Kev nce qib hauv kev kuaj mob thiab kev kho mob ntawm Amyloid nephropathy

Amyloidosis yog ib pawg ntawm cov kab mob sib txawv ntawm cov protein uas tshwm sim los ntawm kev sib txawv etiologies, uas ua rau txawv txav-zoo li folding ntawm precursor proteins, tsim insoluble substructures uas tau tso rau hauv cov ntaub so ntswg thiab cov kabmob, ua rau cov ntaub so ntswg puas tsuaj thiab lub cev tsis ua haujlwm. Lub raum yog ib qho ntawm cov kab mob feem ntau cuam tshuam rau hauv amyloidosis, thiab cuam tshuam rau lub raum kev ua haujlwm thiab kev ua haujlwm tsis zoo yog qhov tseem ceeb ntawm tus kab mob. Amyloidosis nephropathy tau dhau los ua qhov thib ob ua rau mob ntshav qab zib theem nrab hauv cov neeg laus.

Nyem rau Cistanche rau mob raum

Tam sim no, muaj 42 precursor proteins rau amyloidosis, ntawm uas AL amyloidosis account rau 80%, ua raws li SAA hom, thiab kuj muaj qee yam amyloidosis los ntawm noob caj noob ces thiab metabolism. Lub precursor proteins ntawm amyloid tshuaj muaj ntau qhov chaw: (1) siab concentrations ntawm proteins nyob rau hauv ib txwm muaj protein cov ntshav rau lub sij hawm ntev. (2) cov qauv ntawm cov proteins ib txwm tsis ruaj khov, thiab cov khoom tawg ntawm hydrolysis tsim -folded cov qauv, ua rau muaj kev sib sau ntau dhau. (3) nrog rau kev loj hlob ntawm lub hnub nyoog, nws cov protein folding cov yam ntxwv yog txhim kho. (4) Gene mutations ua rau kev hloov pauv ntawm cov protein amino acid sequences. Protein misfolding tsis yog tsuas yog cov yam ntxwv ntawm amyloidosis tab sis kuj koom nrog kev laus, cov kab mob neurodegenerative, thiab lwm yam. Cov yam ntxwv ntawm lub raum amyloidosis nyob ntawm seb hom amyloid protein, qhov chaw thiab tus naj npawb ntawm lub raum deposition, thiab qib ntawm kev koom tes ntawm cov kab mob extrarenal. .

Congo liab staining tseem yog txoj hauv kev tseem ceeb rau kev kuaj mob histological ntawm amyloidosis. Txij li thaum Bennhold tau qhia txog kev siv Congo liab staining los saib xyuas cov qauv ntawm amyloid hauv xyoo 1922, nws yog ib qho tseem ceeb. Tom qab ntawd, Divey et al. piav qhia txog cov yam ntxwv ntawm cov kua ntsuab birefringence nyob rau hauv polarized lub teeb ntawm Congo liab staining ntawm amyloid. Qhov zoo Congo liab staining thiab kua ntsuab birefringence nyob rau hauv lub teeb polarized tseem yog tus qauv kub rau kev kuaj mob ntawm amyloid protein. Lub teeb liab hom ntawm fluorescence microscopy tuaj yeem txhim kho qhov rhiab heev thiab tshwj xeeb ntawm Congo liab staining, thiab dhau los ua ib qho kev pab cuam ntawm kev kuaj mob thaum cov ntsiab lus ntawm amyloid protein nyob rau hauv biopsy yog tsawg. Cov kev tshawb fawb tsis ntev los no tau pom tias qhov zoo ntawm Congo liab staining tsis zoo li amyloidosis. Hauv 2018, Mayo Clinic tau tshaj tawm txog 18 tus neeg mob ntawm Congo liab-zoo fibrillary glomerulonephritis. Tib lub sijhawm, cov txiaj ntsig tsis zoo Congo liab tsis tuaj yeem tshem tawm amyloidosis. Raws li kev tshawb fawb rov qab Congo liab staining ntawm cov neeg laus uas muaj kev hloov pauv nephropathy tsawg tshaj tawm xyoo 2014, amyloid tau kuaj pom hauv 17 tus neeg mob (65%) los ntawm Congo liab staining. Yog li ntawd, rau cov neeg uas muaj kev pheej hmoo siab ntawm lub raum puas, lub raum pathology Congo liab staining thiab electron microscopy yog qhov tsim nyog heev. Cov kua chromatography-tandem huab hwm coj spectrometry tseem ceeb dua rau kev kuaj mob sib txawv ntawm lub raum amyloidosis. Kev tsom xam cov protein spectrum tau dhau los ua ib qho tseem ceeb thiab tseem ceeb txhais tau tias rau kev faib tawm thiab kev kuaj mob sib txawv ntawm lub raum amyloidosis.

Kev faib tawm kev kuaj mob ntawm amyloidosis nephropathy yog qhov tseem ceeb heev rau kev xaiv cov phiaj xwm kho mob thiab kev kwv yees. Tam sim no, 13 ntawm 42 precursor proteins paub tias koom nrog raum, thiab 50% mus rau 80% yog AL-hom. Kwv yees li 12.3% ntawm amyloidosis nephropathy tsis tuaj yeem raug cais tawm los ntawm immunofluorescence. Vim qhov yooj yim adhesion ntawm amyloid, cov txiaj ntsig tsis zoo ntawm immunofluorescence yuav tshwm sim. Qee qhov xwm txheej, kev hloov pauv ntawm cov protein ua ntej hloov pauv thiab poob nws qhov qub antigenic txiav txim thaj tsam, uas yuav ua rau muaj qhov tsis zoo tsis zoo ntawm kev tiv thaiv kab mob. High-performance kua chromatography-tandem huab hwm coj spectrometry yog tam sim no "tus qauv kub" rau kev kuaj mob ntawm amyloidosis nephropathy.

Amyloidosis nephropathy kev faib tawm yog ze rau kev kho mob. Tam sim no, txoj kev kho mob rau AL amyloidosis yog qhov paub tab. D-CyBorD regimen yog thawj qhov kev xaiv. Autologous stem cell transplantation thiab CAR-T therapy yog ob qho tib si siv hauv AL amyloidosis. Cov tshuaj tsom rau cov hmoov txhuv nplej siab xws li CAEL-101, Birtamimab monoclonal antibody, thiab AT-03 Attralus autoantibody tau maj mam muab tso rau hauv kev kho mob. Kev kho mob ntawm amyloidosis nephropathy yog kev loj hlob sai. Kev kuaj mob ntxov thiab kev kho mob tau zoo tuaj yeem txhim kho cov kev mob tshwm sim ntawm cov neeg mob amyloidosis nephropathy.

Cistanche kho mob raum li cas?

Cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrog kab mob raum. Nws yog muab los ntawm cov stems qhuav ntawm Cistanche deserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Cov khoom tseem ceeb ntawm cistanche yog phenylethanoid glycosides, echinacoside, thiab acteoside, uas tau pom tias muaj txiaj ntsig zoo rau lub raum noj qab haus huv.

Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tswv yim.

Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.

Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.

Tsis tas li ntawd, cistanche tau pom tias muaj cov tshuaj tiv thaiv kab mob. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.

Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv kab mob raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.

Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.

Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.

Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.