Abstract: Salvia tau lees paub dav rau nws txoj kev kho mob. Txawm li cas los xij, qhov tseem ceeb ntawm qee hom tsiaj tseem tsis tau paub, uas yog Salvia cacaliifolia Benth. Yog li, txoj kev tshawb no tsom mus nthuav tawm cov tshuaj muaj pes tsawg leeg thiab cov khoom muaj feem cuam tshuam ntawm nws cov roj tseem ceeb (EO). EO yog tus cwj pwm los ntawm GC thiab GC-MS thiab nws cov tshuaj tiv thaiv kab mob tau raug tshuaj xyuas raws li CLSI cov lus qhia ntawm dermatophytes thiab cov poov xab. Lub peev xwm los tiv thaiv kab mob tau raug soj ntsuam ntawm lipopolysaccharide-stimulated macrophages, los ntawm kev ntsuam xyuas cov khoom tsim ntawm nitric oxide (NO) thiab cov nyhuv ntawm cov protein ntau ntawm ob qho tseem ceeb pro-inflammatory enzymes, iNOS thiab COX-2 los ntawm western blot tsom xam. . Lub peev xwm kho qhov txhab tau txiav txim siab siv qhov kev ntsuam xyuas qhov txhab kho qhov txhab, thiab qhov kev tiv thaiv kev laus muaj peev xwm raug soj ntsuam los ntawm kev ntsuas cov cim senescence -galactosidase. Lub EO feem ntau yog tus cwj pwm los ntawm -curcumin, -bisabolene, bicyclo germacrene, thiab curzerenone. Nws muaj txiaj ntsig zoo hauv inhibiting kev loj hlob ntawm dermatophytes thiab C. neoformans. EO txo qis iNOS thiab COX-2 cov protein ntau thiab ua ke txo NO tso tawm. Tsis tas li ntawd, nws tau pom tias muaj peev xwm tiv thaiv kev laus thiab txhawb kev kho qhov txhab. Zuag qhia tag nrho, txoj kev tshawb no qhia txog cov khoom siv tshuaj muaj txiaj ntsig ntawm EO ntawm Salvia cacaliifolia, uas yuav tsum tau tshawb xyuas ntxiv txog kev xav txog kev txhim kho ntawm cov khoom lag luam zoo, tsim tshiab, thiab ib puag ncig ntawm daim tawv nqaij.

Glycoside ntawm cistanche tuaj yeem ua rau muaj kev ua haujlwm ntawm SOD hauv plawv thiab daim siab cov ntaub so ntswg, thiab txo cov ntsiab lus ntawm lipofuscin thiab MDA hauv txhua cov ntaub so ntswg, tshem tawm ntau yam reactive oxygen radicals (OH-, H₂O₂, thiab lwm yam) thiab tiv thaiv DNA puas. los ntawm OH-radicals. Cistanche phenylethanoid glycosides muaj peev xwm tshem tawm cov dawb radicals, muaj peev xwm txo tau ntau dua li cov vitamin C, txhim kho cov haujlwm ntawm SOD hauv cov phev ncua, txo cov ntsiab lus ntawm MDA, thiab muaj qee yam kev tiv thaiv ntawm cov phev ua haujlwm. Cistanche polysaccharides tuaj yeem txhim kho kev ua haujlwm ntawm SOD thiab GSH-Px hauv erythrocytes thiab ntsws cov ntaub so ntswg ntawm cov nas senescent sim los ntawm D-galactose, nrog rau txo cov ntsiab lus ntawm MDA thiab collagen hauv lub ntsws thiab ntshav, thiab nce cov ntsiab lus ntawm elastin, muaj Cov nyhuv scavenging zoo ntawm DPPH, ncua lub sijhawm ntawm hypoxia hauv cov nas senescent, txhim kho cov haujlwm ntawm SOD hauv cov ntshav, thiab ncua lub physiological degeneration ntawm lub ntsws hauv kev sim cov nas nrog cellular morphological degeneration, kev sim tau pom tias Cistanche muaj peev xwm antioxidant zoo. thiab muaj peev xwm los ua ib qho tshuaj tiv thaiv thiab kho cov kab mob ntawm daim tawv nqaij laus. Nyob rau tib lub sijhawm, echinacoside hauv Cistanche muaj lub peev xwm tseem ceeb txhawm rau txhawm rau DPPH dawb radicals thiab muaj peev xwm tshem tawm cov pa oxygen reactive thiab tiv thaiv dawb radical-induced collagen degradation, thiab kuj muaj kev kho zoo ntawm thymine dawb radical anion puas.

