Dyskinesia yog dab tsi?
Feb 22, 2022
Hu rau: Audrey Huaudrey.hu@wecistanche.com
Parkinson tus kab mob yog ib hom kab mob neurodegenerative. Dopaminergic tshuaj hloov kho tuaj yeem txhim kho cov tsos mob ntawm cov neeg mob Parkinson's disease. Nws yog cov tshuaj tseem ceeb rau kev kho tus kab mob Parkinson. Cov tshuaj Dopaminergic tuaj yeem ua rau muaj teeb meem ntawm lub cev muaj zog hauv Parkinson's disease. Cov teeb meem ntawm lub cev muaj zog tuaj yeem muab faib ua ob pawg: lub cev muaj zog hloov pauv thiab dyskinesia.
Anti-Parkinson tus kab mob:tshuaj ntsuab cistanche
1. Kev hloov pauv hloov
Kev hloov pauv ntawm lub cev muaj zog tuaj yeem muab faib ntxiv rau hauv kev txo qis, qhov kawg ntawm koob tshuaj deterioration, hloov phenomena, thiab khov phenomena. Dyskinesia yog ib hom mob hnyav ntawm tus kab mob Parkinson tus kab mob, nrog rau kev txav tsis tau raws li qhov chaw kho mob tseem ceeb, feem ntau tshwm sim raws li episodic, tsis xwm yeem chorea-zoo li, dystonic-zoo li txav, uas cov ceg thiab lub cev muaj kev koom tes ntau dua.
2. Dyskinesia
Dyskinesia tuaj yeem muab faib ua koob tshuaj dyskinesia, bidirectional dyskinesia, thiab dystonia. Vim tias dyskinesia tuaj yeem cuam tshuam rau kev ruaj ntseg ntawm cov neeg mob taug kev thiab sawv, nws ua rau muaj kev cuam tshuam ntau rau cov neeg mob lub neej txhua hnub thiab kev ua haujlwm, thiab txawm tias poob.
Ua raudyskinesia
Cov txheej txheem pathogenic ntawm dyskinesia tseem tsis meej. Cov kev tshawb fawb tshiab qhia tau hais tias qhov tshwm sim ntawm dyskinesia muaj feem xyuam nrog ntau yam kev pheej hmoo, uas tuaj yeem muab faib ua yam tsis muaj kev tswj hwm thiab cov yam ntxwv uas tswj tau. Kev tswj tsis tau muaj feem cuam tshuam nrog tus kab mob nws tus kheej, thiab cuam tshuam los ntawm lub hnub nyoog pib, poj niam txiv neej, kab mob, kab mob hnyav, thiab hom ntawm tus neeg mob; Cov yam ntxwv tswj tau muaj feem xyuam nrog kev kho mob thiab muaj feem xyuam rau lub sijhawm pib kho tshuaj, hom tshuaj, koob tshuaj levodopa thiab lub sijhawm kho. txheej txheem thiab concentration fluctuations. Cov ntawv tshaj tawm txawv teb chaws tom qab 4 txog 6 xyoo ntawm kev kho mob, qhov tshwm sim ntawm levodopa-induced dyskinesia yog ze rau 40 feem pua. Levodopa-induced dyskinesia feem ntau sib raug rau lub sijhawm ntawm cov ntshav ntshav siab levodopa concentration thiab ploj mus nrog txo cov koob tshuaj levodopa. Cov hnub nyoog yau ntawm qhov pib yog qhov tseem ceeb ntawm kev pheej hmoo rau levodopa-induced dyskinesia, yog li peb tawm tswv yim ncua kev siv levodopa thiab txwv cov koob tshuaj levodopa hauv cov neeg mob hluas kom txo tau txoj kev pheej hmoo ntawm dyskinesia.
Kev kho mob ntawm dyskinesia
Tam sim no, feem ntau yog cov hauv qab no rau kev kho mob ntawm dyskinesia: 1. Kho cov koob tshuaj levodopa, siv cov tshuaj me me ntawm levodopa ntau zaus thiab kev kho mob fractionated tuaj yeem pab txo qis cov koob tshuaj dyskinesia. 2. Ntxiv amantadine, tej zaum yuav tshwm sim yog sedation, hallucinations, tsis meej pem, ko taw edema, myoclonus, livedo reticularis thiab corneal edema. 3. Ntxiv cov atypical antipsychotic tshuaj clozapine, tej zaum yuav tshwm sim yog agranulocytosis, salivation, somnolence, qaug dab peg, orthostatic hypotension thiab myocarditis. 4. Rau cov neeg mob hnyav dyskinesia thiab nyuaj rau kev txhim kho los ntawm kev kho cov tshuaj, implantation ntawm lub hlwb pacemaker tuaj yeem ua tiav cov txiaj ntsig zoo, tab sis kev lag luam yuav tsum tau ua. Tsis tas li ntawd, quetiapine, safinamide, istraphylline, etoprazine, thiab lwm yam kuj tau siv rau hauv kev kho mob, tab sis qhov ua tau zoo tseem yuav tau tham txog.
Tsis tas li ntawd, cov tshuaj suav tshuaj ntsuabCistanchekuj muaj kev tiv thaiv zoo thiab kho tau zoo ntawm tus kab mob Parkinson. Raws li cov nroj tsuag uas yog khoom noj thiab tshuaj ntsuab.Cistanche deserticolaMuaj ntau phenylethanoid glycosides, flavonoids, polysaccharides, alkaloids thiab terpenoids. Cov kev tshawb fawb pharmacological niaj hnub tau lees paub tias kev noj tsis tu ncuaCistanchetuaj yeem txo cov hlwb puas thiab cell apoptosis, thiab tuaj yeem tiv thaiv Alzheimer's kab mob thiab Parkinson's disease.
