Kev Tshawb Fawb Kev Tshawb Fawb Txog Cistanche Granule Joint Qianlie Kang Ntsiav Tshuaj Rau Kev Kho Mob Prostatitis
Mar 03, 2022
Hu rau:joanna.jia@wecistanche.com
XU Yuanbing1, GAN Xing1△, HUANG Bo1, PENG Yongtao1, ZHANG Xinhua 2.
1. Department of Urology, Tianmen Hospital of Traditional Chinese Medicine, Tianmen 431700, Hubei, Suav teb;
2. Department of Urology, Zhongnan Tsev Kho Mob ntawm Wuhan University, Wuhan 430071, Hubei, Suav
Cistancheextract muaj cov haujlwm ntawm kev khomob prostate mob
【Abstract】
Lub Hom Phiaj: Tshawb nrhiav kev kho mob curative nyhuv ntawmcistanche granulesib koom QianlieKang ntsiav tshuaj raumob prostatitis. Txoj kev: 90 tus neeg mob uas muaj mob prostatitis (CP) hauv peb lub tsev kho mob txij lub Rau Hli 2015 txog rau Lub Rau Hli 2016 tau suav nrog thiab muab faib rau hauv pab pawg kho mob kom tau txais cistanche granule sib koom Qianlie Kang ntsiav tshuaj thiab cistanche granule tswj pawg thiab QianlieKang ntsiav tshuaj tswj pawg, txhua ntawm 30 tus neeg mob thiab tag nrho rau 12 lub lis piam. NIH - CPSI cov qhab nia, cov qhab nia ntawm cov tshuaj suav tshuaj suav tshuaj, kev kuaj EPS, thiab kev kuaj ntshav hemorheology tau pom ua ntej thiab tom qab kev kho mob, thiab kev kho mob tau muab piv rau. Cov txiaj ntsig: Tom qab kev kho mob, tag nrho cov kev ntsuam xyuas EPS, cov qhab nia ntawm cov tshuaj suav tshuaj suav tshuaj thiab hemorheology hauv txhua pab pawg tau txhim kho thiab NIH － CPSI cov qhab nia poob qis, qhov tseem ceeb hauv pab pawg kho mob dua li ob pawg tswj hwm nrog qhov sib txawv tseem ceeb. . Piv nrog rau ob pawg tswj hwm,qhov mob nyem thiab muaj peev xwm ua neej nyob txhua hnub tau txhim khohauv pab pawg kho mob. Xaus:Kev sib koom ua ke ntawm cistanche granule thiab Qianlie Kang ntsiav tshuaj muaj cov txiaj ntsig zoo hauv kev kho mob, uas tuaj yeem txo cov tsos mob tso zis thiab txhim kho tus neeg mob lub neej zoo.
CistancheExtract muaj kev ua haujlwm ntawm stimulatingtestosteronethiab tiv thaivmob ntevprostatekab mob
【Cov lus tseem ceeb】Cov granule; QianlieKang ntsiav tshuaj; Chronic prostatitis (CP); Kev tshawb fawb soj ntsuam
Chronic prostatitis (CP)yog aCov kab mob genitourinary feem ntau hauv cov txiv neej. Nws yog ibmob ntev ntawm prostatetshwm sim los ntawm kev kis kab mob xws li cov kab mob microorganisms lossis lwm yam, uas ua rautso zis txawv txav, mob hauv cheeb tsam prostate, thiab txawmmob hauv prostate. Yuav cuam tshuam tus neeg mob lub siab puas ntsws [1]. CP yog qhov nyuaj thiab muaj ntau haiv neeg vim nws cov etiology, chav kawm ntawm tus kab mob, cov tsos mob, thiab lwm yam, uas cuam tshuam loj heev.txiv neej kev ua haujlwmthiabkev ua haujlwm ntawm kev ua me nyuam [2].
