Toxicological Advances Of Traditional Medicine hauv 2019

Hu rau:joanna.jia@wecistanche.com/ WhatsApp: 008618081934791

Qhov tseem ceeb

Daim ntawv tshuaj xyuas cov kev tshawb fawb txog cov tshuaj toxicology ntawm cov tshuaj tsoos tshuaj (Traditional Medicine) thiab cov khoom siv ntuj tsim nyob rau hauv 12 lub hlis dhau los, thiab pom tias daim siab,raum, thiab lub plawv yog lub ntsiab toxic lub hom phiaj ntawm lub cevtshuaj kho mob. Ntxiv rau. Kev nyab xeeb tshuaj rau leej niam thiab menyuam tau pib tsom mus rau xyoo 2019. thiab kev soj ntsuam kev nyab xeeb ntawm Aconitum Carmichael Debx, Tripterygium Wilford Hook.f, Srychnos nux-vomica L, Fallopia multiflora (Thumb.) Harald, thiab lwm yam. .

cistanchekho tauraumkab mob txhim kho lub raum ua haujlwm

Kev lig kev cai

Qhov kev tshuaj xyuas txhua xyoo no tau nthuav tawm cov kev tshawb fawb txog kev siv tshuaj toxicology tshiab, cov qauv tshuaj ntsuam xyuas cov qauv tshuaj lom neeg lub cev, kev ntsuam xyuas kev nyab xeeb ntawmTsob tshuajnyob rau hauv ntau hom neeg, thiab nrov kev tshawb fawb teeb meem thiab tshuaj ntsuab nyob rau hauv 2019. Piv rau 2018, ntau lub nroog xws li Australia, Lub teb chaws Yelemees, thiab UK pib ua tib zoo saib xyuas kev soj ntsuam kev nyab xeeb ntawmTsob tshuaj.

Toxicological kev nce qib ntawm cov tshuaj tsoos tshuaj hauv xyoo 2019

Abstract

Muaj ntau hom kev tshawb fawb txog toxicology ntawmtshuaj ntsuabthiab active natural khoom nyob rau hauv 12 lub hlis dhau los. Qhov kev tshuaj xyuas tshuaj toxicology txhua xyoo no tau sau tseg lub hom phiaj ntawm cov tshuaj ib txwm muaj xws li daim siab,raum, thiab lub siab. Kev nyab xeeb tshuaj ntawmTsob tshuajtau txhawj xeeb rau ntau hom neeg, suav nrog cov menyuam mos, menyuam yaus, cev xeeb tub thiab lub sijhawm tom qab yug menyuam, Dhau li nas. zebrafish embryos tau raug suav hais tias yog cov qauv siv los ntsuas kev nyab xeeb ntawm Cov Tshuaj Kho Mob. Cov thev naus laus zis tshiab hauv toxicology tsom rau kev tshuaj xyuas sai thiab txheeb xyuas cov co toxins hauvTsob tshuaj. Multispectral optoacoustic tomography imaging qhov tseeb qhov chaw ntawm Traditional Medicine-induced daim siab raug mob nrog 3D cov ntaub ntawv thiab integrating serum exosomal microRNA thiab daim siab microRNA profiles yog siv los piav qhia txog lub mechanism ntawm tsoos tshuaj-induced hepatotoxicity. Ua ke, kev tshawb fawb txog kev toxicity mechanism ntawm lwm lub hom phiaj hauv nruab nrog cev, kev nyab xeeb tshuaj hauv cov neeg laus, cov qauv tshiab, thiab cov txheej txheem yuav tsum tau them nyiaj mloog mus rau kev tiv thaiv ntawm Traditional Medicine toxicology yav tom ntej.

