Tsoos suav tshuaj nyob rau hauv cov neeg mob nrog thawj Sjogren's Syndrome: Ib qho Randomized, Ob-dig muag, Placebo-Controlled Clinical Trial

Keeb kwm:Sjogren's Syndrome (SS) yog ib hom kab mob autoimmunefeem ntau yog characterized dryness, nkees, thiab mob. Kev kho tam sim no rau SS hauv Westerntshuaj yog txwv. Lub hom phiaj ntawm qhov kev tshawb fawb soj ntsuam no yog los tshawb txog qhov ua tau zoo thiabKev nyab xeeb ntawm kev siv tshuaj suav tshuaj suav tshuaj (TCM) mis rau cov neeg mob thawj SS.

Txoj kev:Peb tau ua 12-lub lim tiam, randomized, ob qhov muag tsis pom kev, tswj cov placeboKev sim tshuaj ntawm Chung Shan Medical University Tsev Kho Mob. Peb suav nrog 42 tus neeg mob nrogSS ntawm cov hnub nyoog ntawm 20 thiab 80 xyoo uas ua tau raws li cov qauv kev faib tawm ntawm covAmerican thiab European Consensus Group (AECG). Cov neeg mob uas muaj lwm yam mob hnyavCov kab mob tshwm sim los yog kab mob raug cais tawm ntawm qhov kev sim no. Tom qab kuaj xyuas,Cov neeg mob tau muab tso rau hauv pawg TCM kho lossis pab pawg placebo (pivntawm 2: 1). Peb kho cov pab pawg TCM nrog 6 g ntawm Gan-Lu-Yin granules tom qab noj tshaisthiab 6 g ntawm Jia-Wei-Xiao-Yao-San ua ke nrog 1 g ntawm Suan-Zao-Ren-Tang thiab 1 g ntawmYe-Jiao-Teng txhua hmo tom qab noj hmo. Cov neeg mob hauv pawg tswj hwm tau kho nrog aplacebo nrog tib qhov tsos thiab tsw tab sis tsuas yog ib feem kaum ntawm qhov ntau npaum li ntawdtau txais los ntawm pab pawg kho mob. European League Tawm tsam Rheumatism Sjogren'sSyndrome Patient-Reported Index (ESSPRI) tau siv los ua thawj qhov kawg ntawm lub lim tiam12. Cov ntsiab lus thib ob yog Sjogren's Syndrome Disease Activity Index (SSDAI),Kev ntsuam xyuas tus kws kho mob thoob ntiaj teb (PGA), pom kev sib piv (VAS), MultidimensionalFatigue Inventory, thiab Medical Outcomes Survey Short Form-36, thiab Pittsburgh Pw tsaug zogCov qhab nia zoo (PSQI). Cov xwm txheej tsis zoo kuj raug kaw.

Cov txiaj ntsig:Ntawm 42 tus neeg mob randomized, 28 tus neeg mob tau muab rau TCMpab pawg kho mob thiab 14 tus neeg mob raug xa mus rau pawg tswj hwm. Thaum kawmlub sijhawm, 5 tus neeg mob tau thim tawm ntawm pawg TCM thiab 7 tau thim tawm ntawm pawg tswj hwm.

Thaum lub lim tiam 12, ESSPRI cov qhab nia ntawm ob pawg tau txhim kho. Tus qhab nia ESSPRI ntawmpab pawg kho mob poob qis los ntawm 0.62 (95 feem pua ​​​​CIP = 0.557) thiab cov placebopawg poob los ntawm 0.91 (P = 0.557). Txawm li cas los xij, tsis muaj qhov sib txawv tseem ceeb tau pomnruab nrab ntawm ob pawg. Lub sijhawm pw tsaug zog hauv PSQI yog−0.61, uas nthuav tawm ib qhokev txhim kho ntau tshaj qhov−0.21 piv nrog cov placebo pawg (P = 0.914).

