Aristolochic Acid Nephropathy: Kev Tshawb Fawb Txog Kev Tshawb Fawb Ntawm Cov Ntawv Sau Los ntawm 1971 txog 2019
Mar 23, 2022
Yog xav paub ntxiv:ali.ma@wecistanche.com
Hongjian Ji, PhD, Jingyin Hu, & et al.
Abstract
Keeb kwm:Aristolochic acid nephropathy(AAN) yog ib hom tshuaj tua kab mob nephropathy uas tuaj yeem ua raumob raum raug mobthiab muaj feem cuam tshuam nrog cov kev kawm uas muaj peev xwm nce qibraumfibrosis thiab sab sauv kab mob urothelial carcinoma. Aristolochic acids (AAs) yog ib pawg ntawm cov co toxins uas muaj nyob rau hauv cov nroj tsuag ntawm genera Aristolochia thiab Asarum, uas muaj nyob thoob plaws ntiaj teb. AAN(Aristolochic acid nephropathy) tseem tshwm sim hauv thaj av Esxias thiab Balkan. Cov kab mob loj zuj zus thiab cov xwm txheej hloov pauv tau pib los ntawm AAs yog qhov hloov tsis tau, thiab tsis muaj kev kho mob zoo rau AAN(Aristolochic acid nephropathy)tau tsim. Tsis tas li ntawd, ntau tus neeg muaj kev pheej hmoo ntawm tus kab mob no vim raug kis rau AAs.Qhov kev tshawb fawb no tau ua qhov kev tshawb fawb tshawb fawb ntawm cov ntaub ntawv tshawb fawb thoob ntiaj teb tsom rau AAN.(Aristolochic acid nephropathy).
Nyem rau cistanche cov txiaj ntsig thiab cov kev mob tshwm sim
Txoj Kev: Lub Web of Science database tau tshawb nrhiav los txheeb xyuas txhua qhov kev tshaj tawm hais txog "Aristolochic acid nephropathy"los yog "Balkan endemic nephropathy" siv cov ntsiab lus no los ua cov lus tseem ceeb los tshawb nrhiav cov ntaub ntawv los ntawm 1971 txog 2019. Cov ntaub ntawv khaws tseg suav nrog hom ntaub ntawv, tus sau, phau ntawv xov xwm, xyoo tshaj tawm, cov ntawv tshaj tawm, thiab lub teb chaws ntawm kev tshaj tawm, thiab tau txheeb xyuas siv cov ntaub ntawv. VOSviewer software.
Cov txiaj ntsig: Tag nrho ntawm 1251 cov ntaub ntawv tau pib pib. Cov ntawv tshaj tawm, suav nrog "kev sib tham paub daws teeb meem." "tsab ntawv," "cov ntaub ntawv kho." thiab "cov ntawv ua tiav" raug cais tawm, uas tshuav 1083 cov ntawv tshaj tawm suav nrog 923 cov ntawv thiab 160 kev tshuaj xyuas. Lus Askiv yog hom lus tseem ceeb ntawm cov ntawv tshaj tawm. Tuam Tshoj tau tshaj tawm cov xov xwm tshaj tawm nrog 217 (20.0 feem pua), tom qab ntawd Tebchaws Asmeskas nrog 186 tsab xov xwm (17.2 feem pua), thiab lub teb chaws Yelemees muaj 138 tsab xov xwm (12.7 feem pua).Lub raumThoob ntiaj teb. Khoom noj khoom haus thiab Tshuaj Toxicology, thiab Toxins yog 3 cov ntawv xov xwm nquag tshaj plaws hauv kev tshaj tawm cov lus hais txog AAN(Aristolochic acid nephropathy). Tag nrho cov naj npawb ntawm cov ntaub ntawv tau txais los ntawm txhua qhov kev tshaj tawm yog 39,970, nrog qhov nruab nrab ntawm 36.91 cov ntawv sau rau ib kab lus (ntau:0-1769). Cov ntawv nyeem feem ntau tsom rau apoptosis, oxidative stress, thiab o hauv AAN(Aristolochic acid nephropathy).
