Cov tshuaj suav tshuaj suav tshuaj los tiv thaiv COVID-19

COVID-19 yog ib qho tshwm sim, hloov zuj zus mus sai sai los ntawm tus mob hnyav ua pa nyuaj ua pa mob coronavirus 2 (SARS-CoV-2). Vim nws cov yam ntxwv tshwj xeeb hauv etiology, kab mob sib kis, thiab pathology, tus kab mob sib kis no ua rau muaj teeb meem loj heev rau kev kuaj mob thiab kho mob [1]. Cov neeg mob nrog COVID-19 feem ntau tau txais kev txhawb nqa thiab kev tswj cov tsos mob, vim tias tseem tsis tau muaj kev kho mob tshwj xeeb rau COVID-19. Ntxiv rau cov hauv paus ntsiab lus ntawm kev cais tawm thaum ntxov, kev tshawb pom ntxov, thiab kev kho mob thaum ntxov [2], kev koom ua ke thaum ntxov ntawm cov tshuaj suav tshuaj (TCM) rau hauv Suav raws tu qauv, piv txwv li, kev koom ua ke ntawm TCM thiab Western tshuaj, kuj tau pab txhawb kev ceev ceev. ntawm COVID-19 hauv Suav teb. TCM tsis tsuas yog muaj keeb kwm ntev tiv thaiv kab mob sib kis tab sis kuj tseem ua lub luag haujlwm tseem ceeb hauv kev tawm tsam COVID-19.

Clinical xyaum

Tom qab muaj kev sib kis ntawm COVID-19, National Health Commission ntawm Tuam Tshoj tau tshaj tawm xya qhov kev kuaj mob thiab kev kho mob raws tu qauv. Kev kho mob suav tshuaj suav nrog hauv cov txheej txheem (3rd tsab), uas tom qab ntawd tau hloov kho thiab hloov kho kom zoo dua qub rau cov xwm txheej tiag tiag. Raws li lub Peb Hlis 30, 2020, TCM cov kev kho mob tau koom nrog hauv 74 886 cov neeg mob uas tau lees paub, 92 feem pua ​​​​ntawm tag nrho cov mob uas tau lees paub. Kev cuam tshuam TCM thaum ntxov hauv Suav teb, nrog rau nws qhov zoo ntawm cov ntaub ntawv kho mob zoo hauv kev tiv thaiv, tus kheej, thiab kev kho ntau hom kab mob, txhim kho cov tsos mob hauv cov neeg mob nrog COVID-19, ua kom cov neeg mob rov zoo, tiv thaiv Cov mob me me lossis nruab nrab los ntawm kev loj hlob mus rau qhov hnyav, thiab pab txo qis kev ntshai thiab kev ntxhov siab ntawm cov pej xeem nyob rau hauv qhov xwm txheej sib kis.

Nyem rau Tsob Ntoo Suav Tshuaj Cistanche herba

Tus qauv ntawm cov tsev kho mob me me [3] tau siv, thawj zaug hauv Suav teb thiab tom qab ntawd hauv ntau lub tebchaws, kom tau raws li qhov xav tau kev kho mob ntawm COVID-19 cov neeg mob. Hauv lub tsev kho mob TCM-taw qhia ua haujlwm coj los ntawm Zhang Boli, tus kws tshaj lij ntawm Tuam Tshoj Academy of Engineering, tsis muaj cov neeg mob tsim mob hnyav tom qab tau txais kev kho TCM (Suav tshuaj ntsuab, zaws, Guashascraping, taw tes thov, thiab kev tawm dag zog ntawm Taiji / Baduanjin) . Qhov "Wuchang qauv" tau npaj los ntawm Tong Xiaolin, tus kws tshaj lij ntawm Suav Academy ntawm Kev Tshawb Fawb thiab tus thawj coj ntawm National TCM Cov Kws Tshaj Lij Ua Haujlwm tau ua pov thawj tias muaj txiaj ntsig zoo los tiv thaiv kev kis tus kabmob. Cov qauv no tau siv TCM los tiv thaiv thiab tswj kev sib kis ntawm cov zej zog nyob rau hauv lub ntsej muag ntawm cov xwm txheej tseem ceeb ntawm kev noj qab haus huv rau pej xeem, tshwj xeeb tshaj yog thaum cov chaw kho mob tsis txaus thiab tsis muaj tshuaj tshwj xeeb. Xws li tus qauv yuav ntau lub sij hawm rau cov neeg mob los kho thiab txo cov neeg tuag thiab mob hnyav. Raws li Huang Luqi, tus kws tshaj lij ntawm Suav Academy ntawm Engineering thiab tus thawj tswj hwm ntawm Tuam Tshoj Academy ntawm Suav Kev Tshawb Fawb Txog Kev Kho Mob, peb cov tshuaj suav tshuaj thiab peb hom tshuaj ntsuab tau raug tshuaj xyuas rau COVID-19 kho.