Xaus:Thaum lub lim tiam 12, ESSPRI cov qhab nia tsis tau qhia tias kev siv TCMCov mis no ua tau zoo rau kev kho cov neeg mob nrog Sjogren's syndrome. Txawm li cas los xij, PSQICov qhab nia tau qhia tias cov qauv no tuaj yeem ua rau tus neeg mob pw tsaug zog ntev. Peb kuj pomtias cov qauv no tuaj yeem txo cov ntshav siab ntawm cov neeg mob.

Keywords: Sjogren's Syndrome, Jia-Wei-Xiao-Yao-San, Gan-Lu-Yin, Cistanche, Anti-Fatigue, randomized soj ntsuam sim, ua tau zoo, kev nyab xeeb

Taw qhia

Primary Sjogren's Syndrome (pSS) yog ib tug mob inflammatory autoimmune kab mob tshwm sim los ntawm sicca syndrome. Ntau tshaj 80 feem pua ​​​​ntawm cov neeg mob mus xyuas cov chaw kho mob qhia cov tsos mob ntawm dryness, nkees, thiab mob (1). Zuag qhia tag nrho, 20-40 feem pua ​​​​muaj feem cuam tshuam los ntawm qhov tshwm sim hnyav ntawm pSS (2, 3). Tsis muaj kev kho mob Western tau pom zoo uas muaj txiaj ntsig zoo rau cov neeg mob. Ntau tus neeg ua haujlwm biologic tau raug sim hauv kev sim tshuaj, tab sis ob peb qhov kev soj ntsuam tau raug tshaj tawm (1). Hauv cov tshuaj sab hnub tuaj, kev cuam tshuam nrog cov tshuaj suav tshuaj (TCM) tau tsim cov txiaj ntsig sib txawv thiab tsis sib xws (4). Qhov no tuaj yeem raug ntaus nqi los ntawm qhov tsis muaj cov ntsiab lus kawg thiab cov pov thawj-raws li kev paub txog qee yam TCMs. Kev faib tawm ntawm cov neeg mob nrog pSS raws li kev kuaj mob hauv cov tshuaj Eastern kuj yog ib txoj haujlwm nyuaj. Cov txheej txheem ntawm Jia-Wei-Xiao-Yao-San (JWXYS) nyob rau hauv cov kab mob autoimmune tau pom kom nce synaptic plasticity thiab txo cov qib ntawm cov cim inflammatory los ntawm upregulating cov lus qhia ntawm hippocampal hlwb-derived neurotrophic factor (BDNF) (5- 7) . Suan-Zao-Ren-Tang (SZRT) tuaj yeem tswj hwm gamma-aminobutyric acid-ergic (GABA) system hauv ntshav uas yog qhov tseem ceeb hauv etiology ntawm kev puas siab puas ntsws (8). Cov txiaj ntsig ntawm kev tshawb fawb ntawm cov tsiaj tau qhia tias Gan-Lu Yin (GLY) tuaj yeem cuam tshuam cov leeg nqaij leeg (9) thiab ua kom muaj kev tiv thaiv kab mob (10-12). Raws li ib txoj kev tshawb fawb, qhov feem ntau ntawm Sjogren's syndrome yog kwv yees li 0.8 feem pua ​​​​hauv Suav teb, thiab feem ntau ntawm cov neeg mob yog cov poj niam ntawm qhov sib piv ntawm 3: 1. Lwm txoj kev tshawb fawb tau tshaj tawm tias ntau dua 90 feem pua ​​​​ntawm cov neeg mob pSS hauv Suav teb raug kho los ntawm cov kws kho mob TCM (13). Txawm li cas los xij, qhov ua tau zoo ntawm TCM rau cov neeg mob pSS hauv qhov chaw kho mob tsis paub meej. Yog li ntawd, lub hom phiaj ntawm txoj kev tshawb no yog los soj ntsuam qhov ua tau zoo thiab kev nyab xeeb ntawm kev siv cov qauv TCM nquag xaiv los ntawm cov ntaub ntawv tau txais los ntawm National Health Insurance system hauv Suav teb.