Xaus: Txoj kev tshawb no qhia tias AAN(Aristolochic acid nephropathy)yog ib lub ntsiab lus tseem ceeb hauv kev tshawb fawb nephrology, raws li qhia los ntawm ntau qhov kev tshaj tawm. Cov ntawv nyeem tau tsom mus rau cov txheej txheem ntawm AA-induced nephropathy.
Cov ntawv luv: AAN=aristolochic acid nephropathy, AAs=aristolochic acids.
Ntsiab lus:Aristolochic acid nephropathy, Balkan endemic nephropathy, scientometrics
1. Taw qhia
Aristolochic acid nephropathy(AAN), uas ua rau lub raum tsis sib haum xeeb feem ntau cuam tshuam nrog urothelial malignancies, tau pib qhia hauv Belgian cov neeg mob tom qab noj cov aristolochic acids (AAs).[1,2] Txawm hais tias botanicals uas paub lossis xav tias muaj AAs tsis muaj lawm. tso cai nyob rau hauv ntau lub teb chaws, qhov tshwm sim ntawm AAN(Aristolochic acid nephropathy)tej zaum yuav siab dua li qhov pib xav, tshwj xeeb tshaj yog nyob rau Asia.[3] Hauv cov tebchaws Esxias, tshwj xeeb tshaj yog Tuam Tshoj, cov tshuaj ib txwm siv rau kev noj tshuaj rau tus kheej lossis cov khoom lag luam ua liaj ua teb muag los ntawm tes hauj lwm tau dhau los ua qhov sib txawv. Raws li cov lus hais zoo sib xws, AA-muaj tshuaj ntsuab ib txwm siv tsis raug rau "mutong" lossis "fangchi," uas yog Akebia Decne genus thiab Menispermaceae tsev neeg, feem.4 Balkan endemic nephropathy yog qhov muaj ntau heev; Txhua xyoo, kwv yees li 25,000 cov neeg raug mob los ntawm tus kab mob no thiab ze li ntawm 100,000 cov neeg muaj kev pheej hmoo nyob rau hauv cheeb tsam Balkan, tshwj xeeb tshaj yog nyob rau hauv cov zos ua liaj ua teb nyob ib ncig ntawm lub zos.5-7Kuv tsis ntev los no kev tshawb nrhiav muaj qhia tau hais tias qhov no yog tshwm sim los ntawm hmoov yog inadvertently kis kab mob ntawm AAs.18,9]
Scientometrics los yog bibliometrics yog methodologicalapproaches tsom rau muab ntau thiab zoo tsom xam ntawm cov ntaub ntawv scientific uas twb muaj lawm nyob rau hauv ntau yam ntawm cov ncauj lus. Cov no tau suav nrog cov ntsiab lus xws li nonalcoholic steatohepatitis, 5 curcumin, 1] Parkinson's disease, 12] thiab Qigong.
Rau peb txoj kev paub, tsis muaj kev tshawb fawb scientometric tau ua nyob rau hauv lub ntiaj teb no kom tsuas yog ntsuas AAN(Aristolochic acid nephropathy). Lub hom phiaj ntawm txoj kev tshawb no yog los muab cov ntaub ntawv tseeb ntawm kev tshawb fawb thoob ntiaj teb kev tsim khoom thiab kev tshaj tawm cov qauv hauv thaj tsam ntawm AAN(Aristolochic acid nephropathy)siv ib txoj hauv kev scientometric.