Nyem rau Desert Cistanche Cov txiaj ntsig

【Yog xav paub ntxiv: david.deng@wecistanche.com / WhatApp:86 13632399501 】

1. Taw qhia

Cov kab mob fungal tseem tsis quav ntsej los ntawm tsoomfwv saib xyuas kev noj qab haus huv, cuam tshuam ntau tshaj li ib txhiab tus neeg nrog 1.5 lab tus neeg tuag hauv ib xyoos [1]. Cov neeg uas muaj kev tiv thaiv kab mob tiv thaiv kab mob ntau dua rau cov kab mob fungal [1], Candida thiab Cryptococcus ob lub ntsiab etiological rau kev kis kab mob [1,2]. Dermatophytes, lwm pab pawg ntawm cov kab mob fungi uas muaj feem cuam tshuam vim lawv lub luag haujlwm hauv cov kab mob cuam tshuam nrog mycoses superficial [3], suav nrog Trichophyton, Epidermophyton, thiab Microsporum hom. Tsis tas li ntawd, lawv tuaj yeem ua rau cov kab mob sib kis hauv cov kab mob tiv thaiv kab mob [4].

Dermatophytes tuaj yeem qhib lub cev tiv thaiv kab mob vim yog kev sib txuas ntawm cov kab mob fungal, xws li mannan [5,6], rau tus xov tooj hu ua receptors (TLRs) yog li ua kom cov kab mob ua rau muaj kev cuam tshuam nrog cov kab mob no. Ib qho xws li cascade yog txoj hauv kev nuclear kappa B (NF-κB), uas thaum kawg ua rau muaj kev nce hauv kev tsim cov cytokines thiab cov protein ntau ntawm cov enzymes tseem ceeb, xws li inducible nitric oxide synthase (iNOS) thiab cycloxygenase. -2 (COX-2) [7]. Lub enzyme iNOS yog lub luag haujlwm rau kev tsim cov nitric oxide (NO), uas yog tus paub zoo tshaj plaws pro-inflammatory mediator overproduced nyob rau hauv ntau cov kab mob uas muaj feem xyuam nrog.

Tsis tas li ntawd, dermatophytes yog txuam nrog kev tsim ntawm daim tawv nqaij lesions [8]. Yog li ntawd, tom qab kev daws teeb meem ntawm tus kab mob, cov txheej txheem kho qhov txhab yuav tsum tshwm sim kom rov tsim cov ntaub so ntswg puas. Cov txheej txheem no suav nrog cov theem sib txawv, uas yuav tsum tshwm sim hauv txoj cai thiab ntawm lub sijhawm raug, txwv tsis pub, qhov txhab yuav mob ntev [9].

Vim muaj kev rov qab los, kev tiv thaiv, thiab cov tshuaj tiv thaiv kab mob, kev kho tshuaj tiv thaiv kab mob tam sim no muaj ntau lub sij hawm tsis muaj txiaj ntsig nrog cov kab mob fungal uas tseem tshuav qhov kev xav tau kho tsis tau [10]. Strikingly, ntau cov ntawv ceeb toom qhia tau hais tias ntau hom kab mob fungal twb tau tsim los tiv thaiv cov tshuaj tiv thaiv kab mob tam sim no [11,12], ua pov thawj rau kev txhim kho cov tshuaj tiv thaiv kab mob tshiab [13]. Tsis tas li ntawd, cov tshuaj tiv thaiv kab mob kuj tau tshaj tawm tias ua rau muaj ntau yam tsis zoo [14]. Nrog rau qhov no hauv siab, cov kws kho mob uas tuaj yeem kho cov kab mob fungal thiab txo cov kab mob sib kis yuav yog qhov tseem ceeb tshaj plaws.