Peb cov tshuaj suav tshuaj patent (pom zoo los ntawm National Medical Products Administration los sau COVID-19 ua ib qho kev qhia ntxiv) yog Lianhua Qingwen Keli/Jiaonang (Forsythiae thiab Honeysuckle Paj Kab Tsuag-Tshuaj Granules/Capsules), Jinhua Qinggan Keli (Honeysuckle Paj Txias-Relieving Granules) thiab Xuebijing (Stasis-Resolving & ToxinRemoving) txhaj. Peb hom tshuaj ntsuab yog Qingfei Paidu Fang (Lung-Cleansing & Toxin-Remove Formula), Huashi Baidu Fang (Dampness-Transforming & Toxin-Remove Formula), thiab Xuanfei Baidu Fang (Lung-Dispersing and Toxin-Remove Formula). Txog niaj hnub no, Lianhua Qingwen Zhiji (Forsythiae thiab Honeysuckle Paj Kab Tsuag-Clearing Preparations) tau tso npe rau hauv qee lub tebchaws xws li Thaib thiab Ecuador thiab tam sim no tos kom tso npe rau ntau lub tebchaws xws li Russia thiab Spain.

Raws li cov ntaub ntawv kho mob muaj, TCM tau qhia plaub qhov zoo hauv kev kho mob COVID-19. Ua ntej, rau cov mob me lossis nruab nrab, nws tuaj yeem ua rau luv luv lub sijhawm hloov pauv tsis zoo ntawm SARS-CoV-2 nucleic acid, lub sijhawm nruab nrab ntawm kub taub hau, thiab lub sijhawm rau defervescence nrog rau txo qhov tshwm sim ntawm mob hnyav lossis mob hnyav. tej yam kev mob. Thib ob, rau cov mob hnyav lossis mob hnyav, kev txhaj tshuaj suav tshuaj tuaj yeem ua kom cov pa oxygen saturation, inhibit cov tshuaj tiv thaiv kab mob, txo cov kab mob exudative, thaiv lossis muaj cytokine cua daj cua dub, thiab txo kev siv kev txhawb nqa thiab tshuaj tua kab mob. Thib peb, rau cov neeg mob nyob rau lub sijhawm convalescent, nws tuaj yeem txhim kho cov tsos mob, ua kom rov qab zoo dua, txo qhov mob ntsws, txo qhov adhesion, thiab pab nrog kev ua haujlwm zoo ntawm lub cev puas. Thaum kawg, nws tuaj yeem txo tus nqi kho mob [1].