Txoj kevKev xaiv tus neeg mob

Cov neeg mob cuv npe hauv qhov kev sim no muaj hnub nyoog ntawm 20 thiab 80 xyooxyoo, tau ntsib cov txheej txheem kev faib tawm ntawm Asmeskas Tebchaws EuropePawg pom zoo, muaj European Pab Koomtes tiv thaiv Rheumatism(EULAR) Thawj Sjogren's Syndrome Patient-Reported Index(ESSPRI) tau qhab nia ntau dua peb lub ntsiab lus, thiab kos npe rau kev ceeb toomdaim ntawv tso cai tom qab nyeem ntawv thiab pom zoo nrog cov ntsiab lus ntawmqhov kev sim no. Cov neeg mob cuv npe yuav tsum ua kom txaus siab li 4ntawm 6 ntawm American European Consensus Group cov txheej txheem,suav nrog No.4 (Histopathology) lossis No.6 (Autoantibodies), lossis 3ntawm 4 lub hom phiaj (xws li No.3, No.4, No.5, lossis No.6).Cov txheej txheem cais tawm yog keeb kwm ntawm cov hlab plawv loj,pulmonary, los yog neuropsychiatric disorders, txawv txav lub raumkev ua haujlwm, cov ntshav dawb hauv cov ntshav qis qis, thiab cev xeeb tub.Hauv kev tshawb nrhiav, cov neeg mob tuaj yeem thim tawm ntawm qhov kev simyam tsis muaj laj thawj. Cov neeg mob ua raws li tus nqi ntawm70 feem pua, qhov qhab nia ESSPRI uas tau nce ntau dua 50 feem pua ​​ob zaug, lossisCov xwm txheej phem heev yuav tsum tau tshem tawm ntawm txoj kev tshawb fawbtom qab kev pom zoo los ntawm tus thawj kws tshawb fawb.

Kawm Tsim

Qhov no yog 12-lub lim tiam, ob qhov muag tsis pom kev, randomized, thiab cov tshuaj placebo tswjkev sim tshuaj. Cov neeg tuaj koom tau raug muab tso ua kerau ib pawg placebo lossis pab pawg kho mob (qhov sib piv ntawm 1: 2).Cov neeg koom yuav tsum tau rov qab mus rau lub tsev kho mob rau kev ntsuam xyuashauv lub lis piam 0, 4, 8, thiab 12.

Kev cuam tshuam

Cov neeg mob raug xa mus rau pawg kho mob ntawm lub hauv paus ntawm qhov ncaujtau txais 6 g ntawm Gan-Lu-Yin (GLY) ib hnub tom qab noj tshais, thiab 6 gntawm Jia-Wei-Xiao-Yao-San (JWXYS) ua ke nrog 1 g ntawm SuanZao-Ren-Tang (SZRT) thiab 1 g ntawm Ye-Jiao-Teng (YJT) tom qab noj hmotxhua hnub rau 12 lub lis piam. Ib qho placebo nrog ib feem kaum ntawm cov koob tshuajTCM cov mis thiab tib lub ntsej muag tau hais lusrau cov neeg mob hauv pawg tswj hwm txhua hnub. Nco ntsoovCov tshuaj ntsuab tau tsim los ntawm Chuang Song-Zongkws tshuaj Hoobkas, thiab txhua tus tau ntsib Zoo ManufacturingXyaum xav tau. Cov neeg koom tsis tau tso cai raunoj lwm yam tshuaj suav tshuaj ntsuab thaum lub sij hawmkawm. Txawm li cas los xij, yog tias cov neeg mob tau pib noj cov hauv qab notso cai noj tshuaj ntau tshaj 2 lub lis piam ua ntej kev tshuaj ntsuam,

