Tsob Ntoo Suav Kho Mob Rau Erectile Dysfunction-Cistanche Tubulosa

Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com

Hao Li, Hongyang Jiang, Jihong Liu

Abstract

Tsoos suav tshuaj (TCM), suav nrog acupuncture thiab suav tshuaj ntsuab, yog siv los ua lwm txoj kev kho mob los ua kom cov nyhuv curative rau erectile kawg (ED). Ntau cov kev tshawb fawb tau ua los tshawb xyuas cov txiaj ntsig thiab cov txheej txheem ntawm TCM rau kev kho ED. Kev kho mob ntawm acupuncture ntawm ED tseem muaj teeb meem tam sim no. Txawm li cas los xij, qee cov tshuaj suav hauv Suav tau nthuav tawm cov txiaj ntsig tau txaus siab thiab lawv tuaj yeem txhim kho erectile muaj nuj nqi los ntawm kev ua kom muaj nitric oxide synthase (NOS)-cyclic guanosine monophosphate (cGMP) txoj hauv kev, nce cyclic adenosine monophosphate (cAMP) qhia, nce qib testosterone, txo qis intracellular Ca2 ntxiv. down-regulating transforming growth factor 1 (TGF 1)/Smad2 signaling pathway, los yog ameliorating oxidative stress.

Ntsiab lus:Kev kho hniav; Suav tshuaj ntsuab; erectile kawg (ED); tshuaj suav tshuaj (TCM)

Kev kho ntawm Erectile kawg (ED): Cistanche

Taw qhia

Erectile dysfunction (ED) yog ib hom kab mob uas cuam tshuam txog ib nrab ntawm cov txiv neej hnub nyoog 40 txog 70 xyoo hauv Asmeskas (1), thiab qhov muaj feem yuav luag zoo ib yam hauv Suav teb (2). Qhov ncauj phosphodiesterase type 5 inhibitor (PDE5-Is) yog thawj kab kev kho rau ED. Txawm li cas los xij, nws qhov txiaj ntsig zoo tsuas yog 60-70 feem pua (3). Nyob rau hauv cov xwm txheej no, ntau yam kev hloov pauv lossis kev kho ntxiv tau raug tshawb xyuas txhawm rau txhim kho cov nyhuv kho rau ED, nrog cov tshuaj suav tshuaj (TCM) nyob rau pem hauv ntej ntawm cov qauv no.

TCM yog ib tug holistic modality derived los ntawm ancient oriental lub tswv yim, uas nws lub tswv yim ntseeg hais tias tib neeg lub cev muaj ib tug txheej ntawm lub sab hauv homeostatic systems tswj los ntawm lub Yin-Yang tshuav nyiaj li cas. Yin thiab Yang yog ob qhov sib txawv tsis tau ntxiv zog, uas tuaj yeem nkag siab tias yog cov txheej txheem anabolic thiab catabolic los ntawm kev xav sab hnub poob (4). Raws li TCM philosophical theories, kab mob tshwm sim los ntawm qhov tsis sib xws ntawm ob lub zog dhau ib lub sijhawm. Li no, lub hom phiaj ntawm kev kho mob yog los kho qhov sib npaug ntawm Yin thiab Yang.

Hauv TCM, cov kua thiab cov ntshav hauv tib neeg lub cev yog tsim thiab faib los ntawm Qi, lub zog tseem ceeb permeating tag nrho lub ntiaj teb. Qi yog tsim los ntawm kev sib cuam tshuam ntawm Yin thiab Yang. Nws ntws los ntawm meridians hauv tib neeg lub cev thiab nourishes lub cev. Tsis tas li ntawd, Qi yog lub luag haujlwm los txhim kho lub cev tiv thaiv kab mob thiab tiv thaiv lub cev los ntawm cov kab mob sab nraud. Txhua lub cev muaj nws tus kheej Qi uas tswj hwm nws txoj haujlwm ib txwm muaj. Los ntawm qhov kev xav ntawm TCM, ib lub cev tsis yog ib qho chaw uas twb muaj lawm tab sis kev tsim theoretical nrog qee yam haujlwm. Txawm hais tias cov kabmob hauv TCM muaj lub npe tib yam li cov kabmob hauv cov tshuaj Western, lawv hais txog cov khoom sib txawv nrog cov haujlwm sib txawv.

