"Tus kab mob-cov tsos mob-tshuaj ntsuab" Supernetwork Analysis Thiab Core Formula Discovery Of Postmarketing Suav Patent Tshuaj Rau Kev Kho Mob Raum-yang Deficiency

Abstract:Lub hom phiaj txhawm rau txheeb xyuas cov khoom lag luam hauv Suav teb patent tshuaj nrog lub ntsiablub raum-yang deficiencylos ntawm kev siv thesupernetwork txoj kev, txhawm rau tshawb nrhiav nws daim ntawv thov kho mob, cov tshuaj ntsuab thiab cov qauv tseem ceeb, thiab tshawb nrhiav daim ntawv thov kev cai lij choj ntawm cov tshuaj suav tshuaj suav tshuaj. Cov txheej txheem

Los ntawm Suav patent tshuaj database thiab lub network ntawm cov tshuaj txawj ntse network, peb tau sau cov postmarketing Suav patent tshuaj rau kev kho mob raum-yang deficiency syndrome, tshawb nrhiav lawv cov kev tshawb fawb soj ntsuam nyob rau hauv cov ntaub ntawv database, thiab soj ntsuam lawv daim ntawv thov. Cov kab mob thiab cov tsos mob koom nrog hauv Suav patentmedicines thiab tshuaj suav tshuaj suav tshuaj tau siv los ua cov nodes ntawm supernetwork, thiab Apriori algorithm tau siv los txheeb xyuas cov kev cai koom nrog ntawm cov nodes, thiab cov koom haum sib txuas nrog kev txhawb nqa thiab kev ntseeg siab tau siv asthe npoo ntawm lub supernetwork tsim lub "kab mob-symptom-tshuaj ntsuab" supernetwork raulub raum-yang deficiency. Networkvisualization thiab topological tsom xam tau ua los ntawm kev siv Cytoscpe3.9.1 software, thiab qhov tseem ceeb ntawm cov nodes hauv lub network tau ntsuas los ntawm hyper degree ntawm tshuaj ntsuab, los ntawm cov kab mob tseem ceeb, cov tshuaj tseem ceeb thiab cov tshuaj sib xyaw ua ke ntawm lub raum yang deficiency syndrome raug mined. Cov txiaj ntsig tau xaiv tag nrho ntawm 191 cov qauv, suav nrog 293 hom tshuaj, 43 kab mob thiab 19 cov tsos mob; Ntawm lawv, 64 cov qauv tau tshaj tawm rau kev siv tshuaj kho mob; Cov qauv tseem ceeb ntawm lub raum-yang tsis muaj peev xwm yog Lurong (Cervi Cornu Pantotrichum), Roucongrong (Cistanches Herba), Yinyanghuo (Epimedii Folium), Dihuang (RehmanniaeRadix), Gouqizi (Lycii Fructus), Renshen (Ginseng Radix thiab Rhizoma (Cumut), Tuscuta. ), Buguzhi (Psoraleae Fructus), Duzhong (Eucommiae Cortex), thiab Fuzi (Aconiti Lateralis Radix Praeparata). Cov kab mob tseem ceeb yog insomnia thiab impotence.

XausRaws li covcore formula ntawm kev kho mob raum-yang deficiency, nws qhia txog kev xav ntawm TCM cov kab mob sib txawv los ntawm ntau qhov ntev thiab muab ib qho kev siv rau kev kuaj mob thiab kev kho mob thiab kev tshawb fawb tshuaj ntsuab tshiab thiab kev loj hlob.

Cov lus tseem ceeb:lub raum-yang deficiency; Suav patent tshuaj; supernetwork; core formula; Cervi Cornu Pantotrichum;CistanchesHerba; Epimedii Folium; Rehmanniae Radix; Lycii Fructus;Ginseng Radix thiab Rhizoma; Cuscutae Semen; Psoraleae Fructus; Eucommiae Cortex; Aconiti Lateralis Radix Praeparata; insomnia; impotence

