Fucoxanthin Inhibits Cov Kab Mob Kab Mob tshwm sim los ntawm hluav taws xob

Hu rau: Audrey Huaudrey.hu@wecistanche.com

Ntu Ⅱ: Fucoxanthin hloov cov apelin -13/APJ txoj hauv kev hauv qee lub cev ntawm -irradiated nas

Nermeen M. El Bakary, Noura Magdy Thabet & et al.

Kev sib tham

Lub hom phiaj ntawm kev kawm tam sim no yogFucoxanthin(FX), vim nws cov khoom siv bioactive; peb tau tshuaj xyuas nws qhov kev txiav txim tawm tsam RAD raug cuam tshuam los ntawm kev hloov pauv hauv apelin-13/APJ txoj hauv kev uas tuaj yeem cuam tshuam lossis cuam tshuam los ntawmmobcov tshuaj tiv thaiv thiab kev hloov pauv hauv cov xwm txheej redox.

Cov ntaub ntawv ntawm txoj kev tshawb fawb tam sim no tau pom tias raug nas mus rau IR ua rau muaj kev cuam tshuam zoo kawg nkaus hauv oxidative lub nra hauv daim siab, ob lub raum, lub ntsws, thiab cov nqaij mos uas tau tshwm sim los ntawm kev tswj hwm ntawm hypoxia biomarker, HIF{{1 }}a, nce hauv MDA (qhov kawg-cov khoom ntawm lipid peroxidation) thiab txo cov cim antioxidant (GSH-PX thiab GSH). Cov ntaub ntawv no tau cuam tshuam nrog kev nce siab ntawm pro-mobmolecules(MCP-1 thiab IL-6) nyob rau hauv cov ntaub so ntswg kuaj, down-regulation nyob rau hauv lub splenic -7nAchR, thiab cuam tshuam nyob rau hauv lub systemicmobmediators (TNF-, IL-1, CRP, thiab IL-10). Cov kev tshawb pom no tau txais kev txhawb nqa los ntawm kev tshawb nrhiav histopathological, qhov kev hloov pauv hauv cov qauv ntawm cov ntaub so ntswg uas teb rau oxidative puas tsuaj thiabmobyog pom tseeb.

Cov txiaj ntsig no tuaj yeem raug ntaus nqi rau txoj kev loj hlob ntawm oxidative kev nyuaj siab, ib qho xwm txheej uas tshwm sim los ntawm ntau tiam ntawm ROS los yog malfunction ntawm cov tshuaj tiv thaiv antioxidant. Yahyapour li al[1] tau tshaj tawm tias o thiab oxidative puas tsuaj muaj feem xyuam rau IR raug. Chatterjee[9] qhia tias kev loj hlob mus ntevmobthiab oxidative kev nyuaj siab yog cuam tshuam rau ntau yam ntawm cov txheej txheem pathological thiab tuaj yeem ua rau muaj kab mob txaus ntshai.Hluav taws xob-induced mob ntsws los ntawm post-hluav taws xobhypoxia yog qhov ua rau muaj kev sib haum xeeb tsis tu ncua ntawm ROS, kev nce hauv leukocyte tsiv teb tsaws, vascular permeability, stimulation ntawm collagen tsim, thiab nce-txoj cai ntawm kev tso tawm ntawmmobcytokines los ntawm ntau lub hlwb xws li endothelial hlwb, alveolar macrophages, pneumocytes, thiab fibroblasts [29]. Cov ntaub ntawv ntawm kev tshawb fawb tam sim no yuav qhia tau tias muaj mob hypoxia. Kev nce ntawm HIF-l hauv cov ntaub so ntswg ntawm cov nas irradiated tuaj yeem qhia qhov tshwm sim ntawm hypoxia tom qab.hluav taws xobraug, uas tuaj yeem koom nrog hauv kev txhim kho oxidative kev nyuaj siab thiabmob. Txoj kev tshawb no ntawm Azab et al [30] tau hais tias raug y-kuj tawg ua rau exaggerated ROSformation thiab coj cov irradiated hlwb mus rau ib tug mob ntawm oxidative kev nyuaj siab uas tau cuam tshuam nyob rau hauv ntau yam txheej txheem ntawm ntuj thiab pathological keeb kwm. Qhov no overproduction ntawm ROS yog nrog los ntawm kev txo cov cellular antioxidant kev ua ub no thiab lipid peroxidation, protein oxidation indices, thiabmobcov cim nyob rau hauv daim siab ntawm irradiated nas. Hauv kev tshawb fawb ntawm Moustafa thiab Thabet [31], irradiation ntawm nas los ntawm y-rays (6 Gy) nce qib MDA thiab txo cov enzymes antioxidant|superoxide dismutase (SOD) thiab catalase (CAT)] thiab thaum kawg ua rau daim siab puas tsuaj. . Tsis tas li ntawd, qhov tshwm sim ntawm cov ntaub so ntswg ntawm lub hlwb mus rau 5 Gy ntawm y-hluav taws xobnce MDA, IL-1 , thiab IL-6, ua ke nrog abrogated antioxidant enzyme kev ua (glutathione S-transferase) uas ua rau lub hlwb raug mob [32].

