luag haujlwm hauv orchestrating lub cev tiv thaiv kab mob. Ib txoj kev tshawb fawb luam tawm nyob rau hauv "Journal of Ethnopharmacology" tau tshawb xyuas cov teebmeem ntawm immunomodulatory ntawm echinacoside hauv cov nas thiab pom tias kev kho mob nrog echinacoside ua rau muaj kev nce ntxiv ntawm IL-2 thiab IFN-, uas ua rau kev txhim kho kev tiv thaiv kab mob.

Ib yam li ntawd, acteoside tau pom tias muaj cov teebmeem immunostimulatory los ntawm kev txhim kho cov haujlwm ntawm lub cev tiv thaiv kab mob thiab txhawb kev tsim cov cytokines. Ib txoj kev tshawb fawb luam tawm nyob rau hauv "Pharmacological Research" tau tshawb xyuas cov kev ua haujlwm immunomodulatory ntawm acteoside hauv vitro thiab pom tias kev kho mob nrog acteoside nce kev loj hlob ntawm T hlwb thiab txhim kho kev tsim tawm ntawm IL-2 thiab qog necrosis factor-alpha (TNF- ), qhia nws lub peev xwm ua tus neeg sawv cev immunomodulatory.

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2.2 Polysaccharides:

Polysaccharides yog complex carbohydrates pom nyob rau hauv Cistanche tubulosa uas muaj zog immunomodulatory zog. Cov tebchaw no tau pom tias txhim khu kev tiv thaiv kab mob los ntawm kev ua kom lub cev tiv thaiv kab mob, txhawb phagocytosis, thiab hloov kho cytokine ntau lawm. Tsis tas li ntawd, polysaccharides muaj cov tshuaj tua kab mob antioxidant thiab tiv thaiv kab mob, uas pab tiv thaiv oxidative kev nyuaj siab thiab txo qhov mob, yog li txhawb kev tiv thaiv kab mob.

Kev tshawb fawb tau pom tias polysaccharides muab rho tawm los ntawm Cistanche tubulosa tuaj yeem txhim kho kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li macrophages thiab dendritic hlwb, ua rau kev txhim kho kev tiv thaiv kab mob. Ib txoj kev tshawb fawb luam tawm hauv "Food Chemistry" tau tshawb xyuas cov tshuaj tiv thaiv kab mob ntawm polysaccharides cais tawm ntawm Cistanche tubulosa hauv cov nas thiab pom tias kev kho mob nrog polysaccharides ua rau muaj zog phagocytic kev ua ntawm macrophages thiab txhim kho kev tsim cov cytokines, xws li interleukin -6 (IL -6) thiab qog necrosis factor-alpha (TNF- ), qhia tias nws muaj peev xwm ua tus neeg sawv cev tiv thaiv kab mob.

2.3 Oligosaccharides:

Oligosaccharides yog luv-chain carbohydrates pom nyob rau hauv Cistanche tubulosa uas muaj immunomodulatory zog. Cov tebchaw no tau pom tias txhim khu kev tiv thaiv kab mob los ntawm kev txhawb nqa kev ua haujlwm ntawm lub cev tiv thaiv kab mob, txhawb phagocytosis, thiab hloov kho cytokine ntau lawm. Tsis tas li ntawd, oligosaccharides muaj cov tshuaj tua kab mob antioxidant thiab tiv thaiv kab mob, uas pab tiv thaiv oxidative kev nyuaj siab thiab txo qhov mob, yog li txhawb kev tiv thaiv kab mob.

Kev tshawb fawb tau pom tias oligosaccharides muab rho tawm los ntawm Cistanche tubulosa tuaj yeem txhim kho cov haujlwm ntawm lub cev tiv thaiv kab mob, xws li macrophages thiab dendritic hlwb, ua rau kev txhim kho kev tiv thaiv kab mob. Ib txoj kev tshawb fawb luam tawm hauv "Carbohydrate Polymers" tau tshawb xyuas cov tshuaj tiv thaiv kab mob ntawm oligosaccharides cais tawm ntawm Cistanche tubulosa hauv cov nas thiab pom tias kev kho mob nrog oligosaccharides ua rau muaj kev tsim cov cytokines, xws li interleukin -10 (IL-10) thiab interleukin-12 (IL-12), qhia nws lub peev xwm ua tus neeg sawv cev tiv thaiv kab mob.