 KIDNEY-YANG DEFICIENCY REATMENT HERBAL CISTANCHE

Nyem kom tau txais cov ntaub ntawv ntxiv

Lub raum yang deficiency syndromehais txog ib hom kev tsis txaus thiab mob khaub thuas uas tshwm sim los ntawm qhov tsis txaus ntawm yang qi hauv lub cev thiab qhov tsis txaus ntawm kev ua haujlwm sov [1]. Cov tsos mob no tuaj yeem tshwm sim hauv cov txheej txheem kev loj hlob ntawm ntau yam kab mob, xws li impotence, insomnia, thiab mob ntshav qab zib late-stage [2], ua haujlwm cem quav hauv cov neeg laus [3-4], thawj osteoporosis [5] thiab perimenopausal syndrome [6] ], thiab lwm yam. Raws li kev coj noj coj ua ntawm lub tswv yim ntawm kev kho cov kab mob sib txawv nrog kev kho tib yam, txawm tias cov kab mob sib txawv, tib txoj kev kho mob feem ntau yog siv thaum lub raum yang deficiency syndrome tshwm sim, thiab cov ntawv tshuaj kuj zoo ib yam lossis zoo sib xws. Tam sim no, muaj ntau yam

Ntau cov tshuaj muaj muag hauv Suav teb tuaj yeem kho cov kab mob uas muaj lub raum-yang deficiency syndrome. Txawm li cas los xij, cov kab mob, cov tsos mob thiab cov tshuaj compatibility cai rau covkho mob raum-yang deficiency syndromelos ntawm Suav patent tshuaj tom qab lawv tso tawm tseem tsis meej.

Tam sim no muaj cov kev tshawb fawb siv Is Taws Nem los tshawb txog "kab mob-tshuaj-tshuaj-tshuaj" tus qauv ntawm kev lag luam Suav cov tshuaj patent [7], thiab tau mus txog qhov xaus nrog qhov tseem ceeb ntawm kev kho mob. Txawm li cas los xij, tsuas yog tsim cov txheej txheem kev tshuaj xyuas ib leeg ntawm cov kab mob, cov tsos mob, thiab tshuaj tsis txaus los nthuav tawm Cov txheej txheem los ntawm cov tshuaj suav tshuaj suav tshuaj zoo kho cov kab mob tsis tuaj yeem cuam tshuam kev sib raug zoo ntawm "mob-cov tsos mob-tshuaj". Hypernetwork [8] yog ib lub network ntau txheej nrog cov ntaub ntawv loj, kev sib txuas nyuaj thiab kev sib koom ua ke. Lub ntsiab lus ntawm nws cov nodes thiab ntug yog txawv los ntawm ib tug txheej txheem network. Nws tsis yog cais piav raws li node lossis ntug. Lub network super hauv hypernetwork Edges yog siv los sawv cev cov kev nyiam sib txuas thiab kev sib txuas ua ke hauv ib pawg, thaum cov nodes sawv cev rau lub network ntawm cov txheej txheem.

Supernetworks tau siv dav hauv kev kho mob hauv xyoo tas los no. Piv txwv li, Hu Ruixue et al. [9] txheeb xyuas qhov cuam tshuam ntawm kev kuaj mob sib txawv thiab kho cov ntsiab lus ntawm qhov sib txawv ntawm cov txheej txheem ntawm cerebral infarction los ntawm kev tsim lub supernetwork rau kev kuaj mob thiab kev kho mob cerebral infarction siv cov tshuaj suav suav thiab Western tshuaj. Li Chanxiu et al. [10] raws liAlzheimer tus kab mobcov ntaub ntawv tsim lub hlwb ua haujlwm hypernetwork los soj ntsuam kev sib koom ua ke ntawm lub paj hlwb cov yam ntxwv thiab cov noob. Tsis tas li ntawd, kev tshawb fawb ntawm evolutionary hypernetworks raws li genetic algorithms faib cov ntaub ntawv xws li mob leukemia thiab mob ntsws cancer, thiab kev faib cov neeg raug thiab nyeem tau ntawm cov txiaj ntsig yog qhov tseem ceeb [11]. Txoj kev tshawb no siv cov txheej txheem hypernetwork los tsim "kab mob-cov tsos mob-tshuaj" network rau lub raum yang deficiency syndrome. Los ntawm kev txheeb xyuas ntawm hyperedges, node hyperdegrees, thiab lwm yam hauv lub network, cov txheej txheem kev sib raug zoo tau piav qhia, cov tshuaj tseem ceeb, cov kab mob thiab cov tsos mob tau tshawb pom, thiab cov ntawv sau tseem ceeb yog mined. Tsab ntawv xov xwm no tshawb txog cov cai siv tshuaj rau kev kho cov kab mob sib txawv nrog cov kab mob no, thiab sim muab cov tswv yim tshiab rau kev kuaj mob thiab kev kho mob thiab kev txhim kho cov tshuaj tshiab hauv Suav teb.