Tam sim no, cov tshuaj siv los ntawm cov tshuaj sab hnub poob los kho CP feem ntau suav nrog cov tshuaj tua kab mob thiab "-receptor blockers thiab yuav tsom mus rau kev tawm tswv yim rau cov neeg mob kev puas siab puas ntsws. Txawm hais tias muaj ntau cov tshuaj rau kev kho CP, tsis muaj kev kho tshwj xeeb, thiab kev kho mob. Cov nyhuv tsis txaus siab heev, Nws yog ib qho yooj yim rau rov qab los yog hnyav dua [3] Xyoo tsis ntev los no, Tuam Tshoj tau ua tiav qee yam kev tshawb fawb ntawm cov tshuaj suav tshuaj hauv kev kho mob ntawm CP [4]. CP tuaj yeem raug suav hais tias yog qhov tsis txaus, qhov tsis txaus, uas yog,lub raum tsis muaj peev xwm, Deficiency ntawm tus po, thiab lwm yam, thaum lub cim tiag tiagdamp-rhaub, stagnation qisthiabntshav stasis, thiab lwm yam. [5-7] Yog li ntawd, feem ntau ntawm kev kho mob ntawm CP yog raws litxhawb cov ntshav ncigthiabtshem tawm cov ntshav stasis.
Txhim khokev sib deevmuaj nuj nqithiab kev ua haujlwm me me nrogcistanche
Cov txheej txheem ntawmclearing damp-heat, soothing daim siab thiab relieving kev nyuaj siab, warming spleen thiab raumib., [8]. Nyob rau hauv xyoo tas los no, hais txog cov kev kho mob no, peb lub tsev kho mob tau xaivcistanche granules los cuam tshuam hauv CPthiab saib nws cov nyhuv curative. Daim ntawv qhia yog raws li nram no.
1 Cov khoom siv thiab cov txheej txheem
1.1 Cov ntaub ntawv kho mob
Kev tshawb fawb nyob rau hauv tsab xov xwm no yog ua raws li cov kev cai ntawm lub tsev kho mob ethics committee; kev sau cov ntaub ntawv ntawm tus neeg mob thiab cov kev sim ua tau ua tiav nrog tus neeg mob qhov kev paub thiab kev pom zoo. cuaj caum tus neeg mob CP tau txij lub Rau Hli 2015 txog rau Lub Rau Hli 2016 hauv peb lub tsev kho mob. Ua raws li lub hauv paus ntsiab lus ntawm randomization, ib leeg-dig muag, thiab kev tswj hwm, lawv tau muab faib ua pawg kho mob ntawmCistancheGranules ua ke nrog Qianliekang thiab pawg tswj hwm ntawmcistancheGranules. Thiab Qianliekang tswj pawg, 30 tus neeg hauv txhua pab pawg. Peb pawg neeg mob ntawm lub hnub nyoog, chav kawm ntawm tus kab mob, NIH-CPSI qhab nia, tus qhab nia ntau ntawm TCM syndromes, thiab lwm yam.
In terms of statistical analysis, there is no significant difference (P>0.05). Saib Table 1. Nyob nruab nrab ntawm kev sib piv.
1. 2 Cov txheej txheem kuaj mob
Western tshuaj ntsuam xyuas cov txheej txheem: Chronic Prostatitis Symptom Index Standard (NIH-CPSI) tsim los ntawm National Institutes of Health [9]. Qhov kev ua tau zoo ntawm kev kho mob raug txiav txim raws li NIH-CPSI tus qhab nia: txo qis cov tsos mob<5 points="" are="" invalid,="" a="" reduction="" of="" 5="" to="" 15="" points="" is="" effective,="" a="" reduction="" of="" 15="" points="" or="" more="" is="" markedly="" effective,="" and="" those="" who="" remain="" asymptomatic="" for="" more="" than="" 4="" weeks="" without="" recurrence="" are="" clinically="" cured="" [10].="" the="" total="" effective="" is="" counted="" as="" cured,="" markedly="" effective,="" and="" effective="">
Diagnostic cov txheej txheem ntawm tsoos suav tshuaj: National Administration ntawm tsoos suav tshuaj "Diagnosis thiab Efficacy Standards ntawm Suav tshuaj kab mob" [11].