Ntsiab lus:Cov tshuaj ib txwm siv, Ntuj cov khoom, tshuaj ntsuab, tshuaj lom neeg, tshuaj lom neeg lub cev, kev soj ntsuam kev pheej hmoo, kev soj ntsuam kev nyab xeeb

Keeb kwm

Kev nyab xeeb, kev ua tau zoo, thiab kev tswj xyuas zoo yog peb yam tseem ceeb ntawm cov tshuaj. Xyoo 2019, muaj ntau cov ntaub ntawv hais txog kev ntsuas kev nyab xeeb ntawm cov co toxins [1] zoo li hlau [2], cov khoom faib hluav taws xob [3], cov protein muaj kuab lom [4, 5], thiab tshwj xeeb theem nrab metabolites hauv cov tshuaj tsoos (Traditional Medicine) ), uas tej zaum kuj yog bioactivation ntawm herbal constituents [6]. Cov tshuaj suav nrog Cuscuta Chinensis Lam epithelium [7], Cassiae phev [8], Ephedra sinica Stapf [9], Melia xa Sieb.et Zucc.[10], Psoralea corylifolia Linn.[11], Gymura segetum(Lour) Merr. [12],Leomurus aremisia (Laur)SY Hu F [13].Polygonum multiflorum [{14}}], Tripterygium Wilford Hook. f. [17,18], Telfaria occidentalis cag [19,20], thiab lwm yam. Tib lub sijhawm, tib neeg tau saib xyuas ntau pawg hnub nyoog xws li menyuam mos [2], menyuam [21-23], laus [24], cev xeeb tub, thiab lub sijhawm tom qab yug menyuam [13,{23}}] hauv Kev siv tshuaj ntsuab. Cov tshuaj suav tshuaj patent kua, tshwj xeeb tshaj yog rau kev txhaj tshuaj tau txais kev soj ntsuam ntau dua li Xiyanping txhaj [28], Tianfoshen qhov ncauj kua [29], thiab txhaj tshuaj motherwort [13]. Kev tshawb nrhiav tshiab thev naus laus zis zoo li multispectral optoacoustic tomography (MSOT) kev tshuaj xyuas qhov chaw 1 ntawm cov tshuaj ntsuab-tshuaj-vim lub siab raug mob nrog 3D cov ntaub ntawv nyob rau hauv txoj kev tsis-invasive siv conjugated-polymer-based ratiometric nanoprobe [14]. Ib txoj hauv kev suav tshuaj toxicology kuj tau siv los tshuaj xyuas cov khoom xyaw hepatotoxic hauv cov tshuaj tsoos [15]. Tsis tas li ntawd, Tuam Tshoj tau ua lub luag haujlwm tseem ceeb hauv kev txhawb nqa kev nce siab sai hauv daim teb no. Kev txheeb xyuas ntawm cov ntawv luam tawm txhua xyoo ntawm toxicological kev tshawb fawb ntawm Cov Tshuaj Kho Mob los ntawm cov txheeb ze feem pua ​​​​ntawm cov teb chaws sib txawv yog pom nyob rau hauv daim duab 1. Tebchaws Asmeskas tau ranked lub teb chaws tseem ceeb thib ob, thaum Is Nrias teb tau khi nrog Canada thiab Brazil ranked thib peb qhov chaw tshawb fawb toxicology ntawm Traditional Medicine. Tsis tas li ntawd, piv rau xyoo 2018, ntau lub nroog xws li Australia, Lub Tebchaws Yelemees, thiab UK tau pib ua tib zoo saib xyuas kev soj ntsuam kev nyab xeeb ntawm Cov Tshuaj Khomob.

