Cov txiaj ntsig ntawm Probiotics Ntawm Cov Kab Mob plab thiab Kab Mob Ntsws hauv Cov Neeg Mob Parkinson's Disease Thiab Constipation Chronic Constipation

Lub 31st European Digestive Disease Week (UEGW) yuav muaj nyob rau hauv Copenhagen, Denmark, txij lub Kaum Hli 14 txog rau 17, 2023. Lub rooj sib tham no tau txais ze li ntawm 2,500 cov lus piav qhia. Cov thawj coj hauv lub rooj sib tham tsis ntev los no tau xaiv 5 cov ntsiab lus nrov tshaj plaws. Tus editor yuav Cov ntsiab lus no tau muab tso ua ke thiab qhia rau cov neeg nyeem. Kab lus no yog plaub qhov kev tshawb fawb nrov tshaj plaws.

Nyem rau qhov zoo tshaj plaws laxative

Kev cuam tshuam ntawm probiotics ntawm lub plab zom mov thiab lub paj hlwb hauv cov neeg mob Parkinson's disease thiab cem quav ntev: kev tshawb nrhiav

Kev cem quav (CC) yog ib qho ntawm feem ntau tsis muaj lub cev muaj zog ntawm tus kab mob Parkinson (PD). Cov kev tshawb fawb yav dhau los tau hais tias CC muaj feem cuam tshuam nrog cov chav kawm thiab qhov hnyav ntawm PD. [1] Tsis tas li ntawd, kev hloov pauv hauv plab hnyuv thiab kev ua haujlwm tsis zoo ntawm lub hlwb lub plab axis (BGA) yog muaj nyob rau hauv PD, thiab cov kev hloov no muaj feem xyuam rau kev kho mob tshwm sim. [2-3] Yog li ntawd, probiotics uas sib npaug plab hnyuv muaj peev xwm ua tau zoo rau cov neeg mob PD.

Lub hom phiaj thiab cov txheej txheem

Lub Hom Phiaj: Txhawm rau ntsuas tus neeg mob siab npaum li cas thiab qhov cuam tshuam ntawm gastroenterological thiab neurological ntawm kev noj cov khoom siv hluavtaws hauv cov neeg mob PD thiab CC.

Txoj Kev: Txoj kev tshawb no suav nrog cov neeg mob uas muaj PD ruaj khov ua ke nrog CC lossis mob plab plob tsis so tswj nrog cem quav (IBS-C) uas tau ua raws li Rome IV cov qauv. Tus neeg mob tau txais 12 lub lis piam ntawm kev kho hluavtaws (Enterolactis®duo, 4 sachets / hnub, muaj cov probiotic Lactobacillus casei thiab prebiotic inulin). Ob lub ntsiab lus kawg raug xaiv los saib xyuas kev txaus siab nrog kev kho mob (SWT).

SWT was defined as patient satisfaction (satisfaction score >4 ntawm 7-point Likert scale) lossis kev txhim kho tom qab kev kho mob (qhov nce hauv ntiaj teb kev hloov pauv qhov qhab nia tsawg kawg yog 2 cov ntsiab lus ntawm −7 rau +7 pom qhov sib piv). Tsis tas li ntawd, Tus Neeg Mob Constipation Symptom Assessment Questionnaire (PAC-SYM) tau siv rau kev ntsuam xyuas plab hnyuv (GI), thiab tus naj npawb ntawm cov plab hnyuv siab raum ib lub lis piam ua ntej thiab tom qab kev kho mob thiab Bristol Stool Character Scale (BSS) raug xam.

Lub Montreal Cognitive Assessment (MoCA), MDS Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Parkinson's Disease Autonomic Dysfunction Scale (SCOPA-AUT), thiab Toronto Alexithymia Scale (TAS-20) tau siv ua ntej thiab tom qab kev cuam tshuam. . ), "Qhov Muag Nyeem Ntawv" Kev Xeem (RMET), Parkinson's Anxiety Scale (PAS), State-Trait Anxiety Inventory (STAI-Y), Beck Depression Inventory (BDI II), Hamilton Depression Rating Scale (HAM-D) Ua ib qho neuropsychological kev soj ntsuam.

tshwm sim

30 patients were consecutively enrolled. The number of patients with post-treatment satisfaction >4 (endpoint 1) nce ntxiv los ntawm 17% mus rau 60%, P=0.002. Cov qhab-nees txaus siab tau zoo dua los ntawm 4 txog 5, P=0.003. 83% ntawm cov neeg mob tau ua tiav kev kho mob tom qab kev txhim kho (kawg 2). Tag nrho cov qhab nia hloov pauv tau hloov pauv ntau ntawm 0 txog 4, P<0.001. In addition, treatment has a beneficial effect on gastrointestinal symptoms.

