Dab tsi yog Kev Noj Qab Haus Huv Factors Associated Nrog Alzheimer's Disease?

Alzheimer tus kab mobkab mob(AD) yog degenerativeneuropsychiatrickab mobTus cwj pwm los ntawm kev tso nyiaj ntawm A plaques ntawm cov neurons hauv lub hlwb thiab cov neurofibrillary tangles ntawm P-tau hauv cov neurons. dementia. Xyoo 2017, WHO tau tshaj tawm hauv "Kaum Qhov Tseeb Txog Dementia" uasADtau dhau los ua lwm tus neeg tua neeg uas ua phem rau tib neeg kev noj qab haus huv tom qab cov kab mob plawv thiab cerebrovascular thiab malignant qog.

Vim lub complex pathogenesis ntawmADthiab kev kho mob qeeb qeeb, tam sim no tsis muaj kev cuam tshuam uas tuaj yeem tiv thaiv lossis thim rov qab qhov kev loj hlob ntawm tus kab mob, tab sis tsuas yog txhim kho ib ntus lossis qeeb ntawm cov tsos mob. Hauv 20 xyoo dhau los, ntau pua cov tshuaj zoo rau kev sim tsiaj tau nkag mus rau kev sim tshuaj thoob ntiaj teb. Yog li ntawd, kev kho cov qauv kev noj haus lossis kev noj zaub mov ntawm cov pab pawg muaj kev pheej hmoo los tiv thaiv qhov tshwm sim thiab kev loj hlob ntawm AD tuaj yeem suav tias yog ib qho kev tiv thaiv thiab kev kho mob zoo, thiab tau nyiam ntau thiab ntau dua los ntawm cov zej zog kev tshawb fawb thoob ntiaj teb.

Hu rau:joanna.jia@wecistanche.com/ WhatsApp: 008618081934791

Cistanche Tiv Thaiv Alzheimer's kab mob, nyem qhov no kom paub ntau ntxiv

Kas fes thiab AD

Ib txoj kev tshawb fawb mus sij hawm ntev tau luam tawm hauv phau ntawv Journal Aging Neuroscience thaum Lub Kaum Ib Hlis 19, 2021, qhia tias haus kas fes ntau tuaj yeem txo qhov kev pheej hmoo ntawmAlzheimer tus kab mob kab mob. Cov kws tshawb fawb ntawm Edith Cowan University hauv tebchaws Australia tau tshawb fawb 227 cov neeg laus uas muaj kev paub zoo txog cov neeg laus kom paub seb puas tau txais kas fes cuam tshuam qhov kev paub txog kev poob qis hauv kaum xyoo dhau los.

Pab pawg tshawb fawb pom tias cov neeg koom nrog haus kas fes ntau dua yam tsis muaj kev nco qab muaj qhov pheej hmoo ntawm kev hloov pauv mus rau qhov tsis txaus ntseeg me me lossis kev loj hlob AD thiab kev haus kas fes ntau dua tuaj yeem ua rau qeeb cov pob txha amyloid hauv lub hlwb, thaum cov hmoov txhuv nplej siab xws li cov protein ntau yog qhov tseem ceeb. qhov tseem ceeb hauv kev txhim kho Alzheimer's disease, thiab yog tias ib tus neeg nce ntawm ib khob mus rau ob khob kas fes (240 g / m ib khob) ib hnub, tus nqi ntawm kev txawj ntse poob qis tom qab 18 lub hlis tuaj yeem ua rau qeeb 8 feem pua, thaum lub tsub zuj zuj. ntawm beta-amyloid nyob rau hauv lub hlwb yuav txo tau 5 feem pua.

Fatty Acids thiab AD

Fatty acids ua lub luag haujlwm tseem ceeb hauv tib neeg kev noj haus thiab kev tswj hwm kev noj qab haus huv. Lub luag haujlwm ntawm fatty acids nyob rau hauv lub hauv nruab nrab lub paj hlwb muaj xws li lub zog qhov chaw, cell membrane Cheebtsam, kev tswj ntawm axonal loj hlob thiab muaj nuj nqi, thiab cov lus teb neuroinflammatory. Lub hlwb yog qhov thib ob feem ntau cov roj nplua nuj nyob hauv tib neeg lub cev, thiab los ntawm kev kho cov khoom noj uas tsis yog-hydrogenated unsaturated fatty acids, tsawg hydrogenated thiab saturated fatty acids, thiab n-3 polyunsaturated fatty acids hauv kev noj haus, kev pheej hmoo ntawm Cov kab mob plawv tuaj yeem txo tau los ntawm Vascular mechanisms uas txo qhov kev pheej hmoo ntawm AD.