Lub cev toxicity

Lub siab raug suav tias yog 1 lub hom phiaj tshuaj lom neeg hauv TV

Lub siab yog lub cev tseem ceeb tshaj plaws ntawm cov tshuaj metabolism thiab detoxification hauv lub cev. Rau cov tshuaj ntsuab ua rau lub siab raug mob yog ib qho teeb meem loj hlob hauv chaw kho mob thiab kev lag luam thoob ntiaj teb, muaj ntau qhov kev tshawb fawb tsom rau lub siab toxicity hauv 2019. Piv txwv li, cov cuab yeej tshawb nrhiav tshiab xws li MSOT imaging qhov tseeb qhov chaw ntawm Fallopia multiflora (Thunb.) Harald- induced daim siab raug mob nrog 3D cov ntaub ntawv tau thov vim oxidative / nitrosative kev nyuaj siab uas ua los ntawm hepaticall-tsim reactive oxygen hom / reactive nitrogen hom [14]. Ib txoj hauv kev suav tshuaj toxicology tau siv los tshuaj xyuas cov khoom xyaw hepatotoxic hauv Fallopia multiflora (Thunb.) Harald [15]. Kev sib xyaw ua ke ntawm cov ntshav exosomal microRNA thiab daim siab microRNA profiles tau siv los nthuav tawm cov txheej txheem ntawm Melia toosendam Sieb.et Zucc.-induced hepatotoxicity hauv nas [10]. Lub caij no, cov metabolism hauv feem ntau tau siv los ua kom pom cov kab mob siab cholestatic los ntawm psoralen 30, isopsoralen 30] thiab Gvura segetum (Louar:) [12], thiab cov kab mob metabolic xws li glycerophospholipid metabolism, thawj cov kua tsib acid biosynthesis, sphingollipid metabolism, phenyrospholipid, tryptophan biosynthesis, thiab tyrosine metabolism los ntawm Daphne genkan Sieb. thiab Zucc.[31]Ghycyrrhia uralensis Fisch.[31], Sophora flavescens Ait. [32] thiab Xysmalobium undulatum [33].

Lub raum raug suav hais tias yog lub hom phiaj thib ob hauv cov tshuaj lom neeg hauv tshuaj

Lub raum cov ntshav ntws muaj ntau, suav txog 25 feem pua ​​​​ntawm cov txiaj ntsig ntawm lub plawv, yog li ntau cov tshuaj tuaj yeem ncav cuag lub raum nrog cov ntshav ntws los ua rau muaj kev hloov pauv pathological. Piv txwv li, aristolochic acid kuv tau lees paub tias yog qhov ua rau aristolochic acid nephropathy ua ntej [34]. Thaum lub sij hawm 2019, untargeted kua chromatograph-mass-spectrometer-based metabonomics tau siv los qhia tias aristolochic acid I inhibited amino acids metabolism, qabzib metabolism, beta-oxidation ntawm fatty acids, thiab tricarboxylic acid voj voog nyob rau hauv txiv neej nas [35]. Aristolochic acid kuv kuj tuaj yeem ua rau cov genomic DNA los tsim cov DNA txuas ntxiv nrog cov purines los ua rau nephrotoxicity [36]. Tshuaj kho mob feem ntau ua rau nephrotoxicity zoo li cisplatin [37| thiab doxorubicin [38]. Hauv xyoo 2019, cov kws tshawb fawb tau tshaj tawm tias cov txiv hmab txiv ntoo pomace tsis tiv thaiv cisplatin-induced nephrotoxicity, tab sis accentuated cov nyhuv tshuaj lom ntawm cisplatin [37]. Dioscorea bulbifera L. ncua lub excretion ntawm doxorubicin thiab sau doxorubicin nyob rau hauv lub cev, uas yog txuam nrog nws inhibition ntawm P-glycoprotein nyob rau hauv daim siab thiab ob lub raum [38]. Tsis tas li ntawd, nws tau tshaj tawm tias cov tshuaj ntsuab tsis sib xws Euphorbia kansui TNLiou ex SB Ho thiab Glycyrrhiza uralensis Fisch. induced hepatotoxicity thiab nephrotoxicity thiab attenuated cov nyhuv ntawm Gansui Banxia decoction [39].

Lwm yam tshuaj lom neeg lub hom phiaj ntawm cov tshuaj

Hauv 2019, kev tshuaj xyuas qhia txog kev lom los ntawm cov nroj tsuag lom hauv Hong Kong. 62 qhov xwm txheej uas muaj 26 hom nroj tsuag lom tau raug txheeb xyuas, ntawm cov Alocasia mycorrhizas (Giant Alocasia), Gelsemium elegans (Graceful Jessamine), thiab Rhododendron (Azalea) hom yog peb feem ntau ntsib. Gastrointestinal toxicity (n=30,48%), neurological toxicity (n= 22,35%), thiab hepatotoxicity (n =6.10%) yog peb qhov teeb meem kev kho mob ntau tshaj plaws. Plaub caug cuaj (79 feem pua) thiab yim (13 feem pua) cov neeg mob muaj mob me me thiab nruab nrab, feem. Lawv txhua tus tau rov qab los sai sai nrog kev txhawb nqa kev kho mob hauv Tshuaj Kho Mob. Qhov seem tsib (8 feem pua) cov neeg mob tau ntsib kev mob hnyav heev uas xav tau kev saib xyuas mob hnyav [40].

