Cov tshuaj suav tshuaj rau Cerebral Ischemia-Reperfusion Injury
Mar 16, 2023
Suav tshuaj ntsuab khub yog ib qho kev sib xyaw ua ke ntawm ob hom tshuaj ntsuab uas nquag siv hauv kev kho mob ntawm cov tshuaj suav tshuaj. Nws yog daim ntawv yooj yim hauv daim ntawv thov ntawm cov tshuaj suav tshuaj suav nrog thiab tus choj tseem ceeb txuas nrog cov tshuaj suav tshuaj thiab tshuaj noj [93]. Cov kev tshawb fawb tau pom tias ntau cov tshuaj suav tshuaj suav tshuaj muaj txiaj ntsig zoo los tiv thaiv CIRI, xws li Danshen-safflower tshuaj khub, Angelica Chuanxiong-xiong tshuaj khub, thiab lwm yam.
Danshen-Safflower Pair
Danshen safflower belongs rau cov tshuaj suav tshuaj ntawm kev txhawb cov ntshav ncig thiab tshem tawm cov ntshav stasis, thiab kev sib xyaw ua ke ntawm ob cov tshuaj no yog ib qho ntawm cov tshuaj sib xyaw ua ke hauv cov tshuaj suav tshuaj suav tshuaj. Kev sib xyaw ua ke ntawm cov tshuaj muaj txiaj ntsig los txhawb cov ntshav ncig thiab tshem tawm cov ntshav stasis, txhawb kev coj khaub ncaws thiab txo qhov mob, thiab tau siv dav hauv kev kho mob gynecology thiab kab mob plawv. Nyob rau hauv xyoo tas los no, cov kev tshawb fawb tau pom tias cov tshuaj siv los tiv thaiv CIRI los ntawm inhibiting oxidative kev nyuaj siab thiab inflammatory teb, thiab txo cov endoplasmic reticulum kev nyuaj siab. Chen Yulin et al [94] tau xaiv cov khoom xyaw tseem ceeb hauv plaub Danshen thiab safflower tshuaj cov ntaub ntawv, danshensu, salvianolic acid A thiab B, thiab hydroxysafflower daj A, raws li cov kev sim tshuaj ntsuam xyuas cov tshuaj tiv thaiv CIRI ntawm Danshen safflower tshuaj ntsuab khub.
Nyem rau cistanche tubulosa capsules rau cerebral ischemia reperfusion raug mob
Cov txiaj ntsig kev tshawb fawb pom tau tias khub tshuaj tuaj yeem txo qis cov ntaub so ntswg puas hlwb los ntawm cerebral ischemia-reperfusion, thiab nws tau kwv yees tias Danshen safflower tshuaj khub tuaj yeem ua tiav cov teebmeem neuroprotective los ntawm kev tiv thaiv kab mob thiab kev tswj hwm ntawm endoplasmic reticulum stress. Xia Ying [95] tau tshawb fawb txog kev tiv thaiv CIRI kev ua haujlwm thiab kev pom zoo ntawm ob lub ntsiab lus ntawm danshensu thiab hydroxysafflower daj A, thiab cov txiaj ntsig tau pom tias kev sib raug zoo ntawm danshensu thiab hydroxysafflower daj A (1: 1) Pab pawg kho mob tuaj yeem ho txhim kho cov qhab nia ntawm neurological kev ua haujlwm ntawm cov nas hauv pawg qauv. Tsis tas li ntawd, lwm txoj kev tshawb fawb tau pom tias kev sib xyaw ntawm Danshen thiab safflower zoo dua hauv kev kho CIRI dua li ob hom tshuaj ntsuab siv ib leeg, uas piav qhia ntxiv txog kev tshawb fawb txog kev sib xyaw ntawm cov tshuaj suav tshuaj [96].