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1 Cov ntaub ntawv thiab cov txheej txheem

1.1 Kev sau cov ntaub ntawv

1.1.1 Kev lag luam tom qab muag cov khoom lag luam suav tshuaj suav tshuaj thiab cov qauv tshuaj xyuas tshuaj

Tuam Tshoj patent tshuaj ntsuam xyuas cov ntaub ntawv database (http://crd.releae.daodikeji.com) yog cov ntaub ntawv tshuaj suav tshuaj uas tsim los ntawm kev sib koom ua ke nrog lub teb chaws Suav tshuaj sau npe database, lub teb chaws tshuaj xyuas database, thiab lwm yam. Cov ntaub ntawv nthuav dav sau cov ntaub ntawv. ntawm Suav cov tshuaj patent uas tau tsim ua ntej 2020, xws li kev ua tau zoo, qeb, kev tsis zoo, thiab lwm yam ntawm cov tshuaj. Txoj kev tshawb no tau khaws thiab txheeb xyuas cov ntaub ntawv los ntawm kev tsim cov ntaub ntawv rau lub Kaum Hlis 1, 2021, thiab ua ke nrog " raum yang deficiency, raum yang deficiency, raum yang deficiency, raum tsis muaj zog thiab txias, raum yang deficiency, raum yang deficiency, raum. yang" Cov ntaub ntawv ntawm Suav cov tshuaj patent rau kev kho mob raum yang deficiency syndrome tau tshawb nrhiav hauv Yaozhi.com (Lub Ib Hlis 2020 - Kaum Ob Hlis 2022) siv cov ntsiab lus " qaug zog, lub raum yang tsis muaj peev xwm, Mingmen hluav taws tsis ua haujlwm, lub raum yin thiab yang deficiency", thiab ib tug standardized database tau tsim. Tshawb nrhiav los ntawm kev ua tau zoo, kev qhia, thiab cov npe ntawm cov tshuaj suav tshuaj kom tau txais cov ntawv sau tshuaj.

Cov tshuaj tshawb nrhiav yog cov qauv thiab txheeb xyuas, thiab cov ntawv sau tshuaj nrog cov npe rov qab, tib cov tshuaj suav suav thiab tib cov tshuaj suav suav tsis suav nrog. Cov tshuaj nrog cov tshuaj suav tsis tiav yog tshawb nrhiav thiab ua tiav los ntawm Pubiao.com (https://db.ouryao.com/); thiab tshem tawm cov khoom xyaw tshuaj thiab cov txheej txheem npaj muaj nyob rau hauv Suav patent tshuaj.

1.1.2 Kev tshawb fawb soj ntsuam ntawm kev lag luam tom qab muag cov tshuaj suav tshuaj

Kev tshawb fawb hauv computer ntawm CNKI, Wanfang, VIP, PubMed, Embase, Cochrane

Lub sijhawm tshawb fawb txwv rau cov ntaub ntawv tshawb fawb soj ntsuam ntawm kev lag luam tom qab muag Suav cov tshuaj patent rau kev kho mob raum-yang deficiency syndrome hauv cov ntaub ntawv xws li Library thiab Web of Science yog los ntawm kev tsim cov ntaub ntawv mus rau Lub Rau Hli 15, 2023. Cov lus tshawb nrhiav Suav Feem ntau yog "lub npe ntawm cov tshuaj suav suav patent", raum yang deficiency, lub raum yang deficiency syndrome, kev tshawb fawb soj ntsuam, soj ntsuam soj ntsuam, randomized tswj kev sim, kev tshuaj xyuas thiab meta-analysis, thiab lwm yam.; Cov lus tshawb fawb lus Askiv feem ntau yog "cov npe ntawm cov npe suav tshuaj patent", Shen YangXu, raum-yang deficiency, raum yang deficiency, raum tsis muaj peev xwm, kev soj ntsuam kev tshawb fawb, kev sim tshuaj,