2. Cov txheej txheem
Peb tau tshawb nrhiav hauv Web of Science database rau lub sijhawm txij li xyoo 1971 txog 2019 txhawm rau txheeb xyuas txhua cov ntawv hais txog "Aristolochic acid nephropathy"los yog"Balkan endemic nephropathy" siv cov ntsiab lus no raws li cov ntsiab lus hauv kev tshawb fawb.Lub Web of Science database tau raug xaiv rau qhov kev tshawb fawb scientometric no vim nws muab cov ncauj lus kom ntxaws txog kev qeb duas ntawm cov kws sau ntawv, kev koom tes hauv lub tebchaws, cov ntawv xov xwm, thiab cov ntaub ntawv pov thawj. Feem ntau cov ntsuas scientometric. muaj nyob rau hauv lub rooj los yog daim duab hom.
2.1. Cov txheej txheem txheeb cais
Peb suav nrog cov kev tshawb fawb luam tawm hauv txhua hom lus. Cov ntaub ntawv khaws tseg suav nrog cov xov tooj ntawm cov ntawv tshaj tawm txhua xyoo, hom ntaub ntawv, Hirschindex (hindex), kev sau ntawv, phau ntawv xov xwm, xyoo tshaj tawm, tus naj npawb ntawm cov ntawv sau, thiab lub teb chaws tshaj tawm. Qhov qeb duas ntawm cov kws sau ntawv, kev koom tes hauv lub tebchaws, cov ntawv xov xwm, thiab cov ntawv pov thawj tau txheeb xyuas los ntawm Microsoft Excel thiab tau nthuav tawm hauv Tables 1-3. Cov ntaub ntawv tag nrho thiab cov ntaub ntawv pov thawj ntawm cov ntawv tshaj tawm no tau muab tso rau hauv VOSviewer rau kev soj ntsuam kev tshawb fawb ntxiv. Kev sib koom ua ke thiab kev txheeb xyuas pawg ntawm cov lus tseem ceeb kuj tau ua los ntawm kev siv VOSviewer software.
2.2. Tsim kev sib tham hauv phau ntawv teev lus siv VOSviewer Software
Lub VOSviewer software (v.1.6.16) tau muab rho tawm thiab tshuaj xyuas cov ntsiab lus ntawm cov neeg sau ntawv thiab cov ntsiab lus ntawm cov ntawv tshaj tawm, cuam tshuam rau lawv cov ntaub ntawv suav suav, thiab tsim ib daim ntawv qhia npuas kom pom cov txiaj ntsig.14 Cov kev ntsuas tsis raug siv rau kev txheeb xyuas thiab tsim cov duab npuas npuas. Qhov loj ntawm font ntawm cov lus nyob rau hauv daim ntawv qhia npuas qhia qhov zaus ntawm qhov tshwm sim (ntau qhov tshwm sim hauv ib qho kev tshaj tawm suav tias yog 1). Ob lo lus nyob ze rau ib leeg yog tias lawv tau sib koom ua ke hauv kev tshuaj xyuas cov ntawv tshaj tawm ntau zaus. Tsuas yog cov lus tseem ceeb uas tshwm sim tsawg kawg yog 1.0 feem pua (n=11) ntawm cov ntawv tshaj tawm tau txheeb xyuas thiab pom. Rau daim ntawv qhia lo lus tseem ceeb, ib txoj kev suav tag nrho tau siv, txhais tau hais tias txhua qhov sib koom ua ke tau nqa qhov hnyav tib yam. Lub neej ntawd "kev koom ua ke lub zog txoj kev" tau siv rau qhov normalization ntawm kev sib koom ua ke matrix nrog rau qhov tseem ceeb ntawm kev nyiam thiab kev tawm tsam.
Kev pom zoo los ntawm Pawg Neeg Saib Xyuas Kev Ncaj Ncees tsis tas yuav tsum tau vim tias tag nrho cov ntaub ntawv tau rov qab los ntawm Web of Science database.