Lub raum thiab lub siab yog ob lub cev tseem ceeb uas cuam tshuam nrog ED hauv TCM kev nkag siab. Lub raum khaws cov ntsiab lus, thaum lub siab khaws cov ntshav. Qhov tseem ceeb tuaj yeem lees paub tias yog lub hwj chim uas muaj lub luag haujlwm rau kev loj hlob, kev loj hlob, thiab kev yug me nyuam. Tsis tas li ntawd, nws koom nrog hauv kev tsim cov ntshav thiab tuaj yeem txhim kho kev tiv thaiv. Ntxiv nrog rau kev khaws cov ntshav, lub siab tuaj yeem hloov kho cov ntshav ntim thiab tswj cov ntshav ntws. Kev ua haujlwm ntawm kev sib deev thiab kev ua me nyuam kuj yog nyob rau hauv kev tswj ntawm lub siab. Yog li ntawd, lub raum thiab lub siab yog ob lub cev tseem ceeb uas muaj ntau yam haujlwm hauv TCM. Ob qho tib si cov ntsiab lus thiab cov ntshav yog Yin hauv qhov xwm txheej, yog li lub raum thiab lub siab xav tau los ntawm tib qhov chaw. Qhov tsis muaj zog ntawm ib lub cev feem ntau ua rau qhov tsis sib xws ntawm lwm tus. Kev kuaj mob ntawm tus kab mob hauv TCM yog nyob rau hauv kev txheeb xyuas cov qauv ntawm kev tsis sib haum xeeb, uas tseem hu ua Syndrome Differentiation (5). ED feem ntau cuam tshuam rau lub raum lossis lub siab cov qauv ntawm kev tsis sib haum xeeb, xws li lub raum yin vacuity, lub raum yang vacuity, thiab khi kev nyuaj siab ntawm daim siab Qi. Kev paub txog kev sib raug zoo ntawm cov kab mob hauv nruab nrog cev hauv ED yog qhov tseem ceeb rau kev npaj kho mob zoo. Ntau yam txuj ci tau ua haujlwm hauv TCM, suav nrog acupuncture, moxibustion, cupping, massage, thiab tshuaj ntsuab. Ntau txhiab xyoo ntawm txoj kev loj hlob, cov kws kho mob ntawm TCM tau tsim ib qho kev qhia dav dav rau kev kho ED. Acupuncture thiab tshuaj ntsuab yog ob qho tib si xav tias muaj txiaj ntsig rau kev ua haujlwm erectile.

Kev kho rau ED: Cistanche ntxiv

Kev kho mob acupuncture rau ED

Acupuncture, txheeb xyuas raws li cov koob txhaj rau hauv acupoints ntawm daim tawv nqaij thiab cov ntaub so ntswg, yog ib qho tseem ceeb kho txoj kev ntawm TCM los kho ntau yam kab mob. Cov acupoints no tau lees paub tias yog cov ntsiab lus tswj ntawm Qi, uas tswj cov ntws ntawm Qi. Lawv tuaj yeem nqa ntau Qi mus rau qhov chaw nqus lossis cov khoom nruab nrog cev thiab tso tawm ntau dhau thaum muaj Qi ntau dhau ntawm qee qhov chaw, yog li tswj hwm lub homeostasis ntawm peb lub cev. Muaj cov pov thawj txaus los txhawb tias acupuncture tuaj yeem tswj hwm kev ua haujlwm ntawm endocrine, circulatory, thiab paj hlwb. Acupuncture tau lees paub tias yog kev kho mob zoo rau ntau yam kab mob los ntawm National Institutes of Health (NIH).

Nws yog tam sim no ntseeg hais tias cov teebmeem neurophysiological ntawm acupuncture tshwm sim los ntawm lub hauv paus paj hlwb ua kom zoo li neurotransmitters modulation (6). Acupuncture tuaj yeem hloov kho qhov tso tawm ntawm nitric oxide (NO) thiab qee cov neuropeptides koom nrog hauv cov txheej txheem ntawm erection (7). Qee qhov kev tshawb fawb tau ua los tshawb xyuas qhov cuam tshuam ntawm acupuncture ntawm kev ua haujlwm erectile hauv cov neeg mob.