Cov nroj tsuag muaj ntxhiab thiab lawv cov metabolites muaj cov yam ntxwv zoo ntawm organoleptic uas tseem ua rau lawv muaj txiaj ntsig zoo hauv kev lag luam tshuaj, agronomic, zaub mov, huv, tshuaj pleev ib ce, thiab tshuaj tsw qab kev lag luam [15], thiab tawm los ua cov neeg sib tw ua cov tshuaj tua kab mob tshiab.

Ntau cov nroj tsuag muaj ntxhiab los ntawm Asteraceae, Apiaceae, thiab Lamiaceae tsev neeg yog cov nplua nuj nyob rau hauv cov roj yam tseem ceeb uas tau pom muaj ntau yam kev lom zem, xws li tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob [16-22]. Lub genus Salvia L., yog ib qho tseem ceeb tshaj plaws ntawm tsev neeg Lamiaceae, yog cultivated los ua zaub mov spices los yog flavoring agents hauv tshuaj pleev ib ce thiab perfumery [23]. Ntau hom tshuaj yog siv los kho cov kab mob microbial, malaria, thiab o, thiab tua kab mob hauv tsev tom qab mob [23]. Salvia hom tau nyiam cov kws tshawb fawb rau lawv cov khoom lom neeg, uas qhia cov kab mob muaj zog, tshuaj tua kab mob, tshuaj tiv thaiv kab mob, thiab tshuaj tiv thaiv kab mob, nrog rau kev txhim kho kev txawj ntse [24-30]. Txawm hais tias cov genus no tau kawm ntau, qee hom tseem tsis paub txog lawv cov tshuaj muaj pes tsawg leeg thiab lawv cov kev txaus siab tshuaj, xws li Salvia cacaliifolia Benth. (syn Salvia atriplicifolia Fernald, Salvia hempsteadiana SFBlake thiab Salvia mendax Epling). S. cacaliifolia yog ib tsob ntoo uas muaj tsob ntoo uas muaj tsob ntoo ntev txog 70 cm hauv qhov siab, nrog cov nplooj peb sab thiab cov racemes loj ntawm xiav sib sib zog nqus, 2-lipped paj 2 cm ntev [31]. Cov tsiaj no loj hlob hauv thaj chaw siab siab ntawm Mexico, Guatemala, thiab Honduras.

Qhov no ua hauj lwm tsom mus rau chemically characterizes cov roj yam tseem ceeb ntawm S. cacaliifolia (cacalia sage) thiab nthuav tawm nws cov antifungal/anti-inflammatory peev xwm. Tsis tas li ntawd, qhov mob-kho muaj peev xwm ntawm cov roj tseem ceeb kuj tau kawm. Txhawm rau txhawb kev txaus siab rau cov tsiaj no, cov peev xwm tiv thaiv kev laus kuj raug tshuaj xyuas.

2. Cov txiaj ntsig

2.1. Tshuaj muaj pes tsawg leeg ntawm S. cacaliifolia Essential Oil

Cov roj tseem ceeb yog tus cwj pwm los ntawm cov roj carbon ntau ntau (70.10 feem pua ​​± 0.119) ua raws li cov pa oxygenated sesquiterpenes (11.71 feem pua ​​± 0). {21}}32), raws li qhia nyob rau hauv Table 1. Hais txog ib tug neeg tebchaw, cov roj yam tseem ceeb yog nplua nuj nyob rau hauv -curcumin (27.64 feem pua ​​± 0.195), -bisabolene (18.01 feem pua ​​± 0.033), bicyclo germacrene ( 8.54 feem pua ​​± 0.074), thiab curzerenone (7.68 feem pua ​​± 0.055).