1. 3 Cov txheej txheem suav nrog thiab cais tawm
Cov txheej txheem suav nrog: (1) Ua tau raws li cov txheej txheem kuaj mob ntawm Western tshuaj thiab TCM; (2) Hnub nyoog 20-50 xyoo. Kev cais tawm: (1) mob prostatitis; (2) benign prostatic hyperplasia; (3) urethral nruj; (4) mob qog noj ntshav prostate; (5) ureteral pob zeb, varicocele, thiab lwm yam kab mob; (6) ua ke nrog lub plawv, hlwb, thiab lwm yam. Cov kab mob loj heev xws li daim siab thiab hematopoietic system; (7) Cov neeg muaj kev fab tshuaj lossis kev fab tshuaj rau ntau yam tshuaj; (8) Cov neeg tsis tuaj yeem koom tes, xws li cov neeg mob hlwb.
1. 4 txoj kev kho mob
Cov pab pawg kho mob tau muab Cistanche Granules (Inner Mongolia Lantai Pharmaceutical Company, National Medicine Zhunzi Z20030099, batch tooj 20140825), 6g ib lub hnab, 1 hnab / sijhawm, 3 zaug / d, infusion ntawm qhov ncauj, 4 lub lis piam raws li 1 chav kho mob, nruam 3 chav kho mob; raws li lub hauv paus no, cov ntsiav tshuaj ntawm qhov ncauj Qianliekang (Zhejiang Kangenbei Pharmaceutical Co., Ltd., National Medicine Standard Z33020303, batch tooj 20140509) 3 pieces/time, 3 times/d. Nyob rau hauv cov pab pawg neeg cistanche Granules, chav kawm ntawm kev kho mob thiab tus naj npawb ntawm koob tshuajGranules ntawm cistanchetaunoj qhov ncaujhauv tib pab pawg kho mob, thiab pab pawg Qianliekang tau noj cov ntsiav tshuaj Qianliekang.
1. 5 Kev ntsuas ntsuas
Txhua tus neeg mob tau ntsuas ua ntej thiab tom qab kev kho mob (1) NIH-CPSI qhab nias; (2) TCM syndrome hloov; (3) EPS kev xeem [12].
1.6 Kev txheeb xyuas cov ntaub ntawv
Cov ntaub ntawv raug qhia raws li qhov txhais tau tias ± tus qauv sib txawv (xx ± s), thiab SPSS16.0 software yog siv rau kev txheeb xyuas cov ntaub ntawv. Kev sib piv ntawm cov txhais tau tias ntawm ntau pab pawg tau ua los ntawm ib txoj kev tsom xam ntawm qhov sib txawv, ua raws li kev soj ntsuam posthoc nrog Dunnett qhov kev xeem, thiab P<0.05 was="" considered="" as="" a="" significant="">
2 kev tshwm sim
2.1 Kev sib piv ntawm NIH-CPSI cov qhab nia thiab kev ua tau zoo ntawm peb pawg neeg mob ua ntej thiab tom qab kev kho mob
Nws tuaj yeem pom los ntawm Tables 2 thiab 3 tias tom qab 12 lub lis piam ntawm kev kho mob hauv pab pawg kho mob, pawg tswj hwm Cistanche, thiab pawg tswj hwm Qianliekang, cov neeg mob NIH-CPSI, qhov mob theem, cov tsos mob ntawm cov zis, thiab lwm yam. Pom tau zoo lawm (P<0.05), the="">
Cov nqi siv tau yog {{0}}. 7 feem pua , 83.3 feem pua , thiab 70.0 feem pua, raws li qhia tau hais tias kev sib xyaw ntawm cistanche granules Qianliekang ntsiav tshuaj thiab cov kev kho mob muab cais tauzoo alleviate tus neeg mob cov tsos mob, thiab los ntawm cov ntaub ntawv, nws tuaj yeem pom tias qhov ua tau zoo ntawm Cistanche Granules ua ke nrog Qianliekang ntsiav tshuajtuaj yeem txo tag nrho cov qhab nia NIH-CPSIthiabtxo tus neeg mob qhov mob. Thiab rautxhim kho lub neej zoo, nws zoo dua li Qianliekang tswj pawg thiab Cistanche granule tswj pawg.
