Qhov Prevalence Thiab Qhov Teeb Meem Ntawm Kev Noj Qab Haus Huv thiab nqos cov teeb meem hauv cov neeg laus nrog Fibromyalgia: Kev Ntsuam Xyuas Txheej Txheem Ntu 2
Oct 10, 2023
Kev sib tham
Qhov kev tshuaj xyuas zoo no sawv cev rau thawj qhov kev sim ntawm kev sib txuas tag nrho cov ntaub ntawv muaj txog kev noj zaub mov, haus, thiab nqos kev txhawj xeeb ntawm cov neeg laus nrog fibromyalgia. Cov kev tshawb pom ntawm qhov kev tshuaj xyuas no qhia tau hais tias kev tshawb fawb tsawg tau ua rau lub ncauj lus no, tsuas yog 6 cov kev tshawb fawb tsim nyog tau txheeb xyuas. Ntxiv nrog rau qhov tsawg ntawm cov ntawv ceeb toom no, cov kev tshawb fawb pom tau muaj ntau yam hauv kev tsim, qauv, thiab cov txheej txheem, thiab kev sib txawv ntawm qhov zoo, tsis suav nrog cov ntsiab lus synthesis lossis meta-analysis feem ntau. Cov ntaub ntawv pov thawj tsis txaus txog cov txiaj ntsig tseem ceeb thiab theem nrab tau pom ntawm no los teb cov lus nug ntsig txog kev tshawb fawb kom raug. Hais txog qhov tshwm sim thawj zaug, kev tshuaj ntsuam meta tsuas tuaj yeem ua tau hais txog qhov tshwm sim ntawm - dysphagia (51.9%) thiab GERD (25.9%). Thaum muaj qhov tshwm sim ntawm dysphagia thiab GERD hauv cov neeg laus uas muaj fibromyalgia tau tshaj tawm hauv cov kev tshuaj ntsuam meta no txhawb kev tshawb fawb uas twb muaj lawm [39, 40], qhov cuam tshuam ntawm cov txiaj ntsig tau raug txwv me ntsis vim qhov tsawg ntawm cov kev tshawb fawb suav nrog hauv txhua qhov kev tshuaj ntsuam meta. . Meta-kev tshuaj xyuas tsis tuaj yeem ua tiav ntawm cov txiaj ntsig thib ob suav nrog, yog li, qhia txog qhov tsis tshua muaj pov thawj ntawm cov ncauj lus no.
Cistanche tuaj yeem ua raws li kev tiv thaiv kev qaug zog thiab lub zog ua kom muaj zog, thiab cov kev tshawb fawb sim tau pom tias decoction ntawm Cistanche tubulosa tuaj yeem tiv thaiv daim siab hepatocytes thiab endothelial hlwb puas hauv cov nas ua luam dej hnyav, txhawb kev qhia ntawm NOS3, thiab txhawb cov kab mob siab glycogen. synthesis, yog li exerting los tiv thaiv qaug zog. Phenylethanoid glycoside-nplua nuj Cistanche tubulosa extract tuaj yeem txo cov ntshav creatine kinase, lactate dehydrogenase, thiab lactate qib, thiab nce qib hemoglobin (HB) thiab piam thaj hauv ICR nas, thiab qhov no tuaj yeem ua lub luag haujlwm tiv thaiv kev qaug zog los ntawm kev txo qis cov leeg nqaij. thiab ncua lub lactic acid enrichment rau lub zog cia hauv nas. Compound Cistanche Tubulosa ntsiav tshuaj ua rau lub sijhawm ua luam dej hnyav, nce siab glycogen cia, thiab txo qis qib urea tom qab kev tawm dag zog hauv cov nas, qhia nws cov nyhuv tiv thaiv kev qaug zog. Lub decoction ntawm Cistanchis tuaj yeem txhim kho kev ua siab ntev thiab ua kom lub cev qaug zog hauv kev tawm dag zog nas, thiab tuaj yeem txo qhov siab ntawm cov ntshav creatine kinase tom qab kev tawm dag zog thiab ua kom lub cev nqaij daim tawv nqaij ntawm cov nas ib txwm muaj tom qab kev tawm dag zog, uas qhia tau hais tias nws muaj cov teebmeem. ntawm kev txhim kho lub cev muaj zog thiab tiv thaiv qaug zog. Cistanchis kuj tseem ua rau lub sijhawm muaj sia nyob ntawm cov nas uas muaj nitrite-poisoned thiab txhim kho lub siab ntev tiv thaiv hypoxia thiab qaug zog.