DAIM 1 |Kev sim profile. 42 tus neeg mob tau muab tso rau hauv TCM thiab cov placebo pawg hauv qhov sib piv ntawm 2: 1. Hauv pawg TCM, 28 tus neeg mob tau txais 6 grams ntawm Gan Lu YinTom qab noj tshais, thiab 6 g ntawm Jia Wei Xiao Yao San ua ke nrog 1 g ntawm Suan Zao Ren thiab 1 g ntawm Ye Jiao Teng tom qab noj hmo txhua hnub. 14 tus neeg mob hais lustau txais ib qho placebo nrog ib feem kaum ntawm TCM cov qauv thiab zoo li qub txhua hnublawv yuav tsum nyob twj ywm nyob rau hauv ib tug ruaj khov koob tshuaj thoob plawslub sijhawm 12-lub lim tiam kawm: cholinergic tshuaj (Salagenlossis Exozac), cov tshuaj tiv thaiv kab mob (Plaquenil, methotrexate, lossisbiologics), hypnotics, thiab anxiolytics (Stilnox, Antivan, los yogXanax), tshuaj tiv thaiv kev nyuaj siab, tshuaj tsis-steroidal tshuaj tiv thaiv kab mob,thiab analgesics (tramadol, Ultracet, lossis Panadol). Tsuas yog rau kev nyab xeebLub hom phiaj tuaj yeem hloov pauv ntau npaum li cas, thiab kev hloov pauv li ntawdtau ua los ntawm tus kws tshawb nrhiav. Lub Tsev Haujlwm Saib Xyuas Kev Ruaj Ntsegntawm Chung Shan Medical University Tsev Kho Mob tau pom zoo tag nrhocov txheej txheem ntawm txoj kev tshawb no.

Cov ntsiab lus kawg

Thawj qhov kawg yog ESSPRI, uas tau siv lossoj ntsuam thawj qhov chaw kho mob uas siv ib zaug 0-10 tus lejtau qhab nia rau txhua qhov ntawm peb qhov ntsuas (dryness, nkees, thiab mob). ACov qhab nia siab dua qhia cov tsos mob hnyav dua.Cov ntsiab lus thib ob thaum lub sijhawm 12- lub lim tiam kawm tauEULAR Sjogren's Syndrome Diseases Activity Index, tus neeg mobKev soj ntsuam thoob ntiaj teb, pom qhov ntsuas ntsuas ntsuas, Cov txiaj ntsig kho mobDaim ntawv ntsuam xyuas luv luv -36, Pittsburgh Pw Zoo Index (PSQI),Multidimensional Fatigue Inventory, thiab SuavMedical Constitution Questionnaire. Lub EULAR Sjogren'sSyndrome Diseases Activity Index tau tsim los ntsuas qhovkev ua haujlwm kab mob hauv kev sim tshuaj rau pSS. Nws tshuaj xyuas12 qhov chaw xaiv ntawm cov kab mob tshwj xeeb hauv lub cev, txhua tusuas tau muab faib ua kev ua haujlwm qis, nruab nrab-kev ua haujlwm, thiabkev ua haujlwm siab (2, 14). Cov tshuaj suav tshuaj suav tshuajConstitutional Scale yog ib qho cuab yeej rau kev kuaj mob thiabkab mob, thiab nws cov txiaj ntsig tuaj yeem siv los txiav txim qhov tsim nyogtxoj kev kho mob.Kev nyab xeeb