Table 2: Kev sib piv ntawm NIH-CPSI cov qhab nia ua ntej thiab tom qab kev kho mob hauv peb pawg
Nco tseg:Piv nrog ua ntej kev kho mob, ** P<0.01, *="" p=""><0. 05;="" after="" treatment,="" compared="" with="" the="" treatment="" group,="" #="" p=""><0. 05,="" ##="" p=""><0.>
Table 3: Kev sib piv ntawm qhov ua tau zoo ntawm NIH-CPSI cov qhab nia ua ntej thiab tom qab kev kho mob hauv peb pawg neeg mob
2. 2 Kev sib piv ntawm cov qhab nia ntau ntawm TCM syndromes ua ntej thiab tom qab kev kho mob hauv peb pawg neeg mob
Nws tuaj yeem pom los ntawm Table 4 tias tom qab 12 lub lis piam ntawm kev kho mob hauv pab pawg kho mob thiab ob pawg tswj hwm, piv nrog cov pab pawg no ua ntej kev kho mob, cov qhab nia ntau ntawm TCM syndromes ntawm cov neeg mob tau qis dua ua ntej (P<0.01), indicating="" that="" cirrhosis="" cistanche="" granules="" combined="" with="" qianliekang="" tablets="" and="">
Cov tshuaj thiab kev kho mob tuaj yeem txo tus neeg mob tus kab mob zoo thiab txhim kho tus neeg mob txoj kev noj qab haus huv Medical syndromes, kev kho mob cov teebmeem yog pom tseeb, thiab cov nyhuv curative ntawm cistanche Granules ua ke nrog Qianliekang ntsiav tshuaj zoo dua li ntawm ob cov tshuaj ib leeg (P<>
2. 3 Sib piv cov ntaub ntawv kuaj EPS ua ntej thiab tom qab kev kho mob ntawm peb pawg neeg mob
Los ntawm Table 5, nws tuaj yeem txiav txim siab tias tom qab 12 lub lis piam ntawm kev kho tshuaj, EPS niaj hnub suav cov qe ntshav dawb thiab lecithin hloov ntawm peb pawg neeg mob tau zoo dua qub (P<0.05). in="" addition,="" the="" curative="" effect="" of="" the="" combination="" of="" cistanche="" granules="" and="" qianliekang="" tablets="" is="" better="" than="" that="" of="" the="" two="" drugs="" alone=""><>
3. Kev sib tham
CP yog ib hom kab mob uas tshwm sim hauv cov txiv neej kev ua me nyuam hauv tsev kho mob [12]. Nws yog tus cwj pwm los ntawm kev qeeb qeeb, lub sijhawm ntev ntawm tus kab mob, rov tshwm sim dua, cov tsos mob sib txawv, thiab nyuaj rau kho. Muaj feem xyuam rau lub cev thiab lub hlwb kev noj qab haus huv thiab lub neej zoo ntawm cov neeg mob [13]. Txog tam sim no, cov tshuaj niaj hnub tau piav qhia. Lub pathogenesis ntawm CP feem ntau yog tsom rau cov kab mob kab mob, cov zis reflux, thiab kev tiv thaiv kab mob.