2.2. Antifungal nyhuv ntawm Salvia cacaliifolia 

Cov tshuaj tua kab mob ntawm cov roj yam tseem ceeb los ntawm S. cacaliifolia, tshwj xeeb tshaj yog tawm tsam dermatophytes thiab cov poov xab, raug soj ntsuam. Raws li pom nyob rau hauv Table 2, cov roj yam tseem ceeb tau zoo tiv thaiv tag nrho cov tshuaj dermatophyte strains, nrog T. mentagrophytes thiab T. rubrum yog cov feem ntau raug (MIC=0.16 µL/mL). Hais txog cov poov xab, C. neoformans yog cov feem ntau raug rau cov roj yam tseem ceeb (MIC=0.64 µL/mL).

2.3. Anti-Inflammatory Potential ntawm S. cacaliifolia

Lub peev xwm tiv thaiv kab mob ntawm S. cacaliifolia tseem ceeb roj tau soj ntsuam siv lipopolysaccharide (LPS)-stimulated macrophages. Raws li qhov xav tau, qhov sib ntxiv ntawm LPS rau 24 h ua rau muaj kev nce ntxiv ntawm nitric oxide (NO) rau cov kab lis kev cai nruab nrab ([NO]=42.8 ± 7.4 µM). Qhov sib ntxiv ntawm qhov sib txawv ntawm cov roj yam tseem ceeb ua rau txo qis ntawm cov tshuaj nitrites pom (IC50=0.49 µL/mL). Ob leeg 1.25 thiab 0.64 µL/mL txo cov nitrites pom (Daim duab 1A). Txiav txim siab tias ntawm 1.25 µL / mL qhov txo qis hauv cell viability tau pom (Daim duab 1B), qhov concentration ntawm 0.64 µL / mL tau siv los nthuav tawm cov txheej txheem hauv qab ntawm cov tshuaj tiv thaiv kab mob ntawm S. cacaliifolia. tseem ceeb roj.

Kev txiav txim siab tias kev khi ntawm LPS mus rau Tus Xov Tooj-zoo li receptor 4 (TLR4) ua rau lub zog hloov pauv ntawm NF-κB uas ua rau muaj kev qhia ntawm inducible nitric oxide synthase (Nos2) thiab cyclooxygenase-2 (Cox2) [ 34], tom qab ntawd peb tau soj ntsuam seb puas muaj cov roj tseem ceeb tuaj yeem hloov kho cov qib ntawm ob qho tib si proteins. Raws li pom hauv daim duab 2A–C, qhov muaj LPS ib leeg ua rau muaj kev nce qib protein ntau ntawm iNOS thiab COX-2. Nyob rau hauv lub xub ntiag ntawm cov roj yam tseem ceeb, ob qho tib si proteins 'qib tau txo, tshwj xeeb tshaj yog cov iNOS (Daim duab 2A, B), qhia tias cov roj impaired NF-κB activation, thiab yog li ntawd cov lus qhia ntawm Nos2 mRNA nrog rau nws cov protein ntau.

2.4. Txoj Kev Kho Mob ntawm S. cacaliifolia Essential Oi

Xav tias ntau cov nroj tsuag los ntawm genus Salvia tau tshaj tawm tias yog cov kab mob kho mob [27,35,36], xav tias S. cacaliifolia tuaj yeem txhawb kev kho qhov txhab. Rau qhov ntawd, peb tau mus rau qhov kev ntsuam xyuas khawb, thiab lub qhov txhab kaw tau raug soj ntsuam nyob rau hauv lub xub ntiag thiab tsis muaj cov roj tseem ceeb hauv fibroblasts. Peb tshaj tawm tias cov roj tseem ceeb tau txhawb nqa kev tsiv teb tsaws ntawm fibroblasts thaum piv rau kev tswj cov hlwb (Daim duab 3A, B) ntawm 0.32 µL/mL, ib qho concentration uas tsis muaj tshuaj lom rau cov fibroblasts (Daim duab 3C).

