Kev kawm txog kev saib xyuas kev saib xyuas lub xeev cov kws kho mob quav ntsej muag los ntawm cov tshuaj laus uas muaj koob yees duab ⅱ

3 kev sib tham

 

3.1 Kev faib tawm cov syndromes thiab lawv cov qauv hloov pauv

Cov syndromes txuam nrog cem quav yog suav nrogLub Synudrome tsis txaus (虚态) thiab ntu kev sib tsoo (壅态), ua rawsKUB KUB SYST (热态), Sryness Syndrome (燥态), Ntshav Stasis synudrome (瘀态), txias syndrome (寒态), thiab stagnation syndrome (郁态)Cov. Raws li cov pathological kev ua tiav ntawm cov syndromes, cem quav nyob rau hauv nws theem ntxov yog feem ntau pom los ntawmThaiv kev sib zog thiab stagnation syndromeCov. Nyob rau hauv nruab nrab-theem, nws feem ntau nthuav qhia raws liTshav kub syndrome thiab dryness syndrome, thaum nyob rau hauv lub caij nyoog theem, nws hloov musSyndrome tsis txaus, txias syndrome, thiab ntshav stasis syndrome.

Qhov kev vam meej ntawm kev hloov pauv ntawm cov txheej txheemhloov los ntawm ntau dhau los ua kom tsis tausCov. Nyob rau hauv thaum ntxov theem, yam muaj xws liKev noj zaub mov tsis txaus, kev xav txog kev ntxhov siab, thiab cuam tshuam QI txavpab txhawb rau stagnation thiab txheej txheem, feem ntau ua manifesting liTshaj syndromesCov. Sij hawm dhau los, ntev qi stagnation thiab phlegm-damamp ntxiv ua rauKev kub hnyiab, ua rauThaum tshav kub kub thiab dryness syndromesCov. Nyob rau hauv tom qab theem tom ntej, vim tias qhov kev kawm tiav ntawm cov zog tseem ceeb thiab ntev ntev muaj ntawm kab mob pathogenic,Lub plab hnyuv yin deficiency thiab txo qis bowel lub zogtej zaum yuav muaj zog, ua rautsis muaj mob syndrices.

Cistanche tseem ceeb rau kev kho mob cem quav

 

3.2 Cov tshuaj yuav khoom thiab cov tshuaj rau cov tshuaj pleev rau quav nciab

3.2.1 Stagnation syndrome (郁态)

Tustsom kwmRau qhov tsis sib luag-hom quav yogLiu Mo Tang (6 磨汤), nrogLub hom phiaj siv tshuaj suav nrog Bai Shao (白芍, Radix Pasma Paeonia Alba) thiab da Fu Pi (大腹皮, areca tev).

Bai Shaden nyob rau hauv lubShen Nong Ben Cao Jing (神农本草经):

"Nws kho cov kab mob pathogenic qi, mob plab, ntshav stasis, thiab ruaj ruaj, thiab daws qhov mob." [2]

Cov kev tshawb fawb ntawm chaw muag tshuaj tau pom tiasTag nrho cov glycosides ntawm Bai Shao tuaj inhibit ua kom muaj kev ua haujlwm ntawm Wnt / -Catenin signaling Kev Taw Qhia, Li no txhim kho cov tsos mob tshwm sim thiab kev cai cem quav cuav cem [{}}].

 

3.2.222 ntu cuam tshuam (壅态)

Tustsom kwmForgtionuction-hom quav cuav suav nrogDa chi tang (大承气汤).

Ntaj cheng qi tang, thaum chiv keeb los ntawmShang Han Lun (伤寒论), muajDa Huang (大黄, Radix thiab Hou PO.