Nws yog ib qho tseem ceeb uas cov -6 tsim los teb rau daim siab thiab lub raum raug mob yog lub teeb liab nyob rau hauv cov ntaub ntawv ntawm cov nqaij puas tsuaj[33-35].TheIL 6 ua nyob rau hauv teb rau lub raum puas ncaj qha ua raumobthiab raug mob rau lub ntsws cov ntaub so ntswg35], uas zoo ib yam nrog cov txiaj ntsig tau pom hauv txoj kev tshawb fawb tam sim no. Txawm li cas los xij, IL-6 activates splenocytes los tsim IL-10 ntawm -7nAchR uas yuav tsum tau ua kom kub hnyiab cov ntaub so ntswg, raws li qhia nyob rau hauv txoj kev tshawb no ntawm Kinsey [35]. Cov y-irradiationmicroenvironment tuaj yeem coj qhov kev ua kom tsis tu ncua ntawm IL. 6 nyob rau hauv cov ntaub so ntswg thiab systemic pro-mobCov neeg kho kom haum xeeb (TNF- thiab IL-1 ) ua rau muaj kev puas tsuaj ntau dua li tsis muaj txiaj ntsig, raws li pom los ntawm kev txo qis ntawm splenic -7nAchR thiab L-10 qib raws li tau pom hauv txoj kev tshawb fawb tam sim no. Txhawb nqa qhov kev pom no, Linard et al. [36] hais tias tom qab tag nrho lub cev y-irradiationntawm nas ntawm 10 Gy, cascades ntawmmobCov lus teb tau raug ntxias los ntawm kev nce ntxiv ntawm IL-6 thiab IL.8 cuam tshuam nrog kev txo qis hauv qib IL-10. Tsis tas li ntawd, Galal et al [37] tau hais tias 7 Gy ntawm y-hluav taws xobnce cov biomarkers ntawm hepatotoxicity thiab txo qis ROS-detoxifying enzymes nyob rau hauv daim siab thiab spleen txuam nrog down-regulation ntawm splenic -7nAchR.Qhov down-regulation ntawm splenic -7nAchR nyob rau hauv cov pab pawg neeg RAD tej zaum yuav muaj feem xyuam. rau cumulative pro-mobthiab poobanti-mobcytokine tso tawm los ntawm NF-KB txoj hauv kev [38]. Tsis tas li ntawd, Wang et al. [39] qhia tau hais tias raug tib neeg umbilical leeg endothelial hlwb rau y-hluav taws xobcuam ​​tshuam cov cellular junctions los ntawm kev ua kom lubmobNF-kB kev taw qhia txoj kev tshwm sim los ntawm kev txhim kho ntawm oxidative thiab nitrosative stresses thiab nce hauv cytokines IL-6 thiab TNF- .

