Pab Pawg ntawm Chongqing Medical University Tsim Ib Tug Silica Nano-tus neeg xa xov liaison los coj Kev Cia Siab Tshiab rau Kev Kho Mob Cerebral Ischemia-reperfusion Injury

"Rau txoj kev kawm txog kev mob stroke, kuj muaj qee yam ntawm tus kheej. Kuv txiv tuag tam sim ntawd vim mob stroke, thiab nws kuj yog vim tus kab mob no uas kuv tsis pom kuv txiv zaum kawg. Qhov no ib txwm ua tau zoo. Kev tu siab hauv kuv lub siab, yog li kuv tuaj yeem tshawb xyuas qee qhov kev qhia no kuj yog kev nplij siab rau kuv tus kheej hauv kuv lub siab. " Associate Professor Wang Jianwei ntawm Chongqing Medical University tau hais.

Nyem rau genghis khan cistanche rau ischemia-reperfusion raug mob

Tsis ntev los no, nws thiab nws cov neeg koom tes tsim ib qho tshwj xeeb "nano-messenger", uas tuaj yeem cuam tshuam nrog ob lub pathogenic mechanisms ntawm o thiab oxidative kev nyuaj siab thaum lub sij hawm reperfusion raug mob thiab tuaj yeem thauj khoom nrog cov tshuaj endogenous rau kev kho mob ntawm ischemia Cov cheeb tsam penumbra muaj qhov qhov zoo ntawm cov nyhuv curative tseem ceeb thiab kev nyab xeeb siab.

Hauv kev nthuav dav, hauv txoj kev tshawb fawb, lawv tau siv isothiocyanate fluorescein-labeled silica (SiO2) nanospheres ua cov cab kuj tseem ceeb thiab thauj khoom anion xa lub cev polyacrylic acid (PAA, Polyacrylic acid) rau ntawm nws qhov chaw los ua ke SiO2@PAA nanospheres. Cov tshuaj endogenous therapeutic agent's melatonin (MT, Melatonin) thiab acetylcholine (acetylcholine, ACh) tau ua ntu zus, thiab tom qab txuas cov tshuaj tiv thaiv C5a aptamer (aC5a) nrog cov txiaj ntsig tsom, nanomedicine —SiO2@ PAA-MT/ACh-aC5a.

Kev tswj tau tso tawm ntawm MT thiab ACh tuaj yeem ua tiav los ntawm cov kua qaub hauv cov pH microenvironment ntawm cerebral ischemia. Ntawm lawv, MT, raws li cov tshuaj tiv thaiv antioxidant, tuaj yeem tshem tawm cov pa oxygen ntau dhau hauv thaj tsam ischemic penumbra, txhawm rau txo qhov kev puas tsuaj los ntawm oxidative kev nyuaj siab.

ACh tuaj yeem khi rau 7 nicotinic acetylcholine receptor (7nAChR) ntawm microglia, yog li ua kom lub cholinergic anti-inflammatory pathway, txhawb cov polarization ntawm microglia rau anti-inflammatory M2 phenotype, yog li txo qhov tso tawm ntawm inflammatory yam, yog li txhim kho kev puas tsuaj. los ntawm inflammatory teb.

Raws li cov tswv yim saum toj no, SiO2@PAA-MT / ACh-aC5a nanospheres tuaj yeem ua kom muaj kev sib koom ua ke ntawm kev kho mob, txo qis cov lus teb inflammatory thiab oxidative kev ntxhov siab tom qab cerebral ischemia-reperfusion, thiab txhim kho lub hlwb ischemic los ntawm kev txo cov neuron tuag. mob stroke prognosis. Rau kev kho mob ntawm cerebral ischemia-reperfusion, cov tshuaj muaj lub luag haujlwm zoo hauv kev txhawb nqa nws.

Nws tau nkag siab tias mob stroke (stroke) yog ib qho ntawm cov kab mob loj uas muaj kev mob siab thiab kev tuag thoob ntiaj teb. Hauv cov ntaub ntawv txheeb xyuas hauv tsev, nws yog tus kab mob uas yog thawj tus neeg mob, kev tuag, thiab kev tsis taus. Ntawm lawv, ischemic stroke account rau ntau tshaj 80 feem pua ​​​​ntawm tag nrho cov kab mob cerebrovascular.

Txawm hais tias tom qab ischemia, cov ntaub so ntswg thiab lub cev ua haujlwm tuaj yeem rov qab los ntawm kev rov ua dua. Txawm li cas los xij, ntau thiab ntau cov kev tshawb fawb tau pom tias thaum kho cov kab mob ischemic, qhov tseem ceeb ua rau cov ntaub so ntswg puas tsis yog ischemia nws tus kheej, tab sis muaj ntau cov pa oxygen dawb radicals thiab inflammatory yam uas tsim los ntawm reperfusion tom qab cov ntshav rov qab. , ua rau apoptosis lossis necrosis ntawm cov hlwb, ua rau cov ntaub so ntswg thiab lub cev puas tsuaj, uas yog, "ischemia-reperfusion raug mob".