Tshawb nrhiav los ntawm Li Zhijun li al. [5] Qhia tias ntaj cheng qi tang yog qhov ua tau zoo hauv kev khotuag tes tuag taw, nrog kev siv hluav taws xob nrogKev Mob Plasma Motilin ntau ntxiv thiab txo cov plab hnyuv rog peptide (VIP), Li no txhim kho lub plab hnyuv peristalsis thiab relieving mob. Kev tshawb fawb los ntawm Nie Ben li al. [6] Hais kom covCem quav-muab kev cuam tshuamntawm ntaj cheng qi tang yuav cuam tshuam nrogTxo Nitric Oxide (Tsis Muaj) Cov Ntsiab Lus thiab Cov Khoom Siv Dawb Radicals.

TusHom PhiajForgtion Altruction kev quav cawv muaj xws liZhi ke (枳壳, paub qab zib txiv kab ntxwv iab), zaul (大黄, radix thiab hou po (厚朴, tawv ntoo).

Zhi shi yog sau tseg hauvShang Han Lun (伤寒论)Raws li hauv qab no:

"Nws kho cov txheej txheem ua kom sov tshav kub, mob plab, thiab tuaj yeem ua ke nrog ntaj huao, thiab hou po, xws li hauv da chi tang." [7]

Zhi shi yog feem ntau siv nyob rau hauv chaw kuaj mob ua ibqi-tswjtshuaj ntsuab, nrog cov ntawv thov sib xws rauZhi keCov. Cov kev tshawb fawb niaj hnub tau pom tiasZhi ke muaj hesperidin, uas tuaj yeem yog metabolized rau hauvhesperetin los ntawm plab microbiota, Txhawb nqaLub plab hnyuv me me hauv nasThiab pab pawg tau tshem tawm cov tshuaj sau ua ke hauv cov hnyuv, yog li unceviating plab [8].

Da huang paub txog nwsmuaj zog purgative cuam tshuam, pab ntxuav kom ntxuav cov hnyuv thiab txhawb cov metabolism. Nws yog dav siv rau kev khocem vim tias ntuCov. Raws li tau teev nyob rau hauvYao Pin Hua Yi (药品化义):

"Da Huang yog hnyav thiab turbid nyob rau hauv xwm, hloov mus sab hauv. Nws muaj lub zog rau kev thaiv thiab qhib lub laj thawj thiab hu ua 'dav dav huang'." [9]

Txuas ntxiv, vim nwstxias thiab iab cov khoom, Ntaj huang kuj yog tsim nyog rau kev khoKev Tiv Thaiv Thaum Tshav Kub Kub-Hom Cuav. Rhein, ib qho lipophilic anthraquinone feem ntau nyob hauv cov tshuaj Rhubarb, yog lub luag haujlwm tseem ceeb ntawm lub luag haujlwm rauNtaj huang txoj kev ua kom muaj kev cuam tshuam[10]. Cov kev tshawb fawb pharmacological tau qhia tiasRhein yog nqus tom qab metabolism los ntawm plab me microbiota thiab tuaj yeem tswj cov ntshav lub Motilin qib, thaum tseemTxo qhov kev hais tawm ntawm aquaporins (Aqps) hauv cov roj colonic ntawm cov nas taws, yog li exerting nws purgative cuam tshuam [11-13]. Ntxiv mus,Da Huang tuaj yeem txhim kho thiab kho cov quav tawv los ntawm kev hloov kho lub arachidonic acid metabolism txoj kev [14].

Hou po tau paub rau nws lub peev xwmKev tswj hwm qi, daws bloating, thiab tshem tawm cov tshuaj accountated, ua nws tus nqi tseem ceeb rau kev khoXuas Txoj Cai TxhuasCov. Nws yog feem ntau siv hauv kev sib xyaw nrogDa Huang, ZHI Shi, thiab lwm yam tshuaj ntsuab, raws li pom hauvHou po San wu tang (厚朴 3 物汤)ntawmJin Gui Yao Lue (金匮要略).