2.5. Anti-Senescence Potential ntawm S. cacaliifolia Essential Oil

Txij li thaum nws paub tias qee hom Salvia nthuav tawm cov khoom tiv thaiv senescence [37,38], peb tau soj ntsuam cov peev txheej los tiv thaiv senescence ntawm S. cacaliifolia tseem ceeb roj siv cov Senescenceassociated -galactosidase (-gal) assay nrog etoposide ua tus neeg sawv cev senescence-inducing. .

Raws li pom nyob rau hauv daim duab 4, qhov sib ntxiv ntawm etoposide (12.5 µM) rau 24 h tom qab rov qab rau 72 h nyob rau hauv kab lis kev cai nruab nrab ib leeg ua rau muaj kev loj hlob ntawm -gal-zoo hlwb, uas qhia tau hais tias etoposide zoo induces cell senescence. Interestingly, thaum nyob rau hauv lub sij hawm rov qab los S. cacaliifolia tseem ceeb roj tau ntxiv rau cov kab lis kev cai nruab nrab qhov feem pua ​​ntawm -gal-zoo hlwb txo qis thaum piv rau kab lis kev cai nruab nrab ib leeg (Daim duab 4A, B), yog li qhia tias S. cacaliifolia kuj tuaj yeem ua tau. tam sim no anti-senescence teebmeem.

3. Kev sib tham

S. cacaliifolia tseem tsis tau paub ntau txog cov tshuaj muaj pes tsawg leeg ntawm nws cov roj yam tseem ceeb nrog rau txhua yam kev ua haujlwm lom neeg. Txhawm rau sau qhov sib txawv hauv kev paub, txoj haujlwm no piav qhia, thawj zaug, cov tshuaj tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv kev laus, thiab qhov txhab-kho cov khoom ntawm cov tsiaj no.

Peb tau tshaj tawm tias S. cacaliifolia cov roj tseem ceeb feem ntau yog cov yam ntxwv ntawm sesquiterpenes, tshwj xeeb tshaj yog -curcumin, -bisabolene, bicyclo germacrene, thiab curzerenone. Ib yam li ntawd, cov roj tseem ceeb ntawm S. scabra thiab S. aurea kuj tseem muaj cov sesquiterpenes (92.4 thiab 75 feem pua ​​​​, feem) [39], nrog -caryophyllene, epi- -cardinal, δ-cadinene yog cov ntsiab lus tseem ceeb hauv S. aurea thaum S. sabra yog tus cwj pwm los ntawm germacrene D, -caryophyllene, germacrene B, thiab -copaene. S. ceratophylla, S. verbenaca, S. stenophylla, S. runcinata, thiab S. repens yog lwm cov piv txwv ntawm Salvia cov roj tseem ceeb uas muaj nplua nuj nyob hauv sesquiterpenes [40–42]. Txawm li cas los xij, tsis muaj cov roj tseem ceeb ntawm Salvia tam sim no muaj ntau ntawm -curcumin, -bisabolene, thiab curzerenone ua cov roj tseem ceeb ntawm S. cacaliifolia. Lwm hom Salvia nthuav tawm cov tshuaj lom neeg sib txawv heev, nrog rau qhov tseem ceeb ntawm monoterpenes, xws li S. officinalis nrog ntau cov cis-thujone thiab camphor [43,44], lossis 1,8-cineole thiab camphor [45] thiab S. rosmarinus nplua nuj nyob rau hauv 1, 8-cineole, -pinene, camphor [46].