Ib yam li ntawd, oligosaccharides tau pom los ua pov thawjantioxidant thiab anti-inflammatory teebmeem, uas pab tiv thaiv oxidative kev nyuaj siab thiab txo qhov mob, yog li txhawb kev tiv thaiv kab mob. Ib txoj kev tshawb fawb luam tawm nyob rau hauv "International Journal of Biological Macromolecules" tshawb xyuas cov kev ua haujlwm antioxidant ntawm oligosaccharides muab rho tawm los ntawm Cistanche tubulosa thiab pom tias cov khoom sib xyaw no tau nthuav tawm muaj zog dawb radical-scavenging kev ua si thiab inhibited lipid peroxidation, qhia lawv lub peev xwm ua cov tshuaj tiv thaiv kab mob.


2.4 Terpenoids:

Terpenoids yog ib chav kawm sib txawv ntawm cov tshuaj muaj nyob hauv Cistanche tubulosa nrog ntau yam tshuaj, suav nrog cov khoom siv tshuaj tiv thaiv kab mob. Cov tebchaw no tau pom tias txhim khu kev tiv thaiv kab mob los ntawm kev ua kom lub cev tiv thaiv kab mob, xws li macrophages thiab lymphocytes, thiab hloov kho cytokine ntau lawm. Tsis tas li ntawd, terpenoids muaj cov tshuaj tua kab mob antioxidant thiab tiv thaiv kab mob, uas pab tiv thaiv oxidative kev nyuaj siab thiab txo qhov mob, yog li txhawb kev tiv thaiv kab mob.

Kev tshawb fawb tau pom tias terpenoids muab rho tawm los ntawm Cistanche tubulosa tuaj yeem txhim kho cov haujlwm ntawm lub cev tiv thaiv kab mob, xws li macrophages thiab lymphocytes, ua rau kev txhim kho kev tiv thaiv kab mob. Ib txoj kev tshawb fawb luam tawm hauv "Phytomedicine" tau tshawb xyuas cov tshuaj tiv thaiv kab mob ntawm terpenoids cais tawm ntawm Cistanche tubulosa hauv cov nas thiab pom tias kev kho mob nrog terpenoids ua rau muaj kev loj hlob ntawm cytokines, xws li interleukin -4 (IL-4) thiab interleukin. -10 (IL-10), qhia nws lub peev xwm ua tus neeg sawv cev immunomodulatory.

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2.5 Cov roj ntsha:

Sterols yog lwm chav kawm ntawm cov tebchaw pom muaj nyob hauv Cistanche tubulosa uas muaj cov cuab yeej immunomodulatory. Cov tebchaw no tau pom tias txhim khu kev tiv thaiv kab mob los ntawm kev ua kom lub cev tiv thaiv kab mob, xws li macrophages thiab lymphocytes, thiab hloov kho cytokine ntau lawm. Tsis tas li ntawd, sterols muaj cov tshuaj tua kab mob antioxidant thiab tiv thaiv kab mob, uas pab tiv thaiv oxidative kev nyuaj siab thiab txo qhov mob, yog li txhawb kev tiv thaiv kab mob.

Kev tshawb fawb tau pom tias sterols muab rho tawm los ntawm Cistanche tubulosa tuaj yeemtxhim khu kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li macrophages thiab lymphocytes, ua rau kev txhim kho kev tiv thaiv kab mob. Ib txoj kev tshawb fawb luam tawm nyob rau hauv "International Immunopharmacology" tau tshawb xyuas cov teebmeem immunomodulatory ntawm sterols cais los ntawm Cistanche tubulosa hauv cov nas thiab pom tias kev kho mob nrog cov tshuaj sterols ua rau muaj kev loj hlob ntawm cytokines, xws li interleukin -12 (IL-12) thiab interferon-gamma (IFN-), qhia nws lub peev xwm ua tus neeg sawv cev tiv thaiv kab mob.

Xaus:

Hauv kev xaus, Cistanche tubulosa tuav cov lus cog tseg loj heev rautxhim khu kev tiv thaivthiab txhawb kev noj qab haus huv thiab kev noj qab haus huv tag nrho. Cov khoom xyaw sib txawv ntawm cov khoom xyaw bioactive pom nyob rau hauv Cistanche tubulosa, suav nrog phenylethanoid glycosides, polysaccharides, thiab oligosaccharides, sib sau ua ke rau nws cov tshuaj tiv thaiv kab mob los ntawm kev ua kom lub cev tiv thaiv kab mob, txhawb phagocytosis, modulating cytokine ntau lawm, thiab txo oxidative kev nyuaj siab. Los ntawm kev siv lub zog ntawm Cistanche tubulosa, peb tuaj yeem qhib nws lub peev xwm ua ib qho kev kho mob rau kev tiv thaiv kab mob thiab tiv thaiv kab mob. Kev tshawb fawb ntxiv yuav tsum tau ua kom paub meej cov txheej txheem ntawm kev ua haujlwm thiab ua kom zoo rau cov tswv yim kho mob kom ua tiav cov tshuaj tiv thaiv kab mob ntawm Cistanche tubulosa.

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