Kev nkag siab ntawm Verbascoside Thiab Nws Cov Tshuaj Pharmacological

Yog xav paub ntxiv, Email:tina.xiang@wecistanche.com

Verbascoside Txheej txheem cej luam

Cistancheyog nplua nuj nyob rau hauv alkaloids, crystalline neutral tshuaj, amino acids, kab kawm, vitamins, thiab lwm yam Cheebtsam. Cov khoom tseem ceeb yoglus verbascoside. Verbascoside muaj cov mis mos molecular ntawm C29H36O15, tseem hu ua Acteoside, uas yog dav faib nyob rau hauv xws li Verbena, Ledanaceae, Scrophulariaceae, Lamiaceae, Leguminosae, thiab Plantain. Ib qho phenylethanol glycoside hauv cov nroj tsuag dicotyledonous. Nws yog ib qho dawb los yog lub teeb daj crystalline hmoov, thiab nws yog ib qho chaw cog qoob loo uas muaj txiaj ntsig zoo rau kev tshawb fawb. Nws muaj hydroxyphenyl thiab caffeoyl, uas yog lub npe hu ua antioxidants. Cov ntaub ntawv tshawb fawb tau pom tias verbascoside kuj muaj ntau yam kev ua ub no, xws lianti-inflammatory, tshuaj tiv thaiv qog, anti-apoptotic, thiab hepatoprotective pharmacological teebmeem, txawm li cas los xij, nws cov peev txheej tiv thaiv AD tsis tau daws. Kuj tau tshaj tawm Dow tau qhia tias verbascoside pom cytotoxicity rau cov qog nqaij hlav cancer mis, tab sis tsis yog rau cov hlwb hauv qhov chaw sib txawv ntawm lub cev (xws li tib neeg lub hlwb, yoov, lossis nas), thiab nws tseem tiv taus ntau yam kev ntxhov siab exogenous. exerted ib tug tej yam kev tiv thaiv, uas tej zaum yuav yog vim nws anti-oxidant-mobilizing zog.

Nyem qhov no kom paub ntau yam khoom

Pharmacological teebmeem ntawm verbascoside

Antioxidant nyhuv

Verbascoside tuaj yeem cuam tshuam lipid peroxidation, yog li txhim kho qhov tsis kam ntawm tus tsiaj lub cevoxidative kev nyuaj siab. Nyob rau tib lub sijhawm, verbascoside tuaj yeem txo DNA kev puas tsuaj los ntawm oxidative kev nyuaj siab. Ntxiv verbascoside rau qhov pub tuaj yeem txhim kho lub peev xwm antioxidant ntawm cov tsiaj thiab muaj kev cuam tshuam zoo rau lawv txoj kev loj hlob thiab kev loj hlob. Cov teebmeem antioxidant ntawm verbascoside kuj muaj cov ntawv thov hauv neuroprotection, nrog verbascoside tswj xyuas kom txo tau qhov tshwm sim ntawm oxidative kev nyuaj siab thiab neuronal apoptosis nyob rau hauv nas hlwb nyob rau hauv ib tug arterial occlusion / reperfusion qauv.

Anti-inflammatory nyhuv

Verbascoside tuaj yeem cuam tshuam cov kab mob lipopolysaccharide-induced neuroinflammatory cov lus teb thiab kev qhia ntawm cov kab mob ntsig txog cov proteins hauv BV-2 microglial hlwb los ntawm inhibiting NF-κB taw qhia txoj hauv kev thiab mob ntsws mob [9]; Nyob rau tib lub sijhawm, verbascoside tuaj yeem cuam tshuam JAK / STAT teeb liab txoj hauv kev los tiv thaiv cov lus teb inflammatory, uas muaj peev xwm kho tau cov kab mob osteoarthritis.