Hauv kev sib piv, kev tswj hwm ntawm ntau koob tshuaj FX (Fucoxanthin) ua ntej y-hluav taws xobnthuav tawm hauv FX (Fucoxanthin)ntxiv rau RAD pab pawg txo qis qhov cuam tshuam hauv oxidant / antioxidant tiv thaiv kab mob thiab pro-/tshuaj tiv thaiv kab moby sib npaug raws li pom nyob rau hauv txoj kev tshawb no. Qhov tshwm sim no yuav yog vim muaj peev xwm antioxidant ntawm FX (Fucoxanthin). Rodrigues et al.40| qhia tias FX (Fucoxanthin), marine carotenoid, muaj lub peev xwm dawb radical-scavenging uas piav qhia nws lub peev xwm antioxidant. Cov peev txheej no tuaj yeem suav nrog nws qhov tshwj xeeb allenic daim ntawv cog lus thiab 5, 6-monoepoxide uas yog qhov tseem ceeb rau kev tshem tawm dawb radicals thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj los ntawm H2O2 thiab UV-B [41]. FX (Fucoxanthin)tau pom kev txhim kho hauv cov qauv kev raug mob ntawm lub hlwb los ntawm kev txo qis MDA cov ntsiab lus thiab rov ua haujlwm ntawm GSH-PX [15]. Nws tuaj yeem ua rau nws cov teebmeem cytoprotective tawm tsam H2O2 oxidative raug mob hauv L02 hlwb (ib txwm tib neeg lub siab kab mob hlwb) los ntawm phosphatidylinositol 3-kinase-dependent induction ntawm Nrf-2(nuclear-factor erythroid ntsig txog yam tseem ceeb{{9 }}) kev taw qhia uas tau tshwm sim los ntawm kev txo qis ntawm LDH thiab intracellular ROS nrog txhim kho intracellular GSH 42|. FX (Fucoxanthin)yog lub luag haujlwm rau kev hloov kho ntawm cellular redox tone thiabmobuas tau pom nyob rau hauv daim siab ntawm irradiated nas ntawm 8 Gy ntawm fractionated (2 Gy × 4; 2 Gyevery3 hnub) Y-rays ntawm kev tswj ntawm TNF- qib, MDA ntau lawm, thiab khaws cia ntawm GSH concentration|43]. Thiab, FX (Fucoxanthin)restores qhov txo qis antioxidant system (GSH, GSH-PX, SOD, thiab CAT) thiab inhibits theem siab ntawm tiam.mobmolecules IL-1 thiab TNF- uas txuas rau kev rog [44]. Tsis tas li ntawd, Grasa-Lopezet al|45| qhia tias FX (Fucoxanthin)muaj kev vam meej los ntawm kev nce covanti-inflammatorycytokine adiponectin thiab txo qis cov pro-inflammatory cytokines leptin thiab CRP. Anti-inflammatory nyhuv ntawm FX (Fucoxanthin)Tej zaum yuav raug ntaus nqi los ntawm inhibition ntawm NF-kB induction thiab kev tawm tsam ntawm mitogen-activated protein kinase (MAPK) phosphorylation uas ua rau txo qis qib ntawm pro-mobCov neeg nruab nrab uas muaj NO, prostaglandin E2, IL-1 , TNF- thiab IL-6hauv lipopolysaccharide-stimulated murine macrophage cells[14].

Cov protein qhia ntawm apelin -13/APJ/NF-KB txoj hauv kev tau nce hauv daim siab, lub raum, lub ntsws, thiab cov nqaij mos ntawm cov nas irradiated ib txhij nrog kev loj hlob ntawm oxidative kev nyuaj siab thiabmob, raws li pom nyob rau hauv txoj kev tshawb fawb tam sim no. Qhov nce pom nyob rau hauv apelin -13, API thiab NF-K B protein qhia tuaj yeem suav nrog qhov ua tau zoo heevmobCov neeg kho kom haum xeeb xws li IL-6 lossis kev txhim kho ntawm oxidative kev nyuaj siab vim yog qhov loj ntawm MDA tsim los teb rau cov khoom siv ntau dhau ROS hauv cov ntaub so ntswg vimhluav taws xobnphav. Han et al. [46] qhia tias lubmob-induced nce nyob rau hauv apelin mRNA qhia tau kho los ntawm IL-6 thiab interferon-y los ntawm stimulation ntawm apelin promoter kev ua, uas nyob rau hauv lem tau kho los ntawm JAK/STAT txoj kev. Helmi et al. 47] tau piav qhia tias qhov kev puas tsuaj rau lub plawv tau pom thaum lub sijhawm ua haujlwm tsis zoo hauv lub cev yog vim qhov nce ntawm cov txheeb ze apelin mRNA qhia, qib MDA siab, thiab nce ntau hauv kev tsim ntawm ROS thaum lub sijhawm hypoxia. Txoj cai ntawmmobCov neeg nruab nrab thiab kev ua kom NF-xB yog cov xwm txheej tseem ceeb tom qab cov txheej txheem inflammatory. Xu et al[48] tau tsim tias qhov kev hloov pauv ntawm NF-xB tau tswj hwm cov lus teb ntawm tes loj rau kev ntxhov siab thiab raug mob los ntawm kev ua kom cov cytokines (xws li TNF- thiab IL-1) thiab oxygen-dawb radicals. Kev khi ntawm apelin -13 rau nws cov receptor APJ tuaj yeem ua rau qhov kev qhia ntawm qhov kev hloov pauv ntawm NF-KB, uas ua rau muaj kev cuam tshuam qhov tshwm sim ntawm chemotactic pro-inflammatory molecule MCP-1 [49,50] thiab cuam tshuam nrog down-regulation ntawm -7nAchR protein qhia [38].

