Kev Tshawb Fawb Kev Tshawb Fawb ntawm Kev Kho Mob thiab Kev Kho Mob ntawm Alzheimer tus kab mob thiab Parkinson tus kab mob los ntawm Dihuang Yinzi ⅱ

3 Kev Tshawb Fawb Kev Tshawb Fawb Txog Kev Tiv Thaiv thiab Kev Kho Pd Siv Rehmannia Glutinosa Yinzi

PD yog qhov thib ob feem ntau cov neurodegenerative kab mob, thiab nws cov kev kuaj mob tuaj yeem yog cov tshuaj ntsuam xyuas tau muab cov kev sib cav sib ceg thiab tsis muaj lub cev muaj zog. Cov kev cuam tshuam tsis zoo tsuas yog suav nrog kev txav mus los, thiab lwm yam kev ntxhov siab, thiab tsis tuaj yeem ua kom zoo rau lubmuaj tshwm sim, kev loj hlob thiab nrog cov tsos mob ntawm PD [29].

Tshuaj ntsuab tshiab ntawm cov kab mob tshiab rau kev tiv thaiv cov kab mob parkinson

 

 

 

3.1 Kev tshawb nrhiav tau Efficacy

Rehmannia Glutinosamuaj cov peev xwm loj thiab tau siv dav hauv lubKev kho mob ntawm kev txav tsis zoo, tsis yog-txav kev cuam tshuam thiab nrog cov tsos mob ntawm Pd. Hauv kev kho mob ntawm Parkinson cov kev ntxhov siab, kev tshawb fawb tau ua pov thawj tias kev kho mob tau zoo ntawm kev sib txuas ntawmRehmannia Glutinosa Yinzi, ShayOya Licorice Decoction thiab Madoba ncav cuag 87.5% [30]; Kev sib xyaw ntawm Rehanmannia Yinzi thiab Letoderazine lossis Dopodorazine cov kev kho mob tuaj yeem txhim kho lub cev muaj zog ntawm Parkinson cov neeg mob [31]; Los ntawm kev tshawb nrhiav ntawm cov tshuaj suav ua cov tshuaj uas tau ntsuas qhov ntsuas thiab cov levodopa ua haujlwm pom tias kev sib xyaw ua ke ntawm Rehwinosa, Levod Acupuncture cov txiaj ntsig tseem ceeb. kev ua tau zoo [32].

Hais txog kev kho mob tsis-txav ntawm pd, kev tshawb fawb tau ua pov thawj ntawm kev sib xyaw ua ke ntawm kev sib xyaw ua ke ntawm kev sib xyaw ua ke ntawm cov neeg phem sib xyaw ua ke ntawm cov neeg levodopa nyob hauv ib pawg [33]. Hais txog kev kho mob ntawm cov tsos mob tuaj nrog Pd, qee qhov kev tshawb fawb tau ua pov thawj nrog cov tshuaj sib xyaw ua ke tuaj yeem kho cov tshuaj hypotty [34]; Ua ke kho nrog acupuncture tuaj yeem txhim kho pw tsaug zog zoo thiab pw lub sijhawm pw hauv Parkinson tus kab mob [35]; DIHUAG YINZI ua ke nrog kev kho kom haum (xws li cov ntsiav tshuaj mydophar, selegphthtive ulocial magnitting, thiab lwm yam) tus kab mob parkson. Kanamori cem quav thiab mob, thiab lwm yam. [36-37].

Hauv cov ntsiab lus, txawm hais tias Dihuang Yinzi tsis tuaj yeem hloov cov tshuaj kho mob tsis tuaj yeem ua rau cov tshuaj lom neeg tsis tuaj yeem ua rau dyskinesia thiab tsis-dyskinesia hauv pd. Nws ua lub luag haujlwm tshwj xeeb hauv kev kho ntawm nws cov tsos mob nrog.