Lub caij no, cov txheej txheem ntawm kev tsim menyuam raug mob los ntawm kev sib xyaw ntawm Daphne genkwa Sieb. thiab Zuc. thiab Glycyrrhiza uralensis Fisch. [31], cardiotoxicity thiab neurotoxicity tshwm sim los ntawm diester thiab monoester diterpenoid alkaloids hauv kev ua tiav Aconitum Carmichael Debx. hauv paus [41], cardiotoxicity induced los ntawm Chloranthus serratus [42], mob plab hnyuv tshwm sim los ntawm Gardenia jasminoides Ellis [43], thiab lwm yam tau piav nyob rau hauv 2019. Cov extracts yuav tsum tau siv ceev faj. Ua ke, kev txheeb xyuas kev txheeb xyuas ntawm cov ntawv tshaj tawm txhua xyoo raug xa mus rau cov kab mob sib txawv ntawm lub hom phiaj tshuaj lom neeg raug ntxias los ntawm Cov Tshuaj Khomob yog sau tseg hauv daim duab 2.

Daim duab 1 Kev txheeb xyuas ntawm cov ntawv tshaj tawm txhua xyoo ntawm kev tshawb fawb toxicological ntawm Cov Tshuaj Kho Mob los ntawm cov txheeb ze feem pua ​​​​hauv ntau lub teb chaws. Tsob tshuaj

Daim duab 2 Kev txheeb xyuas ntawm cov ntawv tshaj tawm txhua xyoo ntawm kev tshawb fawb txog tshuaj toxicological ntawm Cov Tshuaj Kho Mob los ntawm cov txheeb ze feem pua ​​​​ntawm cov kab mob lom sib txawv. Tsob tshuaj

Kev nce qib tam sim no

Zebrafish embryo yog nrov rau kev ntsuas kev nyab xeeb ntawm Cov Tshuaj Kho Mob

Tam sim no, kev soj ntsuam kev nyab xeeb tau siv rau ntawm cov cellular, cov khoom nruab nrog cev & cov qib ib leeg. Cov nas tsuag raug suav tias yog cov qauv ntawm tus kheej los txheeb xyuas kev nyab xeeb ntawm Cov Tshuaj Kho Mob lossis cov khoom ntuj tsim. Lub caij no, zebrafish embryos yog qhov thib ob siv dav vim tias lawv ceev ceev, nruab nrab-throughput, thiab nqi-zoo. Hauv 2019, nws tau siv los ntsuas lub siab tiv thaiv thiab hepatotoxicity ntawm saikosaponin a [44], aloe-emodin [45], thiab triptolide [46], teratogenicity ntawm Momordica charantia noob thiab txiv hmab txiv ntoo [47], lub plawv toxicity ntawm Libidibia ferret ( juca) [48], kev yug me nyuam toxicity ntawm Endopleura Uchi (Huber) Cuatrec [49] thiab lwm yam. Txawm hais tias Caenorhabditis elegans [50] thiab drosophila [51] tau nrov nyob rau hauv kev ntsuam xyuas kev nyab xeeb ntawm ntau yam tshuaj sib xyaw tsis ntev los no, tsis muaj kev tshawb fawb txheeb ze hauv Tshuaj Kho Mob hauv 2019.

Kev soj ntsuam kev nyab xeeb ntawm cov tshuaj ib txwm muaj nyob hauv ntau hom neeg