Xav txog tias qee hom Salvia tau tshaj tawm tias yog cov neeg sawv cev tuaj yeem kho cov kab mob ntawm daim tawv nqaij [36,47], tom qab ntawd peb tsom mus soj ntsuam seb S. cacaliifolia roj tuaj yeem muaj peev xwm tswj tau cov kab mob fungal. Cov roj tseem ceeb tau pom tias muaj kev cuam tshuam rau txhua yam kab mob dermatophyte thiab Cryptococcus neoformans, yog li qhia tias nws tuaj yeem siv los kho cov kab mob fungal, tshwj xeeb yog dermatophytosis, thiab cryptococcosis. Cov roj tseem ceeb los ntawm lwm hom xws li S. officinalis muaj cov nyhuv inhibitory tiv thaiv dermatophytes nrog MIC txij li 0.63 mus rau 2.5 µL / mL [43,45], yog li qhia txog kev ua haujlwm tsis muaj zog tshaj li qhov qhia rau S . cacaliifolia. Ob lub roj tseem ceeb los ntawm S. multicaulis tau nthuav tawm qhov cuam tshuam los tiv thaiv dermatophytic kev ua haujlwm, tshwj xeeb tshaj yog cov chemotype nplua nuj nyob rau hauv nerolidol [48]. Hais txog kev ua haujlwm ntawm cov ntsiab lus tseem ceeb ntawm S. cacaliifolia, tsis muaj kev tshawb fawb tau ua tiav. Txawm li cas los xij, qee qhov kev tshawb fawb tau soj ntsuam cov tshuaj tua kab mob ntawm cov roj yam tseem ceeb uas nplua nuj nyob hauv cov tebchaw no. Qhov tseeb, ib txoj kev tshawb fawb qhia txog kev ua haujlwm ntawm ntau cov roj tseem ceeb los ntawm Helichrysum microphyllum subsp. Tyrrhenian tau qhia tias cov neeg uas muaj cov ntsiab lus siab tshaj plaws hauv -curcumin nthuav tawm cov kev ua haujlwm zoo tshaj plaws los tiv thaiv kab mob [49]. Lwm cov kev tshawb fawb tau tshaj tawm cov tshuaj tiv thaiv kab mob nruab nrab rau cov roj yam tseem ceeb uas nplua nuj hauv -bisabolene [50,51], bicyclo germacrene [51,52], thiab curzerenone [53]. Xav txog qhov tsis muaj zog tiv thaiv kab mob ntawm cov roj yam tseem ceeb uas tau tshaj tawm yav dhau los, peb xav tias qhov kev ua ntawm S. cacaliifolia tej zaum yuav raug ntaus nqi los ntawm kev sib koom ua ke ntawm txhua qhov sib xyaw hauv qhov sib xyaw. Cov txheej txheem ntawm kev nqis tes ua hauv qab cov tshuaj tua kab mob ntawm S. cacaliifolia tseem ceeb roj thiab cov tshuaj sib cais tseem tsis tau paub. Txawm li cas los xij, xav txog lawv qhov xwm txheej lipophilic peb xav tias lawv yuav ua rau muaj kev cuam tshuam ntawm cov kab mob fungal los ntawm kev sib koom ua ke rau hauv cov txheej txheem membrane uas yuav ua rau kom muaj permeability, thiab txhawb kev xau ntawm intracellular Cheebtsam thiab enzyme inactivation [15,54].