Tshawb nrhiav los ntawm Kang Lei li al. [15] Pomaloin, lutolin, thiab naringeninRaws li cov neeg nquag tseem ceeb hauvHou po san wu tanglub luag hauj lwm rau nws cov teebmeem hauv tebchaws. Kev tshawb fawb los ntawm Zhen li al. [16] pom tiasaloin tuaj yeem txhawb kev tso lub plab zom mov los ntawm kev hais tawm Aqp3 hauv cov nqaij plab ntawm cov nasCov. Tsis tas li ntawd, kev tshawb fawb qhia tau tiasNaringenin Alleviates cov tsos mob cem quav los ntawm kev nthuav dav cov tsos mob hlwb thiab AQP3 nyob rau hauv lub Colons ntawm Loperamide-induced convated nas [17].

3.2.6 Syndrome (虚态)

TusHom Phiajrau kev ua tsis taus-hom cem ncauj muajBai Zhu (白术, ib qho kev sib xyaw ua ke), Dang GUI (当归, Angelica Congenis), thiab Rou Con G.

Bai Zhufeem ntau siv rau kev khoTxoj Cai Tsis Txaus-Hom Conchipation, tshwj xeeb tshaj yog nyob rau hauv cov tib neeg nrogSpleen Qi tsis muaj peev xwmCov. Tshawb nrhiav los ntawm nws li al. [32] pom tiasAtractorylenolide I thiab IIItuaj yeem tseem ceebInhibit cov neeg kho mob uas ua los ntawm macrophages thiab txo qhov qhia ntawm inducible Nos (Inos).

Rou Conng rong (cistanche Squaticola)yog paub rau nws cov kev cuam tshuam ntawmTasinging Rabney Yang, Novagishing essence thiab ntshav, thiab moistening cov hnyuv los daws cov quav tawvCov. Nws yog siv tau tshwj xeeb thaumUa ke nrog lwm cov tshuaj ntsuab los kho cov khoom siv txias-hom tsis tsim nyog vim lub raum Yang deficiency, uas feem ntau pom hauv cov neeg mob laus.Rou Conng rong feem ntau tau ua khub nrog Bai Zhu los txhim kho ob qho tib si qi-toneling-tswj hwm kev cuam tshuam.

Liu Yuanhong li al. [33] uaKev Tshawb Nrhiav NetworkTxheeb xyuasQhov tseem ceeb ua haujlwm sib txuas thiab hom phiaj proteinnyob rau hauvBai Zhu-Rou Conng Rongua ke. Lawv cov kev sim tshawb fawb pom tias cov khoom xyaw nquag tuaj yeemcuam ​​tshuam cov hom phiaj tseem ceeb xws li PTGS2, AKT1, TNF, thiab IL -6, tswj hwm ntau txoj kev pom txoj hauv kev rau kev zam kev cem quav.

Dang GUI (Angelica Sinenis)yog aNtshav-Toninging Tshuaj Ntsuabnrog amuaj zog aroma thiab qab zib, pungent, thiab me ntsis iab sajCov. Nws tsuas yog nkag mus rauMob siab, lub siab, thiab popids meridiansthiabnourishes cov ntshav kom moisten lub hnyuv, ua kom nws pab tauQhov Tsis Txaus-Hom Kev Hloov Chaw.

Du Lidong ET AL. [34] Tshawb pom tias covkev mechanism nram qab Dang GUI laxative teebmeemTuaj yeem koom nrogCov kev cai ntawm PLC-IP {1}}} cam thiab AC-Camp-Pka Signaling Txoj kev, raws liModulating cov kev hais tawm ntawm aquaaporins (Aqps) hauv cov ntaub so ntswg colonic.

3.2.7 Cov Mob Txias (寒态)

TusCov tshuaj yuav khoomRau cov khaub thuas khaub thuas-hom muajJi Chuan Jian (济川煎) thiab Fu Zi Lis Zhong Wan (附子理中丸), nrogLub hom phiaj tshuaj xws li Gan Jiang (干姜, Lub ntsej muag qhuav), XIAO.

Ji chuan jianyog paub rau nws cov kev cuam tshuam ntawmUa kom sov ob lub raum, tonifying essence, thiab noo noo cov hnyuv los daws cov quav tawv, thiab yog feem ntau siv los khoRaum deang tsis txaus thiab kua tsis txausCov. Yog li ntawd,ob qho tib yam tsis muaj hom thiab hom kev cem quavtuaj yeem kho nrogJi chuan jian.