Tsis ntev los no, tshuaj tiv thaiv kev nyab xeeb tau cuam tshuam rau ntau hom neeg, xws li menyuam mos [2], menyuam [21–23], laus [24], thiab niam [13, 25–27]. Hauv 2019, kev tshuaj xyuas qhia txog kev nyab xeeb ntawm cov tshuaj ntsuab tshuaj ntsuab siv thaum cev xeeb tub thiab tom qab yug menyuam [25]. Nyob rau hauv tsab ntawv ceeb toom no, almond roj yuav ua rau yug ntxov ntxov, kev siv ntawm qhov ncauj raspberry nplooj muaj feem xyuam rau kev yug me nyuam; daim ntawv thov siv licorice hnyav yog txheeb ze rau kev yug ntxov ntxov los ntawm 3.{10}}fold. African herbal tshuaj mwanaphepo kuj tau tshaj tawm tias muaj feem cuam tshuam nrog niam txiv morbidity, neonatal tuag, lossis morbidity [25]. Lub caij no, lwm cov kws tshawb fawb tau tshaj tawm tias Anastatica hierochuntica aqueous extract [26] thiab Snus haus luam yeeb [27] pom muaj peev xwm toxicity thaum cev xeeb tub. Tsis tas li ntawd, nws tau nyiam cov kev ntsuam xyuas kev nyab xeeb ntawm cov tshuaj lom hauv cov khoom siv tshuaj ntsuab hauv Jordanian kev ua lag luam [2], cov khoom sib xyaw uas muaj cov hauv paus marshmallow, paj chamomile, tshuaj ntsuab horsetail, nplooj walnut, yarrow tshuaj ntsuab, ntoo qhib tawv, thiab dandelion tshuaj ntsuab nyob rau hauv cheeb tsam ib txwm tshuaj ntawm mob non-bacterial tonsillitis [21], thiab ntsuab tshuaj yej [22] rau cov me nyuam.

Tshiab toxicology kawm technology

Hauv xyoo 2019, cov thev naus laus zis tshiab tau siv hauv kev tshuaj ntsuam toxicology. Piv txwv li, ib txoj hauv kev suav tshuaj toxicology kuj tau siv los tshuaj xyuas cov khoom xyaw hepatotoxic hauv cov tshuaj tsoos [15]. Electrospray laser desorption ionization mass spectrometry tau siv los txheeb xyuas cov tshuaj ntsuab sai sai [1]. MSOT imaging conjugated nrog polymer-raws li ratiometric nanoprobe tau thov rau qhov tseeb qhov chaw ntawm Tsoos Tshuaj-vim lub siab raug mob nrog 3D cov ntaub ntawv nyob rau hauv ib tug noninvasive txoj kev [14]. Tsis tas li ntawd, kev sib koom ua ke ntawm cov ntshav exosomal microRNA thiab daim siab microRNA cov ntaub ntawv tau siv los nthuav tawm cov txheej txheem ntawm Cov Tshuaj Khomob-induced hepatotoxicity hauv nas [10].

Xaus

Ua ke, kev tshawb fawb txhua xyoo qhia tau hais tias lub siab, lub raum, thiab lub plawv yog lub hom phiaj tseem ceeb ntawm cov tshuaj lom neeg hauv cov tshuaj. Lawv cov tshuaj lom neeg muaj xws li cell apoptosis, metabolic tsis meej, oxidative kev nyuaj siab, inflammatory puas, daim siab thiab lub raum fibrosis thiab txawm inducing carcinogenesis. Kev nyab xeeb tshuaj ntawm Cov Tshuaj Kho Mob tau muaj kev txhawj xeeb rau ntau hom neeg, xws li cov me nyuam mos. menyuam thiab niam. Dhau li ntawm nas, zebrafish embryos tau raug suav tias yog cov qauv siv los ntsuas kev nyab xeeb ntawm Cov Tshuaj Kho Mob. Cov thev naus laus zis tshiab hauv toxicology tsom rau kev tshuaj ntsuam thiab txheeb xyuas cov co toxins hauv Cov Tshuaj Khomob, yuav ua li cas txhawm rau txheeb xyuas qhov tseeb ntawm Cov Tshuaj Khomob-induced cov ntaub so ntswg raug mob nrog 3D cov ntaub ntawv, thiab yuav ua li cas piav qhia txog cov txheej txheem ntawm Cov Tshuaj Khomob-induced toxicity. Nyob rau hauv lub neej yav tom ntej, kawm txog toxicity mechanism ntawm lwm lub hom phiaj ntawm lub cev, kev nyab xeeb tshuaj nyob rau hauv cov laus, cov qauv tshiab thiab cov txheej txheem yuav tsum tau siv nyob rau hauv kev tiv thaiv ntawm tsoos tshuaj toxicology.

Cov ntaub ntawv

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