Antioxidants thiab AD

Cov neeg uas muaj kev pheej hmoo tsawg ntawm AD tom qab ntxiv cov tshuaj antioxidant ntxiv

Oxygen-dawb radicals muaj feem xyuam rau kev puas tsuaj neuronal hauv AD. Ntau cov pa oxygen dawb radicals thiab oxidative kev nyuaj siab nyob rau hauv cov ntaub so ntswg ntawm lub paj hlwb yuav ua rau kom cov tsub zuj zuj ntawm amyloid. Los ntawm kev ntxiv cov qauv kev noj haus ntawm cov tshuaj antioxidants vitamin E, anti-vitamin C, thiab carotene kom tsawg Yuav kom txo tau lipid peroxidation thiab inflammatory signaling cascades nyob rau hauv lub cev, yog li txo qhov kev pheej hmoo ntawm mob stroke nyob rau hauv cov pej xeem, thiab mob stroke yog ib tug ntawm cov high-zoo. -kev pheej hmoo rau AD, kev tshawb fawb xyoo 2004 hais txog 4,000 cov neeg laus uas muaj hnub nyoog tshaj 65 xyoo pom tias kev noj cov vitamin C thiab E ntxiv tuaj yeem txo qhov kev pheej hmoo ntawm AD, lwm txoj kev tshawb fawb suav nrog 5395 cov neeg laus dua. 55 pom tias tom qab kho qhov kev noj haus ntawm cov vitamin E thiab C los ntawm kev noj zaub mov, qhov kev pheej hmoo ntawm AD tau qis dua hauv cov pejxeem, thiab nws tseem ceeb dua rau cov neeg haus luam yeeb, uas suav tias yog cuam tshuam rau lawv tus kheej hnyav oxygen dawb radical lub nra.

Dietary polyphenols thiab AD

Kev noj zaub mov polyphenols yog cov metabolites theem nrab nrog cov qauv polyphenolic, uas muaj dav hauv cov txiv hmab txiv ntoo noj txhua hnub, zaub, tshuaj yej, cawv liab, thiab lwm yam zaub mov cog. Nyob rau hauv xyoo tas los no, ntau cov kev tshawb fawb tau muab pov thawj muaj zog rau kev noj haus polyphenols hauv kev tiv thaiv AD. Ntawm lawv, curcumin, resveratrol, EGCG, thiab lwm yam tau tshaj tawm. 1 Curcumin yog ib lub ntiaj teb loj tshaj plaws-muag zaub mov xim. , muaj zoo antioxidant thiab anti-inflammatory teebmeem. Cov kev tshawb fawb tau pom tias curcumin inhibits qhov poob ntawm mitochondrial membrane muaj peev xwm los ntawm kev tswj cov kev qhia ntawm Bcl -2, txo DNA puas thiab ROS tsub zuj zuj, thiab thaum kawg reverses H2O2-induced apoptosis. Tsis tas li ntawd, hauv kev sim tsiaj, curcumin tau pom tias txo qis oxidative kev nyuaj siab thiab neurodegeneration hauv AD nas tom qab 7 lub lis piam ntawm kev saib xyuas. 2 Resveratrol muaj nyob rau hauv lub epidermis ntawm ntau cov nroj tsuag noj tau xws li mulberries, txiv hmab txiv ntoo, txiv laum huab xeeb, thiab pomegranates. Cov txiaj ntsig ntawm kev sim tsiaj hauv tsev tau pom tias piv nrog AD qauv pab pawg, kev kawm thiab kev nco muaj peev xwm ntawm pab pawg kho resveratrol tau txhim kho. , cov ntsiab lus ntawm glutathione peroxidase, superoxide dismutase, thiab malondialdehyde hauv cov ntshav thiab lub paj hlwb poob qis, thiab muaj qhov sib txawv tseem ceeb, qhia tias resveratrol muaj kev tiv thaiv ntawm kev paub txog kev ua haujlwm hauv AD nas, thiab Nws tuaj yeem txhim kho lub peev xwm antioxidant ntawm AD nas. ib qho twg.