Thoob plaws lub sijhawm kawm tag nrho, cov cim tseem ceeb tau raug kaw thiabkuaj lub cev ntawm txhua qhov kev mus ntsib. LaboratoryCov txiaj ntsig rau kev kuaj ntshav thiab biochemistry tau saib xyuas ntawm lub lis piam0 thiab 12. Tag nrho cov xwm txheej tsis zoo raug kaw. TCM cov lus nugraug soj ntsuam ntawm lub lis piam 4, 8, thiab 12. Cov kws saib xyuas neeg mob tau soj ntsuamcov neeg mob siv cov tshuaj concomitant thiab kev lav phib xaub tshuajkev soj ntsuam thiab tshuaj xyuas tshuaj ntawm txhua qhov kev mus ntsib.Kev txheeb cais

Cov ntaub ntawv qub raug sau thiab txheeb xyuas los ntawm cov neeg saib xyuas txhuamus xyuas. Cov ntaub ntawv ntxhib tau muab tso rau hauv cov ntaub ntawv thiab tshuaj xyuaslos ntawm cov kws tshawb fawb siv SAS software. Kom tsis txhob muaj kev tsis ncaj nceeslos ntawm cov ntaub ntawv ploj lawm, cov txiaj ntsig tau hloov kho raws lilub hom phiaj-to-treat. Nruam variables ntawm covcov ntsiab lus kawg tau muab piv nrog cov hauv paus ntsiab lus siv ib qhotsom xam ntawm qhov sib txawv los yog Tub Kawm Ntawvt- kuaj. Tom qab ua covcategorical variables, cov kws tshawb fawb siv Fisher qhov kev xeem, covchi-square test, lossis Cochran-Mantel-Haenszel xeem los soj ntsuamqhov tshwm sim.Qhov kwv yees qhov loj me yog xam raws li qhov kev xavntawm 5 feem pua ​​​​ntawm hom 1 yuam kev tus nqi thiab 20 feem pua ​​​​ntawm hom 2 yuam kev. Covkev xav tau txhais tau tias hloov pauv hauv ESSPRI cov qhab nia ntawm lub lim tiam 12 ntawmkev cuam tshuam yog plaub lub ntsiab lus hauv pab pawg kho mob thiab obcov ntsiab lus nyob rau hauv pawg placebo, thiab tus qauv sib txawv tau teeb tsaua 2,75. Ib qho piv txwv loj ntawm 30 tus neeg mob tau muab los muab20 feem pua ​​​​lub zog rau kev sib piv cov txiaj ntsig ntawm ob pawg sivib ob sabt-test thiab Wilcoxon rank-sum test. Vim lubqhov kev xav rho tawm yog 30 feem pua ​​​​thiab cov placebo thiab TCMpab pawg muaj cov neeg koom nrog 1: 2, 72 cov neeg mob soj ntsuamyuav tsum tau ua ua ntej pib cuv npe. Raws li qhov tshwm sim ntawmCov kev txwv nyiaj txiag, kev nrhiav neeg ua haujlwm rau txoj kev tshawb fawb no raug txiav thiabKev tshuaj xyuas tau ua tom qab tso npe ntawm 42 tus neeg mob.