Nyem rau qhov xav tias nkees txhua lub sijhawm
【Yog xav paub ntxiv:george.deng@wecistanche.com / WhatsApp:8613632399501】
Tsis tas li ntawd, cov teeb meem feem ntau tau tshaj tawm los ntawm cov neeg mob kom tsis zoo cuam tshuam rau lawv txoj haujlwm thiab kev noj qab haus huv (xws li, glossodynia lossis dysgeusia, odynophagia, lossis kev xav ntawm pharyngeal bolus sticking) tau pom tias tsis tshua muaj qhov tseem ceeb ntawm cov kev tshawb fawb ntawm no thiab tau txais tsawg heev. mloog nyob rau hauv cov ntaub ntawv luam tawm. Tsis tas li ntawd, cov teeb meem tsis tu ncua raug txheeb xyuas raws li cov kev paub tseem ceeb ntawm dysphagia ntawm lwm qhov chaw kho mob feem ntau tsis tau hais txog txhua yam hauv cov kev tshawb fawb suav nrog ntawm no (xws li, tsis muaj zog, mob, lossis nkees mastication, aspiration / penetration, thiab unintentional yuag poob) [41, 42]. Yog li ntawd, raws li cov teeb meem tseem ceeb ntawm cov neeg mob no tsis tshua muaj kev tshawb fawb kom ntxaws, peb tau sau tsuas yog qee cov ntaub ntawv tshiab ntawm lawv qhov xwm txheej, qhov tshwm sim, lossis cuam tshuam los ntawm kev tshuaj xyuas ntawm no. Txawm li cas los xij, cov ntaub ntawv pov thawj los ntawm lwm pab pawg neeg mob ua rau pom qhov tsis zoo ntawm lub cev thiab kev puas siab puas ntsws ntawm kev nyob nrog cov teeb meem no yam tsis muaj kev tswj xyuas kev kho mob tsim nyog, ntxiv rau qhov muaj peev xwm ua rau muaj kev mob hnyav ntxiv thiab kev tuag yog tias lawv tsis tau hais meej meej. Yog li, qhov no ua rau muaj peev xwm vim tias tsis muaj kev tshawb fawb hauv cheeb tsam no, cov kws kho mob yuav tsis paub txog tag nrho cov spectrum ntawm nqos nyuaj uas nws pawg neeg qhia, thiab yog li ntawd, cov neeg mob yuav tsis tau txais kev kho mob tshwj xeeb uas lawv xav tau kom nyob zoo nrog. cov teeb meem no, ua rau cov txiaj ntsig kev kho mob tsis zoo thiab txo kev txaus siab rau kev saib xyuas. Txawm hais tias cov kev txwv no, qhov kev tshuaj xyuas tam sim no qhia tau hais tias noj mov, haus dej, thiab nqos cov teeb meem tau ntsib los ntawm cov neeg laus uas muaj fibromyalgia thiab cov pov thawj xav tau rau kev tshawb fawb zoo thiab cov neeg mob hauv lub ntsiab lus no yav tom ntej los txhim kho kev xa cov pov thawj-raws li. thiab empathetic tu.