Puas tau txij li thaum muaj kev sib kis ntawm COVID-19, ntxiv rau qhov kev tawm tsam pem hauv ntej tiv thaiv COVID-19, TCM cov kws kho mob thiab cov kws tshawb fawb tau koom nrog hauv kev tshawb fawb soj ntsuam suav nrog kev sim tswj kev sim [4]. Cov txiaj ntsig ntawm ntau daim ntawv tshaj tawm tau tshaj tawm tau qhia tias muaj txiaj ntsig zoo ntawm TCM hauv COVID-19 kev kho mob [4–6]. Txawm li cas los xij, tseem muaj ntau qhov kev txwv hauv kev tshawb fawb tsim thiab kev ua tau zoo, tshwj xeeb tshaj yog nyob rau hauv cov ntsiab lus ntawm kev sib kis. Cov lus qhia hauv Suav teb rau Kev Tswj Xyuas Kev Ncaj Ncees Kev Ncaj Ncees hauv Kev Kab Mob Sib Kis tau raug tso tawm thaum Lub Ob Hlis 19, 2020, txhais los ntawm Pawg Saib Xyuas Kev Ncaj Ncees ntawm Lub Ntiaj Teb Federation of Chinese Medicine Societies thiab luam tawm los ntawm Tuam Tshoj Xovxwm ntawm Cov Tshuaj Suav Tshuaj.

Keeb kwm kev paub

Txawm hais tias COVID-19 yog tus kab mob kis tau tshwm sim, nws tsis yog qhov xwm txheej uas TCM ua lub luag haujlwm hauv nws txoj kev kho mob. Nyob rau hauv ancient sij hawm, txawm hais tias tsis muaj lub tswv yim ntawm cov kab mob hauv cov tshuaj suav tshuaj, kev tawm tsam tiv thaiv kab mob nrog rau cov kab mob kis tau mus rau ntau txhiab xyoo. Kev nkag siab ntawm kab mob kis tau raug sau tseg thoob plaws hauv keeb kwm ntawm cov tshuaj suav tshuaj. Kev ntsuas tau zoo thiab cov qauv tau sau tseg hauv ntau TCM classics, rau npe rau ob peb, Huangdi Neijing (Daj Emperor's Internal Classic), Shanghan Lun (Treatise on Cold Damage), Zhou Beiji Fang (Cov qauv xwm txheej kub ceev kom khaws ib lub tes tsho), Qianjin Yaofang (Cov qauv tseem ceeb muaj nqis ib txhiab nyiaj kub), Wenyi Lun (Treatise on Kab Tsuag), Shanghan Wenyi Tiaobian (Systematic Differentiation of Cold Damage and Warm Epidemics), thiab Wenbing Tiaobian (Systematic Differentiation of Sov Kab Mob). Cov tshuaj decoction, suav tshuaj patent, acupuncture, moxibustion, thiab lwm yam kev kho mob ntawm TCM tau siv los ntawm kev sib txawv ntawm cov kab mob sib kis. Hauv TCM, cov ntsiab cai tseem ceeb rau kev tiv thaiv kab mob sib kis thiab kev kho mob yog los txhawb kev noj qab haus huv (anti-pathogenic) qi thiab tshem tawm cov kab mob.

Txhawm rau txhawb nqa kev noj qab haus huv qi txhais tau hais tias tswj hwm lub cev lub luag haujlwm, ua tiav homeostasis, thiab ua kom lub cev tiv thaiv tus kheej muaj peev xwm los txo qis kev puas tsuaj ntawm lub cev thiab ua kom rov zoo. Tshem tawm cov kab mob pathogenic txhais tau tias txhim kho cov tsos mob sai thiab tiv thaiv kab mob tsis zoo. Qee qhov piv txwv ntawm kev muaj tswv yim zoo los ua qhov kev tshoov siab rau kev kho mob niaj hnub no, xws li kev hloov pauv rau kev tshem tawm cov kab mob me me, thiab kev tshawb pom ntawm artemisinin rau malaria. TCM tau qhia txog qhov ua tau zoo tshaj plaws rau tus kab mob SARS tshwm sim xyoo 2003: nws tuaj yeem txhim kho kev rov zoo thiab txo qis kev tuag thiab teeb meem. Cov qauv pom zoo nyob rau hauv Suav raws tu qauv rau kev kuaj mob thiab kev kho mob ntawm COVID-19 txhua tus tau ua pov thawj tias muaj txiaj ntsig zoo hauv keeb kwm ntev ntawm kev tawm tsam cov kab mob sib kis. Cov qauv no tau muaj sia nyob dhau lub sijhawm thiab tseem suav tias muaj qhov cuam tshuam zoo hauv ib puag ncig niaj hnub no. Kev nyab xeeb thiab kev ua tau zoo ntawm qee cov qauv tau raug pov thawj los ntawm cov pov thawj-raws li kev sim tshuaj, piv txwv li, Ma Xing Shi Gan Tang (Ephedra, Apricot Kernel, Gypsum, thiab Licorice Decoction) — Yin Qiao San (Lonicera thiab Forsythia Powder) rau H1N1 [ 7].

