Kev Tshawb Fawb Txog Kev Ua Haujlwm Ntawm Cistanche Tag Nrho Glycosides Ntawm Kab Mob Hlwb Kab Mob Raws Li Kev Siv Tshuaj Kho Mob thiab Tsiaj Tsiaj Ⅳ

4 Kev sib tham

IBD tuaj yeem ua raumob mobthiabulcers ntawm plab hnyuv mucosa, uas tsis tuaj yeem kho tau los ntawm cov tshuaj Western niaj hnub no thiab cuam tshuam rau tus neeg mob lub neej zoo [23-25]. Cov tshuaj suav tshuaj suav hais tias kho cov zaub mov tuaj yeembalance yin thiab yang hauv lub cevthiab pabtxo cov mob plab hnyuv[26]. Cov tshuaj suav tshuaj noj kev noj haus tuaj yeem ua lub luag haujlwm zoo hauv kev pabcuam kev kho mob ntawm cov kab mob plab hnyuv. Cistanche deserticola tuaj yeem siv los ua cov khoom noj noj qab haus huv ib txwm muaj los pab rau hauvkev kho mob ntawm inflammatory kab mob plab.

Kev tshuaj ntsuam xyuas lub network tau pom tias tag nrho cov glycoside Cheebtsam ntawm Cistanche deserticola muaj 254 lub hom phiaj uas muaj kev tiv thaiv ntawm IBD. GO enrichment cov txiaj ntsig tau pom tias Cistanche deserticola tag nrho glycosides 'kev cuam tshuam hauv IBD tuaj yeem cuam tshuam nrog cov teeb liab hloov pauv, protein phosphorylation, kev tswj tsis zoo ntawm cov txheej txheem apoptosis, proteolysis, innate tiv thaiv kab mob, kev tswj hwm zoo ntawm cell proliferation, cell sib txawv, kev cai zoo ntawm DNA template transcription , protein Binding, ATP binding, hlau ion binding, zinc ion binding, protein serine / threonine / tyrosine kinase kev ua, enzyme khi thiab lwm yam kev lom neeg thiab molecular zog. Active ingredient-target-pathway network analysis qhia tau hais tias cov khoom xyaw nquag ntawm Cistanche deserticola tuaj yeem tswj cov kab mob qog noj ntshav, mTOR txoj hauv kev, TGF- txoj hauv kev, JAK-STAT txoj hauv kev, AMPK txoj hauv kev, thiab lwm yam, yog li cuam tshuam rau cell signaling, proliferation, sib txawv, apoptosis, lwm.

Raws li kev txheeb xyuas cov kws tshuaj hauv lub network, DSS-induced IBD nas qauv raug xaiv los simulate cov tsos mob zoo sib xws ntawm cov neeg mob IBD los txheeb xyuas cov txiaj ntsig kev soj ntsuam. Cov kev tshawb fawb uas twb muaj lawm qhia tias TGF- ua thoob plaws

Nws ua lub luag haujlwm tseem ceeb hauv kev tsim thiab tshwm sim ntawm IBD. Kev nthuav qhia loj ntawm TGF- 1 yuav ua rau muaj kev puas tsuaj ntawm epithelial thiab kho qhov txawv txav ntawm txoj hnyuv, myofibroblast proliferation thiab subbasal membrane fibrosis, thaum kawg ua rau muaj qhov tshwm sim ntawm IBD [27]. Raws li ib qho tseem ceeb ntawm cov protein, mTOR yog lub hauv paus tswj kev loj hlob ntawm tes thiab kev loj hlob [28-29]. mTOR tau koom nrog hauv kev tswj hwm ntau cov txheej txheem ntawm tes tseem ceeb, suav nrog kev txhais lus, kev hloov pauv, thiab autophagy. Ntawm lawv, AMPK / mTOR teeb liab txoj hauv kev tuaj yeem sib koom ua ke ntawm tes

Intracellular anabolic thiab catabolic txheej txheem [30-31]. Tsis tas li ntawd, txoj kev AMPK/mTOR kuj tau lees paub tias yog txoj hauv kev tseem ceeb hauv kev tswj hwm tus kab mob IBD [32]. mTOR yog ib qho tseem ceeb downstream signaling molecule ntawm AMPK, uas ua lub luag haujlwm tsis zoo hauv kev tswj hwm ntawm autophagy. TGF- 1 kuj tseem tuaj yeem cuam tshuam autophagy los ntawm kev tswj cov theem qhia ntawm mTOR-txog kev taw qhia txoj hauv kev, thiab tuaj yeem cuam tshuam ncaj qha rau cov hlwb los ntawm kev sib kho SMADS txoj kev taw qhia. mus rau kev tswj cov nyhuv [31, 33]. Qhov kev sim no tsom rau kev txheeb xyuas mTOR thiab TGF-

Kev nthuav qhia ntawm ob lub cim qhia txoj hauv kev noob. Cov txiaj ntsig tau pom tias Cistanche deserticola tag nrho glycosides tuaj yeem txo qhov hnyav thiab fecal los ntshav ntawm cov nas mob, txo qhov qhab nia DAI, thiab inhibit qhov kev qhia ntawm mTOR thiab TGF- signaling pathways hauv tus po. Functional annotation tsom xam ntawm PICRUST2 noob los ntawm 16S rDNA amplicon sequencing ntawm nas quav. Cov txiaj ntsig tau pom tias qhov kev qhia ntawm COG1132, COG0745, COG1131, COG1961, COG0438, COG0534, COG0642, COG1595, COG0463, COG4974, COG2207, COG1136, thiab kev ua haujlwm ntawm cov kab mob COG130 tau nce ntxiv. Tom qab kev cuam tshuam nrog Cistanche deserticola tag nrho glycosides

Qhov kev qhia ntawm 13 noob tau rov qab mus rau qhov qub, thaum COG1028 thiab COG0451 cov noob tau nthuav tawm heev. Nws tau kwv yees tias Cistanche deserticola tag nrho glycosides tuaj yeem tswj hwm lipid metabolism, qabzib metabolism thiab cuam tshuam txog kev tiv thaiv hauv nas.

Cov teeb liab hloov pauv thiab lwm yam txheej txheem kev siv tshuab los daws kev puas tsuaj hauv IBD nas. Cov txiaj ntsig kev sim saum toj no yog qhov pib zoo ib yam li cov kev tshuaj ntsuam xyuas tshuaj hauv network.

Hauv cov ntsiab lus, Cistanche deserticola tag nrho glycosides kho cov kab mob plab hnyuv los ntawm ntau cov khoom, ntau lub hom phiaj, thiab ntau txoj hauv kev sib koom ua ke. Nws lub hom phiaj yuav tsum muaj feem xyuam rau IL2, mTOR, TGF-, JAK-STAT, NF-κB, thiab lwm yam. Nyob rau tib lub sijhawm, cov txiaj ntsig kev sim qhia tau tias Cistanche deserticola tag nrho glycosides tuaj yeem kho cov kab mob inflammatory feem ntau los ntawm inhibiting kev qhia ntawm TGF- thiab mTOR. qhia txoj kev. Enteropathy. Qhov kev sim no muab ib txoj hauv kev tshiab los qhia txog kev kho mob ntawm Cistanche deserticola hauv kev kho IBD. Txawm li cas los xij, nws cov txheej txheem tshwj xeeb thiab cov khoom siv hauv paus xav tau kev tshawb fawb ntau ntxiv.

Cov ntaub ntawv

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[7] Zhou SQ, FENG D, ZHOU Y, et al. Txo cov inflammatory hyperplasia nyob rau hauv txoj hnyuv nyob rau hauv

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