Covanti-mobeffect FX (Fucoxanthin)tawm tsam y-hluav taws xob-induced ntaub so ntswgmobtuaj yeem txhais los ntawm nws lub peev xwm los tswj lub apelin / APJ / NF-kB axis. Cov ntaub ntawv tam sim no tau taw qhia txog qhov tseem ceeb ntawm amelioration hauv apelin / APJ / NF-kB kev taw qhia txoj hauv kev hauv nas uas tau txais FX (Fucoxanthin)thiab tom qab ntawd tau nthuav tawm rau y-hluav taws xob. Nws tuaj yeem xav tias kev tswj hwm ntawm txoj kev taw qhia no yuav raug ntaus nqi rau lub luag haujlwm ntawm NF-KB raws li tus tswj hwm ntawm txoj kev apelin txuas rau kev sib txuas rau apelin qhov inhibition ntawmmobTus neeg nruab nrab nce-txoj cai thiab kev tawm tsam ntawm NF-kB ua kom cov ntaub so ntswg raug kev txom nyem los ntawmmob. Kim et al.|14]and Choi etal51|postulated that FX (Fucoxanthin)Nws muaj txiaj ntsig zoo li kev kho mob los tiv thaiv kab mob vim tias nws inhibitory cuam tshuam ntawm NF-kB ua kom thiab MAPK phosphorylation.

Hauv txoj kev tshawb fawb tam sim no, qhov tsis sib xws ntawm MMP-2, MMP-9, thiab TIMP-1 tau kuaj pom hauv daim siab, lub raum, ntsws thiab tus po ntawm cov nas uas raug y-irradiationpiv nrog cov nas tswj. Qhov no tau nrog kev nce ntxiv hauv LDH kev ua haujlwm hauv txhua lub cev, kev cuam tshuam hauv lub siab ua haujlwm enzymes (raws li qhia los ntawm kev ua haujlwm ntawm AST thiab ALT) thiab lub raum ua haujlwm (raws li qhia los ntawm qib urea thiab creatinine) thiab kev hloov pauv hauv cov khoom siv hauv nruab nrog cev. cov ntaub so ntswg uas tau pom nyob rau hauv cov ntaub so ntswg photomicrographs ntawm pawg RAD. Induction ntawm oxidative kev nyuaj siab,mob, thiab up-regulation ntawm apelin/APJ/NF-kB signaling pathway tom qab y-irradiationtuaj yeem ua rau muaj qhov tshwm sim saum toj no thiab tom qab tawg ntawm lub cev ua haujlwm hauv cov nas irradiated. Yahyapour et al. [1 hais tias qhov xwm txheej ntawm oxidative kev puas tsuaj, ntevmob, thiab nws cov txiaj ntsig uas tshwm sim tom qab IR tuaj yeem cuam tshuam cov haujlwm ntawm cov kabmob irradiated. Galis thiab Khatri52|hais txog qhov tsis sib xws ntawm MMPs thiab TIMPs, thiab kev txhawb nqa ntawm vascular remodeling rau induction ntawm oxidative kev nyuaj siab thiab kev loj hlob ntawmmobteb. Tsis tas li ntawd, Nguyen et al.|53| tau soj ntsuam qhov induction ntawm MMP-2 thiab MMP-9andreduction ntawm TIMP-1 nyob rau hauv teb rau up-regulation ntawm NF-B nyob rau hauv PMA (phorbol 12-myristate 13- acetate)-induced human fibrosarcoma. Tsis tas li ntawd, nyob rau hauv cov neeg mob qog nqaij hlav hauv plab, kev txhim kho ntawm oxidative kev nyuaj siab txhim kho cov cell membrane lipid peroxidation, ua rau muaj kev puas tsuaj ntawm daim nyias nyias permeability thiab to ntawm LDH thiab malate dehydrogenase (MDH) mus rau hauv txoj kev [54]. Lub outflow ntawm cytosolic enzyme LDH muaj feem xyuam rau cellular viability, thiab yog li nws yog ib qho yooj yim ntsuas ntawm membrane puas. Ntau qhov kev tshawb fawb tau lees paub tias LDH yog ib qho cim ntawm kev raug mob ntawm lub cev thiab cuam tshuam nws qhov nce hauv cov ntaub so ntswg nrog oxidative kev nyuaj siab thiabmobtej yam kev mob 55-58]. Yog li, qhov nce hauv LDH uas tau pom nyob rau hauv tag nrho cov kabmob ntawm qhov kev tshawb fawb tam sim no qhia txog kev puas tsuaj ntawm cov kabmob tom qab raug rau y-kawg.

