Daim Ntawv Thov Cistanche hauv Cov Khoom Noj Ua Si hauv Suav Teb-Puas Cistanche nce Dopamine?

3 Kev soj ntsuam kev nyab xeeb ntawm Cistanche deserticola

3.1 Kev nyab xeeb kev kawm ntawm Cistanche deserticola thiab nws cov extracts

Huang Zongxiu et al[9] soj ntsuam kev nyab xeeb noj tau ntawmCistanche, thiab cov txiaj ntsig tau pom tias qhov mob qhov ncauj qhov siab siab tshaj plaws (MTD) ntawmCistancheyog ntau tshaj 20 g / kg, thiab nws tau txiav txim raws li ib tug tsis muaj tshuaj lom cov khoom raws li tus mob toxicity grading ntsuam xyuas tus qauv; Kev kuaj genotoxicity ntawm Ames, phev deformity nyob rau hauv nas thiab pob txha hlwb micronucleus yog tag nrho cov tsis zoo, tsis muaj mutagenic nyhuv. Saib pom kev tsis zoo tshwm sim. Bai Guohui et al[10] uamob toxicitythiab 90-hnub pub mis kuaj rauCistanche deserticola, and the results also showed that the MTD of the acute toxicity test was >15000 mg / kg, uas yog qib tsis muaj tshuaj lom. Lin Jian et al. [11] kuj tau pom cov teebmeem ntawm cov koob tshuaj sib txawv ntawm Cistanche deserticola ntawm SD cov nas cev xeeb tub. Cov txiaj ntsig tau pom tias piv nrog rau pawg tswj hwm tsis zoo, qhov siab tshaj plaws ntawm Cistanche deserticola 3.33 g / kg BW muaj cov txiaj ntsig tseem ceeb ntawm cov cim qhia lub cev, tsim embryo thiab kev loj hlob ntawm fetus thiab kev loj hlob ntawm cov nas cev xeeb tub. Tsis muaj qhov cuam tshuam tseem ceeb ntawm cov ntsuas, thiab tsis pom muaj cov tshuaj lom.

Tsis tas li ntawd, cov granules thiab allantoin extracts ntawmCistanche deserticolafeem ntau yog ua los ntawmCistanche stannate extract, thiab cov txiaj ntsig ntawm kev soj ntsuam kev nyab xeeb toxicological qhia tias tsis muaj kev mob toxicity, genotoxicity thiab subacute toxicity tshuaj [12-14]. Cov txiaj ntsig saum toj no tag nrho qhia tau hais tias ntau npaum li cas ntawm Cistanche deserticola thiab nws cov extracts lossis kev npaj tau muaj kev nyab xeeb thiab tsis muaj tshuaj lom nyob rau hauv qee yam.

3.2 Kawm txog kev nyab xeeb ntawm Cistanche Tubulosa thiab nws cov extracts

Cov txiaj ntsig ntawm kev ntsuas kev nyab xeeb ntawmCistanche tubulosa extractpom tau tias nws qhov siab tshaj plaws tau txais koob tshuaj (MTD) nyob rau hauv qhov mob qhov ncauj toxicity test yog ntau dua 10 g / kg BW, thiab nws tau txiav txim siab tias tsis muaj tshuaj lom raws li kev soj ntsuam.

Cov ntawv; nws Ames, pob txha pob txha micronucleus thiab phev deformity kuaj pom tau hais tias cov tshuaj tsis muaj mutagenic nyhuv; Nyob rau tib lub sijhawm, teratogenicity kuaj cov txiaj ntsig tsis zoo, qhia tias nws tsis muaj cov nyhuv teratogenic [15]. Tsis tas li ntawd, qee cov kws tshawb fawb tau ua rau mob toxicity, peb genotoxicity, thiab 90-hnub pub mis rau cov extract ntawmCistanchetau los ntawm tsuas yog crushing, extracting, tsom, kom qhuav thiab lwm cov kauj ruam. Txhua tus nas tsis pom muaj qhov tshwm sim ntawm kev lom thiab lub hom phiaj ntawm lub cev toxicity. Pathological kev hloov pauv,Cistanche extracttsis muaj qhov cuam tshuam tseem ceeb rau biochemical, ntshav niaj hnub thiab lwm yam ntsuas ntawm cov tsiaj [16].