3. Cov txiaj ntsig
Peb tau txheeb xyuas 1251AAN(Aristolochic acid nephropathy)-related records. Thawj tsab xov xwm hais txog AAN(Aristolochic acid nephropathy)tau luam tawm xyoo 1971 los ntawm Prodanovand Astrug.15 Txij thaum ntawd los, cov ntawv xov xwm ntawm AAN(Aristolochic acid nephropathy) tau maj mam nce txhua xyoo mus txog rau xyoo 2000, tom qab ntawd muaj kev loj hlob ntxiv hauv 2 xyoo dhau los (Daim duab 1).Cov ntaub ntawv sau tseg hauv 5 xyoo dhau los (2015-2019) suav txog 23.8 feem pua (298) ntawm tag nrho cov ntawv tshaj tawm.
Daim duab 1. Tus naj npawb ntawm cov ntawv tshaj tawm ntawm aristolochic acid nephropathy (AAN) txhua xyoo
Raws li tsab ntawv ceeb toom ntawm Zhou et al, [3] lo lus tseem ceeb "kev sib ntsib paub daws teeb meem," "tsab ntawv," "cov ntaub ntawv kho," lossis "cov ntawv ua tiav" raug tshem tawm, tawm hauv 923 cov ntawv qub thiab 160 kev tshuaj xyuas uas yog rau npe rau kev tshuaj xyuas ntxiv hauv txoj kev tshawb no; Lus Askiv (1047; 96.7%) yog thawj hom lus ntawm cov ntawv, tom qab ntawd yog Fabkis (15; 1.4%) thiab German (7; 0.6%).
Cov kws sau ntawv los ntawm 79 lub teb chaws sib txawv tau pab txhawb rau kev tshaj tawm. Cov kws sau ntawv los ntawm Tuam Tshoj yog cov neeg coob tshaj plaws (217; 20.0 feem pua), raws li Asmeskas (186; 17.2 feem pua) thiab lub teb chaws Yelemees (138; 12.7 feem pua). Tuam Tshoj kuj muaj cov ntawv tshaj tawm ntau tshaj plaws. 10 lub teb chaws uas muaj cov ntawv tshaj tawm ntau tshaj plaws tau pom hauv daim duab 2.
Daim duab 2. Sab saum toj 10 lub teb chaws tsim khoom tshaj plaws.
Table 1 qhia txog 10 phau ntawv journal nrog ntau cov ntawv tshaj tawm ntawm AAN(Aristolochic acid nephropathy), nrogLub raumThoob ntiaj teb muaj cov khoom lag luam ntau tshaj plaws (44; 4.1 feem pua ), ua raws li Cov Khoom Noj thiab Tshuaj Toxicology (30; 2.8%), Toxins (24; 2.2%), Nephrology Diahysis Transplantation (23; 2.1 feem pua), Lub raum Failure (21; 1.9 feem pua), Archives of Toxicology (19; 1.8 feem pua), Toxicology (17; 1.6 feem pua), PLOS Ib (16; 1.5 feem pua), American Journal ofKab mob raum(14; 1.3%), thiab Kev Tshawb Fawb Tshuaj hauv Toxicology (14; 1.3%).
Table 1: Sab saum toj 10 cov ntawv sau tau zoo tshaj plaws ntawm aristolochic acid nephropathy (AAN)
Tag nrho cov naj npawb ntawm cov ntawv tshaj tawm yog 39,970. Txhua qhov kev tshaj tawm tau raug suav nrog tsawg kawg 36 zaug nrog qhov nruab nrab ntawm 36.91 cov ntawv tshaj tawm hauv ib qho kev tshaj tawm (xws li ntawm 0 txog 1769).H-index ntawm 1083 cov ntawv luam tawm thiab tshuaj xyuas yog 91. Qhov qeb duas ntawm 10 feem ntau cov ntawv tshaj tawm cuam tshuam nrog kev siv cov AAN(Aristolochic acid nephropathy)yog qhia hauv Table 2.
Table 2 Sab saum toj 10 cov ntawv tshaj tawm xaiv los ntawm cov ntawv pov thawjntawm aristolochic acid nephropathy (AAN).