Cerebral ischemia-reperfusion raug mob yog ib qho mob hnyav dua thiab ntau qhov chaw kho mob tau ntsib los ntawm cov neeg mob stroke ischemic tom qab kho cov ntshav. Rau kev tswj ntawm kev raug mob reperfusion, ib qho kev daws teeb meem tseem tsis tau pom, thiab nws tawm tsam keeb kwm yav dhau los uas qhov kev tshawb fawb no tau ua.

Raws li cov lus ceeb toom, cov tshuaj nano-tshuaj tsim lub sijhawm no tuaj yeem thauj khoom nrog ntau yam tshuaj tib lub sijhawm kom paub txog kev sib koom ua ke ntawm ntau yam tshuaj. Nws tsis tsuas yog txhim kho cov txiaj ntsig ntawm kev kho tshuaj, tab sis kuj txo qis cov tshuaj lom thiab kev phiv ntawm cov ntaub so ntswg.

Wang Jianwei tau hais tias: "Tsis tas li ntawd, peb cov nqi tshuaj synthesis tsawg tsawg, lub hauv paus ntsiab lus ntawm synthesis yog yooj yim, thiab nws yog ib qho yooj yim mus cuag cov loj-scale ntau lawm. yuav tsum tau siv raws li kev kho thawj kab. Kev kho mob cerebral ischemia-reperfusion raug mob. "

Tsis tas li ntawd, nanosystem yog lub platform rau kev xa tshuaj thiab tso tawm. Los ntawm kev hloov cov tshuaj thauj khoom, nws tseem tuaj yeem paub txog kev kho mob ntawm lwm yam kab mob, thiab nws yog universal rau mob qog noj ntshav, rheumatoid mob caj dab, thiab lwm yam kab mob.

Saib rov qab rau txoj kev tshawb fawb, Wang Jianwei tau hais tias: "Dab tsi ua rau kuv zoo siab tshaj plaws yog kuv qhov kev paub ntawm kev tsim tsiaj qauv ntawm kev raug mob rov qab rau kuv cov menyuam kawm ntawv. Txawm hais tias kuv tau ua ntau yam kev sim tsiaj nrog nas, nrog loj nws yog thawj zaug. lub sij hawm uas nas tab tom ua lub hlwb thwmsim, thiab nyob rau hauv cov txheej txheem no, dab tsi txawv ntawm ib txwm yog kev hloov ntawm lub luag hauj lwm.

Cov tub kawm ntawv txawj ua tsiaj sim ntau tshaj kuv, thiab lawv yog cov uas qhia kuv. Thiab cia lawv Integrating kev kawm rau hauv kev qhia kuj yog lub hauv paus ntawm Feynman txoj kev kawm (Editor's Note: Ib txoj kev qhia los ntawm Nobel nqi zog yeej Richard Feynman (Richard Feynman)).

Wang Jianwei tau hais ntxiv: "Kev ua haujlwm hnyav ntawm cov tub ntxhais kawm kuj ua rau kuv xav tsis thoob. Yog tias qhov kev sim ua tsis tiav, lawv yuav tsis noj hmo. Lawv yuav tsum hais kom ua tiav qhov kev sim ua ntej. Cov txiaj ntsig zoo."

Ob peb hnub dhau los, ib daim ntawv hais txog "Acetylcholine thiab Melatonin los ntawm C5a-Targeted Aptamers Effectively Attenuates Reperfusion Injury of Ischemic Stroke" (Acetylcholine thiab Melatonin los ntawm C5a-Targeted Aptamers Effectively Attenuate Reperfusion Stroke) tau tshaj tawm txog kev lom zem ntawm Ischemic Stroke. 1].

Xinyu Xiao yog thawj tus sau; Wang Jianwei, Associate Professor Peng Qiling, thiab Associate Professor Jiang Ning los ntawm tib lub tsev kawm ntawv yog cov kws sau ntawv sib koom ua ke.

Tam sim no, hauv cov qauv ntawm tes thiab cov qauv tsiaj, cov tshuaj nano no tau raug pov thawj tias muaj txiaj ntsig zoo thiab muaj kev nyab xeeb zoo.

Tom ntej no, lawv tab tom yuav ua kev sim tshuaj. "Peb lub tsev kawm ntawv nws tus kheej muaj ntau lub tsev kho mob koom nrog nrog cov xwm txheej zoo rau kev sim tshuaj. Tam sim no peb tab tom npaj koom tes nrog cov kws kho mob txhawm rau thawb cov tshuaj nano mus rau hauv kev siv tshuaj kho mob sai li sai tau." Wang Jianwei hais.

Cistanche extract yuav pab txhim kho lub hlwb puas?

