Vim li cas Gout Attacks yuav hnyav dua tom qab noj cov tshuaj Uric Acid-txo?

1. Ob hom uric acid nrog cov khoom sib txawv

Uric acid yog cov kua qaub tsis muaj zog nrog pKa=5.75 hauv cov ntshav. Nws yog me ntsis soluble hauv dej thiab yooj yim tsim muaju. Nyob rau hauv tej yam kev mob ntawm tib neeg lub cev kub ntawm 37 degree thiab pH nqi 7. Peb hu nws soluble uric acid (UA), nrog rau solubility ntawm li 380 μmol / L, ntxiv rau ib feem me me khi rau cov plasma proteins (kwv yees li 25 μmol / L), tag nrho cov saturation ntawm uric acid nyob rau hauv cov ntshav yog txog 400 μmol / L. Kev ua kom siab tshaj qhov no yuav yooj yim tsim cov urate (MSU) crystals thiab tso rau hauv cov pob qij txha, cov hlab ntsha, thiab lwm qhov chaw, ua rau gout lossis ua rau muaj kev pheej hmoo ntawm cov kab mob plawv.

Nyem rau Cistanche rau mob raum

Hauv cov zis, qhov ionization tas li ntawm uric acid yog 5.35. Hauv cov zis, thaum pH yog 5.35, uric acid saturation yog 90 mg / L (li 54 μmol / L). Yog li ntawd, thaum cov zis pH tsawg dua 5.5, qhov nyiaj tshuav hloov mus rau sab laug, nrog rau cov concentration ntawm uric acid ntau dua thiab qis dua ntawm urate. Vim hais tias uric acid yog insoluble, qhov tshwm sim ntawm qhov kev hloov no yog tsim ntawm ntau uric acid precipitates, feem ntau nyob rau hauv acidic ib puag ncig, xws li nyob rau hauv lub raum los yog tso zis, as opposed to urate crystals nyob rau hauv plasma los yog pob qij txha. H +, sawv cev rau hydrogen ion.

2. Ob hom uric acid muaj qhov sib txawv

•Soluble UA ncaj qha inhibits CD38 ( tswj kev tiv thaiv kab mob thiab lub zog metabolism, thiab lwm yam) nyob rau hauv ib qho allosteric yam, thiab cov nyhuv inhibitory yog txwv rau UA hauv purine metabolism, qhia tias UA muaj lub luag haujlwm tshwj xeeb ntawm lub cev.

•MSU crystals qhib CD38 los ntawm kev ua kom cov protein qhia ntawm CD38 hauv macrophages, ua rau muaj kev nce hauv cov kab mob IL-1 thiab txo qis hauv cov protein tiv thaiv kev laus NAD+.

•Qhov tseeb, cov qib physiological ntawm UA tuaj yeem cuam tshuam CD38 kev ua haujlwm, yog li txwv NAD + degradation thiab mob ntau dhau, qhia tias UA yog qhov tseem ceeb rau kev tswj hwm NAD + muaj thiab kev tiv thaiv kab mob. UA thiab MSU crystals muaj qhov cuam tshuam rau kev mob thiab kev tiv thaiv hauv lub cev.

• Cov qib UA tsawg tsawg tuaj yeem nce CD38 kev ua haujlwm, yog li ua rau tsis zoo rau kev noj qab haus huv, ib feem piav qhia txog kev sib koom ntawm cov uric acid tsawg thiab kab mob.

Yog li ntawd, txawm tias UA thiab MSU yog ob hom ntawm uric acid, lawv hlub thiab tua ib leeg. UA exerts anti-inflammatory beneficial effect, MSU exerts pro-inflammatory harmful effects, and UA checks and balances the adverse effects of MSU.

3. Cov tshuaj uric acid-txo cov tshuaj ua rau qhov sib npaug, tab sis qhov sib npaug yuav tsum tau rov tsim dua

•Qee cov neeg mob uas asymptomatic hyperuricemia tsim MSU crystal deposition yam tsis muaj gout tawm tsam. Qhov no tej zaum yuav yog vim hais tias cov kua dej UA txwv tsis pub cov inflammatory teb tshwm sim los ntawm MSU crystals los ntawm inhibiting CD38 nyob rau hauv tej yam kev mob, tso cai rau lub cev los tiv thaiv gout.

• Ib qho kev paub zoo ntawm kev kho urate-txo hauv cov neeg mob gout yog tias kev txo qis urate sai thaum pib kho yuav ua rau muaj kev pheej hmoo ntawm gout tawm tsam; Yog li ntawd, tam sim ntawd txo qis hauv UA theem nrog cov tshuaj urate-txo ua ntej MSU crystals yaj tuaj yeem cuam tshuam lub cev tsis muaj zog los ntawm kev tso tawm CD38 sai, ua rau muaj kev tawm tsam gout hauv cov neeg mob.

•Soluble UA thiab MSU crystals kuj qhia qhov cuam tshuam ntawm 2 integrin koom nrog hauv kev nrhiav neeg ua haujlwm neutrophil. Kev txo qis hauv cov ntshav UA qib tau pom thaum muaj kev tawm tsam gout, thiab kev daws teeb meem ntawm gouty o yog nrog los ntawm kev rov ua kom cov ntshav UA qib.

•Tab sis thaum kawg nws yog ib qho tsim nyog yuav tsum tau cia siab rau qhov txo qis ntawm UA qib los txhawb kev sib cais ntawm MSU crystals thiab thaum kawg txo cov kev tawm tsam gout hauv cov neeg mob.

Yog li ntawd, thaum siv cov tshuaj uric acid-txo thawj zaug, UA txo qis, uas ua rau lub cev tiv thaiv kab mob ib ntus thiab ua rau muaj kev tawm tsam gout. Kuj tseem muaj qhov laj thawj uas tom qab txo qis cov ntshav uric acid, cov urate crystals hauv cov pob qij txha tawg, yog li inducing gout thiab ua rau mob crystal-solving. Txawm li cas los xij, qhov kawg, qhov nyiaj tshuav no yuav tsum tau tawg kom ua rau cov ntshav UA poob, kom MSU crystals thiaj li yaj, thiab MSU crystals nyob rau hauv cov pob qij txha thaum kawg raug tshem tawm kom cov pob qij txha kho tau.

Cistanche kho mob raum li cas?

Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrograumkab mob. Nws yog muab los ntawm qhuav stems ntawmCistanchedeserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Lub ntsiab active Cheebtsam ntawm cistanche yogphenylethanoidglycosides, echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rauraumnoj qab haus huv.

Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tshuab.

Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.

Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.

Tsis tas li ntawd, cistanche tau pom tias muaj cov nyhuv anti-inflammatory. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.

Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv kab mob raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.

Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.

Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.

Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.