Tshuaj ntsuab Cistance rau kev tiv thaiv cov kab mob ua si

 

3.2 Cov mechanism ntawm kev ua

 

Cov pathogenesis ntawm pd yog ze ze rau qhov poob ntawm dopaminin neuron kuj yog lub pathology, ntxiv rau cov pathology thiab kev ua tau zoo ntawm PD [38]. Raws li cov tshuaj uas ib txwm siv rau kev kho cov tshuaj tiv thaiv PD hauv cov tshuaj Hmoob, Dihuang Yinzi muaj kev tiv thaiv Mitochondrial tiv thaiv, kev cai ntawm -Ynuclein thiab neuroprotection. Nyob rau hauv cov nqe lus ntawm mitochondrial tiv thaiv, Rehmannia Gleutinosa tuaj yeem txo cov kws kho mob xov tooj ntawm tes Nyob rau hauv cov nqe lus ntawm cov kev cai -synlein, Rehmannia Glutinosa tuaj yeem txo cov kev qhia ntawm lub midbrain, yog li txo qhov kev cuam tshuam ntawm lub cev muaj nuj nqi [40]; Nyob rau hauv cov nqe lus ntawm kev neurochnia, Rehmannia Glutinosa tuaj yeem tswj cov tshuaj hypothalamus ntawm kev ua kom cov nqaij mos, txo cov ntsiab lus ntawm cov pob hlwb, txo qis kev puas tsuaj ntawm dopaminergic neurons nyob rau hauv lub txiaj ntsig nigra [41], thiab ua kom txoj kev qhia ntawm neurotrophic yam los ua ib lub luag haujlwm neuroprotrotective [42].
Ntxiv rau kev sim sim, molecular docking kev sim kuj tseem ua lub luag haujlwm ntawm PD los ntawm kev cuam tshuam rau kev ua haujlwm ntawm PD
Los ntawm cov pov thawj kev tshawb fawb saum toj no, nws tuaj yeem xaus lus tias kev cuam tshuam ntawm Rehmannia Decoction muaj qhov kev txhim kho tseem ceeb ntawm PD, thiab qhov xaus no yog ua raws li ntau txoj kev kawm. Lub tshuab ua tau los ntawm qhov uas cov compound no cov khoom ua tau zoo yog cuam tshuam nrog ntau lub zog muaj zog. Tam sim no, kev tshawb fawb ntawm cov txheej txheem ntawm kev ua ntawm Rehmannia Decoction hauv kev txhim kho PD npog ntau, tab sis qhov tob tsis txaus. Feem ntau cov kev tshawb fawb tsuas yog nyob ntawm qhov kev tshawb nrhiav ntawm cov phiaj xwm ntawm kev ua, thiab feem ntau ntawm cov ntawv sau tseg, tsis muaj kev txheeb xyuas cov khoom siv tau zoo thiab kev tshawb nrhiav ntawm lub hom phiaj ntawm kev nqis tes ua. Tsis tas li ntawd, nws tseem tsis tau paub seb Rehmanmtion tuaj yeem muaj kev cuam tshuam cov nyhuv ntawm kev muaj nuj nqi ntawm pd xeev. Muab cov nam ntawm cov xwm txheej ntawm cov pov thawj tuaj yeem qhia tau cov peev txheej ntawm cov tshuaj cuam tshuam tshuaj.

 

3.3 Kev tshawb nrhiav cov khoom xyaw nquag

 

Txhawm rau kom tau txais kev xaiv cov tshuaj kho mob rau PD, thiab zoo dua rau cov kev tshawb fawb ntawm Monomer cov khoom sib txawv ntawm kev kho mob ntawm Pd. Zoo ib yam li Rehmannia Decoction rau kev kho ntawm AD, lub ntsiab anti-pd Cheebtsam ntawm Rehmannia Decoction yog Glycosides thiab Lignans. Glycosides ntawm Rehmannia Decoction rau kev kho mob ntawm PD nyuam qhuav suav nrog Catalolol, polygala Saponin,Tag nrho glycosides ntawm cistanche Squaticola, Echinacoside, Loganin,Cistanche Squaticola athiab verbarcoside. Kev tshawb fawb txog kev ua tau zoo thiab kev siv tshuab ntawm ib leeg teb tau pom tias:

 

Catalol tau txo cov kev ploj ntawm dopamininic neurons los ntawm kev cuam tshuam ntau xws li anti-apoptosis, antixidant cuam tshuam, thiab antioxidant cuam tshuam [43]; Polygala Tenuifolia Saponins tuaj yeem tiv thaiv neurons los ntawm kev txhim kho kev kis tus kab mob los tiv thaiv kab mob [44]; Cistanche Squaticola Ib qho tuaj yeem txhawb kev sib sau ntawm pitochondrial puas tsuaj los ntawm kev ua kom lub lc3 thiab p {} kho cov tshuaj lom neeg los tiv thaiv dopamine neurons [45]; Echinacoside muaj peev xwm txo tus naj npawb ntawm monoamine neurotransmitters, tswj hwm cov ntaub ntawv uas ntsiag to {}} methyl -4- phenylpridinium Ion / {1- Methyl -4- p38 mitogen-{{mitogen-{{{{າ} ™ P52 signaling plays lub luag haujlwm neuroprotrotsistive [46]; Loganin tau inhibit o, autophagy thiab apoptosis hauv pd qauv nas [47], ua si lub luag haujlwm neuroprotrotive; Verbascoside muaj peev xwm ncaj qha khi rau cysteine ​​protection 3 ua ib qho nyuaj tshiab, uas tsis muaj neuronal cell Apoptosis [48]. Raws li Lignan, Schisandra chinensis ib tug neeg nyob hauv PC5 qauv qauv los ntawm txhim kho lub peev xwm antioxidant ntawm cov hlwb [49].