Cistanche extract, tseem hu ua Rou Cong Rong hauv cov tshuaj suav tshuaj, yog cov tshuaj ntsuab nrov uas paub txog nws cov txiaj ntsig kev noj qab haus huv. Nws yog muab los ntawm cov nroj tsuag Cistanche, uas feem ntau pom nyob rau hauv Tuam Tshoj thiab lwm qhov chaw ntawm Central Asia. Cov tshuaj ntsuab tau ib txwm siv rau ntau pua xyoo los txhim kho txiv neej kev ua haujlwm ntawm kev sib deev thiab muab kev pab ntawm qee yam mob. Cov kev tshawb fawb tsis ntev los no tau pom tias Cistanche extract plays lub luag haujlwm tseem ceeb hauv kev txhim kho lub hlwb. Kab lus no yuav tham txog yuav ua li cas Cistanche extract tuaj yeem pab txhim kho lub hlwb.

Cistanche extract yog nplua nuj nyob rau hauv antioxidants thiab anti-inflammatory tebchaw uas ua lub luag haujlwm tseem ceeb hauv kev saib xyuas lub hlwb kom zoo. Cov kev tshawb fawb pom tau hais tias ntuj sib xyaws hauv Cistanche extract tuaj yeem pab txo qhov mob hauv lub hlwb, uas yog ib qho tseem ceeb rau kev loj hlob ntawm ntau yam kab mob neurological. Los ntawm kev txo qhov mob hauv lub hlwb, Cistanche extract tuaj yeem pab txhim kho kev nco, kev kawm, thiab kev txawj ntse.

Cov kev tshawb fawb kuj tau pom tias Cistanche extract tuaj yeem pab txhim kho lub hlwb. Qhov no yog qhov tseem ceeb vim tias lub paj hlwb xav tau cov khoom noj tsis tu ncua ntawm oxygen thiab cov as-ham kom ua haujlwm zoo. Kev ua haujlwm tsis zoo hauv lub hlwb tuaj yeem ua rau muaj ntau yam teeb meem kev paub, suav nrog kev nco tsis tau, kev nyuaj siab, thiab tsis nco qab. Los ntawm kev txhim kho lub hlwb ncig, Cistanche extract tuaj yeem pab txhim kho lub hlwb ua haujlwm, nco, thiab kev xav.

Lwm txoj hauv kev uas Cistanche extract tuaj yeem pab txhim kho lub hlwb tsis zoo yog los ntawm kev tsim cov paj hlwb loj hlob. Cov paj hlwb loj hlob ua lub luag haujlwm tseem ceeb hauv kev loj hlob, kev loj hlob, thiab kev saib xyuas cov paj hlwb hauv lub hlwb. Cov kev tshawb fawb tau pom tias cov khoom sib xyaw ntuj hauv Cistanche extract tuaj yeem pab txhawb kev tsim cov paj hlwb, uas tuaj yeem pab txhim kho lub hlwb ua haujlwm thiab txo qhov kev pheej hmoo ntawm ntau yam kab mob neurological.

Kev tshawb fawb kuj tau pom tias Cistanche extract tuaj yeem pab txo qis kev pheej hmoo ntawm cov kab mob neurodegenerative xws li Alzheimer's thiab Parkinson's disease. Lub ntuj tebchaw hauv Cistanche extract tuaj yeem pab tiv thaiv lub hlwb los ntawm kev puas tsuaj los ntawm cov dawb radicals, uas yog ib qho tseem ceeb rau kev loj hlob ntawm cov kab mob no. Los ntawm kev muab lub paj hlwb nrog cov tshuaj tiv thaiv, Cistanche extract tuaj yeem pab txo qis kev pheej hmoo ntawm kev tsim cov kab mob debilitating.

Hauv kev xaus, Cistanche extract yog cov tshuaj ntsuab zoo heev nrog ntau cov txiaj ntsig kev noj qab haus huv, suav nrog nws lub peev xwm los txhim kho lub hlwb. Lub ntuj tebchaw hauv Cistanche extract ua lub luag haujlwm tseem ceeb hauv kev txhim kho lub hlwb kev ua haujlwm, kev nco, thiab kev xav, thiab txo qis kev pheej hmoo ntawm ntau yam kab mob neurological. Nws yog ib qho tseem ceeb uas yuav tau sab laj nrog ib tus kws kho mob ua ntej qhia txog cov tshuaj ntxiv rau kev noj qab haus huv.

Cov ntaub ntawv:

1. Xiao, X., Gao, Y., Liu, S., Wang, M., Zhong, M., Wang, J., ... & Peng, Q. (2023). Ib "Nano-Courier" rau kev xa khoom ntawm Acetylcholine thiab Melatonin los ntawm C5a-Targeted Aptamers Zoo Attenuates Reperfusion Injury ntawm Ischemic Stroke. Advanced Functional Materials, 2213633.