Tam sim no abnormality, qis urothelial dysfunction, puas siab puas ntsws yam, thiab lwm yam. [14, 15]. Vim yog CP Cov laj thawj thiab cov txheej txheem ntawm tus kab mob yog qhov nyuaj thiab ntau haiv neeg, yog li ntau tus kws tshawb fawb tau txais "snowflake model" los kawm CP los ntawm ntau lub ces kaum, uas coj qhov kev nkag siab tshiab rau kev kho mob ntawm CP [5]. Cov tshuaj suav tshuaj suav hais tias CP belongs rau qeb ntawm "qhov tseem ceeb thiab turbidity" thiab "txias turbidity". Nws cov pathogenesis feem ntau suav nrog raum tsis muaj peev xwm raws li cov hauv paus hniav, damp-heat raws li tus qauv, thiab ntshav stasis raws li kev hloov. Cov tshuaj kho mob tuaj yeem muab faib ua damp-heat accumulation syndrome thiab qi stagnation thiab ntshav stasis. Syndrome, Yin Deficiency Fire Prosperity Syndrome thiab raum Yang Deficiency Syndrome [5,16].
Hauv tsab xov xwm no,kev siv cistanche granules los kho cov neeg mob nrog CP tau ua tiav cov txiaj ntsig zoo.Cistanche Granules yog ib qho kev npaj sib xyaw uas suav nrog Cistanche, Morinda Officinalis, Cuscuta, Poria, Psyllium, thiab Schisandra. Ntawm lawv, Cistanche yog cov tshuaj huab tais, uas muaj covcov teebmeem ntawm nourishing lub raumthiabzog yang, thiabpuv lub plab; supplemented nrog dodder, nwsmuaj cov nyhuv ntawm nourishing lub siab thiab lub raum, ntxiv dag zog rau cov leeg thiab pob txha; Morinda Officinalis yog ib qho tshuaj tiv thaiv, uas tuaj yeem ua rau lub raum qi; Schisandra yog ib qho adjuvant thiab tuaj yeem ua rau Astringent raum qi,astringent phev, calming lub siab thiab soothe cov hlab ntsha; Tsis tas li ntawd, Poriainvigorates tus po thiab oozes dampness, nourishes lub plawv thiab calms cov hlab ntsha; hos Psyllium yog ib yam tshuaj uas yuav pab tau yin thiab invigorate qi, thiab qhia tshuaj rau lub raum [12,17, 18].
CistancheCov txiaj ntsig kev noj qab haus huv: Kev Tiv Thaiv Kev Ua Haujlwm rauNtev ProstateKab mob
Cov txiaj ntsig ntawm kev soj ntsuam kev soj ntsuam tau pom tias Qianliekang thiabCistanche Granules tuaj yeem txhim kho cov neeg mob NIH-CPSI, qhov mob degree, cov tsos mob tso zis, thiab kev ntsuas ntau ntawm TCM syndromes thiab cov txiaj ntsig kho ntawm Cistanche Granules yog qhov pom tseeb dua.; Ntxiv rau, ob cov tshuaj no tuaj yeem txhim kho EPS. Cov kev tshawb fawb tau pom tias qhov nce hauv EPS-pH muaj feem cuam tshuam nrog kev txhim kho CP kev sib raug zoo [19]. Tsis tas li ntawd, nws kuj muaj qee yam cuam tshuam rau SOD scavenging oxygen dawb radicals. EPS-pH feem ntau yog siab dua li ib txwm, uas qhia tau hais tias cov neeg mob prostate ntawm CP raug tshem tawm los ntawm lub peev xwm ntawm lub hauv paus raug txo, thiab qhov no yuav ua rau cov lus teb inflammatory ntawm cov ntaub so ntswg prostate [20-22]. Nws yog tsim nyog sau cia tias yog tias ob cov tshuaj siv ua ke, cov nyhuv zoo dua li kev siv ib zaug (P<0.05). these="" results="" indicate="" that="" cistanche="" granules="" may="" be="" a="" better="" choice="" for="" the="" treatment="" of="">
Cov ntaub ntawv
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