Xyoo 1997, Aydin et al. nqa nyob rau hauv ib tug randomized tswj txoj kev tshawb no nrog 60 cov neeg mob uas tsis yog-organic ED, nyob rau hauv uas cov neeg mob tau kho nrog acupuncture ntawm ob txhais ceg thiab plab mog rau 6 lub lis piam. Cov txiaj ntsig tau pom tias 60 feem pua ntawm cov neeg mob hauv pab pawg kho mob tau txaus siab rau kev sib deev tom qab kev kho mob acupuncture piv nrog 43 feem pua ntawm cov placebo pab pawg, tab sis qhov sib txawv ntawm ob pawg tsis tseem ceeb (8). Txawm li cas los xij, cov txiaj ntsig ntawm lwm txoj kev tshawb fawb tau qhia tias acupuncture yog ib qho kev kho mob zoo rau psychogenic ED. Tag nrho ntawm 68.4 feem pua ntawm cov neeg mob hauv pab pawg kho mob tau pom cov lus teb txaus siab, uas yog siab dua li cov placebo pawg (6).

Cov txiaj ntsig los ntawm lwm cov kev tshawb fawb kuj tsis sib xws. Yog li, cov pov thawj muaj nyob rau tam sim no tsis txaus los ua pov thawj acupuncture los ua kev cuam tshuam zoo rau kev kho ED (9,10). Kev tshawb nrhiav ntxiv yuav tsum tau ua kom paub meej txog kev kho mob ntawm acupuncture rau ED.

Suav tshuaj ntsuab kho rau ED

Ntau cov tshuaj suav tshuaj suav tshuaj tau siv los kho ED, thov ib leeg lossis hauv cov qauv sib xyaw. Feem ntau ntawm cov tshuaj ntsuab yog siv empirically thiab yog li tsis ntseeg. Hauv qhov xwm txheej no, ntau qhov kev tshawb fawb tau ua los tshawb xyuas lub hauv paus txheej txheem ntawm cov tshuaj suav suav siv cov biotechnology niaj hnub no.

Ib leeg suav tshuaj ntsuab los yog tshuaj ntsuab rho tawm

Nws tau tshaj tawm tias cov txheej txheem ntawm Suav tshuaj ntsuab rau kev kho ED yuav cuam tshuam txog kev hloov pauv hauv nitric oxide synthase (NOS)-NO-cyclic guanosine monophosphate (cGMP) txoj hauv kev, cyclic adenosine monophosphate (cAMP), qib testosterone, hloov kev loj hlob 1 (TGF 1). ) / Smad2 txoj kev, oxidative kev nyuaj siab nrog rau intracellular Ca2 ntxiv rau concentration. Qee cov tshuaj suav suav ameliorate ED los ntawm ib txoj hauv kev, lwm tus koom nrog ntau txoj hauv kev (Table 1).

Angelica Sinensis: koj puas xav tau ntau tus thwjtim?

Angelica Sinensis yog lub hauv paus qhuav ntawm angelica, uas nws lub luag haujlwm tseem ceeb yog ua kom cov ntshav ntim thiab txo qhov mob hauv TCM. Intrapelvic txhaj tshuaj ntawm Angelica Sinensis tuaj yeem zam qhov txo qis ntawm NOS kev ua los ntawm cavernous hlab ntsha raug mob hauv nas (11).

Ligusticum chuanxiong Hort

Ligusticum chuanxiong Hort yog cog feem ntau nyob rau sab hnub poob ntawm Tuam Tshoj, uas feem ntau yog siv los txhawb cov ntshav ntws thiab txo qhov mob. Ligustrazine yog ib qho vasoactive tivthaiv cais tawm ntawm Ligusticum chuanxiong Hort thiab tau pom tias muaj txiaj ntsig zoo hauv kev so luav cavernosal du nqaij. Cov nyhuv yog ib nrab kho los ntawm kev nce cov ntsiab lus ntawm cAMP thiab cGMP (12).