Frankincense-Myrrh Pair
Ob qho tshuaj frankincense thiab myrrh yog cov tshuaj suav tshuaj uas txhawb cov ntshav ncig thiab txo qhov mob. Tom qab ob qho tshuaj sib xyaw ua ke, ob qho tib si qi thiab ntshav tau muab coj los rau hauv tus account, thiab cov txiaj ntsig ntawm kev txhawb nqa cov ntshav ncig thiab txo qhov mob, txo qhov o thiab txhawb kev loj hlob ntawm cov leeg nqaij. Neonatal thiab lwm txoj hauv kev kom ua tau zoo dua neuroprotection. 11-carbonyl- -acetylboswellic acid thiab Z-bisabolsterone yog cov khoom xyaw tseem ceeb ntawm cov tshuaj tsw qab thiab tshuaj tsw qab hauv kev kho mob ntawm CIRI. Cov kev tshawb fawb tau pom tias ob qho khoom xyaw saum toj no ib leeg tau pom muaj txiaj ntsig zoo ntawm CIRI qauv nas.
Wang Jitao et al[97] tau kawm txog kev kho cov nyhuv ntawm kev siv ua ke ntawm 11-carbonyl- -acetylboswellic acid thiab Z-bisabolone, thiab cov txiaj ntsig tau pom tias kev sib xyaw ua ke ntawm ob lub ntsiab lus saum toj no tuaj yeem txo qis. Kev puas tsuaj rau lub paj hlwb ntawm CIRI qauv nas Rau qee qhov, nws qhia tau hais tias muaj qee qhov kev sib raug zoo ntawm koob tshuaj, thiab nws cov txheej txheem ntawm kev ua haujlwm yuav cuam tshuam rau cov kev cai ntawm cov protein qhia ntawm vascular endothelial kev loj hlob yam tseem ceeb (vascular endothelial kev loj hlob yam, VEGF) thiab delta- zoo li ligand 4 (DLL4).
Astragalus-Safflower Pair
Astragalus muaj cov nyhuv ntawm invigorating nruab nrab thiab nourishing Qi thiab invigorating tus po, thiab yog ib tug nquag siv tshuaj suav tshuaj rau invigorating qi nyob rau hauv kev kho mob xyaum, thaum safflower muaj cov nyhuv ntawm kev txhawb cov ntshav ncig, dredging menstrual flow, dispelling ntshav stasis thiab relieving. mob, thiab yog ib hom tshuaj suav tshuaj siv los txhawb cov ntshav ncig hauv kev kho mob. Kev kho mob Syndrome muaj kev kho mob zoo. Kev sib xyaw ua ke ntawm astragalus thiab safflower tuaj yeem tiv thaiv kev tiv thaiv CIRI los ntawm inhibiting o thiab oxidative kev nyuaj siab teb thiab txhawb nqa angiogenesis.
Cov ntaub ntawv qhia tias astragaloside IV thiab astragalus polysaccharide hauv Astragalus membranaceus, thiab hydroxysafflower daj A hauv safflower tag nrho muaj qee yam kev tiv thaiv ntawm CIRI. Txoj kev tshawb nrhiav pom tias kev sib xyaw ua ke ntawm Astragalus thiab safflower hauv kev kho mob ntawm CIRI tau zoo dua li ntawm ob hom tshuaj ntsuab ib leeg, thiab cov txheej txheem tiv thaiv CIRI cuam tshuam nrog kev tswj hwm ntawm kev hloov pauv kev loj hlob thiab B-cell lymphoma{{2 }}, qhov kev qhia ntawm Bcl-2) muaj feem xyuam nrog [98-99].
Angelica Chuanxiong Herbal Pair
Angelica muaj cov teebmeem ntawm kev noj qab haus huv thiab ua kom cov ntshav, tswj kev coj khaub ncaws thiab txo qhov mob, feem ntau txhawb cov ntshav, thaum Ligusticum chuanxiong muaj cov txiaj ntsig ntawm kev txhawb nqa qi, ua kom ntshav, tshem tawm cua thiab txo qhov mob, feem ntau txhawb qi, thiab sib txuas qi thiab ntshav los txhim kho. cov nyhuv ntawm nourishing thiab activating ntshav. Tam sim no, cov tshuaj yog dav siv nyob rau hauv gynecology thiab cerebrovascular kab mob. Kev sib xyaw ua ke ntawm Angelica thiab Chuanxiong tuaj yeem ua lub luag haujlwm kho mob hauv kev kho cov kab mob cerebrovascular los ntawm kev txhim kho neuroplasticity thiab tswj kev ruaj ntseg ntawm cov ntshav-hlwb barrier.