Los ntawm cov ntaub ntawv qhia nyob rau hauv txoj kev tshawb no, FX (Fucoxanthin)kev tswj hwm ua ntej y-hluav taws xobKev raug txo qis oxidative kev nyuaj siab thiab tib lub sijhawm tiv thaiv MMP-2, MMP-9/TIMP-1 imbalance thiab tswj cellular integrity raws li pom tau los ntawm kev txo qis LDH los ntawm daim siab, raum, ntsws thiab spleen ntawm irradiated nas. Cov kev tshawb pom no tuaj yeem suav nrog cov tshuaj antioxidant thiabanti-mobkev ua ntawm FX (Fucoxanthin), uas ua rau muaj kev tswj hwm ntawm apelin -13/API/NF-xB signaling axis raws li yav dhau los txhais. Lub FX (Fucoxanthin)kev tswj hwm txo cov cellular MMP-2 thiab MMP-9 cov dej num ua ke nrog nce hauv cov ntaub so ntswg MMP inhibitors, xws li TIMP-1hauv PMA-induced human fibrosarcoma hlwb ntawm inhibition ntawm NF-kB, JNK thiab p38-MAPK[53]. Tsis tas li ntawd, kev kho ua ntej los ntawm FX (Fucoxanthin)ua rau txo qis ntawm LDH to, txo cov ntsiab lus ntawm intracellular ROS thiab txhim kho intracellular GSH [42]. Qhov inhibition ntawm LDH txo qis hepatic necrosis, apoptosis thiab cov tsos ntawm pro-mobCov neeg kho kom haum xeeb hauv tus qauv nas nrog lub siab tsis ua haujlwm [58] uas tuaj yeem piav qhia txog kev txhim kho uas tau pom hauv lub cev ntawm FX (Fucoxanthin)ntxiv rau RAD pawg. Kev tshuaj xyuas histopathological ntawm daim siab, lub raum, lub ntsws thiab tus po nyob rau hauv qhov kev tshawb fawb tam sim no qhia tias FX (Fucoxanthin)muaj lub peev xwm zoo tshaj plaws hauv xov tooj cua tiv thaiv raws li tau hais los ntawm nws qhov kev txo qis ntawm cov kev hloov pauv tsis zoo tshwm sim los ntawm IR ntawm biochemical profile. Cov ntaub ntawv no tau pom zoo nrog cov ntawm Bharathriraja li al. [59], Zheng HJ et al. [60] thiab Wang et al [61] uas postulated cytoprotective kev ua tau zoo ntawm FX (Fucoxanthin)tawm tsam ntau yam deleterious yam nyob rau hauv ntau yam kabmob thiab ntaus nqi cov teebmeem rau nws cov antioxidant thiabanti-inflammatorykhoom. Ntawm qhov kev ceeb toom, txoj kev tshawb fawb tam sim no tso lub teeb rau ntawm cov txheej txheem tshiab uas tuaj yeem pab txhawb rau cytoprotective kev ua tau zoo ntawm FX (Fucoxanthin)los ntawm kev sib koom ua ke ntawm splenic cholinergicanti-inflammatorynicotinic receptor ( -7nAchR) thiab apelin -13/APJ txoj hauv kev hauv lub cev.