Folium Ginkgo Bilobae

Folium Ginkgo Biloba yog nplooj ntawm Ginkgoaceae cog, uas loj hlob thoob plaws hauv Suav teb. Ginkgo Biloba extract tau pom tias muaj vasoprotective thiab neuroprotective teebmeem. EGb761 yog ib qho zoo extract los ntawm Folium Ginkgo Bilobae. Nws tau tshaj tawm tias EGb761 khaws cia cov neural nitric oxide synthase (nNOS)-zoo paj fibers tom qab cavernous hlab ntsha raug mob hauv nas (13). Tsis tas li ntawd, kev tswj hwm ntawm EGb761 muaj peev xwm txhim kho qhov tsis sib cuag erection, ib rab qau erection pib los ntawm cov chaw hauv hlwb, hauv cov txiv neej nas los ntawm kev nce cov ntsiab lus dopamine hauv qee qhov ntawm lub hlwb (14,15).

Common Cnidium Txiv Hmab Txiv Ntoo

Cnidium Fruit yog cov txiv hmab txiv ntoo ntawm Cnidium monnieri. Nws tau siv los kho cov kab mob ringworm, o ntawm cov poj niam qhov chaw mos thiab txiv neej impotence. Osthole yog ib qho tseem ceeb ntawm Cnidium Txiv Hmab Txiv Ntoo, uas tau pom tias muaj cov nyhuv vasodilating. Nws tau tshaj tawm tias ostiole muaj cov nyhuv relaxant ntawm ib daim hlab ntawm luav corpus cavernosum, uas tej zaum yuav muaj kev tso tawm NO los ntawm endothelium thiab inhibition ntawm phosphodiesterase (16). Ib co lwm cov extracts ntawm Common Cnidium Txiv Hmab Txiv Ntoo xws li imperatorin thiab xanthotoxin kuj nthuav tawm cov nyhuv so ntawm luav corpus cavernosum nrog cov endothelium tsis zoo (17).

Tribulus Terrestris

Tribulus Terrestris yog cov txiv hmab txiv ntoo ntawm cov nroj tsuag Zygophyllaceae, uas loj hlob feem ntau hauv North China. Nws tau raug lees paub tias yog ib qho tshuaj aphrodisiac txij thaum ancient sij hawm. Ntau qhov kev sim tsiaj tau tshawb pom tias Tribulus Terrestris tuaj yeem txhim kho erectile muaj nuj nqi. Nws tau dav ntseeg yav dhau los tias cov cuab yeej aphrodisiac ntawm Tribulus Terrestris yog vim nws lub peev xwm androgen-txhim kho (18). Txawm li cas los xij, ntau thiab ntau cov kev tshawb fawb niaj hnub no qhia tias Tribulus Terrestris supplementation tsis tuaj yeem nce qib testosterone hauv cov ntshav ntau (19,20). Li no tus txheej txheem meej hauv qab nws cov cuab yeej pro-erectile yuav tsum tau tshawb xyuas ntxiv.

Morinda Officinalis Ua li cas

Morinda officinalis Yuav ua li cas yog lub hauv paus qhuav ntawm morinda officinalis thiab yog dav siv nyob rau hauv Suav teb. Hauv TCM, nws feem ntau yog siv los kho mob rheumatoid mob caj dab thiab impotence. Nws tau pom tias pretreatment nrog aqueous extract los ntawm Morinda officinalis Yuav ua li cas los txhim kho kev sib deev kev ua tau zoo thiab ua rau kom cov ntshav testosterone qib ntawm cov txiv neej nas raug kev txom nyem los ntawm kev ua me nyuam tsis taus (21). Qhov no tau ua raws li cov txiaj ntsig ntawm lwm txoj kev tshawb fawb, uas tau nthuav tawm tias kev tswj hwm ntawm qhov ncauj bajijiasu, ib qho extract los ntawm Morinda officinalis Yuav ua li cas, txhim kho tus cwj pwm kev sib deev thiab nce testosterone concentration ntawm ob qho tib si thiab lub raum-yang-tsis muaj nas (22). Txawm li cas los xij, lub hauv paus mechanism xav tau kev tshawb nrhiav ntxiv.