Lin Junbin [100] tau tshawb fawb txog kev tiv thaiv CIRI ntawm kev sib xyaw ntawm Angelica thiab Chuanxiong nrog Angelica polysaccharide thiab Ligustrazine ua cov khoom xyaw tseem ceeb. Cov txiaj ntsig ntawm txoj kev tshawb fawb tau pom tias ib pawg tshuaj kho mob ntawm angelica thiab chuanxiong, thiab kev kho mob sib xyaw ua ke ntawm angelica thiab chuanxiong tuaj yeem txhim kho lub paj hlwb kev ua haujlwm ntawm focal reperfusion raug mob qauv nas. Ua haujlwm zoo tshaj plaws. Cov nyhuv anti-CIRI ntawm angelica thiab chuanxiong muaj feem xyuam rau cov kev cai ntawm neuroplasticity thiab txo cov ntshav-hlwb barrier permeability los ntawm polysaccharides ntawm angelica thiab ligustrazine.
Tsis tas li ntawd, txoj kev tshawb fawb pom tau hais tias lub hlwb cov ntaub so ntswg ntawm nas kho nrog CIRI txo qis nrog lub sijhawm ntev ntawm kev kho mob ntawm ischemia-reperfusion raug mob. Yog li ntawd, nws tuaj yeem kwv yees tias kev rov qab los ntawm kev ua haujlwm ntawm lub paj hlwb ntawm cov ntaub so ntswg tom qab ischemia-reperfusion raug mob yuav tsis tsuas yog kho los ntawm cov tshuaj, tab sis kuj muaj cov txheej txheem ntawm kev rov qab los ntawm tus kheej.
Cov tshuaj suav tshuaj suav tshuaj suav tshuaj rau kev kho mob CIRI
Cov tshuaj suav tshuaj suav tshuaj yog daim ntawv tseem ceeb ntawm TCM cov tshuaj kho mob. Cov kev tshawb fawb tau pom tias ntau cov tshuaj muaj npe nrov muaj cov tshuaj tiv thaiv CIRI, xws li Buyang Huanwu Decoction, Taohong Siwu Decoction, thiab lwm yam. Tsis tas li ntawd, qee cov tshuaj suav niaj hnub siv tshuaj xws li Mailuoning Txhaj thiab Naojianjian Granules kuj muaj kev tiv thaiv ntawm CIRI.
Buyang Huanwu Decoction
Buyang Huanwu Decoction los ntawm "Yilin Gaicuo" sau los ntawm Wang Qingren, kws kho mob nto moo hauv Qing Dynasty. Nws yog ib daim ntawv tshuaj classic rau tus kab mob, thiab nws cov kev kho mob curative nyhuv yog tseeb. Buyang Huanwu Decoction tuaj yeem ua lub luag haujlwm tiv thaiv CIRI los ntawm inhibiting platelet activation thiab tso tawm ntau dhau ntawm glutamate, thiab inhibiting toxicity ntawm excitatory amino acids. Zhao et al [108] pom tias Buyang Huanwu Decoction tuaj yeem txo cov ntaub so ntswg puas hlwb los ntawm ischemia-reperfusion, thiab txiav txim siab tias lub sijhawm kho mob zoo tshaj plaws rau qhov sib xyaw no yog nyob rau hauv 4 teev ntawm ischemia-reperfusion, qhia tias nws yuav tsum tau siv rau hauv theem pib ntawm CIRI. Cov nyhuv kho ntawm Buyang Huanwu Decoction yog qhov zoo dua. Tsis tas li ntawd, nws yog speculated tias cov nyhuv curative ntawm Buyang Huanwu Decoction muaj feem xyuam rau cov kev cai ntawm glutamate receptors thiab inhibition ntawm glutamate tso tawm. Lwm txoj kev tshawb fawb qhia tau hais tias Buyang Huanwu Decoction exerts anti-CIRI nyhuv los ntawm kev ua kom cov antioxidant theem ntawm lub hlwb cov ntaub so ntswg, txo qhov degree ntawm lipid peroxidation puas, inhibiting platelet aggregation thiab ua kom, tswj PI3K / Akt signaling pathway, thiab txhawb ischemia-reperfusion raug mob tom qab lub kho lub hlwb thiab ua tiav [109-110].