Jiang Zhongren et al [17] kev sim tau pom tias qhov kev kuaj mob toxicity tshwm sim ntawm 75 feem pua ​​​​ethanol extract ntawmCistanchetsis pom muaj toxicity. Zhang Ya'an et al. [18] pom tias cov ntsiav tshuaj compound ua los ntawmCistanchepipiensis ua ke nrog Epimedium, taurine thiab zinc gluconate tau txiav txim siab kom muaj kev nyab xeeb thiab tsis muaj tshuaj lom tom qab kev soj ntsuam kev nyab xeeb toxicological. Tag nrho cov txiaj ntsig saum toj no qhia tau hais tias Cistanche deserticola thiab nws cov extracts muaj kev nyab xeeb thiab tsis muaj tshuaj lom ntawm cov koob tshuaj zoo.

Cov zaub mov noj qab haus huv yog cov khoom noj tshwj xeeb uas tuaj yeem noj tau ntev. Thaum ua ntawv thov rau cov khoom noj uas muaj feem xyuam rau kev noj qab haus huv, nws yog ib qho tsim nyog yuav tsum tau ua tib zoo saib xyuas cov khoom lag luam kev nyab xeeb ntawm txhua cov khoom siv raw thiab cov mis tom qab kev sib raug zoo. Ua ke nrog kev tshawb fawb cov ntaub ntawv thiab cov kev ntsuam xyuas tsiaj uas tsim nyog, nws tuaj yeem lees paub tias cov qauv kev sib raug zoo thiab cov khoom siv raw muaj kev nyab xeeb noj. Ua cov kev tshawb fawb txog kev noj qab haus huv. Los ntawm txoj kev, nws muaj kev nyab xeeb sivCistanche deserticolathiab nws cov extracts, thiabCistanchethiab nws cov extracts nyob rau hauv tus nqi txwv los ntawm cov kev cai, yog li ntawd lawv yuav siv tau raws li kev noj qab haus huv zaub mov raw khoom.

Nyem qhov no kom tau txais Cov Qauv Dawb ntawm Cov Khoom Siv Zoo Cistanche Extract

4 Kev noj qab haus huv ua haujlwm ntawm Cistanche

Bioactive Cheebtsam ntawmCistanchefeem ntau yogphenylethanoid glycosides, iridoids, thiab lawv cov glycosides, lignans thiab lawv glycosides, polysaccharides, thiab lwm yam, uas muaj antioxidant, tiv thaiv kev qaug zog, tiv thaiv kev laus, tiv thaiv qog, tiv thaiv kab mob, daim siab tiv thaiv, kev tiv thaiv kev tiv thaiv, kev txhim kho kev sib deev, kev tswj hwm. ntawm lub hauv paus paj hlwb, kev tswj hwm ntawm endocrine, txhim kho kev nco, tiv thaiv Alzheimer's kab mob, tiv thaiv osteoporosis thiab txhawb kev tsim cov pob txha thiab lwm yam teebmeem [19].

4.1 Relieve lub cev qaug zog ntawm Cistanche

Cov kev tshawb fawb tau pom tiasCistanchethiab nws cov extracts muaj cov nyhuv ntawm relieving lub cev qaug zog [2,20-21]. Piv txwv li, Wang Xiaoxin et al. [22] pom tias cov tshuaj aqueous npaj nrog 100 mg / kg ntawm Cistanche hmoov tuaj yeem txhim kho lub sijhawm incubation ntawm lub platform dhia sim hauv nas; nce lub sijhawm ua luam dej nrog qhov hnyav hauv nas, uas tuaj yeem txhim kho kev kawm, nco thiab tiv thaiv kev qaug zog.Cistanchepolyphenols kuj tseem tuaj yeem ua rau lub sijhawm ua luam dej ntawm cov nas; nce qib ntawm daim siab qabzib thiab cov leeg glycogen hauv cov nas sim; Ua kom muaj txiaj ntsig zoo rau kev ua haujlwm ntawm lactate dehydrogenase thiab txo cov qib ntawm lactic acid, yog li nws muaj txiaj ntsig zoo rau kev txo lub cev qaug zog [20]. Yan Li et al. [21] pom tias polysaccharide ntawm Cistanche deserticola ntawm ib koob ntawm 100 mg / kg tuaj yeem ua rau lub sijhawm ua luam dej hnyav ntawm D-galactose-induced aging nas, txo cov ntshav urea nitrogen (BUN) thiab lactic acid (LA) qib. Hauv cov qauv nas, ua kom lub siab thiab cov leeg glycogen nce qib, thiab nce superoxide dismutase (superoxide dismutase (SOD)) hauv daim siab cov ntaub so ntswg ntawm cov laus qauv nas. SOD) thiab glutathione peroxidase (GSHPX) cov kev ua ub no, thiab txo qis malondialdehyde (MDA) cov ntsiab lus, qhia tias Cistanche deserticola polysaccharide muaj qee yam kev tiv thaiv qaug zog rau cov nas laus.