Herba Cistanche

Herba Cistancheyog lub qia qhuav ntawm cistanche hom, uas loj hlob nyob rau hauv tsis tshua muaj arid cheeb tsam nrog intensive tshav ntuj. Nws yog siv raws li ib tug tonic rau mob raum kab mob, impotence, thiab tej yam kab mob gynecological. Ntau yamChemical constituents ntawm Herba Cistanchetau kawm thiab tau qhia tias muaj qee yam kev ua haujlwm xws li tshuaj tiv thaiv oxidation, neuroprotection, thiab antiaging (23). Nws tau qhia tiasCistanche extractshortened lub erectile latency thiab ncua lub sij hawm erectile nyob rau hauv castrated nas. Extract los ntawm HerbaCistanchetau tshaj tawm tias yuav nce qib ntawm kev sib deev hauv cov nas (24). Lwm cov extract ntawm Herba Cistanche, echinacoside, tuaj yeem tshem tawm cov endothelium-dependent so ntawm aortic rings los ntawm NO-cGMP txoj hauv kev hauv nas (25). Txawm li cas los xij, sebHerba Cistanchetxhim kho erectile muaj nuj nqi ntawm txoj kev no xav tau kev tshawb fawb ntxiv.

Semen cuscutae

Semen cuscutae yog cov txiv hmab txiv ntoo qhuav ntawm Cuscuta Chinensis Lam. Nws tau siv los kho impotence thiab seminal emission rau ntau txhiab xyoo hauv Suav teb. Cov flavones los ntawm Semen cuscutae tuaj yeem thim rov qab cov tsos mob ntawm lub raum-yang deficiency los ntawm kev kho cov qib testosterone thiab androgen receptor qhia hauv lub raum thiab cov noob qes (26).

Ginseng

Ginseng yog lub hauv paus ntawm qee cov nroj tsuag Araliaceae, uas loj hlob nyob rau sab qaum teb ntawm Tuam Tshoj. Ginseng yog ib qho khoom kim heev thiab nrov suav tshuaj ntsuab uas tau siv dav hauv ntau lub tebchaws Esxias. Nws tau siv los tswj hwm homeostasis thiab txhim kho lub zog tseem ceeb hauv tib neeg lub cev rau ntau txhiab xyoo. Nws tau raug lees paub los ntawm ntau qhov chaw, tshuaj placebo-tswj, thiab ob qhov muag tsis pom kev soj ntsuam kev tshawb fawb tias kev tswj hwm mus sij hawm ntev ntawm Kauslim liab ginseng rho tawm tuaj yeem txhim kho kev ua haujlwm erectile hauv cov neeg mob (27). Ginsenosides yog cov khoom tseem ceeb hauv ginseng thiab muaj cov teebmeem ntawm kev tiv thaiv kab mob, tiv thaiv qog, antioxidant, nrog rau apoptosis inhibition. Ntawm ntau hom ginsenosides, ginsenoside Rg3 tau txais kev mloog zoo tshaj plaws. Qhov ncauj gavage nrog Rg3 tuaj yeem tiv thaiv lub peev xwm erectile hauv cov nas mob ntshav qab zib los ntawm kev tiv thaiv cov degeneration ntawm neurons hauv dorsal penile qab haus huv thiab txo cov oxidative kev nyuaj siab hauv corpus cavernosum (28).

Lycium barbarum L

Lycium barbarum L yog cov txiv hmab txiv ntoo ntawm Lycium barbarum thiab muaj ntau yam kev lom zem. Nws ua lub luag haujlwm tseem ceeb hauv kev kho qee cov kab mob ntev, xws li hyperlipidemia, kab mob siab, mob ntshav qab zib thiab txiv neej infertility. Polysaccharides muab rho tawm los ntawm Lycium barbarum nthuav tawm cov khoom muaj zog antioxidant, uas tuaj yeem ua kom luv ntawm noov erection latency thiab mount latency ntawm hemicastrated nas (29). Tsis tas li ntawd, kev tswj hwm ntawm Lycium barbarum polysaccharides tuaj yeem txhawb kev tsim cov paj hlwb thiab rov ua haujlwm erectile hauv cov nas uas raug mob los ntawm cov hlab ntsha tawg (30).