 

 

4 kev sib tham

 

Hauv cov ntsiab lus xaus, neurodegenerative sawv cev sawv cev los ntawm AD thiab PD muaj xws li etiology thiab pathogenesis thiab kev kho cov ntsiab cai hauv TCM kev tshawb xav. Lub raum tsis muaj peev xwm thiab kev txo pob txha caj qaum yog cov kab ke sib xws ntawm ob kab mob. Tus neeg pom zoo lub raum-tonifug Yinzi muaj qhov kev sim siab thiab cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam nrog kev cuam tshuam thiab kev sib cav sib ceg thiab kev mob siab rau hauv PD; Nyob rau hauv cov kev cai ntawm kev ua haujlwm ntawm kev tshawb fawb: kev ua ntawm Dihualoid protrolves ntawm kev kho cov qauv ntawm cov qauv ntawm cov qauv ntawm Synaptic thiab Mitochondrial mechanism; Hais txog cov khoom xyaw nquag ntawm cov tshuaj: cov khoom xyaw nquag hauv cov khoom xyaw, tag nrho cov khoom xyaw, thiab cov khoom xyaw nquag uas ua rau PDAsacchar Saponin, tag nrho glycosides ntawm cistanche Squaticola, Echinacoside, Loganin, capisandra Sequicola, tag nrho cov khoom xyaw uas nquag muaj: Ciav tshuaj Schisandrae a.

 

4.1 Kev kuaj mob ntawm Rehmannia Decoction hauv kev tiv thaiv thiab kho cov ad thiab pd yog qhov tseeb, tab sis muaj qhov tsis muaj pov thawj ua pov thawj

Los ntawm kev txheeb xyuas, nws tau pom tias nyob rau hauv cov kev tshawb fawb yav dhau los uas muaj cov ntaub ntawv tshawb fawb txog kev kho mob uas muaj cov kab mob hauv cov neeg soj ntsuam muaj sawv cev, thiab tseem muaj cov xwm txheej ua pov thawj raws li kev tshawb fawb tau hais txog kev tshawb fawb tau hais tias, thiab tseem muaj cov ntaub ntawv ua pov thawj ua pov thawj. Cov kauj ruam tom ntej yuav tsum yog ua kom muaj qhov systematic, muaj ntau-qhov muag tsis pom kev sib txuas los txuas ntxiv kom meej meej cov kev kho mob lossis cov nyhuv cuam tshuam ntawm cov compound.

 

4.2 Muaj qhov tsis muaj kev tshawb fawb ntawm cov txheej txheem ntawm kev ua ntawm Rehmannia mechanchism ua rau cov tsos mob zoo li yuav tsum tau qhia ntxiv

 

Tam sim no, tseem muaj qhov tsis muaj kev tshawb fawb txog cov txheej txheem ntawm Rehmannia Decoction hauv kev tiv thaiv thiab kho cov AD thiab PD. Nws muaj tshwj xeeb qhia hauv peb yam: thawj zaug, hauv kev tshawb fawb tshaj plaws ntawm chaw kuaj mob kev tshwm sim los ntawm chaw kho mob kev tshwm sim los ntawm chaw kho mob kev tshwm sim, thiab tom qab noj rov qab mus rau chaw kho mob. Qhov no tsis muaj peev xwm ua rau muaj kev txhim kho tiag tiag ua los ntawm kev xav ntawm "txais kev ncaj ncees, ua kom muaj kev ncaj ncees thiab ua kom zoo tshaj" nyob ib puag ncig. Thib ob, kev tsim ntawm qee cov kev sim tshuaj ntsuam lossis cov kev sim tsiaj yog qhov khuam thiab tsis tsim nyog. Muaj ntau qhov pov thawj ntawm kev sib txheeb ntawm tus kab mob-yeeb tshuaj-kev siv hluav taws xob, tab sis muaj tsawg dua cov pov thawj kom xauv rau hauv qhov kev sib txheeb zoo, uas ua rau kev txiav txim siab tsis paub. Nyob rau hauv tom qab kev cob qhia tom ntej, nyob rau hauv cov kev taw qhia ntawm ib txwm muaj tshuaj, ntsuas tsom xam cov kev tshawb fawb niaj hnub txhais tau tias yuav tsum tau nqa tawm. Tom qab pom cov kev nqis tes ua ntawm cov khoom siv yeeb tshuaj, nws tuaj yeem kuaj xyuas los ntawm cov kev sim vitro cus nrog rau Vivo Animitents kom tau txais cov lus xaus ua haujlwm. Thaum lub chaw kuaj mob, cov qauv neeg ua kuaj mob tau sau kom ntau li ntau tau, thiab ua kom muaj txiaj ntsig los pab qhov ua tau zoo txuas ntxiv ntawm kev kho mob ntawm cov tshuaj.