10 cov ntawv tshaj tawm muaj cov kws sau ntawv los ntawm 7 lub tebchaws (Is Nrias teb, Belgium, Tebchaws Asmeskas, Askiv, Canada, Croatia, thiab Fabkis) thiab tau luam tawm hauv 9 phau ntawv xov xwm: Lancet(2), New England Journal of Medicine (1), Molecular Nutrition 必Kev Tshawb Fawb Khoom Noj (1), Cov Ntawv Tshaj Tawm ntawm Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Ntiaj Teb (1), Raum International (1), Kev Ua Haujlwm ntawm National Academy of Sciences ntawm Tebchaws Meskas (1), Mutagenesis (1), Phau Tsom Faj Tsiaj (1) , thiab International Journal of Coal Geology (1).
Table 3 Sab saum toj 20 cov ntsiab lus rov ua dua los ntawm cov lus tseem ceeb ntawm aristolochic acid nephropathy (AAN).
Muaj 157 lo lus tseem ceeb uas tshwm sim hauv tsawg kawg yog 1.0 feem pua (n=11) ntawm cov ntawv txheeb xyuas. Qhov saum 20 cov lus tseem ceeb uas tshwm sim tau teev nyob rau hauv Table 3. Los ntawm kev txheeb xyuas cov ntsiab lus ntawm 1083 cov ntawv tshaj tawm, peb pom tias tag nrho cov kev sib txuas ntawm cov ntsiab lus tseem ceeb muaj feem xyuam rau cov txheej txheem ntawm AA toxicity, xws li apoptosis (n=73, citations) ib daim ntawv tshaj tawm =6.7 feem pua , mob (n=58, citations per publication=5.3%), thiab oxidative stress (n=38, citations per publication{{ 14}}.5 feem pua). Daim ntawv qhia npuas ntawm tag nrho qhov txuas lub zog ntawm cov ntsiab lus, tshwj xeeb tshaj yog apoptosis, o, thiab oxidative kev nyuaj siab, yog qhia hauv daim duab 3.
Daim duab 3. Bubble daim ntawv qhia pom cov lus los ntawm cov ntsiab lus ntawm 1083 aristolochic acid nephropathy cov ntawv luam tawm.Tsuas yog cov lus uas tshwm sim tsawg kawg yog 1.0 feem pua ntawm cov ntawv tshaj tawm tau raug tshuaj xyuas thiab pom.
4. Kev sib tham
Rau qhov kev tshawb fawb scientometric no, peb xaiv lub Web of Science database los ua peb qhov chaw los khaws tag nrho cov ntaub ntawv hais txog kev tshawb fawb tawm hauv thaj chaw ntawm AAN(Aristolochic acid nephropathy). Lub Vev Xaib ntawm Kev Tshawb Fawb yog qhov loj tshaj plaws thiab ib qho ntawm cov ntaub ntawv txhim khu kev qha tshaj plaws rau kev tshaj tawm thiab cov ntaub ntawv pov thawj, muab ntau (ntau cov kev tshawb fawb) nrog rau cov ntaub ntawv zoo, suav nrog kev cuam tshuam (h-index).l26]
Peb suav nrog 1251 cov ntaub ntawv hais txog AAN(Aristolochic acid nephropathy)hauv txhua hom lus. Tus naj npawb ntawm cov ntawv sau tau loj hlob tsis tu ncua, nrog kev nce ntxiv hauv 2 lub xyoo dhau los, qhia tau tias AAN(Aristolochic acid nephropathy)tau yog ib qho kev nthuav qhia rau kev tshawb fawb tshawb fawb hauv thaj tsam ntawm nephropathy. Tuam Tshoj, Tebchaws Asmeskas, thiab Lub Tebchaws Yelemees tau pom tias yog lub tebchaws tsim khoom tshaj plaws hauv qhov no.