Cistanche extract

Suav herbal compound formula

Qhov tseeb, feem ntau cov tshuaj suav suav tam sim no siv rau hauv daim ntawv sib xyaw ua ke raws li qee txoj cai nruj. Ib hom tshuaj suav tshuaj suav suav suav nrog plaub yam tseem ceeb ua haujlwm sib txawv: "Monarch", "Minister", "Assistant" thiab "Servant", txhua tus yuav suav nrog ib lossis ntau yam tshuaj. Qhov kev sib xyaw ua ke no tuaj yeem txhim kho cov txiaj ntsig kho mob thiab txo cov tshuaj toxicity ntawm ib qho tshuaj ntsuab (43). Ntau hom kev sib xyaw ua ke tau tsim los kho ED, xws li Shuganyiyang capsule thiab Yidiyin.

Tshuaj capsule

Shuganyiyang capsule yog ib qho qauv tsim los ntawm 15 Suav tshuaj ntsuab, uas tuaj yeem ua rau cov ntshav ncig, qhib Yang thiab ntxiv cov ntsiab lus tseem ceeb ntawm tib neeg lub cev. Nws tau tshaj tawm tias Shuganyiyang capsule txhim kho lub siab intracavernous hauv arteriogenic ED hauv cov nas los ntawm kev ua kom NOS- cGMP txoj hauv kev thiab txo qhov kev qhia ntawm PDE5 (44).

Yidyin

Yidio, Suav tshuaj ntsuab decoction siv los kho mob ntshav qab zib ED, tau pom tias txhim kho erectile muaj nuj nqi hauv cov neeg mob ntshav qab zib thiab nas. Kev siv Yidiyin thiab cov tshuaj hypoglycemic ua ke tuaj yeem ua rau cov neeg mob cov qhab nia nce ntxiv ntawm qhov ntsuas thoob ntiaj teb kev ua haujlwm erectile -5 (IIEF-5) ntau dua li cov tshuaj hypoglycemic ib leeg. Tsiaj thwmsim qhia tau hais tias kev tswj hwm ntawm Yidiyin nce nas 'erectile muaj nuj nqi los ntawm activating NOS-cGMP txoj kev (45).

Ntxiv rau ob cov qauv no, qee cov qauv kuj tseem siv los kho ED hauv kev kho mob, suav nrog tshuaj Yougui, Xiaoyao ntsiav tshuaj, Fufangxuanju capsule, thiab lwm yam. Txawm li cas los xij, qee qhov kev tshawb fawb hauv paus tau ua los tshawb xyuas lawv cov txheej txheem txog tam sim no. Peb cia siab tias yuav muaj kev tshawb fawb ntxiv rau yav tom ntej.

Cov lus xaus

TCM yog ib txoj kev kho mob zoo rau ED. Niaj hnub no muaj ntau yam tshuaj suav suav siv rau cov neeg mob ED hauv kev kho mob thiab qhia tau tias muaj txiaj ntsig zoo. Qhov tshwm sim ntawm qee qhov kev tshawb fawb pom tau hais tias suav tshuaj ntsuab tuaj yeem txhim kho kev ua haujlwm erectile los ntawm kev ua kom NOS-NO-cGMP txoj hauv kev, nce cAMP kev qhia, nce qib testosterone, txo qis intracellular Ca2 ntxiv rau cov concentration, lossis txo cov kev ntxhov siab oxidative. Qhov no ua rau peb nkag siab txog cov txheej txheem thiab cov txiaj ntsig ntawm Suav tshuaj ntsuab. Txawm li cas los xij, feem ntau ntawm cov kev tshawb fawb no tau ua rau tsiaj. Txhawm rau kom paub meej ntxiv txog cov teebmeem thiab kev kho mob ntawm Suav tshuaj ntsuab thiab cov qauv tshuaj ntsuab, RCTs tsim tau zoo yuav tsum tau ua. Tsis tas li ntawd, kev kho mob ntawm acupuncture ntawm ED tseem muaj teeb meem tam sim no. Yog li ntawd, nws yog ib qho tsim nyog yuav tau nrhiav txoj kev kho mob acupuncture zoo dua. Tag nrho hauv tag nrho, TCM yog txoj kev kho mob zoo rau ED thiab xav tau kev tshawb fawb ntxiv.

Cov ntaub ntawv

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