Qee cov kws tshawb fawb tau ua qhov kev ntsuam xyuas tsiaj los tiv thaiv kev qaug zog ntawm cov ntsiav tshuaj npaj los ntawmCistanche ua ke nrog Epimedium, taurine thiab zinc. Cov txiaj ntsig tau pom tias cov ntsiav tshuaj sib xyaw tuaj yeem ua kom ntev lub sijhawm ua luam dej ntawm cov nas thiab ua kom cov ntshav lactate tshem tawm tau zoo, nce qib ntawm daim siab glycogen cov ntsiab lus, muaj txiaj ntsig zoo ntawm kev txo lub cev qaug zog [22].Tsis tas li ntawd, cov tshuaj ntsiav npaj nrog Cistanche deserticola thiab Tiebang yam tuaj yeem txo qhov tsim ntawm MDA hauv daim siab thiab cov leeg pob txha ntawm cov qauv nas, thiab nce qib ntawm SOD thiab CAT, uas muaj kev ua haujlwm ntawm kev txhim kho kev tawm dag zog vim qaug zog [23 ].

4.2 Antioxidant

Kev ua haujlwm antioxidant yog ib qho ntawm cov kev tshawb fawb tseem ceeb thiab kev txhim kho ntawm cov tuam txhab kev noj qab haus huv cov khoom lag luam.Cistanchethiab nws cov active Cheebtsam muaj antioxidant zog. Xu Hui et al. [24] kev tshawb fawb tau qhia tiasCistanche deserticola polysaccharidestuaj yeem txo cov ntsiab lus ntawm MDA thiab kev ua haujlwm ntawm PLA2, nce kev ua haujlwm ntawm Ga2 ntxiv -ATPase, fluidity ntawm daim siab mitochondrial membrane, txhim kho mitochondrial zog metabolism, thiab txhim kho kev ua pa. Chain complex I plus III, II plus III kev ua, daim siab mitochondrial antioxidant muaj peev xwm.

Wu Bo et al. [25] pom tias polysaccharides ntawm Cistanche deserticola thiab tag nrho cov glucosides ntawm Cistanche deserticola tuaj yeem txhim kho cov nyhuv anti-lipid peroxidation ntawm cov nas laus, nce SOD kev ua haujlwm hauv cov ntshav thiab daim siab, thiab txo cov ntsiab lus ntawm lipid peroxides, qhia tias polysaccharides. ntawm Cistanche deserticola tuaj yeem tiv thaiv hypoxia. Lipid peroxidative raug mob nyob rau hauv cov nas mob, yog li ua tus antioxidant.

4.3 Txhim kho kev nco

Cov kev tshawb fawb tau pom tias Cistanche tuaj yeem txhim kho kev nco thiab tiv thaiv Alzheimer's kab mob [19]. Kev tshawb fawb los ntawm Wang Lu et al. [27] pom tias tag nrho cov glucosides ntawm Cistanche deserticola ntawm ib koob ntawm 100 mg / kg tuaj yeem txhim kho kev kawm thiab kev paub tsis zoo ntawm Alzheimer tus kab mob qauv nas. Cov txheej txheem ua tau yog los txo cov tiam ntawm cov dawb radicals thiab tshem tawm cov peroxide ntau dhau. Nws tuaj yeem txhim kho synaptic plasticity thiab ua lub luag haujlwm hauv kev txhim kho kev kawm thiab kev paub.

Zhang Jing li al[28] tau pom tias 100 mg / kg.d koob tshuaj ntawm tag nrho cov glucosides ntawm Cistanche deserticola tuaj yeem ua rau muaj cov pyramidal hlwb thiab cov apical dendritic spines nyob rau hauv hippocampal CA1 cheeb tsam; nce lub hippocampal synaptophysin, Protein qhia ntawm postsynaptic membrane ntom thiab hlwb-derived neurotrophic yam, nrog txhim kho qauv

Cov nas muaj peev xwm kawm paub paub.

Tsis tas li ntawd, qee qhov kev tshawb fawb tau pom tias Cistanche deserticola polysaccharide muaj kev tiv thaiv tseem ceeb ntawm cov paj hlwb hauv cov nas laus subacute, thiab txhim kho kev kawm thiab kev nco muaj peev xwm ntawm cov qauv tsiaj. PKA/CREB signaling pathway exerts its function [19].