TAB 1 |Cov yam ntxwv tseem ceeb ntawm cov neeg koom nrog kev kawm

TSEEM CEEBNtawm 42 tus neeg mob kuaj, 28 tau muab tso raupab pawg kho mob thiab 14 tau muab rau cov placebopab pawg. Tag nrho ntawm tsib tus neeg koom hauv pawg placebo yogtshem tawm ntawm qhov kev sim; peb raug rho tawm los ntawmkev kho mob tsis muaj txiaj ntsig thiab lwm yam ob leeg tau txais kev lees paub.Hauv pawg TCM, 7 tus neeg mob yeem thim tawm thiab 21cov neeg mob ua tiav qhov kev sim 12-lub lim tiam. Ib tug muaj kev phiv loj heevkev tshwm sim (hydronephrosis), peb yeem thim rov qab, ib qho tsis muajkev ua tau zoo, thiab lwm qhov peb tau poob ntawm kev rov qab (Daim duab 1). Feem ntau hais lus, kev noj qab haus huv ntawm cov neeg mob hauv TCMpab pawg tau phem dua li cov neeg mob hauv pawg placebo ntawmlub hauv paus. PSQI cov qhab nia ntawm cov neeg mob hauv pawg TCMtau siab dua cov neeg mob hauv pawg placebo (11.25± 4.27 vs 10.57 Nws± 5.03; P <>0.650). Rau cov tsoos suavMedical Constitutional Scale tau tshwm sim, tag nrho peb hom kev cai lij chojyog qhov tseem ceeb hauv TCM thiab cov placebo pawg (Table 1). Covprevalence ntawm hom kev cai lij choj nyob rau hauv pawg tswj yogsiab dua li hauv pawg TCM (64.29 vs. 57.14 feem pua ​​).Lub lim tiam 12, txawm hais tias tsis muaj kev hloov pauv tseem ceeb hauv feem ntaucov ntaub ntawv yooj yim thiab biochemistry, qib IgG ntawm pab pawg kho mobtau txo los ntawm 39.64 (P = 0.042∗ ), tseem ceeb heev. ESSPRIcov qhab nia ntawm ob pawg tau txhim kho. Txawm li cas los xij, ESSPRI cov qhab niantawm pab pawg kho mob txo los ntawm 0.62 (P = 0.557) thiab covntawm cov placebo pab pawg txo qis los ntawm 0.91 (P = 0.557). ESSPRIcov qhab nia ntawm cov neeg mob hauv pab pawg kho mob tau siab dua li covntawm cov neeg mob hauv pawg tswj hwm (Rooj 2; Daim duab 2). Piv raulub lim tiam 0, ESSDAI cov qhab nia ntawm pab pawg kho mob loj heevtxhim kho. Tab sis tsis muaj qhov sib txawv tseem ceeb hauv ESSDAI cov qhab nia yogpom ntawm ob pawg. Ntxiv mus, PGA cov qhab nia muajtxo qis hauv pab pawg kho mob (−1.37 ± 2.37∗, P = 0.075) dua li hauv pawg placebo (−0.24 ± 1.36, P = 0.075). Hauvlub ntsej muag ntawm General Health hauv SF-36, cov qhab nia ntawm kev kho mobpab pawg (7.14± 11.82∗, P = 0.330) tau pom tseeb tau tsa los ntawm cov ntawdntawm pawg placebo (−3.57 ± 9.29, P = 0.330). Lub sijhawm pw tsaug zograu PSQI yog−0.61, nthuav qhia kev txhim kho ntau ntxivtshaj qhov−0.21 piv nrog cov placebo pawg (P = 0.914; Daim duab 3). Tsis muaj lwm qhov kawg ntawm qhov kawg rau obCov pab pawg tau pom tias TCM cov qauv siv tau zoo. IbQhov tshwm sim tsis zoo tshwm sim los ntawm hydronephrosis, tab sis qhov no yogtsis cuam tshuam rau TCM formula.