Anti-tumor nyhuv

Verbascoside tuaj yeem cuam tshuam rau kev ua haujlwm ntawm cov txheej txheem tswj hwm cov protein hauv cov qog cell kab thiab inhibit matrix metalloproteinases los ntawm inhibiting protein kinase C, yog li tsim cytotoxicity rau cov qog hlwb; Nws tseem tuaj yeem txhawb cov qog cell apoptosis los ntawm Multi-target, ntau txoj hauv kev los inhibit qog cell loj hlob, muaj peev xwm cuam tshuam, thiab tshuaj tiv thaiv, thiab kev sib koom ua ke nrog lwm cov tshuaj. Nyob rau tib lub sijhawm, verbascoside kuj muaj cov haujlwm ntawm inducing kev tuag ntawm tib neeg promyelocytic mob leukemia hlwb Anti-apoptotic nyhuv verbascoside tuaj yeem inhibit autophagy-induced apoptosis ntawm retinal ganglion hlwb los ntawm OPTN thiab PI3K / AKT / mTOR txoj hauv kev thiab tuaj yeem siv ib leeg lossis ua ke nrog cov tshuaj kho mob glaucoma[5]; Cov kev cai ntawm apoptosis proteins Bax thiab Bcl-2 muaj kev tiv thaiv ntawm vascular endothelial cell apoptosis thiab oxidative puas nyob rau hauv hyperlipidemia qauv nas; Nyob rau tib lub sijhawm, verbascoside tuaj yeem ua rau muaj kev tiv thaiv kab mob thiab tshuaj tiv thaiv apoptotic ntawm endotoxic shock nas. paj hlwb tiv thaiv.

Tiv thaiv lub siab

Verbascoside tuaj yeem kho tus mob diethylnitrosamine-induced hepatocellular carcinoma hauv nas los ntawm kev hloov kho oxidative kev nyuaj siab thiab apoptosis txoj hauv kev uas nyob ntawm STAT-3. Nyob rau tib lub sijhawm, nws tuaj yeem txo qis hepatocellular carcinoma nodules, hepatocyte puas, necrosis, thiab inflammatory teb, thiab txo ROS theem ntawm hepatocytes, tiv thaiv kev poob ntawm mitochondrial membrane peev xwm; Tsis tas li ntawd, verbascoside tuaj yeem inhibit qhov induction ntawm D-galactosamine thiab lipopolysaccharide los ntawm D-galactosamine thiab lipopolysaccharide. daim siab tsis ua haujlwm thiab ua rau hepatocyte apoptosis hauv cov nas.

Qhia txog kev ua haujlwm lom neeg ntawm Verascoside:

1) Kev ua haujlwm hauv vitro

Verbascosideua raws li ATP-kev sib tw PKC inhibitor nrog IC50 ntawm 25 μM. Verbasin qhia Kis ntawm 22 thiab 28 μM txheeb ze rau ATP thiab histones, feem. Verbasin muaj zog antitumor ua haujlwm tawm tsam L-1210 hlwb nrog IC50 ntawm 13 μM[1]. Verbasin (5,10 μM) inhibits 2, 4-dinitrochlorobenzene (DNCB)-induced activation ntawm T cell costimulators CD86 thiab CD54, proinflammatory cytokines, thiab NFκB txoj hauv THP-1 hlwb.

2) Hauv vivo kev ua si

Verbascoside (1 feem pua ​​) txo qis tag nrho kev khawb tus cwj pwm tshwm sim thiab qhov mob ntawm daim tawv nqaij mob nyob rau hauv ib tug 2, 4-dinitrochlorobenzene (DNCB)-induced nas qauv ntawm atopic dermatitis (AD). Verbasin tseem thaiv cov kev qhia ntawm proinflammatory cytokines TNF- , IL-6, thiab IL-4 mRNA hauv DNCB-induced tawv nqaij lesions[2]. Verbasin (50,100 mg / kg, ip) tsis hloov khaub thuas allodynia los ntawm kev raug mob ntev compression (CCI). Verbasin (200 mg / kg, ip) txo qis kev mob khaub thuas stimuli rau acetone hauv nas hnub 3. Verbasin kuj txo qis tus cwj pwm hloov pauv cuam tshuam nrog neuropathy. Tsis tas li ntawd, verbascoside txo Bax thiab nce Bcl -2 rau hnub 3.