Randomized tswj kev sim, RCT, kev tshuaj xyuas, Meta tsom xam, thiab lwm yam. Lub tswv yim tshawb nrhiav txais kev sib txuas ntawm cov lus kawm thiab cov lus pub dawb. Cov ntawv sau lus Askiv los ntawm Suav cov ntawv xov xwm suav tau suav tias yog Suav phau ntawv xov xwm thiab tsis suav nrog cov ntawv Askiv.

Cov txheej txheem suav nrog: (1) luam tawm cov ntawv xov xwm; (2) Kev kho mob niaj hnub nrog tshuaj ib leeg lossis kev sib xyaw ntawm cov tshuaj chemical; (3) Cov ntaub ntawv luam tawm tag nrho. Cov txheej txheem cais tawm: (1) Kev sib xyaw ua ke nrog kev kho sab nraud (acupuncture, massage thiab lwm yam kev kho lub cev); (2) Cov ntawv pov thawj; (3) Cov ntaub ntawv sib tham; (4) Kev tshuaj xyuas.

1.2 Data standardization

1.2.1 Kev tsim qauv ntawm cov ntaub ntawv ntawm cov tshuaj suav ua tswv

Cov tshuaj uas tau txais tom qab tshem tawm cov duplicates yuav muab faib ua cov lus los ntawm lo lus raws li "kev ua haujlwm thiab cov lus qhia" thiab "sib xyaw ntawm cov tshuaj suav tshuaj" hauv cov lus qhia, thiab peb feem ntawm cov kab mob, cov tsos mob, thiab cov tshuaj suav tshuaj. yuav standardized nyob rau hauv terminology. Txhawm rau kom ntseeg tau qhov nruj thiab qhov tseeb ntawm kev tshawb fawb, cov kws tshawb fawb tau sib tham thiab txiav txim siab nrog ntau dua 3 tus neeg thaum lub sijhawm tshuaj ntsuam ntawm Suav patent tshuaj tebchaw thiab cov ntaub ntawv kho mob, cov ntaub ntawv rho tawm, thiab kev faib tawm ntawm cov tshuaj suav tsis ntseeg suav nrog cov tshuaj thiab lawv cov ntaub ntawv, thiab txheeb xyuas. tawm cov npe tshuaj, kev ua haujlwm thiab kev qhia ntawm Suav patent tshuaj. , kev ua tau zoo, tshuaj muaj pes tsawg leeg thiab lwm yam ntaub ntawv.

(1) Standardization ntawm cov ntaub ntawv kab mob: raws li International Classification of Diseases

(Kev faib tawm thoob ntiaj teb ntawm cov kab mob, ICD10/11) coding [12] standardizes cov kab mob koom nrog hauv cov lus qhia ntawm Suav patent tshuaj. Tus kab mob lo lus tseem ceeb segmented lo lus los ntawm lo lus yog tshawb hauv ICD10/11, thiab cov txiaj ntsig tshawb fawb tau khaws cia ua cov kab mob sib txuas. , vim tias ICD11 suav nrog cov npe tshuaj kho mob ib txwm muaj, nws muaj peev xwm ua tau tias TCM cov npe kab mob thiab cov npe tshuaj Western cov kab mob sib koom ua ke thaum muaj kab mob.

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(2) Symptom information standardization: Cov tsos mob kev sib raug zoo segmented lo lus los ntawm lo lus

Cov lus tseem ceeb tau tshawb nrhiav thiab muab piv rau hauv "Terminology Standards for Common Clinical Symptoms of Traditional Chinese Medicine" thiab cov kev tshawb fawb tau khaws cia. Cov npe ntawm cov tsos mob uas tsis suav nrog yog khaws cia sib koom ua ke thiab ua haujlwm hauv cov kab mob hauv lub network. Cov ntsiab lus uas nws lub ntsiab lus tsis zoo ib yam li cov hauv "Cov ntsiab lus" tau txiav txim siab muab tshem tawm lossis khaws cia tom qab kev sib tham. Piv txwv li, qaug zog yog cais raws li qaug zog thiab qaug zog; frailty nyob rau hauv cov neeg laus yog cais raws li lub cev tsis muaj zog; oliguria thiab pom cov zis yog cais raws li qhov nyuaj hauv kev tso zis, thiab lwm yam.