Thaum lub etiology ntawm fibromyalgia-koom nrog noj, haus, thiab nqos cov teeb meem yog complex thiab ua rau tseem tsis tau tag nrho tsim, nws yog paub tias lub hauv paus rhiab heev ntawm lub paj hlwb plays lub luag hauj lwm nyob rau hauv txoj kev loj hlob thiab kev kho mob ntawm fibromyalgia thiab tau txuam nrog. ib qho mob orofacial mob mob hu ua burning mouth syndrome. Burning qhov ncauj syndrome, tseem hu ua glossodynia yog ib qho mob oropharyngeal mob mob uas tshwm sim los ntawm qhov kub hnyiab ntawm qhov ncauj mucosa thaum tsis muaj qhov txhab lossis qhov txawv txav [43]. Cov mob feem ntau cuam tshuam rau cov poj niam peri- thiab postmenopausal thiab feem ntau cuam tshuam nrog dysgeusia, dysphagia, thiab xerostomia. Lub pathophysiology ntawm burning qhov ncauj syndrome yog suav hais tias yog multifactorial thiab complex. Nws yog feem ntau tus cwj pwm li neuropathic nyob rau hauv keeb kwm thiab muaj ntau yam pab. Peripheral thiab central rhiab heev tau raug tshaj tawm tias muaj nyob rau hauv cov neeg mob uas kub hnyiab qhov ncauj thiab xav tias ua lub luag haujlwm tseem ceeb hauv kev txhim kho thiab kho tus mob [44, 45]. Thaum lub hauv paus rhiab heev tuaj yeem ua rau muaj peev xwm ua rau noj, haus, thiab nqos cov teeb meem hauv cov neeg mob fibromyalgia, lwm cov kev xav hauv cov ntaub ntawv tsim nyog tau hais. Piv txwv li, lub plawv dhia hloov pauv tau piav qhia tias yog ib qho kev ntseeg siab biomarker rau kev ua haujlwm tsis zoo ntawm lub paj hlwb (ANS) thiab tau pom tias tau hloov pauv hauv cov neeg mob uas muaj ntau yam mob xws li fibromyalgia, GERD [46], thiab IBS [47]. Cov kev hloov pauv hauv ANS uas tau tshaj tawm suav nrog kev ua siab zoo siab thiab txo qis parasympathetic muaj nuj nqi [48]. Kev hloov kho rau cov kev ntxhov siab sab nraud, xws li kev mob siab rau, tsis tshua muaj txiaj ntsig hauv fibromyalgia, nrog cov neeg mob uas muaj kev xav siab dua nrog kev rov qab los ntawm parasympathetic tsawg dua [49–51]. Cov kev tshawb fawb tsis ntev los no tau pom tias muaj kev hloov pauv hauv lub plawv nqos lub plawv hloov pauv nrog kev nqhis dej ntawm cov neeg noj qab haus huv [52, 53]. Txawm hais tias qhov kev sib txuas tsis tuaj yeem raug pov thawj, ib tus tuaj yeem xav tias hauv cov neeg uas muaj kev nkag siab ntawm lub hauv paus, cuam tshuam rau peripheral paj hlwb teeb meem, thiab ib qho twb dysregulated ANS cov kev hloov pauv uas pom thaum lub sij hawm nqos ib txwm yuav nthuav dav thiab txawv txav, yog li ua rau muaj kev paub txog fibromyalgia- txuam dysphagia. Kev tshawb fawb ntxiv nyob rau hauv cheeb tsam no yog li lav tau los txhim kho peb txoj kev nkag siab ntawm tus mob no.
Thaum kawg, vim muaj qhov nyuaj ntawm fibromyalgia, ntau tus neeg mob tau sau ntau dua ib qho tshuaj los tswj ntau yam tsos mob thiab nrog rau kev kho mob thiab kev puas siab puas ntsws uas koom nrog fibromyalgia [54, 55]. Txawm hais tias qhov no polypharmacy tuaj yeem yog ib qho kev kho mob zoo rau cov neeg mob fibromyalgia, cov ntsiav tshuaj no yuav nyuaj rau kev noj ntawm qhov ncauj yog tias muaj teeb meem nqos, thiab cov kev mob tshwm sim tuaj yeem tshwm sim uas tuaj yeem cuam tshuam rau tus neeg mob kev noj qab haus huv thiab kev noj qab haus huv. Ntau cov tshuaj siv los kho mob fibromyalgia thiab lwm yam mob hauv nruab nrab muaj peev xwm ua rau xerostomia, tsaug zog, thiab plab hnyuv tuaj yeem ua rau muaj teeb meem nqos, noj mov nyuaj, thiab teeb meem kev sib txuas lus. Kev sib txuas lus zoo ntawm tus neeg mob thiab lawv cov kws kho mob yuav yog txoj hauv kev zoo tshaj plaws los tswj cov kev mob tshwm sim uas tau pom nrog polypharmacy. Tsis tas li ntawd, kev nkag siab txog tus neeg mob keeb kwm kev kho mob (nrog rau lawv cov tshuaj ua ntej thiab tam sim no), kev saib xyuas tsis tu ncua ntawm cov xwm txheej tsis zoo, thiab sib tham txog cov hom phiaj kev kho mob tuaj yeem siv los kho cov tshuaj kho mob zoo thaum sim txo qis kev cuam tshuam thiab cov kev mob tshwm sim. Kev siv tshuaj kho mob thiab nws yuav tsum tau pab txhawb rau / tshem tawm cov teeb meem nqos ntawm pab pawg no tau kawm ntxiv rau yav tom ntej kom tso cai rau kev txhim kho cov kev tswj hwm zoo rau pab pawg no.