Xav txog tias cov kab mob fungal ua rau kev ua kom lub cev tiv thaiv kab mob [55], qhov muaj peev xwm tiv thaiv kab mob ntawm S. cacaliifolia kuj tseem ceeb hauv txoj kev tshawb fawb tam sim no txij li qhov txo qis hauv TSIS tso tawm tau ua tiav thaum macrophages tau kho ua ntej nrog cov roj tseem ceeb. ua ntej LPS stimulation. Txhawm rau nthuav tawm cov txheej txheem hauv qab ntawm qhov muaj peev xwm tiv thaiv kab mob ntawm S. cacaliifolia, cov txiaj ntsig ntawm cov roj tseem ceeb ntawm cov qib protein ntawm iNOS thiab COX-2, ob qho tshuaj tiv thaiv kab mob cuam tshuam nrog TLR4 / NF-κB teeb liab txoj kev, raug soj ntsuam. Kev txo qis hauv ob qib protein tau pom, yog li qhia tias qhov txo qis hauv TSIS tso tawm yuav yog vim muaj kev cuam tshuam ntawm NF-κB txoj hauv kev. Tseeb tiag, ib qho ntawm cov txheej txheem tseem ceeb ntawm cov txheej txheem molecular uas ua rau muaj kev pheej hmoo ntawm kev mob mus ntev yog qhov ua kom muaj NF-κB signaling cascade, uas tau tshwm sim los ua tus thawj tswj hwm ntawm o thiab innate immune homeostasis. Kev ua kom muaj qhov hloov pauv ntawm NF-kB ua rau muaj kev cuam tshuam ntawm COX-2, iNOS, thiab tseem muaj qhov tsis txaus ntseeg ntawm inflammatory cytokines qog necrosis factor (TNF)- , IL-1 , IL-6 , uas tuaj yeem ua rau cov hlwb nyob ib puag ncig tsis zoo thiab lub sijhawm ntev tuaj yeem ua rau muaj mob ntev. Cov kev tshawb fawb ntxiv yuav tsum tau ua kom nkag siab ntxiv txog tag nrho cov txheej txheem tom qab lub peev xwm tiv thaiv kab mob ntawm S. cacaliifolia cov roj tseem ceeb, xws li kev hloov pauv ntawm lub zog ntawm p65. Hais txog lwm hom Salvia, nws tau pom tias S. officinalis tseem ceeb roj ntawm 0.64 µL/mL tuaj yeem txo NO ntau lawm los ntawm 30–40 feem pua ​​[45], whereas cov roj tseem ceeb ntawm S. cacaliifolia ntawm lub tib koob tshuaj txo NO ntau lawm los ntawm 70 feem pua. Hauv kev tawm tsam, cov roj tseem ceeb los ntawm S. ceratohyal inhibits NO ntau lawm (IC50=90 µg/mL) [40]. Lub peev xwm ntawm Salvia hom los hloov kho txoj hauv kev NF-kB tau tshaj tawm. Tseeb tiag, S. officinalis tuaj yeem txo qhov kev qhia ntawm NF-kB [44]. S. ceratophylla muaj zog inhibits NF-κB nrog IC50 ntawm 38 µg/mL [40]. Nws tau pom tias Helichrysum italicum tseem ceeb roj nplua nuj nyob rau hauv -curcumin, lub ntsiab compound ntawm S. cacaliifolia roj, muaj peev xwm txo NO ntau lawm, uas yog nyob ntawm cov ntsiab lus nyob rau hauv no compound, uas yog corroborated los ntawm fractioning ntawm cov roj yam tseem ceeb nyob qhov twg lub curcumin-nplua nuj feem induced siab tshaj inhibition [56]. Cov teebmeem zoo sib xws tau piav qhia rau -curcumin chemotype ntawm H. italicum [57]. Nws tau pom tias cov roj yam tseem ceeb uas muaj cov txiaj ntsig tseem ceeb ntawm -bisabolene [58] thiab bicyclo germacrene [59] tau cog lus los tiv thaiv kev mob. Hais txog curzerenone, tsis muaj kev tshawb fawb tau soj ntsuam nws cov peev xwm tiv thaiv kab mob. Txawm li cas los xij, nws tau tshaj tawm tias ob lub roj tseem ceeb uas nplua nuj nyob hauv curzerenone muaj cov khoom muaj txiaj ntsig antioxidant [60,61], uas tuaj yeem ua rau muaj kev tiv thaiv kev ua haujlwm ntawm S. cacaliifolia los ntawm kev tso cai NO scavening. Muaj qhov no nyob rau hauv lub siab, nws muaj peev xwm hais tias -curcumin, lub ntsiab compound ntawm cov roj yam tseem ceeb, tej zaum yuav yog tus loj players lub luag hauj lwm rau S. cacaliifolia anti-inflammatory kev ua si, txawm li cas los xij, kev koom tes ntawm cov tseem ceeb sib txuas tsis tuaj yeem muab pov tseg.