Pharmacological kev tshawb fawb

Raws li tus kab mob ua rau muaj tus mob coronavirus, SARS-CoV-2 tsis yog tsuas yog cuam tshuam nrog nws cov yam ntxwv lom neeg, tab sis kuj nrog cov lus teb rau tus tswv tsev. Cov kev tshawb fawb ntawm lub network pharmacology thiab kev tshuaj xyuas virtual ntawm Suav tshuaj / cov khoom siv ntuj tsim tau ua rau lub hom phiaj muaj peev xwm xws li 3CL protease, papain-zoo li protease (PLpro), RNA polymerase (RdRp), thiab spike glycoprotein (Spike) ntawm SARS-CoV{{ 5}} ib. Muaj ntau yam khoom siv hauv Suav teb (xws li Huang Qin (Radix Scutellariae), Sang Ye (Folium Mori), He Zi (Flos Chrysanthemi), Ju Hua (Flos Chrysanthemi), Tou Hua Liao (Polygonum capitatum), Jin Yin Hua (Flos Lonicerae). Japonicae), Sheng Jiang (Radix et Rhizoma Rhei), thiab Da Huang (Radix et Rhizoma Rhei)) thiab lawv cov khoom tau pom tias muaj kev tiv thaiv SARS-CoV-2 kev ua haujlwm lossis kev tiv thaiv kab mob [8]. Cov khoom siv ntuj tsim siv hauv TCM tseem yog qhov muaj txiaj ntsig zoo rau kev txheeb xyuas cov tshuaj kho tshiab tawm tsam SARS-CoV-2.

Piv txwv li, pab pawg tshawb fawb ntawm Academician Rao Zihe thiab Academician Jiang Hualiang [9] tau ua tiav kev soj ntsuam cov qauv kev daws teeb meem siab ntawm lub ntsiab protease (Mpro, cov protein tseem ceeb hauv tus kab mob lub neej voj voog) thiab txheeb xyuas rau 6 cov tshuaj siv lead ua siv virtual thiab Kev tshuaj ntsuam xyuas siab tshaj ntawm ntau dua 10 000 cov tshuaj ib txwm siv, tshuaj kho mob, thiab cov khoom siv ntuj tsim. Nws tau raug tshaj tawm tias qee qhov sib xyaw tseem ceeb suav nrog scutellarein qhia tau tias muaj peev xwm kho tus mob coronavirus rau tib neeg. Cov kev tshawb pom no tau muab cov hmoov txhuas tshiab, cov hom phiaj, thiab cov tswv yim tshawb fawb ntxiv rau hauv vivo thiab hauv vitro kev tshawb fawb txog tshuaj tiv thaiv SARS-CoV-2 [10]. Qee cov tshuaj suav teb tau raug sim ntawm qib cellular hauv P3 lub chaw soj nstuam, piv txwv li, pab pawg tshawb fawb ntawm Academician Zhong Nanshan tau pom tias Lianhua Qingwen npaj tuaj yeem tiv thaiv SARS-COV-2 replication, kho cell raug mob thiab mob los ntawm cov Yuav ua li cas tiv thaiv tus kab mob [11].