(3) Standardization ntawm tsoos suav tshuaj cov ntaub ntawv: Raws li "Suav Pharmacopoeia" [13] thiab "Tsev Suav

Materia Medica" [14], cov npe ntawm cov tshuaj suav tshuaj hauv cov lus qhia yog tus qauv, thiab cov khoom xyaw tshuaj, excipients, thiab cov txheej txheem raug tshem tawm. Piv txwv li, velvet antler (hairless) / antler slices yog koom ua ke li velvet antler, Polygonum multiflorum ua los ntawm taum (soybean roasted nyob rau hauv cawu cub) yog unified li Polygonum multiflorum, golden cherry txiv hmab txiv ntoo (nqaij / extract) yog koom ua ke raws li golden cherry txiv hmab txiv ntoo, dogwood (wine npaj) yog unified as dogwood, thiab lwm yam. Cov txheej txheem tau siv raws li ib txwm Suav. tshuaj network nodes.

1.2.2 Kev tsim qauv ntawm cov ntaub ntawv cov ntaub ntawv

Siv EndNoteX9.

1.3 Data Mining

1.3.1 Kev piav qhia piav qhia siv Excel 2019 rau kev txheeb xyuas zaus, thiab suav thiab suav cov kab mob, cov tsos mob thiab zaus ntawm kev siv tshuaj ib leeg ntawm Suav cov tshuaj patent rau raum yang deficiency syndrome [16], qhov feem pua ​​​​ntawm kev siv tshuaj ib zaug rau tag nrho tus lej ntawm kev siv tshuaj, thiab Kev faib tawm ntawm kev lag luam Suav patent tshuaj ntau npaum cov ntaub ntawv thiab concurrent syndromes rau kev kho mob raum-yang deficiency syndrome.

1.3.2 Kev soj ntsuam ntawm kev siv tshuaj kho mob ntawm cov tshuaj suav siv tshuaj patent

Cov ntaub ntawv sau tseg ntawm Suav thiab Askiv cov ntaub ntawv khaws tseg tau piav qhia, thiab cov ntawv sau tshuaj nrog ntau cov ntaub ntawv Ntau dua lossis sib npaug li 10 tau muab rho tawm, suav nrog cov ntawv sau tshuaj, cov kws sau ntawv, cov kab mob sib xws, kev cuam tshuam, kev kho mob, cov teebmeem thiab cov txiaj ntsig ntsuas, thiab lwm yam.

1.3.3 Kev soj ntsuam ntawm "kab mob-cov tsos mob-tshuaj" koom haum cov cai rau lub raum-yang deficiency syndrome

Apriori algorithm plug-in hauv IBM SPSS Modeler 18.0 software tau siv los tshuaj xyuas peb pawg ntawm cov kab mob, cov tsos mob, thiab cov tshuaj kho mob raum yang deficiency syndrome ntawm Suav cov tshuaj patent ntawm lub khw [ 16], txhawm rau tshawb nrhiav cov kev cai sib haum xeeb ntawm cov tshuaj sib xyaw thiab kev sib raug zoo ntawm cov tsos mob thiab cov kab mob, thiab teeb tsa qhov kev txhawb nqa yam tsawg kawg nkaus Lub degree yog 10%, kev ntseeg siab yog 80%, qhov siab tshaj plaws ntawm cov neeg mob ntshav qab zib yog 1, nrog rau cov kab mob, cov tsos mob , thiab cov tshuaj raws li cov nodes, lub koom haum kev sib txuas ua ke uas ua tau raws li kev txhawb nqa qib siab dua lossis sib npaug li 10% thiab kev ntseeg siab Ntau dua lossis sib npaug li 80% yog cov npoo ntawm lub network super.