Ib qho ntxiv, los ntawm kev sib txuas ua ke cov kev tshawb fawb saum toj no, nws tuaj yeem pom tias Rehmannia Decoction kuj tseem muaj cov txiaj ntsig tseem ceeb ntawm cov kev cai rau cov nyiaj sib txawv ntawm AD thiab PD, tab sis cov mechanism yuav luag tsis muaj qab. Qhov no qhia tau tias nyob rau hauv cov ntawv thov kev kho mob yav tom ntej, los ntawm kev sib xyaw nrog cov tshuaj tseem ceeb nrog cov tsos mob tseem ceeb, muaj txiaj ntsig zoo yuav ua tiav. Ib qho ntxiv, kev kawm txog cov txheej txheem ntawm Rehmannia Decoction rau cov tsos mob sib txawv ntawm tus kabmob tau dhau los ua qhov kev xav tau sai.

4.3 Lub Rehuamnia Decoction yog ua kom yooj yim, thiab yooj yim rau kev tshawb fawb rau kev ua tau zoo thiab kev tshawb fawb mechanism yuav pab kho mob kev hloov pauv

 

Lub ntsej muag ua kom zoo nkauj yog cov nyom thiab muaj ntau cov tshuaj tsw qab, uas ua rau muaj qee yam teeb meem hauv chaw kuaj mob thiab kev tshawb fawb mechanism. Cov lus sib txuam sib txuam tuaj yeem nqa tawm raws cov txheej txheem yav dhau los, thiab cov tshuaj uas muaj feem-sib piv ntawm cov qauv kev siv tshuaj-cov tshuaj sib xyaw ua ke ntawm cov tshuaj tiv thaiv kab mob. Ntxiv rau, nws tau pom tias cov txheej txheem ntawm kev ua thiab monomer muaj txiaj ntsig zoo ntawm Rehmannia Decoction hauv kev txhim kho AD thiab PD tau qee qhov rov ua dua. Qhov no qhia tau tias ob tus kabmob muaj kev sib xws hauv kev kho tshuab, thiab muab cov tshuaj sib txawv, lees paub txoj kev ua tau zoo ntawm Rehmannia Decoction. Yog li ntawd, ua kev tshawb fawb ntawm cov tshuaj yooj yim dua los yog cov khoom sib xyaw no tuaj yeem pab cov kev kho mob kev hloov kho ntawm cov lag luam no.

 

5 Cov ntsiab lus thiab Outlook

Raws li ib qho ntawm cov tshuaj quintess ntawm Suav tshuaj, cov tshuaj suav suav ua tau qhia tau zoo hauv kev kho mob hauv cov kab mob neurodegenerative sawv cev los ntawm AD thiab Pd.
Los ntawm cov etiology thiab pathogenesis, nws tau pom tias lub raum tsis txaus thiab caj ces yog qhov tseem ceeb rau cov kab mob nevodegenerative. Lub raum nrov-tonifug Hauv qab cov lus qhia ntawm cov kev tshawb fawb ib txwm muaj, qhia meej cov khoom siv tshuaj tiv thaiv kev ua haujlwm ntawm cov tswv yim, uas yog qhov ua tau los muab cov tswv yim tshiab rau cov neeg Suav Tshuaj Kho Mob Numodegenerative cov kab mob thiab kev pom tshiab rau txoj kev xav ntawm "kho cov kab mob sib txawv nrog tib txoj kev".