Cov kev tshawb fawb tau pom tiasJi Chuan Jian muab nws cov kev kho mob ntawm cem quav los ntawm kev tswj hwm plab hnyuv ua haujlwm, nrog kev siv hluav taws xob nrogNce cov kev qhia ntawm c-cov protein hauv colonic cov ntaub so ntswg thiab txo ntshav vip qib[{35-37]. Qhov ua tau zoo ntawmJi chuan jiantau pom tias yogzoo correlated nrog nws concentration.

Tsis tas li ntawd,bioinformatics kev tshawb nrhiavQhia tiasJi Chuan Jian yuav siv nws cov kev cuam tshuam los ntawm kev hloov kho ntau lub hom phiaj xws li Mapk3, Mapk1, Mapt1, Bax, thiab Raf1, uas cuam tshuam nrog ntau yam kab mob hauv txoj kev [38].

Fu Zi Lis Zhong Wanfeem ntau siv los khoSpleen thiab lub plab tsis txaus-txias syndromesCov. Txawm li cas los xij, nws yuav tsum tau siv nrog kev ceev faj, raws liFU Zi (附子, aconite) yog qhov ua kom sov siab heev thiab tsis haum rau cov tib neeg uas muaj cua sov ntau tshaj plaws hauv cua sov.

Li dong'an li al. [39] pom tiasFu Zi Lis Zhong WantauInceptantly thaiv ural motibition inhibition ntxias los ntawm adrenalinal thiab daws cov plab hnyuv los tshwm sim los ntawm acetylcholine, yog li rov qab kho cov hnyuv num.

 

3.2.8 Ntshav Stasis syndrome (瘀态)

TusPhiaj Yeeb Tshuajrau cov ntshav stasis-hom cem quav yogTao ren (桃仁, phev persicae).

Tao r nkag nkag siab lub siab, mob siab, thiab cov hnyuv rau cov hnyuv lojthiab muajTshuaj cov ntshav tawm tsam, tshem cov ntshav ntshav, noo noo cov hnyuv, thiab pab kom cov teebmeem cem quav.

RauCov ntshav ntshav-ntsig txog cov ntshav, Tao ren tsis tsuas yog txhawb kev cov ntshav ncig mus daws qhov mob tab sis kuj pab txhawb cov ntshav qis thaum nqus cov hnyuv los pab txhawb cov hnyuv.

Vim nwsCov roj ntau cov ntsiab lus, Tao npe yog tshwj xeeb rau kev kho cua durner-hom quavCov. Ib yam li ntawd, lwm yamRoj-nplua nuj Suav Tshuaj xws li Bai Zi Ren (柏子仁, Platycladus Noob) thiab Ku Xing Ren (苦杏仁, Ntseeg Axricot Noob)kuj muajnoo noo thiab laxative cov khoom.

 

4 TAWG

Hauv cov ntsiab lus, raws li kev qhia ntawm lub hom phiaj hauv xeev thiab kev kho mob cov cai tswj hwm thiab kev kho mob cov cai txhawb nqa thiab kev kho mob ntawm cov kws kho mob suav cov yeeb yam.

 

Ntawv Sawv cev

[1] jiang Lingfang. Kev tshawb fawb ntawm daim ntawv thov ntawm Acupuncture (cov cua sov Nanchang: Tsev kawm ntawv ntawm tshuaj, Nchang University, 2023.
[2] Xu Linghai. Shennong Bencao Jing Baizhonglu [m]. Beijing: Tuam Tshoj Kev Tshawb Fawb Kev Tshawb Fawb thiab Tshuab Cav, 2016.
[3] Ma x, Chi Yh, Niu M, li al. Cov metabolomics txuas nrog cov ntaub ntawv tshaj tawm thiab kev txheeb xyuas cov kab ke ntawm cov peev xwm biomarcers hauv cov nyhuv Lactiflora pall [j]. Pem hauv ntej lub tsev khw, 2016, 7: 14.