Dab tsi yog qhov cuam tshuam ntawm SGLT2 Inhibitors Rau Lub Neej Zoo Ntawm Cov Neeg Mob Lub Siab Tsis Ua Haujlwm?
Sep 29, 2024
Sodium glucose co-transporter 2 (SGLT2) inhibitors yog ib lub hauv paus ntawm kev kho mob plawv. Txawm hais tias cov txiaj ntsig ntawm SGLT2 inhibitors nyob rau hauv cov nqe lus ntawm lub plawv tsis ua hauj lwm nyob rau hauv tsev kho mob thiab kev tuag tau tsim tau zoo, lawv cov teebmeem ntawm lub neej zoo (QoL) tsis tau kawm ua haujlwm. Kev tshuaj xyuas zoo tshaj plaws thiab kev tshuaj xyuas meta-kev soj ntsuam ntawm randomized tswj kev sim (RCTs) tsis ntev los no tau tshaj tawm hauv European Heart Journal - Cardiovascular Pharmacotherapy teb cov lus nug saum toj no.
Nyem rau Cistanche rau mob raum
01 Kev tshawb fawb lub hom phiaj thiab cov txheej txheem
Qhov kev tshuaj xyuas thiab kev tshuaj ntsuam xyuas meta yog lub hom phiaj los ntsuas qhov cuam tshuam ntawm SGLT2 inhibitor kev kho mob ntawm lub neej zoo ntawm cov neeg mob plawv tsis ua haujlwm los ntawm kev txheeb xyuas cov ntaub ntawv los ntawm kev sim tshuaj ntsuam xyuas randomized. Tag nrho ntawm 23 randomized tswj kev sim tau suav nrog. Cov RCTs no tau tshawb nrhiav qhov cuam tshuam ntawm SGLT2 inhibitors ntawm lub neej zoo (kuaj xyuas siv Kansas City Cardiomyopathy Cov Lus Nug Tag Nrho Cov qhab nia [KCCQ-OSS]) ntawm cov neeg mob plawv tsis ua hauj lwm nrog sib txawv sab laug ventricular ejection fractions (LVEF) thiab tau ua raws li tsawg kawg 3. hli. Qhov kev ntsuas tau tshwm sim yog qhov sib txawv ntawm qhov kev hloov pauv hauv KCCQ-OSS ntawm SGLT2 inhibitor pawg thiab pawg neeg saib xyuas tus qauv (SOC) ntawm 3 thiab 6 lub hlis tom qab pib.
02 Kev tshwm sim
Tag nrho ntawm 21,737 tus neeg mob los ntawm 14 randomized tswj kev sim tau suav nrog hauv kev tshuaj xyuas. Kev txhim kho tseem ceeb hauv KCCQ-OSS lub sijhawm tau pom nyob rau hauv ob qho tib si SGLT2 inhibitor thiab cov txheej txheem kho mob (p<0.001). Compared with the standard therapy group, the mean change in KCCQ-OSS at 3 months in the SGLT2 inhibitor group was significantly improved by 1.94 points (95%CI, 1.41-2.46), and the mean change in KCCQ-OSS at 6 months was significantly improved by 2.18 points (95%CI, 1.13-3.24), which was independent of LVEF.
Cov neeg mob uas mob plawv tsis ua hauj lwm tsis ntev los no tau muaj kev txhim kho ntau dua hauv KCCQ-OSS piv nrog cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev.
03 Cov lus xaus
Hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm, qhov sib ntxiv ntawm SGLT2 inhibitors rau cov qauv kev kho mob pom tau tias muaj kev txhim kho tseem ceeb hauv lub neej zoo li thaum ntxov li 3 lub hlis tom qab, tsis hais txog ntawm sab laug ventricular ejection feem thiab kev kho mob.
Cistanche kho mob raum li cas?
Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrograumkab mob. Nws yog muab los ntawm qhuav stems ntawmCistanchedeserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Lub ntsiab active Cheebtsam ntawm cistanche yogphenylethanoidglycosides, echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rauraumnoj qab haus huv.
Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tswv yim.
Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.
Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.
Tsis tas li ntawd, cistanche tau pom tias muaj cov nyhuv anti-inflammatory. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo qhov tsim ntawm pro-inflammatory cytokines thiab inhibit qhov kev ua ntawm txoj kev yuav tsum tau rau o, yog li alleviating o nyob rau hauv lub raum.
Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv kab mob raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.
Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.
Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.
Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm lub cev thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.