Thaum qhov kev tshawb fawb no sawv cev rau thawj kauj ruam hauv peb txoj kev nkag siab ntawm fibromyalgia-associated dysphagia, tseem muaj qee qhov cuam tshuam rau kev kho mob thaum ntxov no. Piv txwv li., nws yog ib qho tseem ceeb uas cov kws kho mob paub txog lub peev xwm rau dysphagia ntawm cov neeg uas muaj fibromyalgia, thiab hais tias lawv npaj mloog thiab saib xyuas cov kev ua neej nyob ntawm lawv cov neeg mob, tawm tswv yim rau kev xa mus rau cov kws kho mob dysphagia (xws li, hais lus thiab Cov kws kho lus hais lus (SLTs)) tau xav tau, thiab pab txhawb thiab siv kev tshawb fawb yav tom ntej ntawm cov ncauj lus no raws li qhov tsim nyog. Tsis tas li ntawd, raws li qhov kev tshawb fawb no qhia tias pawg neeg ntawm cov neeg nyob nrog fibromyalgia uas nthuav tawm rau cov chaw kho mob muaj kev sib txawv thiab tam sim no tsis kho cov teeb meem noj thiab haus, nws yog ib qho tseem ceeb los tsim, ntxiv dag zog rau, thiab ua kom muaj kev sib raug zoo ntawm ntau tus kws kho mob xws li neurologists, rheumatologists, internists, kws kho hniav, SLTs, physiotherapists, dieticians, thiab lwm yam cov kws tshaj lij los txhim kho kev saib xyuas yav tom ntej
Kev txwv
Txawm hais tias txoj kev tshawb fawb no nthuav tawm thawj qhov kev sim los ntsuas qhov ntau ntawm kev noj mov, haus dej, thiab nqos cov teeb meem ntawm cov neeg laus uas muaj fibromyalgia, nws yog qhov ua tau kom nco ntsoov tias tsis muaj kev tshawb fawb tsis muaj kev txwv.
Txhawm rau pib, muaj qhov hloov pauv yav dhau los hauv kev kuaj mob ntawm fibromyalgia, nws cov npe cuam tshuam, thiab cov txheej txheem kuaj mob. Yog li ntawd, txoj hlua tshawb nrhiav tej zaum yuav tsis tau kuaj pom qee yam kev tshawb fawb uas tsis ua raws li cov qauv kev tshuaj ntsuam xyuas cov qauv siv. Tsis tas li ntawd, kev tshaj tawm kev tsis ncaj ncees kuj tseem tuaj yeem ntxiv rau kev tshawb nrhiav los ntawm kev tshawb nrhiav tsawg dua qhov kev tshawb fawb uas muaj peev xwm ua tau. Txawm li cas los xij, txhawm rau txo qhov peev xwm no, cov kws tshawb fawb tau tshawb fawb ntau cov ntaub ntawv, kev sib tham sib tham, thiab cov npe siv los ua kom muaj kev pab cuam ntawm kev tshawb fawb.
Tsis tas li ntawd, vim muaj tsawg tsawg ntawm cov kev tshawb fawb muaj nyob rau hauv cov ncauj lus no, cov qauv piv txwv uas suav nrog hauv kev tshuaj ntsuam me me, thiab kev kawm tsim qauv thiab cov pej xeem tau sib txawv. Qhov no txwv tus kws tshawb fawb lub peev xwm los ua qhov loj-loj ntsuas ntsuas, yog li cuam tshuam cov kws tshawb fawb hauv kev teb cov lus nug tshawb fawb txaus.