Raws li tau tshaj tawm hauv Mun et al.[62], muaj ntau lub xov tooj cua tiv thaiv uas tau tshawb xyuas nrog cov txheej txheem sib txawv ntawm kev tiv thaiv xws li: bergenin (Caesalpinia digyna) uas ua rau MAPK thiab ERK txoj hauv kev los hloov kho.hluav taws xobkev puas tsuaj; N-acetyl tryptophan glucopyranoside (Bacillus subtilis) uas dhau los ntawm hluav taws xob vim kev puas tsuaj los ntawm kev rov qab cytoprotective cytokines thiab antioxidant enzymes; zymosan A (Saccharomyces cerevisiae) uas tiv thaivhluav taws xob-induced DNA puas los ntawm up-regulating cov theem ntawm cytokines, thiab psoralen nyob rau hauv (Psoralea cory li folia) uas inhibits lub radiation-induced PI3K-IKK-IcB signaling pathway, COX-2 thiab kev qhia ntawm pro-mobcytokines. N-acetyl cysteine ​​​​thiab resveratrol tau pom tias txo DNA kev puas tsuaj los ntawm induction ntawm ntuj antioxidants (GSH, SOD thiab CAT); vitamin C, hauv poly Eglucoside thiab quercetin-3-O-rhamnoside-7-O.glucoside, qhia kev tiv thaivhluav taws xoblos ntawm kev txo qis hauv lipid peroxidation, raws li qhia hauv Smith thiab al 63]. Oh, thiab al|64| qhia tias algal natural khoom xws li tus thawj coj,fucoxanthin tshuaj, astaxanthin, thiab algae extracts muaj radioprotective teebmeem nrog rau radical scavenging thiab antioxidant zog. Txawm li cas los xij, qhov kev tshawb pom tshiab ntawm txoj kev tshawb fawb tam sim no ua rau pom kev tshiab ntawm FX (Fucoxanthin)raws li ib tug radioprotector tiv thaiv y-hluav taws xob-induced puas tsuaj nyob rau hauv lub cev tau kawm los ntawm nws concerted kev cai ntawm apelin/APJ/NF-kB signallingpathwayandsplenic -7nAchR, ib tug thawj receptor ntawm cholinergicanti-inflammatorytxoj kev, raws li nws muaj antioxidant thiabanti-inflammatoryCov teebmeem uas ua rau kev hloov pauv ntawm cov cim kev puas tsuaj (MMP-2, MMP-9, TIMP-1 thiab LDH) thiab kev ua haujlwm ntawm lub cev.

Ua ke, cov txiaj ntsig ntawm kev tshawb fawb tam sim no qhia tiashluav taws xobKev cuam tshuam los ntawm kev cuam tshuam ntawm apelin-13/APJ signaling uas tuaj yeem raug ntaus nqi los ntawm kev cuam tshuam ntawm oxidative kev nyuaj siab (raws li tau tshwm sim hauv txoj kev tshawb no los ntawm kev nce ntawm HIF-1 thiab MDA, thiab txo qis ntawm GSH thiab GSH- PX) as well asmob(raws li tau tshwm sim los ntawm kev nce hauv MCP-1, I-6 thiab NF-KB thiab txo qis hauv IL-10 thiab -7nAchR). Tsis tas li ntawd, qhov nce ntawm oxidative kev nyuaj siab thiabmobCov neeg kho kom haum xeeb tau ua rau muaj kev puas tsuaj hauv cov khoom nruab nrog cev (raws li pom los ntawm kev nce hauv MMP-2, MMP-9 thiab LDH, thiab qhov txo qis hauv TIMP-1 tau lees paub los ntawm kev kuaj mob histopathological). Nyob rau hauv lem, lub kaw lus ua kom apelin signaling nyob rau hauv lub irradiated pab pawg neeg tshwm sim los koom nyob rau hauv lub surge pom nyob rau hauv oxidative kev nyuaj siab thiabmob. Peb tuaj yeem hais tias kev tswj hwm kev tswj hwm ntawm FX (Fucoxanthin)muaj txiaj ntsig zoo tiv thaiv oxidative puas tsuaj thiabmobxwm txheej. Txoj cai ntawm apelin-13/API/NF. kB signaling axis tuaj yeem sawv cev rau lub hauv paus ntawm cov txheej txheem tiv thaiv ntawm FX (Fucoxanthin)tawm tsamhluav taws xobkev phom sij uas ua rau kev puas tsuaj ntawm tes thiab kev ua haujlwm ntawm lub cev. Raws li kev pom zoo. FX (Fucoxanthin)tej zaum yuav siv tau raws li lub peev xwm radioprotector nyob rau hauv cov ntaub ntawv ntawmhluav taws xobnphav.

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