Tshwj xeeb, PAC-SYM cov lus nug tau poob los ntawm 1.42 rau 0.91, P<0.001, the number of bowel movements per week increased from 3 to 5.5 times, P<0.001, and the BSS increased from 2 to 3, P<0.001. PD patients performed better in motor and non-motor aspects after treatment. Among them, the TAS-20 score changed from 55.0 to 49.5, P=0.03, the SCOPA-AUT score changed from 17.0 to 13.5, P=0.002, the MDS-UPDRS first part score changed from 13.5 to 9.0, P=0.001, and the HAM-D score changed from 17.0 to 13.5, P=0.002. 12.5 becomes 9.0, P=0.045.

nyob rau hauv xaus

Cov txiaj ntsig tshawb fawb pom tau tias ntau tus neeg mob nrog PD ua ke nrog CC lossis IBS-C txaus siab rau kev tso quav tom qab kho. Cov tsos mob ntawm plab hnyuv thiab lub cev muaj zog thiab cov yam ntxwv tsis yog lub cev muaj zog txhim kho hauv cov neeg mob PD. Cov ntaub ntawv no qhia tau hais tias qhov sib ntxiv ntawm cov hluavtaws Enterolactis® duo tuaj yeem yog ib qho kev kho mob zoo rau PD, tejzaum nws ua rau lub plab-hlwb- plab axis.

Ntuj Herbal Tshuaj Rau Relieving cem quav-Cistanche

Cistanche yog ib tug genus ntawm parasitic nroj tsuag uas belongs rau tsev neeg Orobanchaceae. Cov nroj tsuag no paub txog lawv cov khoom siv tshuaj thiab tau siv hauv Cov Tshuaj Suav Tshuaj (TCM) rau ntau pua xyoo. Cov hom Cistanche feem ntau pom muaj nyob hauv thaj av qhuav thiab suab puam ntawm Tuam Tshoj, Mongolia, thiab lwm qhov chaw ntawm Central Asia. Cistanche nroj tsuag yog tus cwj pwm los ntawm lawv cov nqaij tawv, yellowish stems thiab muaj nuj nqis heev rau lawv cov txiaj ntsig kev noj qab haus huv. Hauv TCM, Cistanche ntseeg tau tias muaj cov khoom siv tonic thiab feem ntau yog siv los kho lub raum, txhim kho qhov tseem ceeb, thiab txhawb kev ua haujlwm ntawm kev sib deev. Nws kuj yog siv los daws cov teeb meem ntsig txog kev laus, qaug zog, thiab kev noj qab haus huv tag nrho. Thaum Cistanche muaj keeb kwm ntev ntawm kev siv tshuaj ib txwm siv, kev tshawb fawb tshawb fawb txog nws txoj kev ua tau zoo thiab kev nyab xeeb yog tsis tu ncua thiab txwv. Txawm li cas los xij, nws paub tias muaj ntau yam bioactive tebchaw xws li phenylethanoid glycosides, iridoids, lignans, thiab polysaccharides, uas tuaj yeem ua rau nws cov teebmeem tshuaj.

Wecistanche covcistanche hmoov, cistanche ntsiav tshuaj, cistanche capsules, thiab lwm yam khoom tsim los sivsuab puamcistancheraws li cov khoom siv raw, txhua yam muaj txiaj ntsig zoo rau kev tshem tawm cem quav. Cov txheej txheem tshwj xeeb yog raws li hauv qab no: Cistanche ntseeg tau tias muaj cov txiaj ntsig zoo rau kev tshem tawm cem quav raws li nws cov kev siv ib txwm siv thiab qee cov tshuaj uas nws muaj. Txawm hais tias kev tshawb fawb tshawb fawb tshwj xeeb ntawm Cistanche qhov cuam tshuam rau cem quav yog txwv, nws tau xav tias muaj ntau lub tswv yim uas yuav ua rau nws muaj peev xwm txo tau cem quav. Laxative nyhuv:Cistanchetau ntev tau siv nyob rau hauv tsoos suav tshuaj raws li ib tug tshuaj rau cem quav. Nws ntseeg tau tias muaj cov nyhuv laxative me me, uas tuaj yeem pab txhawb kev zom zaub mov thiab ua rau cem quav. Cov nyhuv no tuaj yeem raug ntaus nqi rau ntau lub tebchaw nyob hauv Cistanche, xws li phenylethanoid glycosides thiab polysaccharides. Moistening cov hnyuv: Raws li kev siv ib txwm siv, Cistanche suav hais tias muaj cov khoom siv moisturizing, tshwj xeeb yog tsom rau cov hnyuv. Txhawb nqa dej thiab lubrication ntawm txoj hnyuv, nws yuav pab tau cov cuab yeej soften thiab yooj yim dua, yog li no relieving cem quav. Anti-inflammatory Effect: cem quav tej zaum yuav txuam nrog o nyob rau hauv lub plab zom mov. Cistanche muaj qee qhov sib txuas, suav nrog phenylethanoid glycosides thiab lignans, uas ntseeg tau tias muaj cov tshuaj tiv thaiv kab mob. Los ntawm kev txo cov kab mob hauv cov hnyuv, nws tuaj yeem pab txhim kho kev zom zaub mov tsis tu ncua thiab txo qhov cem quav.

cov ntaub ntawv:

1. Krogh K, Ostergaard K, Sabroe S, Laurberg S. Kev kho mob ntawm cov tsos mob ntawm plab hnyuv kab mob Parkinson. Acta Neurol Scand. 2008; 117(1):{4}}.

2. Shen T, Yue Y, He T, Huang C, Qu B, Lv W, Lai HY. Lub Koom Haum Nruab Nrab ntawm Gut Microbiota thiab Parkinson's Disease, Meta-Analysis. Pem Hauv Ntej Laus Neurosci. 2021 Peb 12:13:636545.

3. Scheperjans F, Aho V, Pereira PA, et al. Gut microbiota muaj feem xyuam rau Parkinson tus kab mob thiab kev kho mob phenotype. Mov Disord. 2015; 30(3):{4}}.