Coptis detoxification kua zaub
Huanglian Jiedu Decoction yog ib qho tshuaj tua hluav taws kub hauv kev kho mob. Nws yog tsim los ntawm plaub yam tshuaj suav tshuaj: Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendron thiab Gardenia. Huanglian Jiedu Decoction tuaj yeem ua lub luag haujlwm tiv thaiv CIRI los ntawm inhibiting oxidative kev nyuaj siab thiab inflammatory teb, tswj lub zog metabolism thiab mitochondrial muaj nuj nqi, thiab inhibiting cell apoptosis. Cov kev tshawb fawb tau tshaj tawm tias baicalin thiab lwm yam khoom siv hauv Scutellaria baicalensis muaj cov teebmeem zoo los tiv thaiv CIRI.
Wang et al. [111] siv 1H-NMR metabolomics ua ke nrog ntau qhov sib txawv ntawm kev txheeb xyuas los ntsuas qhov kev tiv thaiv CIRI ntawm Huanglian Jiedu Decoction. Cov ntaub ntawv 1H-NMR ntawm nas cov ntshav thiab cov qog nqaij hlav hlwb tau pom tias Huanglian Jiedu Decoction tuaj yeem txo qhov kev puas tsuaj metabolic tshwm sim los ntawm CIRI, txhim kho cov qib metabolites xws li lactic acid, qabzib thiab creatinine, thiab tiv thaiv mitochondrial membranes, tswj cov neurotransmitters thiab tiv thaiv. - inflammatory teebmeem. Oxidation, tiv thaiv kab mob thiab lwm txoj hauv kev tuaj yeem kho cov ntaub so ntswg hauv lub hlwb kom zoo li qub thiab yog li ua lub luag haujlwm tiv thaiv hauv lub hlwb. Tsis tas li ntawd, kev tiv thaiv kev ua haujlwm ntawm Huanglian Jiedu Decoction ntawm lub paj hlwb raug mob los ntawm ischemia-reperfusion tuaj yeem ua kom muaj kev qhia ntawm hypoxia-inducible factor-1 los ntawm PI3K / Akt signaling pathway, yog li inhibiting neural apoptosis induced los ntawm ischemia. -reperfusion, thiab lwm yam kom ua tiav [112-114].
Rehmannia Yinzi
Dihuang Yinzi yog cov tshuaj ib txwm siv los ntawm 12 cov tshuaj suav tshuaj, suav nrog rehmannia glutinosa, Morinda officinalis, dogwood, dendrobium, cistanche, aconite, schisandra, official laurel, dawb poria cocos, Ophiopogon japonicus, calamus thiab polygala ntawm cov tshuaj, Suav tshuaj. Cov teebmeem ntawm lub raum yin, tonifying raum yang, thiab resuscitating phlegm tuaj yeem ua lub luag haujlwm tiv thaiv CIRI los ntawm kev txhawb nqa kev loj hlob ntawm neural qia hlwb, txo oxidative kev nyuaj siab puas tsuaj, inhibiting cell apoptosis, thiab txhawb angiogenesis. Hauv kev xyaum kho mob niaj hnub no, Rehmannia Yinzi tau maj mam siv los ua ib qho tshuaj zoo rau kev kho CIRI. Cov kev tshawb fawb tau pom tias Dihuang Yinzi tuaj yeem txhim kho kev ua haujlwm ntawm lub paj hlwb ntawm CIRI qauv nas los ntawm kev ua kom lub Notch signaling txoj hauv kev, uas muaj qee yam kev sib raug zoo ntawm koob tshuaj [115]. Lwm txoj kev tshawb fawb tau pom tias Dihuangyinzi tuaj yeem ua rau muaj kev cuam tshuam ntau ntxiv ntawm Bax, Bcl-2, Caspase-3 proteins thiab VEGF hauv lub hlwb ntawm cov nas qauv ntawm ischemia-reperfusion raug mob, qhia tias Dihuangyinzi tuaj yeem cuam tshuam. oxidation, Inhibit paj hlwb apoptosis thiab txhawb angiogenesis kom alleviate paj hlwb kev puas tsuaj los ntawm ischemia-reperfusion [116].