4.4 Laxative

Cistanche, me ntsis sov nyob rau hauv cov xwm, qab zib thiab ntsev nyob rau hauv saj, belongs rau lub raum thiab cov hnyuv loj meridians, thiab muaj cov nyhuv ntawm moistening cov hnyuv thiab laxatives. Nws cov extracts tag nrho oligosaccharides, tag nrho polysaccharides, tag nrho saponins thiab noj fibers tuaj yeem txhim kho qhov quav ntawm cov nas cem quav, cov uas tag nrho cov oligosaccharides muaj qhov pom tseeb kho cov nyhuv. Tsis tas li ntawd, Yang Jianhua et al. [29] pom tias cov extract ntawm Cistanche salina tuaj yeem txo qis thawj lub sijhawm tso quav hauv cov nas cem quav, thiab nce tus naj npawb, qhov zoo thiab lub plab zom mov nrawm ntawm cov quav hauv 6 teev. Cov tshuaj suav tshuaj suav nrog Cistanche deserticola raws li cov khoom siv raw kuj muaj qee yam tshuaj laxative. Hauv kev tshawb fawb soj ntsuam, cov neeg mob cem quav tau txais los ntawm 2017 txog 2018 tau kho nrog tshuaj ntsuab decoction nrog Cistanche deserticola ua cov tshuaj tseem ceeb, thiab 61 cov neeg mob tau kho. muab faib ua pawg tswj (serving

Siv cov ntsiav tshuaj domperidone) thiab pab pawg kho mob (nojCistanchedecoction), cov txiaj ntsig tau pom tias tag nrho cov txiaj ntsig zoo ntawm pab pawg kho mob tau nce siab dua li ntawm pawg tswj hwm, uas muaj txiaj ntsig kev kho mob rau kev txhim kho cem quav [30].

4.5 Lwm yam kev noj qab haus huv ntawm Cistanche

Cistancheyog nplua nuj nyob rau hauv cov as-ham thiab kev ua hauj lwm Cheebtsam, yog li nws kuj muaj lwm yam kev kho mob functions xws li tswj kev tiv thaiv kab mob, txhim kho pob txha ceev, txhim kho daim siab puas thiab regulating plab hnyuv flora.

5 Outlook ntawm Cistanche Function

Cistanchemuaj cov khoom noj muaj txiaj ntsig zoo thiab muaj nplua nuj nyob hauvphenylethanolglycosides, iridoids thiab lawv glycosides, lignans thiab lawv glycosides, thiab lwm yam. Looseness thiab ntau lwm yam kev noj qab haus huv functions.

Raws li keeb kwm ntawmCistanche cog thiab kev loj hlob, kuv lub teb chaws muaj qhov tshwj xeeb zoo rau kev tsim nws ua zaub mov noj qab haus huv thiab tau sau ntau xyoo ntawm kev tshawb fawb thev naus laus zis thiab kev cog qoob loo. Tam sim no, lub functional kev loj hlob ntawmCistanchenyob rau hauv kuv lub teb chaws tsuas yog tsom rau kev tiv thaiv qaug zog, kev tiv thaiv kab mob, thiab tiv thaiv oxidation.

Hauv kev tshawb fawb niaj hnub no,Cistanchemuaj txiaj ntsig tseem ceeb hauv kev pab txhim kho kev nco, laxative, thiab lwm yam kev kho mob. Yog li ntawd, nws tuaj yeem ua ke nrog cov kev tshawb fawb tshiab tshaj plaws thiab ntxiv los ntawm kev sim tshuaj xyuas, thiab lwm yam kev kho mob tuaj yeem tsim kho. Tsis tas li ntawd, seb cov khoom puas tuaj yeem ua rau nws txoj kev saib xyuas kev noj qab haus huv zoo tshaj plaws yog feem ntau cuam tshuam nrog nws txoj kev cog thiab khaws cov thev naus laus zis, kev ua haujlwm sib sib zog nqus, thiab lwm yam, yog li nws tseem ceeb heev rau kev cob qhia cov kws tshaj lij thiab cov kws tshawb fawb. Cov tuam txhab lag luam yuav tsum tau ntxiv dag zog rau kev nqis peev hauv kev cob qhia txuj ci thiab kev qhia txuj ci, nce kev sib sib zog nqus thiab kev siv cov khoom siv ntawmCistanche deserticola, kev rho tawm thiab sib cais tshuab ntawm cov khoom xyaw nquag,kev tshawb fawb txog kev ua haujlwm thiab kev tshawb nrhiav cov txheej txheem ntawm kev ua haujlwm, thiaj li mus cuag ib theem siab ntawm industrialization, standardization thiab standardization. Ua ke nrog kev tshawb fawb thiab thev naus laus zis txhais tau tias thiab kev xav tshiab, siv tag nrho cov kev siv ua haujlwm thiab kev ua haujlwm ntawmCistanche, kom nws tuaj yeem txhim kho ntau dua thiab zoo dua tshiab cov khoom noj khoom haus noj qab haus huv, thiab txhim kho nws daim ntawv thov tus nqi thiab kev xav tau kev lag luam.

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