Tsis tas li ntawd, FM yog qhov kev kuaj mob uas tuaj yeem pom hauv cov neeg mob uas muaj lwm yam kev mob nkeeg uas tuaj yeem ua rau noj, haus, thiab nqos cov teeb meem (xws li mob stroke, ntau yam sclerosis, rheumatologic disorders). Lub ntsiab lus no tseem ceeb vim tias txoj haujlwm tam sim no tsom rau cov kev tshawb fawb ua tiav hauv cov neeg mob FM, txawm li cas los xij, kev tshawb fawb nruj yav tom ntej tau lees paub los txheeb xyuas seb qhov ntxiv ntawm FM kuaj mob muaj teeb meem ntxiv thaum muaj cov kab mob sib kis no. Yog li ntawd, nws tuaj yeem ua ke nyob rau hauv cov teeb meem uas tuaj yeem ua rau nqos tau.
Thaum kawg, ntau cov tshuaj siv los kho FM tuaj yeem ua rau muaj kev phiv uas yuav ua rau noj, haus, thiab nqos teeb meem. Feem ntau cov kev tshawb fawb suav nrog hauv qhov kev tshuaj xyuas no tsis tau tswj xyuas kev siv cov tshuaj no hauv FM cov neeg txaus siab, thiab yog li qhov cuam tshuam ntawm cov tshuaj no rau kev txhim kho thiab kev saib xyuas kev noj haus, haus, thiab nqos cov teeb meem tsim nyog yuav tsum tau tshawb xyuas ntxiv.
Yog li ntawd, cov kev tshawb fawb yav tom ntej hauv cheeb tsam no yuav tsum siv zog los nrhiav cov qauv loj dua, cov neeg sawv cev ntawm cov neeg muaj mob fibromyalgia los pab txhawb kev tshawb fawb ntau dua thiab txhim khu kev qha ntawm qhov muaj ntau, xwm txheej, thiab kev ua neej nyob ntawm fibromyalgia-koom nrog dysphagia. Nws tau qhia tias cov kev tshawb fawb no tshawb xyuas lub luag haujlwm ntawm cov kab mob sib kis lossis cov tshuaj siv rau kev kho mob ntawm cov teeb meem no ntawm cov neeg uas muaj mob fibromyalgia-txog dysphagia, siv cov txheej txheem kuaj mob, hauv cov qauv neeg sawv cev loj. Qhov no yuav pab txhawb kev nkag siab ntau dua ntawm cov tsos mob tshwm sim hauv cov pab pawg no, nrog rau kev pom los txhim kho cov neeg mob hauv nruab nrab thiab pov thawj-raws li cov phiaj xwm kev tswj hwm yav tom ntej.
Cov lus xaus
Txoj kev tshawb no tau qhia tias cov ntaub ntawv tshawb fawb tsawg muaj nyob ntawm qhov muaj ntau thiab qhov xwm txheej ntawm dysphagia ntawm cov neeg laus nrog fibromyalgia. Txawm li cas los xij, txawm tias muaj kev tshawb fawb tsawg tsawg, cov kev tshawb fawb pom ntawm no qhia tias qhov no yog ib qho kev tshawb fawb tshiab uas yuav tsum tau muaj kev saib xyuas ntau dua yav tom ntej. Txoj kev tshawb no kuj tau txheeb xyuas cov txheej txheem kev txwv tsis pub dhau ntawm cov ntaub ntawv muaj uas yuav cuam tshuam rau cov txiaj ntsig ntawm cov txiaj ntsig, yog li rov hais dua qhov xav tau rau yav tom ntej thiab cov neeg mob coj kev tshawb fawb soj ntsuam cov kab mob sib kis, xwm txheej, cuam tshuam, thiab kev tswj hwm ntawm fbromylagiarelated noj thiab nqos cov teeb meem los xyuas kom meej. tias cov neeg mob tau txais kev txhawb nqa txaus los ua neej nyob nrog cov teeb meem no.
Nyiaj txiagOpen Access nyiaj txiag yog muab los ntawm IReL Consortium. Qhov project no tsis tau txais kev txhawb nqa los ntawm lwm cov nyiaj txiag.
Cov ntaub ntawv
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