Kev sib tham

Hauv 12-lub lim tiam no, ob qhov muag tsis pom kev, kev sim tshuaj placebo,peb xaus lus tias GLY thiab JWXYS TCM formula tsis muajCov txiaj ntsig tseem ceeb rau cov neeg mob pSS piv nrog cov placebo,raws li ESSPRI cov qhab nia. Tsim nyog ceeb toom, piv nrogcov placebo, cov qauv TCM tuaj yeem ncua sijhawm pw tsaug zog tag nrholos ntawm kwv yees li ib nrab ib teev, raws li PSQI cov qhab nia.Thiab, IgG uas yog ib qho kev paub zoo ntawm pSS rauimmunological hyper-responsiveness txo qis heev ntawmqhov kawg ntawm kev kawm. Qhov txo qis ntawm ESSDAI thiab PGAthiab kev txhim kho General Health tau pom tom qabtau txais kev kho mob TCM. Kev nyab xeeb profiles tau qhia tias qhov noCov mis tuaj yeem zam tau los ntawm cov neeg mob pSS, txawm tiasnquag me me tshwm sim nyob rau hauv lub plab systemtau tshaj tawm.Kev kho mob tsis zoo ntawm TCM tuaj yeem raug ntaus nqirau ntau yam hauv qhov kev sim no. Ua ntej, tus qauv TCM los yogosage peb siv los kho cov neeg mob pSS tej zaum yuav tsis muajtau siv rau cov pej xeem peb suav nrog. Txawm tias covKev kho mob tshwm sim ntawm pawg TCM tau hnyav dua ntawmlub hauv paus, tsis muaj qhov sib txawv ntawm qhov sib txawv ntawm obpab pawg. Cov kev kho mob tshwm sim ntawm pawg TCM yoghnyav dua ntawm lub hauv paus. Siv lwm yam tshuaj ntsuablos yog ntau npaum li kev cuam tshuam yuav tau txais txiaj ntsig zoo duarau cov neeg mob. Qhov thib ob, lub sijhawm taug qab tau luv heev rauua kom pom qhov ua tau zoo ntawm cov tshuaj ntsuab. Cov ntaub ntawv pov thawjcov ntaub ntawv hais txog GLY thiab JWXYS tseem tsis muaj, thiab feem ntauTCM cov kws kho mob sau tshuaj kho raws li lawv qhov chaw kho mobkev paub tsis muaj kev txhawb zog los ntawm cov pov thawj scientific.Thib peb, kev noj qab haus huv ntawm cov neeg mob hauv ob pawg tsis yogsib npaug ntawm lub hauv paus. Cov kev hloov pauv tsis sib xws tuaj yeem ua raudeviations nyob rau hauv cov kev tshwm sim. Qhov loj ntawm cov qauv loj tuaj yeemtxo qhov kev sib txawv no.Kev txhim kho ntawm kev pw tsaug zog zoo thiab lub sijhawm tuaj yeem yog ib qhoqhov tshwm sim ntawm JWXYS thiab SZRT. Kev tshawb nrhiav pov thawj yav dhau losua qauv qhia tias JWXYS thiab SZRT cov qauv tuaj yeem kho tauteeb meem pw tsaug zog hauv cov poj niam climacteric. JWXYS muaj txiaj ntsigrau kev kho insomnia, thiab SZRT tuaj yeem ncua sijhawm pw tsaug zog los ntawm∼1 h tom qab 1 lub hlis ntawm kev kho mob (15–17). Cov txiaj ntsig ntawm kev tshawb fawbua rau tsiaj txhu tau qhia tias GLY tuaj yeem cuam tshuamvascular smooth nqaij ua haujlwm (9). Txoj kev tshawb no muaj qee qhov kev txwv. Ua ntej, tus qauv loj yogme me thiab lub sijhawm kawm luv luv. Tab sis rau kev kawm tsav,peb ntseeg tias qhov kev tshawb nrhiav no tseem tuaj yeem muab qhov tseem ceebcov ntaub ntawv. Thib ob, kev siv tshuaj thiab tshuaj ntsuab ua ke tautxiav txim siab los ntawm kev kho mob ntawm TCM cov kws tshaj lij, tab sis tsis yog kev kho mob ua ntejkev tshawb fawb lossis theem II kev tshawb fawb txog koob tshuaj. Txawm li cas los xij, pebntseeg tias TCM kev sim tshuaj tuaj yeem pib nrog theem II tsavkawm txij li cov qauv no tau siv rau hauv kev kho mob raupua pua xyoo. Thaum kawg, cov txiaj ntsig kev tshawb fawb tsis tuaj yeem hais dav davrau lwm cov pejxeem, lwm cov qauv TCM lossis ntau npaum li cas vim qhov noyog ib qho kev tshawb nrhiav me me, ib qho kev tshawb nrhiav me me (18–23). 