Cov lus qhia yav tom ntej

TCM tau hloov zuj zus thiab ua lub luag haujlwm tseem ceeb hauv kev tswj kev sib kis. Nws tuaj yeem sib xyaw ua ke muaj txiaj ntsig zoo nrog cov tshuaj Western, ua kom zoo dua ntawm cov yam ntxwv zoo tshaj plaws ntawm txhua qhov system thiab them nyiaj rau qee qhov tsis muaj zog hauv txhua qhov thiab. Kev koom ua ke TCM thiab Western tshuaj tuaj yeem muaj kev sib kis zoo dua thiab txo cov nqi noj qab haus huv thiab kev sib raug zoo. Txawm hais tias COVID-19 tau muaj nyob hauv Suav teb, SARS-CoV-2 yuav tsis ploj mus ntawm nws tus kheej, thiab peb tseem tuaj yeem ntsib qhov kev sib tw loj ntawm qhov muaj peev xwm thib ob ntawm COVID-19. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum tau kawm los ntawm kev xyaum kho mob, thiab kawm seb TCM ua haujlwm li cas rau COVID-19. Hauv TCM, COVID-19 poob rau hauv qeb kab mob.

Kev cuam tshuam thaum ntxov yog qhov tseem ceeb los tiv thaiv nws qhov kev puas tsuaj. TCM muaj ob yam uas paub qhov txawv ntawm cov tshuaj allopathic: ib qho yog kev pom holistic thiab lwm yam yog kev txheeb xyuas tus qauv. Tus nqi kho mob ntawm TCM yuav tsum raug soj ntsuam raws li TCM txoj kev xav raws li kev siv tshuaj pov thawj. Txhawm rau teb rau qhov kev txhawj xeeb ntawm lub zej zog kev kho mob thoob ntiaj teb rau nws txoj kev nyab xeeb thiab kev ua tau zoo [12], nws yog qhov nrawm dua li puas tau muab cov pov thawj muaj txiaj ntsig zoo. Txog niaj hnub no, ntau txoj kev qhuab qhia, kev siv cov ntaub ntawv tshawb fawb, cov txheej txheem biology, thiab kev tshawb fawb tsis yooj yim tau siv los nthuav tawm qhov paub tsis meej ntawm lub neej thiab kab mob. Cov txheej txheem tshiab thiab cov kev xav no tuaj yeem pab peb nkag siab zoo dua rau ntau hom qauv, kev tswj kom zoo, thiab ntau lub hom phiaj ntawm TCM.

Cov lus teb rau cov teeb meem tseem ceeb no tuaj yeem txhawb nqa qhov qub txeeg qub teg thiab kev tsim kho tshiab ntawm TCM. Biomedicine niaj hnub no yog tam sim no hloov mus rau hauv holistic lossis systems tshuaj, thiab cov tshuaj ib txwm hloov los ntawm lub regional mus rau lub ntiaj teb no. Thaum lub Tsib Hlis 2019, ib tshooj ntawm cov tshuaj ib txwm muaj nyob rau hauv 11th hloov kho ntawm World Health Organization (WHO) International Statistical Classification of Diseases (ICD-11). Nyob rau hauv lub siab ntawm kev cia siab, COVID-19 hloov qhov kev sib tw loj rau hauv lub sijhawm zoo rau Tuam Tshoj txhawm rau txhim kho TCM lub hnub nyoog ntxiv thiab ua haujlwm tshiab rau tib neeg kev noj qab haus huv.

Ua raws li kev coj ncaj ncees

Kaixian Chen thiab Hongzhuan Chen tshaj tawm tsis muaj teeb meem ntawm kev txaus siab. Cov ntawv sau no tsis suav nrog cov txheej txheem tshawb fawb uas xav tau kev pom zoo los ntawm pawg saib xyuas lub koom haum lossis pawg tswj hwm kev ncaj ncees.

Cov ntaub ntawv

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Kaixian Chen, Hongzhuan Chen

Shanghai University of Traditional suav tshuaj, Shanghai 201203, Suav

Higher Education Press 2020

Yog xav paub ntxiv:ali.ma@wecistanche.com