 

Ntawv Sawv cev

1 Wilson DM, Cookson Mr, Cookson Mr, Van Den Bosch L, li al. Cov kab mob ntawm cov kab mob neurodegenerative. Cell, 2023, 186 (4): 693-714.
2 Kalia LV, Lang AE. Tus kab mob Parkinson. Lancet, 2015, 386 (9996): 896-912.
3 Inglis F. Qhov kev ua kom muaj kev ruaj khov thiab kev nyab xeeb ntawm cov cholineterase inhibitors hauv kev kho mob dementia. Cov kev kawm rau hauv lub pob khomob Eit Jet, 2002 (127): 45-63.
4 Cen Chuan, nws Jiancheng. Kev tshawb fawb kev kawm ntawm kev phiv los ntawm levodopa hauv kev tiv thaiv thiab kho cov kab mob Parkinson nrog tshuaj suav tshuaj. Cov ntawv xov xwm Suav ntawm cov tshuaj suav tsoos, 2009, 27 (12): {{4 4}}.
5 FENG Shiyu, Ren Lu, LI MOCHUE, li al. Acupuncture kev kho ntawm Alzheimer tus kab mob (poolney tsis muaj zog hom) pab txhawb kev tshawb fawb sib xyaw. Acupuncture cov tshuaj ntsuam xyuas, 2022, 38 (12): 59-64.
6 Zang Caixia, Bao Xiuqi, Sun Hua, li al. Kev Tshawb Fawb Kev Kawm ntawm Suav Tshuaj Herbal Compound hauv kev kho mob ntawm Alzheimer tus kab mob. Suav Chaw Tshuaj thiab Tsev Kho Mob, 2016, 32 (4): 157-161.
7 Tian J, Wang XQ, Tian Z. tsom rau kev ua yeeb yam: kev txiav txim siab tsis ntev los no rau nws cov peev xwm neurrotrotective. Pem hauv ntej lub tsev muag tshuaj, 2022, 13: 905898.
8 Zhang na, Wang Le, Ma Tao, li al. Cov nyhuv ntawm Rehmannia Decoction ntawm Kev Ua Haujlwm hauv kev txawj ntse hauv cov neeg mob uas muaj Alzheimer me me. Suav phau ntawv xov xwm, 2019, 16 (35): {{4 4}}.
9 Jia Qian, LUO HAI, XU WEIWEI, li al. Soj ntsuam ntawm kev ua tau zoo ntawm hloov kho Rehmannia Gluutinosa hauv kev kho mob ntawm Alzheimer tus kab mob. Suav phau ntawv xov xwm ntawm kev tshuaj xyuas kev siv tshuaj yeeb thiab kev tsom xam, 2018, 18 (4 (4 (4 (4) {}}}, 503.
10 Yao Aina, Wang Xuan, Dong Lianling, li al. Soj ntsuam ntawm kev ua tau zoo ntawm hloov kho Rehmannia Gluutinosa hauv kev kho mob ntawm Alzheimer tus kab mob. World Journal phau ntawv xov xwm ntawm kev sib xyaw tshuaj Suav thiab Western tshuaj, 2016, 11 (5): {{4 {}.
11 zuo qinjing. Kev soj ntsuam ntawm kev hloov kho Rehmannia Glutinosa hauv kev txhim kho kev nyuaj siab cuam tshuam nrog Alzheimer tus kab mob. Shanxi phau ntawv xov xwm ntawm Tsoos Suav Tshuaj, 2017, 33 (8): 47, 49.
12 Yan Yan, Han khiav, Gao Junfeng, li al. Mechanism ntawm Rehmannia Glutinosa hauv kev txhim kho mitochondrial biogenesis thiab oxidative kev puas tsuaj hauv lub hlwb cov ntaub so ntswg ntawm cov nas. Suav phau ntawv xov xwm ntawm kev sim tshuaj suav kev sim tshuaj, 2018, 24 (21): 105-110.
13 yu miao, xie ning, guan huibo, li al. Kev cuam tshuam kev cuam tshuam kev cuam tshuam ntawm Rehanronnia Glutinosa ntawm tiam ntawm ib lub hlwb ntawm cov qauv ad. Cov ntawv xov xwm Suav ntawm cov tshuaj suav tsoos, 2016, 31 (6): 2281-2284.
14 yu hongni, lub hnub mengjie, han guanghui, li al. Lub tshuab ntawm Rehmannia Glutinosa hauv kev txhim kho astrocyte kev puas tsuaj hauv cov qauv admin thiab tswj hwm synaptic thiab kev ua haujlwm. Suav phau ntawv tshaj tawm ntawm kev sim tshuaj suav cov tshuaj, 2023,