Cistanche thiab AD

Ob lub ntsiab tseem ceeb ua haujlwm hauvCistanche

Echinacea: Antioxidant thiab Alzheimer's, tiv thaiv kab mob plawv thiab cerebrovascular

Verascoside: invigorating lub raum thiab cov ntsiab lus, tiv thaiv daim siab, thiab txhim kho kev tiv thaiv

Raws li kev tshawb fawb ntawm Peking University cov xibfwb:

Qhov tseem ceeb extracts ntawmCistanchedeserticola, "echinacoside" thiab "verascoside", tuaj yeem nkag mus rau hauv lub hlwb los ntawm cov hlab ntsha-hlwb barrier los pab cov paj hlwb regeneration thiab kho;

"Echinacea" thiab "verbasin" kuj muaj cov teebmeem antioxidant, uas tuaj yeem kho mitochondrial kev puas tsuaj los ntawm oxidation, rov ua haujlwm mitochondrial mus rau qhov qub, thiab tom qab ntawd rov ua haujlwm thiab ntxiv dag zog rau lub hlwb, txhim kho elasticity ntawm hlwb cell membranes, thiab txhim kho lub hlwb muaj peev xwm. Ua kom lub hlwb hlwb thiab txhawb lub hlwb cell metabolism.

Hauv kev tshawb nrhiav kev sim ntawmCistanchedeserticola hauv kev kho mob Alzheimer's, 124 cov neeg mob uas muaj Alzheimer's kab mob tau muab faib ua ob pawg. Rau 12 lub lis piam, cov qhab nia ntawm Clinical Dementia Scale (CDR), Mini-Mental State Examination (MMSE), thiab Kev Saib Xyuas Tus Kheej Ntawm Txhua Hnub (ADL) scale tau sau ua ntej thiab tom qab kev kho mob txhawm rau txheeb xyuas qhov degree ntawm dementia thiab tus kheej. muaj peev xwm saib xyuas cov neeg mob.

Cov txiaj ntsig tau pom tias: tom qab 12 lub lis piam, CDR thiab ADL ntawm ob pawg tau txo qis, thiab MMSE tau nce ntau. Nws qhia tau hais tias tag nrho cov glucosides ntawm Cistanche deserticola muaj kev kho mob rau cov neeg mob AD thiab tuaj yeem ncua kev loj hlob ntawm dementia.

Hauv kev kho mob vascular dementia (VD) nrogCistanchedeserticola • 70 cov neeg mob uas muaj mob me me thiab nruab nrab kev paub tsis meej tau muab faib ua tag nrho cov glucosides ntawm Cistanche deserticola thiab Naofukang tswj pawg. Ob pab pawg tau kho nrog qhov ncauj enteric-coated aspirin thiab nimodipine. Tag nrho cov glucosides ntawm Cistanche deserticola tau ntxiv rau pawg, thiab Naofukang tau ntxiv rau pawg tswj hwm. Lub sijhawm kho yog 16 lub lis piam. Cov neeg mob raug kuaj ib zaug txhua 4 lub lis piam ua ntej thiab tom qab noj tshuaj. Kev saib xyuas tus kheej muaj peev xwm sau cov kev phiv tsis zoo, kev tshuaj xyuas lub cev thiab kev kuaj xyuas, thiab lwm yam.

Cov txiaj ntsig tau pom tias: tom qab 12 lub lis piam, CDR thiab ADL ntawm ob pawg tau txo qis, thiab MMSE tau nce ntau. Nws qhia tau hais tias tag nrho cov glucosides ntawm Cistanche deserticola muaj kev kho mob rau cov neeg mob AD thiab tuaj yeem ncua kev loj hlob ntawm dementia.

Lub hlwb-txhim kho mechanism ntawmCistancheFeem ntau yog los ntawm 5 txoj hauv kev los txhim kho kev nco thiab kev tiv thaiv kab mob, thiab tiv thaiv Alzheimer's kab mob:

1. Tiv thaiv cov paj hlwb thiab inhibit paj hlwb apoptosis;

2. Txhawb kev loj hlob thiab kho cov paj hlwb;

3. Ua kom tso tawm cov neurotransmitters hauv lub hlwb;

4. Txhim kho cerebral ncig;

5. Invigorating lub raum thiab nourishing essence, txhim kho kev tiv thaiv.

Xaus: Cov metabolites ntawm Phenylethanoid glycosides, uas yog cov khoom siv ua haujlwm hauv Cistanche Cistanche, tuaj yeem dhau los ntawm cov ntshav-hlwb teeb meem thiab ua ncaj qha rau cov hlwb hlwb kom txo tau kev ntxhov siab, hloov kev noj qab haus huv, nce lub hlwb, thiab txhawb lub hlwb cell metabolism, yog li ncua lub hlwb ua haujlwm. Cell aging, txhim kho kev nco, tswj lub hlwb ua haujlwm ntev ntawm tes. Nws muaj txiaj ntsig zoo los txhim kho kev soj ntsuam, kev mloog zoo, kev muaj peev xwm xav, kev xav, kev muaj peev xwm ua rau muaj peev xwm, thiab kev muaj peev xwm kawm.