Kev txiav txim siab tias kev kis kab mob dermatophyte tuaj yeem ua rau muaj cov kab mob ntawm daim tawv nqaij [8], peb tau soj ntsuam seb S. cacaliifolia tuaj yeem txhawb qhov txhab kho. Peb cov txiaj ntsig tau pom tias cov roj tseem ceeb no txhawb nqa kev tsiv teb tsaws ntawm fibroblasts, yog li qhia tias nws tuaj yeem ua lub luag haujlwm hauv kev kho qhov txhab. Cov roj tseem ceeb los ntawm H. italicum nplua nuj nyob rau hauv -curcumin txhawb qhov txhab kho mob hauv cov nas mob ntshav qab zib [62], yog li peb xav tias qhov txhab kho qhov txhab ntawm S. cacaliifolia tej zaum yuav raug ntaus nqi rau cov khoom siv no.

Xav tias ntau hom Salvia tuaj yeem ua cov tshuaj tiv thaiv kev laus [37], peb tsom los nthuav tawm yog S. cacaliifolia kuj tuaj yeem thim rov qab senescence. Qhov tseeb, qhov txo qis hauv kev ua ntawm senescence-induced pH-dependent -galactosidase tau pom. Qhov kev ua no yuav raug ntaus nqi feem ntau yog muaj -bisabolene txij li cov roj tseem ceeb nplua nuj nyob rau hauv cov compound no kuj tau nthuav tawm cov nyhuv anti-senescence ntawm fibroblasts [63].

4. Cov lus xaus

Txoj haujlwm no qhia txog cov tshuaj muaj pes tsawg leeg ntawm Salvia hom, uas tseem tsis tau paub ntau, thiab qhia tau tias cov nroj tsuag no muaj ntau yam kev ua ub no. Cov roj tseem ceeb los ntawm S. cacaliifolia nthuav tawm cov tshuaj muaj pes tsawg leeg, feem ntau yog nplua nuj nyob rau hauv -curcumin, -bisabolene, bicyclo germacrene, thiab curzerenone. Tsis tas li ntawd, qhov no yog thawj daim ntawv tshaj tawm qhia txog cov tshuaj tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv kev laus, thiab kho cov khoom ntawm S. cacaliifolia cov roj tseem ceeb, tawm tswv yim tias nws muaj peev xwm siv tau los ua cov khoom siv rau kev tsim cov khoom siv tshuaj pleev ib ce rau kev tiv thaiv ntawm daim tawv nqaij, thiab. raws li kev kho mob ntawm dermatophytosis thiab mob o.

5. Cov ntaub ntawv thiab cov txheej txheem

5.1. Cov khoom cog

Salvia cacaliifolia seedlings tau loj hlob los ntawm cov noob hauv "Planta Medica" tsev xog paj hauv Laboratory of Plant Biology thiab Pharmaceutical Botany ntawm University of Cagliari (UNICA). Cacalia sage noob, ntawm Mexican keeb kwm, tau yuav los ntawm Italian khw tshwj xeeb. Tom qab 5 lub lis piam, cov noob tau hloov mus rau "Planta Medica" tsev xog paj rau eco-physiological xav tau ntawm hom. Tom qab 2 xyoos ntawm kev loj hlob, cov nroj tsuag tau sau (lub sij hawm flowering) thiab qhuav nyob rau hauv ib tug kuaj rau ob hnub. Daim ntawv pov thawj (6/23.9/V1) tau muab tso rau hauv Herbarium Karalitanum (CAG), University of Cagliari, Viale S. Ignazio, 13 Cagliari, Ltalis.

【Yog xav paub ntxiv: david.deng@wecistanche.com / WhatApp:86 13632399501 】