Feem ntau ntawm AAN(Aristolochic acid nephropathy)tau nce thoob ntiaj teb nyob rau hauv 2 lub xyoos dhau los, ua ke nrog kev nce zuj zus ntawm apoptosis, [27,28]
(29,30] thiab o, 31,32] tag nrho cov uas yog oxidative kev nyuaj siab, mechanisms tseem ceeb rau AAN(Aristolochic acid nephropathy). Cov tshuaj tiv thaiv kab mob los yog tshuaj tiv thaiv apoptotic tuaj yeem dhau los ua cov tswv yim kho mob yav tom ntej,[27,33,34]
Peb txoj kev tshawb fawb muaj ob peb qhov zoo thiab kev txwv. Peb tau siv lub vev xaib ntawm Kev Tshawb Fawb Txog Kev Tshawb Fawb los ua qhov chaw los khaws tag nrho cov ntawv tshaj tawm hais txog AAN(Aristolochic acid nephropathy)raws li nws yog cov ntaub ntawv lees paub tshaj plaws rau kev tshuaj xyuas cov ntaub ntawv tshawb fawb hauv qee qhov fifields ntawm kev tshawb fawb. Txoj kev tshawb no yog thawj zaug los tshuaj xyuas cov haujlwm tshawb fawb hauv fifield ntawm AAN(Aristolochic acid nephropathy), qhia txog kev nce ntxiv ntawm cov ntawv tshaj tawm. Txawm li cas los xij, los ntawm kev siv Web of Science database ib leeg, kev koom tes ntawm lwm cov ntaub ntawv yuav raug kwv yees. Tsis tas li ntawd, cov txiaj ntsig ntawm kev muab rov qab yog qhov tsis ncaj ncees rau qee qhov, tshwj xeeb tshaj yog cov ntawv tshaj tawm los ntawm Finkelman li al, [25] uas suav tias Balkan endemic nephropathy cuam tshuam nrog qhov sib thooj ntawm pliocene lignite deposits, tsis sib haum xeeb nrog Markovic-Lipkovsk li al. [9] Yog li ntawd, qhov tseeb ua rau qhov tshwm sim no yog ib qho kev tshawb nrhiav tas li.
Rau peb txoj kev paub, qhov no yog thawj qhov kev tshawb fawb bibliometric los txheeb xyuas thiab ntsuas cov txiaj ntsig kev tshawb fawb thoob ntiaj teb ntsig txog AAN(Aristolochic acid nephropathy). Txawm li cas los xij, nws yuav tsum tau hais tias Zhang et al tsis ntev los no tau tshaj tawm cov kev tshawb fawb bibliometric thiab kev tshuaj xyuas cov ntaub ntawv thoob ntiaj teb hais txog cov qauv hauv AAs, [3] thaum peb txoj kev tshawb fawb suav nrog tsuas yog cov ntawv tshaj tawm txog AAN.(Aristolochic acid nephropathy).
5. Cov lus xaus
Txoj kev tshawb no qhia tau hais tias apoptosis, oxidative kev nyuaj siab, thiab o yog cov ntsiab lus tseem ceeb hauv cov txheej txheem ntawm AAN.(Aristolochic acid nephropathy)thiab muab cov kws tshawb fawb thiab kws kho mob kev nkag siab txog qhov kev tshawb fawb no.
Cov ntaub ntawv
[1] Grollman AP.Chemical biology ntawmAristolochic acid nephropathy, tus kab mob thoob ntiaj teb. Chem Res Toxicol 2010; 23:288.
[2] Markovic-Lipkovski J, Tulic C, Vuksanovic A, et al. Morphology ntawm Balkan endemic nephropathy: lub xeev tam sim no. Clin Nephrol 2012; 77:2 5-31.
[3] Ishii T, Kumagae T, Wakui H, et al. Cov qog xanthine oxidoreductase kev ua haujlwm hauv nas qauv ntawmAristolochic acid nephropathy. FEBS Qhib Bio 2021; 11:507-18.