1.3.4 Kev tsim kho ntawm ib txheej txheej ntawm cov tshuaj, cov tsos mob thiab cov kab mob cuam tshuam nrog rau lub raum-yang deficiency syndrome thiab kev txheeb xyuas cov tub ntxhais ntawm ib txheej txheej network

Node koom haum ntawm tib hom ntaub ntawv tsim ib txheej txheej network. Nyob rau hauv txhua txheej ntawm lub network, kev txiav txim siab yog muab rau cov

Number centrality (nruab nrab ntawm centrality, BC), closeness centrality (closeness centrality, CC) thiab degree centrality (degree centrality, DC) [17] yog siv los tshuaj xyuas qhov tseem ceeb ntawm txhua txheej ntawm lub network.

KIDNEY-YANG DEFICIENCY REATMENT HERBAL CISTANCHE

1.3.5 Kev tsim kho ntawm "mob-cov tsos mob-tshuaj" super network rau lub raum yang deficiency syndrome

Raws li cov txheej txheem ib leeg, muaj kev sib raug zoo ntawm ob lossis peb ntawm cov kab mob, cov tsos mob, thiab tshuaj. Nyob rau lub sijhawm no, ntug ntawm ob lossis peb qhov heterogeneous nodes tuaj yeem suav tias yog hyperedge, thiab ntau txheej txheej ntawm cov tshuaj suav tshuaj rau kev kho mob raum-yang deficiency syndrome (tom qab no hu ua super-network ntawm lub raum- yang deficiency syndrome) tau pib.

Cov nodes tseem ceeb ntawm tag nrho cov super network tau txheeb xyuas los ntawm kev suav cov node hyperdegree tus nqi hauv lub raum yang deficiency syndrome hypernetwork. Qhov node hyperdegree tus nqi [18] tseem hu ua hyperdegree centrality, uas suav nrog tus naj npawb ntawm hyperedges ntawm node. Cov ntsiab lus tseem ceeb yog qhov muaj txiaj ntsig zoo rau cov naj npawb ntawm hyperedges nws nyob. Cov txiaj ntsig tau raug xa mus rau hauv Cytocape 3.9.1 rau kev pom lub network.

1.3.6 Super network core node txheeb xyuas thiab nrhiav pom cov ntawv sau tseem ceeb

Xam thiab txheeb xyuas cov node tshaj qhov tseem ceeb ntawm cov tshuaj suav tshuaj nyob thoob plaws 3-txheej network hauv tag nrho "kab mob-cov tsos mob-tshuaj" super network, noj 10 cov tshuaj sab saum toj, thiab tshuaj xyuas cov tshuaj uas muaj ntau dua 30 kom tau txais cov tshuaj tseem ceeb ntawm lub raum yang deficiency syndrome super network, thiab tom qab ntawd tshuaj xyuas cov tshuaj tseem ceeb rau kev kho mob raum yang deficiency syndrome.

Nyob rau hauv tib txoj kev, xam cov node tshaj qhov tseem ceeb thoob plaws hauv 3-txheej network rau cov tshuaj uas kho cov kab mob tseem ceeb ntawm lub raum-yang deficiency syndrome thiab txheeb lawv, thiab noj cov tshuaj sab saum toj 10 los tshawb pom cov ntawv tseem ceeb rau cov kab mob loj.

KIDNEY-YANG DEFICIENCY REATMENT HERBAL CISTANCHE

1.3.7 Kev txheeb xyuas qhov sib piv ntawm cov ntawv sau tshuaj zoo sib xws thiab cov qhab nia ntawm cov tshuaj sib raug zoo rau cov kab mob loj

Tshawb xyuas thiab sib piv qhov sib xws ntawm cov ntawv sau tseem ceeb rau kev kho mob raum yang deficiency syndrome thiab cov tshuaj siv ntau zaus xaiv hauv txoj kev tshawb no, nrog rau qhov zoo sib xws ntawm cov ntawv sau tseem ceeb rau lub raum yang deficiency syndrome thiab cov tshuaj tseem ceeb ntsig txog. cov kab mob tseem ceeb; thiab txheeb xyuas qhov zoo sib xws ntawm cov lag luam Suav patent tshuaj rau kev kho mob raum yang Tshuaj compatibility cov cai rau cov kab mob loj nrog deficiency syndrome.