Tongxinluo Capsules
Tongxinluo Capsule yog cov tshuaj suav tshuaj suav tshuaj ua los ntawm 12 cov tshuaj suav tshuaj suav nrog ginseng, leech, scorpion, av beetle, centipede, cicada slough, liab peony cag, sandalwood, borneol, balsamic xyab, frankincense, thiab jujube noob. Nws muaj cov nyhuv ntawm dredging collaterals thiab relieving mob. Tam sim no, cov tshuaj no feem ntau yog siv los kho cov kab mob plawv thiab cerebrovascular. Lub mechanism ntawm kev txiav txim ntawm Tongxinluo Capsules hauv kev kho mob stroke ischemic muaj xws li inhibiting inflammatory teb, txhim kho cov ntshav-hlwb barrier permeability thiab txhawb angiogenesis, thiab lwm yam. Gao Zhijie et al [117] siv tsiaj thwmsim ua ke nrog network pharmacology txoj kev tshawb xyuas cov nyhuv tiv thaiv thiab mechanism. ntawm Tongxinluo Capsules ntawm CIRI. Cov kev sim tsiaj tau raug soj ntsuam nrog cov qhab nia neurobehavioral, qib kev raug mob ntawm lub hlwb, thiab cerebral infarct loj raws li qhov ntsuas. Cov txiaj ntsig tau pom tias Tongxinluo Capsules muaj kev tiv thaiv pom tseeb ntawm cov ntaub so ntswg ntawm lub hlwb ntawm CIRI nas, thiab muaj qee yam cuam tshuam txog kev noj tshuaj.
Tsis tas li ntawd, txhawm rau txhawm rau tshawb nrhiav cov tshuaj lom neeg thiab cov txheej txheem ntawm kev ua hauv Tongxinluo Capsules uas ua rau muaj txiaj ntsig zoo, 132 cov khoom xyaw nquag thiab 240 cov noob uas cuam tshuam nrog cerebral ischemia lub hom phiaj noob tau tshuaj xyuas los ntawm 12 Suav tshuaj hauv Tongxinluo Capsules los ntawm kev siv network. kws tshuaj. Gene. Raws li lub network pharmacology cov txiaj ntsig, recombinant cAMP-dependent protein kinase A catalytic subunit a (protein kinase cAMP-activated catalytic subunit alpha, PRKACA), adenylate cyclase 1, dopamine D2 receptor, thiab lwm yam Cov noob caj noob ces, cAMP thiab cyclic guanosine monophosphate. cyclic guanosine monophosphate kinase (cyclic guanosine monophosphate, cGMP/cyclicguanosate-dependent protein kinase, PKG) yog lub ntsiab lus qhia txoj hauv kev rau Tongxinluo capsule ua haujlwm. Txoj kev tshawb fawb tob tob ntawm cov txheej txheem ntawm kev ua ntawm Xinluo Capsules muab qee qhov kev txhawb nqa theoretical. Tsis tas li ntawd, cov kev tshawb fawb tau pom tias Tongxinluo Capsules tuaj yeem tiv thaiv cov hlab ntsha hauv hlwb, yog li muaj kev tiv thaiv kab mob CIRI [118].
Cistanche
Cistanche muaj ntau yam khoom xyaw xws li echinacoside thiab acteoside, uas tau pom tias muaj zog antioxidant thiab tiv thaiv kab mob. Thaum cerebral ischemia (tsis muaj cov ntshav ntws mus rau lub hlwb) tshwm sim, nws tuaj yeem ua rau muaj kev puas tsuaj ntawm cov dawb radicals thiab o, ua rau cov cell puas thiab tuag. Thaum cov ntshav ntws rov qab thaum lub sijhawm rov ua dua, nws tuaj yeem ua rau muaj kev puas tsuaj ntxiv rau cov ntaub so ntswg ntawm lub hlwb los ntawm cov lus teb inflammatory hu ua reperfusion raug mob. Cistanche cov khoom xyaw nquag tuaj yeem pab txo cov teebmeem no los ntawm kev tshem tawm cov dawb radicals thiab txo qhov mob, yog li tiv thaiv cov ntaub so ntswg ntawm lub hlwb los ntawm kev puas tsuaj thiab txhim kho cov txiaj ntsig zoo.