XAIV

Lub lim tiam 12, ESSPRI cov qhab nia tsis tau qhia txog qhov ua tau zoo ntawm TCM cov mis hauv kev kho cov neeg mob Sjogren's syndrome. Txawm li cas los xij, PSQI cov qhab nia tau qhia tias cov qauv no tuaj yeem ncua sijhawm pw tsaug zog ntawm cov neeg mob. Peb kuj tau tshawb pom tias cov qauv no tuaj yeem txo cov ntshav ntshav ntawm IgG thiab ntshav siab thaum kawg ntawm txoj kev tshawb no. Tsuas yog ob peb yam xwm txheej me me tau pom.

DATA AVAILABILITY STATEMENT

Thawj qhov kev koom tes uas tau nthuav tawm hauv txoj kev tshawb fawb no suav nrog hauv tsab xov xwm / Cov Khoom Siv Ntxiv, cov lus nug ntxiv tuaj yeem xa mus rau tus kws sau ntawv / s.

ETHICS STATEMENT Kev tshuaj xyuas kev ncaj ncees thiab kev pom zoo tsis tas yuav tsum muaj rau txoj kev tshawb fawb ntawm tib neeg cov neeg koom nrog raws li txoj cai hauv zos thiab cov kev cai hauv tsev. Cov neeg mob/cov neeg tuaj koom tau muab lawv daim ntawv tso cai tso cai los koom rau hauv txoj kev tshawb no.

AUTHOR CONTRIBUTIONS

H-HC, J-NL, M-CY, thiab C-YC pab txhawb rau txoj kev xav thiab tsim kev kawm. H-HC tau sau thawj tsab ntawv ntawm cov ntawv sau. J-NL tau pab txhawb rau kev nrhiav nyiaj txiag thiab kev tswj xyuas qhov project. M-CY thiab C-YC teeb tsa cov ntaub ntawv thiab ua qhov kev txheeb xyuas kev txheeb xyuas. Y-TH thiab Y-FH tau sau ntu ntawm cov ntawv sau. JW tau pab txhawb rau kev tsim qauv ntawm txoj kev tshawb fawb, ua qhov kev sim, kev txhais cov ntaub ntawv thiab kev hloov kho tseem ceeb / kev pom zoo kawg ntawm cov ntawv sau. Txhua tus kws sau ntawv tau pab kho cov ntawv sau, nyeem, thiab pom zoo cov ntawv xa tawm.

Nrhiav qhov zoo tshaj plaws BOTANICAL HOLISTIC CARE rau RELIEVING FATIGUE

Peb ua tib zoo xuas tes ua Neuro Regen mis muaj xws li tshuaj ntsuab tshawb fawb zoo tshaj plaws. Txhua qhov qhia tau hais tias muaj peev xwm zoo rau kev tswj hwm kev qaug zog, ntxiv rau cov paj hlwb thiab kev txhawb nqa neuron tag nrho.

Xws li:

Relieve lub cev qaug zog-

① Cistanchemuaj ntau yam polyphenols xws li echinacoside thiab verbascoside, uas tuaj yeem ua rau muaj kev ua haujlwm ntawm antioxidant enzymes thiab muaj cov haujlwm ntawm kev tshem tawm cov dawb radicals;

③ Cistanchemuaj lub luag haujlwm ntawmnourishing lub raum thiab ntxiv dag zog rau yang,thiab tuaj yeem txhim kho cov hypothalamus-pituitary-hypophysis tshwm sim los ntawm kev ua haujlwm hnyav Lub zog ntawm gonadal axis txhawb kev tso tawm ntawm testosterone, muaj txiaj ntsig zoo rau lub cev anabolism, thiab muaj kev tiv thaiv kev qaug zog;

④ Cistanchemuaj ntau yam khoom xyaw zoo, uas tuaj yeem txhawb lub cev lub zog metabolism thiab ua sianti- nkees nyhuv.